巻号一覧
73 巻 (1997)
- 6 号 p. 591-
- 5 号 p. 15-
- 4 号 p. 503-
- 3 号 p. 409-
- 2 号 p. 24-
- 1 号 p. 1-
前身誌
73 巻, 3 号
選択された号の論文の9件中1～9を表示しています
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稲田 満夫1997 年 73 巻 3 号 p. 409-422
発行日: 1997/05/20
公開日: 2012/09/24
ジャーナル フリーPDF形式でダウンロード (1433K) -
福地 総逸1997 年 73 巻 3 号 p. 423-429
発行日: 1997/05/20
公開日: 2012/09/24
ジャーナル フリーSelective hypoaldosteronism is the syndrome with hyperkalemia due to aldosterone deficiency without lack of the other steroids. The syndrome is classified to two types: primary selective hypoaldosteronism caused by congenital (familiar) or acquired defect in aldosterone biosynthesis resulting in high renin activity; and secondary selective hypoaldosteronism caused by primary deficiency of renin production or storage in juxtaglomerular apparatus resulted from chronic renal disorder, such as diabetic nephropathy, in addition to which adrenal defects in aldosterone biosynthesis are also detected. On the other hand, pseudoaldosteronism is caused by congenital or acquired disorder in aldosterone receptors of renal tubules, with normal aldosterone biosynthesis in adrenal glomerular cells.
It is suggested that a selective lack of aldosterone should be considered in all cases of otherwise unexplained hyperkalemia.抄録全体を表示PDF形式でダウンロード (726K) -
治療による諸ホルモンの変動松田 彰, 紅粉 睦男, 伊古田 明美, 山崎 雅勇, 小泉 茂樹, 水本 博章, 渡辺 武夫, 松谷 久美子, 国田 晴彦, 真尾 泰生1997 年 73 巻 3 号 p. 431-438
発行日: 1997/05/20
公開日: 2012/09/24
ジャーナル フリーThe subject of our study was a 53-year-old Japanese man who complained of being easily fatigued, edema and bradypragia (sluggish movements). The symptoms gradually appeared from early August 1994. A physical examination of the patient on September 22 revealed mild edema of the lower limbs. His serum free T4 level was 0.47 ng/dl, and serum TSH levels were 7.53μU/ml. The patient was diagnosed with hypothyroidism and was treated with 1-thyroxine (25μg/day). The edema diminished slightly, but other symptoms did not change. The patient was admitted to our hospital to rule out the possibility of hypopituitarism. He had no relevant experiences or family history. The basic level of TSH was slightly elevated, while the levels of serum and urine cortisol, 17-OHCS, and parathyroid hormone were low. The pituitary hormones tolerance tests showed no response to ACTH and low response to GH. As a result of continuous ACTH stimulation, serum cortisol level increased. Partial hypopituitarism (ACTH and GH) was suspected, and supplementary cortisol therapy was started. The pituitary hormones tolerance tests demonstrated a normal response to GH, and TSH returned to a normal level after the therapy. Since no abnormalities of the pituitary gland were detected in the MRI, he was diagnosed as isolated ACTH deficiency. Since urinary Ca excretion and intact-PTH increased after the supplementary therapy, we presume that it is the lack of inhibitory action of Ca reabsorption at the renal tubules due to the hypocortisolism. Relative hyperphosphatemia was caused by hypoparathyroidism associated with hypercalcemia. Inhibition of Ca reabsorption at the renal tubules seems to be the most important action of cortisol for the regulation of serum Ca level.抄録全体を表示PDF形式でダウンロード (737K) -
南部 昭1997 年 73 巻 3 号 p. 439-449
発行日: 1997/05/20
公開日: 2012/09/24
ジャーナル フリーEndogenous nitric oxide (NO), identified as one of the endothelium-derived relaxing factors, exists not only in the vascular endothelium, but also in other organs and tissues including the brain. Although the physiological roles of NO are not clearly defined yet, NO may be involved in the pressor mechanisms of salt loaded hypertension. To study the role of brain NO in the cardiovascular regulation of salt loaded hypertension, we measured semiquantitatively the constitutive NO synthase (cNOS) messenger RNA in salt-restricted or salt-loaded rats, and DOCA-salt hypertensive rats by using a reverse transcription-polymerase chain reaction. Relative expression levels of cNOS messenger RNA in the hypothalamus of the DOCA-salt hypertensive rats were significantly reduced as compared to those in the control rats, whereas urinary excretions of arginine vasopressin and norepinephrine were significantly increased in DOCA-salt hypertension. cNOS messenger RNA in the hypothalamus of salt-restricted rats showed a tendency to increase as compared to those in the high salt loaded rats. These results suggest that NO synthesized by cNOS in the hypothalamus may attenuate both the vasopressin releases and sympathetic nervous activities, which result in the inhibition of the pressor mechanisms of salt loaded hypertension.抄録全体を表示PDF形式でダウンロード (1163K) -
