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60 巻, 5 号
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松岡 賢光, 井村 裕夫, 麻生 武志, 奥田 喜代司1984 年 60 巻 5 号 p. 647-658
発行日: 1984/05/20
公開日: 2012/09/24
ジャーナル フリーPlasma hormonal changes were analysed in patients with hyperprolactinemia who conceived following Bromocriptine therapy. Following the administration of HMG-HCG and Bromocriptine, serial plasma samples were collected from the cases. Plasma levels of FSH, LH, prolactin (PRL), estrone (E1), estradiol (E2), 17-hydroxyprogesterone (17-P), 20a-dihydroprogesterone (20α-P), progesterone (P) were determined simultaneously using specific radioimmunoassays. Pretreatment PRL levels, 180-420 ng/ml, were normalized by 7.5-12.5 mg/day of Bromocriptine treatment causing a rapid decrease in plasma PRL, reaching a plateau within several days. The first LH surge at midcycle after the start of the Bromocriptine treatment was established at 10-50 days. In the patients the first midcycle LH surge was observed, but the luteal phase was definitely short, as demonstrated by plasma progestins levels. The results from the present longitudinal studies on hyperprolactinemia revealed characteristic changes accompanied by the restoration of the hypothalamic-pituitary-ovarian function during the treatment period.抄録全体を表示PDF形式でダウンロード (1069K) -
真鍋 亮子, 本多 正信, 波多野 道信1984 年 60 巻 5 号 p. 659-671
発行日: 1984/05/20
公開日: 2012/09/24
ジャーナル フリーIn this study, the effects of angiotensin II (A II, Asn-Arg-Val-Tyr-Val-His-Pro-Phe) and angiotensin III (A III, Arg-Val-Tyr-Ile-His-Pro-Phe) on blood pressure (B.P.), pulse rate, several hormones [plasma renin activity (PRA), plasma aldosterone (PA), ACTH, plasma cortisol (PC), urinary catecholamines and urinary aldosterone] and urinary electrolytes were investigated in 9 male patients with essential hypertension [mean age 36.2 ± 4.1 (S.E.) years]. A II and A III infusions (8 ng/kg/min, 60 min) were started from 0900h and blood samples were drawn before, at 15, 30, 45, 60 min after the beginning of the infusions, and at 15 min after their cessation.
Urinary samples were collected within 2 hrs before and after the infusions, respectively.
A II significantly increased B.P. (p<0.01) during the infusions, whereas A III did not increase B.P.
PRA significantly decreased after the infusions of A II and A III (p<0.05), but the potency of A II was significantly greater than that of A III (p<0.01).
PA was increased after both infusions, but in response to A III, a peak was observed at 30 min after the infusion and subsequently, the levels decreased gradually. Significant differences between both responses were found at 45 and 60 min (p<0.05) after the infusions.
ACTH was unchanged during the infusions, but PC was equipotentially suppressed during the infusions, with the suppression of A II being similar to that of A III.
In the responses of urinary catecholamines, noradrenaline and dopamine were equipotentially decreased after the infusions (p<0.05).
The results of the present study clearly indicate that several differences exist between the biological activities of A II and those of A III. Further systematic experimental studies are needed to resolve the details.抄録全体を表示PDF形式でダウンロード (948K) -
深澤 洋, 桜田 俊郎, 吉田 克己, 山本 蒔子, 海瀬 和郎, 海瀬 信子, 貴田岡 博史, 鈴木 道子, 野村 隆, 斉藤 慎太郎, ...1984 年 60 巻 5 号 p. 672-683
発行日: 1984/05/20
公開日: 2012/09/24
ジャーナル フリーIn a previous study, we showed that immunosuppressive acidic protein (IAP) was markedly increased in the acute phase in patients with subacute thyroiditis (SAT).
In order to investigate the immunological abnormalities in SAT, peripheral K lymphocytes in SAT and hyperthyroidism were measured by the plaque-forming technique using sheep-red-blood cells as a target. The effect of the patients' serum on K-cells in normal lymphocytes was also investigated.
The percentages of K-cells in 5 patients with SAT in the acute and recovery phases were 2.3 ± 1.9 (mean ± S.D.) and 5.3 ± 2.2%, respectively. The former was significantly lower than the latter (p<0.05). Furthermore, the value in the acute phase showed a significant decrease against that of the normal controls (7.3 ± 3.4, n = 14, p<0.01).
The percentage of K-cells in 16 patients with hyperthyroidism was 2.8 ± 2.2%, which was also significantly lower than that of the normal controls (p<0.05).
The degree of inhibition of K-cells in normal lymphocytes by sera from 12 SAT in the acute and recovery phases was 69 ± 21% and 35 ± 22%, respectively, which was significantly higher (p<0.01 and p<0.05, respectively) than that in 12 normal sera (15 ± 20%). Furthermore, the inhibition was markedly higher in the acute phase than in the recovery (p<0.01).
