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51 巻, 4 号
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三好 正規1975 年 51 巻 4 号 p. 193-201
発行日: 1975/04/20
公開日: 2012/09/24
ジャーナル フリーIt is well known that serum TSH levels are elevated in most patients with chronic thyroiditis, even if the patient exhibits normal thyroid function tests. The determination of serum TSH levels in these patients is thought to be the most sensitive indicator of subclinical hypothyroidism.
In this study, the hypophyseo-thyroid functions of untreated euthyroid patients with chronic thyroiditis were evaluated.
Serum T3 levels in most of these patients were raised or at high normal levels, although serum T4 levels were in the low normal range.. Serum T4 levels in patients with raised basal TSH were distruibted in the low normal range.
Hence, it is suggested that the decreased serum T3 stimulates TSH secretion which in turn stimulates T3 (and T4) secretion from the thyroid and the elevated T3 maintains the patient's euthyroid condition.
Basal TSH levels in these patients varied from 2.5 to 37.0 μU/ml and mean±SD was was 12.9±9.6 μU/ml. Thirteen out of 30 patients (43%) with normal free T4 indices showed elevated basal TSH levels.
TSH responses to TRH injection were exaggerated in all euthyroid patients with raised basal TSH levels, as well as in 11 out 14 patients (78.6%) with normal basal TSH levels as well. But the maximum TSH responses after TRH injection were well correlated with basal TSH levels (γ=0.79).
The percent increases of serum T3after TRH injection in those patients were less than those of the normal person, and there was no difference in T3 response between the normal TSH group and the group with raired TSH.
Eight patients who suffered from collagen diseases (SLE : 6, RA : 1, PSS : 1) without any evidence of thyroid disease also exhibited exaggerated TSH responses to TRH. In five out of these eight patients (62.5%) antithyroglobulin antibody was positive.This may indicate the presence of the so-called asymptomatic autoimmune thyroiditis in these patients.
It is suggested that the elevated basal TSH levels in euthyroid patients with chronic thyroiditis are a much more sensitive indicator of thyroid failure than any other routine thyroid function tests. Moreover, the exaggerateed TSH responses to TRH in patients with normal basal TSH levels indicated that the TRH-test is more useful for the detection of minimal thyroid failure, especially in patients having such conditions as asymptomatic automimune thyroiditis.抄録全体を表示PDF形式でダウンロード (1130K) -
奥野 巍一1975 年 51 巻 4 号 p. 202-208
発行日: 1975/04/20
公開日: 2012/09/24
ジャーナル フリーThe effect of various doses of glucagon on hyperglycemic action and insulin secretion was studied in 12 healthy volunteers to determine whether 1.0 mg of glucagon, the usual dose, is indeed necessary to obtain an adequate hyperglycemic response. For this purpose 2.0, 1.0, 0.5, 0.1 and 0.01 mg of glucagon (Novo) were used respectively to confirm the existence of a dose response relationship. Of these doses, three different doses were administered to one subject within a week after overnight fasting. Maximum increment of blood glucose was not statistically significant between 1.0 (32.5±4.4 mg/dl) and 0.01 mg (29.5±2.7 mg/dl), averaging about 30 mg/dl. The peak time of blood glucose concentration was 30 min. with 1.0 mg, and 10 min. with 0.01 mg. On the contrary, insulin secretion after glucagon injection decerased as the dose decreased. Maximum blood insulin (I RI) concentration was 69.7±17.2 pu/ml with 1.0 mg, and 25.3±11.3 μu/ml with 0.01 mg (p<0.05). The peak time of insulin concentration was 2 min. with 1.0 mg, and 10 min. with 0.01 mg. From these data it is concluded that the dose response relationship after intravenous glucagon injection of between 1.0 mg and 0.01 mg doses exist concerning insulin sercretion, but not concerning hyperglycemic response.抄録全体を表示PDF形式でダウンロード (646K) -
-高位中枢の感受性の日内変動について-上條 桂一, 鈴木 三章, 大原 弘通, 和田 武雄1975 年 51 巻 4 号 p. 209-216
発行日: 1975/04/20
公開日: 2012/09/24
ジャーナル フリーIn order to investigate the relationship if any between the circadian rhythm of the hypothalamic-pituitary-adrenal system and of feedback sensitivity in the hypothalamic-pituitary axis, temporal changes of serum corticoid level and of ACTH responsiveness to metyrapone were studied in 5 controls, 4 patients with loss of consciousness due to central nervous system diseases (Group A), 2 blind subjects (Group B) and 2 patients with psychiatric disorders accompanied with sleep-wake cycle disturbance (Group C).
Two patients in Group A with normal circadian rhythm of serum corticoid levels exhibited abnormal rhythm in ACTH responsiveness to metyrapone. In contrast, 2 other patients in Group A with normal rhythm in ACTH responsiveness to metyrapone exhibited abnormal circadian rhythms of serum corticoid levels. In spite of the disturbed circadian rhythm of serum corticoid levels, 2 patients in Group B showed normal rhythm. in ACTH responsiveness to metyrapone. Two patients in Group C exhibited abnormalities in both circadian changes.
It was concluded that there might be different control mechanisms between the circadian rhythmicity of the hypothalamic-pituitary-adrenal system and of the feedback sensitivity.抄録全体を表示PDF形式でダウンロード (860K) -
波佐谷 兼綱1975 年 51 巻 4 号 p. 217-227
発行日: 1975/04/20
公開日: 2012/09/24
ジャーナル フリー1) To clarify the role of adrenal enucleation on plasma renin activity (PRA), plasma renin substrate (PRS), PRA response to furosemide administration and vacular reaction to renin in adrenal regeneration hypertension (ARH), serial changes of PRA and PRS during adrenal regeneration, PRA response to furosemide administration, and pressor response to exogenous renin in ARH were investigated by comparison with those of intact rats, unilaterally adrenalectomized rats, and unilaterally nephroadrenalectomized rats with contralateral adrenalectomy or with contralateral adrenal exploration (control) on both tap water and high sodium intake.