今野 則道1997 年 73 巻 3 号 p. 451-461
発行日: 1997/05/20
公開日: 2012/09/24
ジャーナル フリーThe prevalence of subclinical autoimmune thyroid diseases (AITD) was investigated with determinations of highly sensitive anti-thyroid peroxidase antibody (TPOAb), anti-thyroglobulin antibody (TgAb) and thyroid stimulating hormone (TSH) in serum samples obtained from 2,647 ostensibly healthy subjects (1,887 males and 760 females, aged 46.0±10.4 years, Mean±SD) residing in Sapporo who were recruited at the hospital for medical examinations. The prevalence of thyroid autoantibodies (TAA) was 9.1% (n=242), among which 23.6% was TgAb positive only (>1.83 U/ml), while 46.3% was TPOAb positive only (>0.34 U/ml), and the remaining 32.2% were both TPOAb and TgAb positive. TAA was positive in 6.5% for males and 15.8% for females (P<0.001) with an age-related increase. The prevalence of subclinical hyperthyroidism (TSH<0.15 mU/L) was 0.79%, of which 42.1% was positive for TAA. The prevalence of subclinical hypothyroidism (TSH>5.0 mU/L) was 1.1%, of which 20% were TAA positive. The overall prevalence of subclinical autoimmune thyroiditis as defined by TAA positive eu- and hypothyroidism was 8.8%; 6.3% for males and 15.5% for females (P<0.001). There was a significant inverse correlation between TPOAb and TSH levels (r=-0.21, P<0.05, n=112) in subjects with TPOAb positive only and also a significant correlation between TgAb and TSH levels in subjects with positive TgAb with or without TPOAb (r=0.27, P<0.01, n=130). This study indicates that the combined analysis of TPOAb, TgAb and TSH may provide more accurate information on the prevalence of AITD in the population study.抄録全体を表示PDF形式でダウンロード (1098K) -
吉田 諭史, 瀬戸口 洋一, 山本 匡介, 梶原 進, 原 俊哉, 水田 敏彦, 福島 範子, 堺 隆弘, 藤山 千里1997 年 73 巻 3 号 p. 463-469
発行日: 1997/05/20
公開日: 2012/09/24
ジャーナル フリーThe suppression of anterior pituitary hormones with excessive glucocorticoids has been described by several investigators. To evaluate the effect of hypercortisolemia on the pituitary gland, we describe a 40-year-old woman with an adrenal adenoma causing Cushing's syndrome in whom pituitary function was estimated before and after successful removal of a left adrenal tumor.
She was admitted because of fatigue. Physical examination and laboratory data suggested Cushing's syndrome. No change in serum ACTH, an impaired response of serum GH and serum TSH, and a paradoxical rise in prolactin were recorded after administrations of insulin, TRH, and LH-RH suggested that the anterior pituitary functions were abnormal. In 1993, left adrenal gland (measuring 4.0×2.5cm) was resected. The tumor consisted of two parts: a reddish red brown cortical adenoma (4.0×2.5 cm) and white pheochromocytoma (0.8×0.7 cm).
One year after tumor excision, all pituitary hormonal responses to various stimuli had returned to normal. Thus, we report an extremely rare case of Cushing's syndrome (cortical adenoma) associated with pheochromocytoma showing as hypothyroidism.抄録全体を表示PDF形式でダウンロード (1199K) -
井樋 慶一, 菅原 明, 木村 時久, 阿部 圭志, 佐々木 毅1997 年 73 巻 3 号 p. 471-476
発行日: 1997/05/20
公開日: 2012/09/24
ジャーナル フリーThe CRF-test is quite useful in evaluating hypothalamic-pituitary-adrenal (HPA) function and used widely in clinical practice. Combined administration of CRF, TRH, LHRH, and GRF has been known to be feasible for assessing anterior pituitary function. Since the rapid ACTH-test is still a necessary adjunct for evaluation of adrenal function, we sought to examine whether simultaneous administration of ACTH had any significant effect on other anterior pituitary function tests, i.e., TRH-, LHRH-, and GRF-tests.
Provocative tests were carried out on 15 healthy volunteers using multiple hormones in the following combinations:(1) ACTH, GRF, TRH, LHRH;(2) GRF, TRH, LHRH;(3) TRH, LHRH; or (4) ACTH alone. After 30 min bed rest in the morning, blood was drawn for measurement of baseline hormone levels, then drugs were administered iv and blood was drawn after 15, 30, 45, 60, 90, and 120 min. Serum levels of anterior pituitary hormones and cortisol were measured by specific enzyme immunoassays.