The sera from 10 patients with hyperthyroidism also inhibited K-cells of normal lymphocytes (p<0.01).
It was suggested tht in the sera of SAT and hyperthyroidism there is some factor which inhibits K-cells.抄録全体を表示PDF形式でダウンロード (1121K) -
衛藤 雅昭, 渡辺 清, 加賀谷 寿孝, 酒井 芳紀, 吉田 征子, 大山 公三, 二木 源, 斉藤 達也, 建部 高明, 石井 兼央1984 年 60 巻 5 号 p. 684-695
発行日: 1984/05/20
公開日: 2012/09/24
ジャーナル フリーThe effect of long-term oral synthetic protease inhibitor (FOY 305) administration on fasting blood sugar (FBS), body weight, glucose tolerance, plasma insulin and glucagon levels, pancreatic insulin and glucagon contents, hepatic enzyme activities, and plasma lipids in normal and streptozotocin (STZ) -induced diabetic rats was studied.
Normal rats treated with oral FOY 305 for 9 weeks were found to have pancreatic hypertrophy and decreased body weight gain as compared with the untreated normal controls. FBS, glucose tolerance, plasma insulin and glucagon levels, pancreatic insulin and glucagon contents, and plasma lipids were uninfluenced in FOY 305 treated normal rats. STZ-induced diabetic rats treated with oral FOY 305 were found to have decreased FBS for 5 weeks after the beginning of FOY 305 administration as compared with the untreated diabetic controls, whereas at the 7th and 9th week after treatment there was no difference in FBS between FOY 305 treated and untreated diabetic rats. In the metabolic balance ob-served at the 4th week after treatment, a slight improvement of the diabetic state was found in FOY 305 treated diabetic rats. There was no apparent difference in the blood sugar curve and insulin response following oral glucose load between diabetic rats treated for 7 weeks and untreated diabetic rats.
All the rats were sacrificed after 9 weeks of treatment. Diabetic rats treated with oral FOY 305 for 9 weeks showed pancreatic hypertrophy and decreased plasma glucagon level and decreased pancreatic glucagon content as compared with the untreated diabetic controls, whereas there was no difference in body weight, plasma insulin level and pancreatic insulin content between FOY 305 treated and untreated diabetic rats. Furthermore, oral FOY 305 treatment improved hyperlipidemia in STZ-induced diabetic rats and also significantly improved the hepatic pyruvate kinase and phosphoenlpyruvate carboxykinase activities of diabetic rats.
These improvements might partly be due to a decreased pancreatic content and secretion of glucagon and/or a direct action of the synthetic PI, FOY 305 to tissues.抄録全体を表示PDF形式でダウンロード (1014K) -
川崎 晃一, 中牟田 澄子, 村谷 博美, 尾前 照雄1984 年 60 巻 5 号 p. 696-705
発行日: 1984/05/20
公開日: 2012/09/24
ジャーナル フリーA method of radioimmunoassay for urinary aldosterone excretion (AER) using 125 I-labeled ligand [ALDOCTK-125KIT] is described. The sensitivity, specificity, reproducibility and accuracy of this method were compared with the 3H-RIA method previously reported. Since the extraction method using ALDOCTK-125KIT was considered to be preferable to the direct method, the former method was applied to the present study. An excellent cor-relation was found between the values determined by the 3H-RIA method and the extraction method (r = 0.935, p<0.001, Y = 0.89X + 0.80, n= 146). The within-assay and the between-assay coefficient of variation was 7.7 - 15.0% and 9.7-12.2%, respectively.
As a clinical application, the circadian variation of AER was investigated in 5 control subjects and groups of essential hypertension (EHT), primary aldosteronism (PA), chronic glomerulonephritis (CGN) and Cushing's syndrome, each of which consisted of 5 patients, all of which had serum creatinine concentrations of less than 1.2 mg/dl. Under a control diet containing 10 g of salt per day, urine was collected in 4-hour pools starting at 8 : 00 for the ensuing 24 hours, and AER was determined by means of both 3H-RIA and the extraction method. The difference of the values between the peak and the nadir in each subject was statistically significant, and marked and identical circadian variations of AER with the peak and the nadir at the period of 4 : 00 to 12 : 00 and 20 : 00 to 4 : 00 were observed in the control, EHT, PA and CGN groups. In the Cushing group, however, the circadian variation of AER was different from the other 4 groups : the peak and the nadir of AER occurred at the period of 20 : 00 to 24 : 00 and 4 : 00 to 8 : 00, respectively. The circadian variation of AER became more obvious in all groups including the Cushing, when each value was expressed in the percentage of the mean.
AER under the control diet was 9.38 ± 2.04 μg/day in the control subjects. In PA and CGN, AER was significantly higher, and in the Cushing group, it was significantly lower than that observed in the control. However, no difference was found in AER between the control and EHT.