2) The control rats drinking saline, when compared with intact rats drinking tap water, showed significant decreases in PRA and, concomitantly, significant increases in PRS throughout the experimental period. In the unilaterally nephroadrenalectomized rats drinking saline, two days after adrenal enucleation or adrenalectomy, a significant increase in PRA, with a concomitant decrease in PRS, was observed. Those changes were less pronounced in the adrenal enucleated group than in the adrenalectomized group. Ten days later PRA markedly decreased to the control level in both groups. PRS rose to the control level on the 10th day after adrenal enucleation without increasing further, while that in the adrenalectomi zed group remained as low as before.
3) No significant differences in any of the experimental groups were found in diuresis, natriuresis, or in changes in body weight and hem atocrit during the one and a half hours after furosemide administration performed at the 9th experimental week. The basal PRA was significantly decreased in the other groups with unilateral nephroadrenalectomy and/or a high sodium intake as compared with the unilaterally adrenalectomized rats drinking tap water. The decrease in basal PRA was much more pronounced in the unilaterally nephroadrenalectomized rats drinking saline, with or without adrenal enucleation. After furosemide administration, PRA significantly increased in the unilaterally adrenalectomized rats drinking saline as well as in the unilaterally nephro adrenalectomized rats drinking tap water, with or without adrenal enucleation, while PRA values in three groups were only a half of the unilaterally adrenalectomized rats drinking tap water. An insignificant increase was found in the unilaterally nephroadrenalectomized rats drinking saline, independent of adrenal enucleation.
4) Pressor responses to hog renin in rats with ARH at the 10th postoperative day, and the 4th and 9th postoperative week did not show any significant differences as compared with those of intact rats drinking tap water and unilaterally nephroadrenalectomized rats drinking saline.
5) The effects of adrenal enucleation on PRA, PRS, PRA response to furosemide administration and pressor response to renin in ARH were discussed based on the observed results.抄録全体を表示PDF形式でダウンロード (1246K) -
第1編 : 情動刺激 (novel stimulus) とplasma corticosteroneの変動について北中 勇1975 年 51 巻 4 号 p. 228-239
発行日: 1975/04/20
公開日: 2012/09/24
ジャーナル フリーThe effect of emotional stress on the pituitary-adrenocortical system in the rat was studied. Hall's open field apparatus was used to give a novel stimulus, a mild and purely not show any signifidcant differences among all the experimental groups.
psychological stimulus produced by a novel environment. Animals were male albino rats of the Wistar-strain, bred in groups and weighing about 250 gm. They were taken out of their home cage and placed gently in the centre of an open field, a novel environment. After a certain period of time, they were returnend to the cage and decapitated. Plasma corticosterone was determined by the fluorometric method of van der Vies. The results were as follows :
1. When the animals were exposed to the novel stimulus for 3 min., plasma corticosterone showed a definite increase 15 min. after the end of the stimulus, reached a maximal level at 30 min. and returned to the resting level at 60 min.
2. When the duration of the stimulus, i.e. time spent in the open field, was changed, a 15min.-stay in the field gave the maximal rise of plasma corticosterone and 30, 45, 60min.-stays maintained the plateau level. When the 3 min. open field test was repeated every day, the plasma coritcosterone response was definite in the first trial, but was suppressed at the second and absent at the third and fifth episodes. The results indicate that the acquisition of adaptation to a novel stimulus depends upon the repetition, but not upon the duration of the stimulus.
3. Plasma corticosterone responded in the same manner as in the standard open field test, even when olfactory, visual and rpecial factorr were changed. This indicates that no special cue (s) is responsible for the adrenocortical response to a novel stimulus.
4. The pretreatment of the animals with tranquilizers such as chloropromazine and diazepam showed no inhibitory effect on the plasma corticosterone rerponse to novel stimulus.抄録全体を表示PDF形式でダウンロード (1413K) -
第2編 : 情動刺激の種類および生体側の情動状態の相違のplasma corticosteroneの反応に及ぼす影響北中 勇1975 年 51 巻 4 号 p. 240-246
発行日: 1975/04/20
公開日: 2012/09/24
ジャーナル フリーIn the previous paper the author described the effect of one kind of emotional stress (novel stimulus) on adrenocortical activity. In this study, two experiments were performed; the first experiment was to determine the relationship between the emotional state and adrenocortical response. The second experiment was to compare the effects of different kinds of emotional stress on corticosterone response.
1. An abnormal emotional state, i.e. a hyperemotional state, was induced by raising animals in a solitary condition for 3 weeks. Both group- and single-housed rats were subjected to repeated 3-min open field tests every day. At the first exposure to the stimulus, both rats responded with an almost indentical rise of plasma corticosterone. In contrast with the group-housed animals, in which plasma corticosterone response to the stimulus diminished progressively during the repeated trials, plasma corticosterone in the single-housed rats continued to respond with almost the same magnitude as in the first trial. This indicates a defect in adaptation to a novel stimulus in rats raised alone.
2. Another type of emotional stress (communicated anxiety) was produced by an apparatus, called a communication box, in which test animals can sense the reaction of foot-shocked animals in the neighboring compartments. In contrast with the novel stimulus in the open field, the effect of communicated anxiety on plasma corticosterone did not diminish by repetition of the stimulus. This suggests that adaptation to a communicated anxiety stimulus is difficult to acquire as compared to that of a novel stimulus.抄録全体を表示PDF形式でダウンロード (783K)
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