ACTH administration in combination with GRF, TRH, and LHRH evoked significantly greater GH responses compared with combined administration of GRF, TRH, and LHRH. However, ACTH in combination with three other hormones had no significant effects on TSH, PRL, LH, or FSH responses. GRF administration in combination with TRH and LHRH did not affect significantly TSH, PRL, LH, or FSH responses compared with combined administration of TRH and LHRH. Finally, cortisol response following ACTH administration was not affected significantly by simultaneous administration of GRF, TRH, and LHRH. From these results it is proposed that combined administration of ACTH, TRH, and LHRH may be used as a single test. Combined administration of GRF, TRH, and LHRH may also be used as a single test. However, ACTH administration in combination with GRF may affect GH responses, and therefore, these two agents should be administered separately.抄録全体を表示PDF形式でダウンロード (554K) -
胎盤絨毛上皮刷子縁膜の血小板凝集阻止活性に及ぼす脂質過酸化の影響阪本 義晴1997 年 73 巻 3 号 p. 477-485
発行日: 1997/05/20
公開日: 2012/09/24
ジャーナル フリーThe influences of lipid peroxidation on the impairment of placental microcirculation in preeclampsia were studied.
Lipid peroxides and vitamin E concentrations in the blood and the placental brush border membrane (PBBM) of the women with preeclampsia were measured by the TBA and HPLC methods, and the platelet aggregation inhibitory activity and ADP degrading activity of PBBM were analyzed using Born's Method and 14C-ADP degrading assay. Lipid peroxides concentrations both in the blood and in the PBBM were significantly increased (p<0.001, p<0.01 respectively), but plasma vitamin E concentrations were significantly reduced (p<0.01) in the women with preeclampsia. Significant reduction of platelet aggregation inhibitory activity (p<0.005) and ADP degrading activity (p<0.001) of PBBM were observed in preeclampsia. The influences of artificial peroxidation of PBBM by tertiary-butylhydroperoxide (t-BHP) on the platelet aggregation inhibitory activity and ADP degrading activity of PBBM were investigated in vitro assay using normal PBBM. Significant reduction of platelet aggregation inhibitory activity (p<0.005) and ADP degrading activity (p<0.001) of PBBM were observed in this artificially peroxidated PBBM. The effects of vitamin E on the artificial peroxidation of t-BHP were also investigated in the same in vitro assay. Vitamin E prevented the artificial peroxidation of PBBM, and at the same time the platelet aggregation inhibitory activity and ADP degrading activity of PBBM were reduced depending on the concentration (p<0.005, p<0.001). Furthermore, high concentrated vitamin E (500 μg/ml) demonstrates platelet aggregation inhibitory activity by itself, and low concentrated vitamin E (20μg/ml) promotes the potential platelet aggregation inhibitory activity of PBBM.
These results suggests that lipid metabolism in the women with preeclampsia are under severe oxidative stress, and that in preeclampsia, the lipid peroxidation of PBBM plays an important role on the impaired placental microcirculation by reducing the platelet aggregation inhibitory activity, and vitamin E preserves the platelet aggregation inhibitory activity by preventing the lipid peroxidation of PBBM or by another mechanism.抄録全体を表示PDF形式でダウンロード (1070K) -
織田 直久, 澤井 喜邦, 伊藤 靖敏, 早川 伸樹, 加藤 律子, 嶋崎 恵子, 杢野 武彦, 小竹 素子, 西田 有子, 浜田 美智子, ...1997 年 73 巻 3 号 p. 487-493
発行日: 1997/05/20
公開日: 2012/09/24
ジャーナル フリーUsing three month-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats as a NIDDM model and Long-Evans Tokushima Otsuka (LETO) rats as the control, we examined the effect of ACEI on the onset of diabetes mellitus. Oral administration of captopril (ACEI) was started from the age of 13 to 32 weeks (A group) and from the age of 25 to 32 weeks (B group). Oral GTT (oGTT) was performed at 4-week intervals from 12 weeks to 32 weeks of the age in OLETF and LETO rats. Body weights did not change significantly in either the A or B groups, compared with that in the control group. In oGTT for OLETF rats at 28 and 32 weeks of age, blood glucose levels in the A group were lower at 120 min after glucose administration than those in the B and control groups. In LETO rats, there were no significant changes in blood glucose levels in oGTT in any group. GLUT4 protein concentrations in the skeletal muscle and adipocytes were not significantly changed in any group. These data suggest that ACEI improves the glucose intolerance in NIDDM model rats through some factor other than changes in GLUT4 concentrations.抄録全体を表示PDF形式でダウンロード (1057K)
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