AERs in both 4-hour and 24-hour urine specimens measured by ALDOCTK-125KIT were consistent with those by the 3H-RIA method.抄録全体を表示PDF形式でダウンロード (854K) -
前坂 機江, 立花 克彦, 諏訪 〓三1984 年 60 巻 5 号 p. 706-715
発行日: 1984/05/20
公開日: 2012/09/24
ジャーナル フリーBasal and LH-RH induced plasma FSH and LH levels were determined longitudinally in 41 patients aged 4 to 22 years with Turner's syndrome and in 4 male patients with prepubertal castration. In 12 patients with Turner's syndrome over 18 yrs of age without pubertal change, basal and LH-RH induced FSH levels studied at age 11 - 22 yrs were all significantly increased over normal levels. However, some of these patients had normal basal and LH-RH induced LH levels. In 5 patients with mosaic Turner's syndrome with spontaneous puberty, basal and LH-RH induced FSH and LH levels studied at age 6 - 12 yrs were always within the normal range for age-matched controls. In 10 patients studied at age 11 - 18 yrs, basal and LH-RH induced FSH levels were also strikingly increased over normal levels except for one patient. This patient had normal basal FSH and LH levels and serum estradiol level was increased from 49 to 199 pg/ml after HMG test. In 14 patients aged 4 10 years, nine patients had elevated basal FSH levels and abnormally high responses to LH-RH. The remaining 5 patients had normal basal FSH levels, and 3 of them also had normal FSH responses to LH-RH. The data on the 5 patients studied again at the age of >13 yrs rose to high levels in adult castrated ranges. In 24 patients aged 4 to 17 years, 23 patients were thought to have no ovarian function, and one was thought to have spontaneous puberty.
In 4 male patients with prepubertal castration, basal and LH-RH induced FSH levels were increased over normal levels after 11 yrs of age. However, basal LH levels in some patients were within the normal range for age-matched controls after 12 yrs of age. From these results, we conclude that basal and LH-RH induced FSH levels may provide definitive evidence of absent ovaries or testes in patients over 11 yrs of age with primary hypogonadism.抄録全体を表示PDF形式でダウンロード (906K) -
山門 実1984 年 60 巻 5 号 p. 716-726
発行日: 1984/05/20
公開日: 2012/09/24
ジャーナル フリーThis study was designed to examine the effects of aldosterone on the distribution of extracellular fluid between the intra- and extra-vascular compartments, and to relate the changes in the fluid distribution to blood pressure in nephrectomized and nephrectomized-adrenalectomized male Wistar rats.
Polyethylene catheters were inserted into the right common carotid artery and the right jugular vein, and bilateral nephrectomy with or without adrenalectomy was performed. The animals were divided into three groups : 10 nephrectomized rats (NX), 10 nephrectomized-adrenalectomized rats (NX-AX), and 10 nephrectomized-adrenalectomized and aldosterone treated rats (NX-AX-A). Aldosterone (250μg/rat : Aldocorten, Ciba), mixed with sesame oil, was given subcutaneously in the NX-AX-A. After these procedures, food and water were withheld. Twenty four hours later, blood pressure and body fluid volumes were measured in the unanesthetized unrestricted condition. Mean arterial pressure (MAP) was directly recorded through the carotid catheter using electric manomater. Plasma volume (PV) and extracellular fluid volume (ECFV) were measured according to the dilution principle using 131 I-RISA and 35 S-Na2SO4, respectively. Interstitial fluid volume (IF) defined as ECFV minus PV and PV/IF ratio was also calculated. In NX, NX-AX and NX-AX-A, the transcapillary escape rate of albumin (TER) was determined after 6 hours. TER was obtained by measuring the disappearance of intravenously injected 131 I-RISA for 2 hours after injection.
The initial body weight and the changes in body weight were similar among the three groups. MAP was definitely higher in the NX than in the NX-AX and the NX-AX-A. More-over, it was significantly higher in the NX-AX-A than in the NX-AX (p<0.001). Although ECFV and IF were equally and significantly reduced in the NX-AX-A and the NX-AX as compared to the NX, PV was significantly higher in the NX-AX-A than in the NX-AX (p<0.01), leading to a significantly lower PV/IF ratio in the latter than in the former (p<0.02). When a relationship between MAP and PV was examined in the rats as a whole, a significant positive correlation was found between the two parameters (r = 0.69, p<0.001). This relationship still held in the NX-AX and the NX-AX-A in combination (r= 0.69, p<0.001). TER was significantly higher in the NX AX than in the others (p<0.001 vs NX, and p<0.02 vs NX-AX-A).
These results suggest that aldosterone may redistribute the extracellular fluid between the intra- and extravascular (interstitial) compartments so as to maintain the intravascular volume, partly inhibiting the transcapillary escape rate of albumin, and that the extrarenal effect of this hormone, together with its renal effect, may contribute to the blood pressure homeostasis.抄録全体を表示PDF形式でダウンロード (1087K)
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