巻号一覧
5 巻, 4 号
選択された号の論文の12件中1～12を表示しています
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YOSOJI ITO, MASATO SHINODA1958 年 5 巻 4 号 p. 221-226
発行日: 1958年
公開日: 2011/01/25
ジャーナル フリーThe influence of tryptic digestion on the biological activities of Parotin, the salivary gland hormone, were determined. The serum calcium level decreasing activity of Parotin was slowly diminished and almost destroyed after digestion for 24 hrs. by trypsin. The decreasing activity on the number of circulating leucocytes was rapidly diminished while the increasing acitivity of leucocytes was relatively resistant to the action of trypsin, and remained even after digestion for 24 hrs. The total serum protein decreasing activity of Parotin was not comparatively diminished by trypsin, and was shown no significance between digesting time and the activity.抄録全体を表示PDF形式でダウンロード (491K) -
YOSOJI ITO, MASATO SHINODA1958 年 5 巻 4 号 p. 227-231
発行日: 1958年
公開日: 2011/01/25
ジャーナル フリーThe influence of tryptic digestion on the chemical and physico-chemical properties of Parotin were determined. The free amino-nitrogen content in Parotin was rapidly increased within 1hr. The isoelectric point (pH 5.4) of Parotin was easily changed on the digestion. The ultraviolet absorption of the trichloroacetic acid soluble fraction in digested Parotin was rapidly increased. By the paper chromatography, 2 or more hydrolyzates were recognized in non-protein fraction of the digested Parotin.抄録全体を表示PDF形式でダウンロード (423K) -
KICHINOSUKE TATAI1958 年 5 巻 4 号 p. 232-242
発行日: 1958年
公開日: 2011/01/25
ジャーナル フリーCapillary resistance, plasma and urinary pepsinogen, and urine volume were determined in eight healthy young males, when they were treated with saline (S), chlorpromazine (CP), adrenaline (A), noradrenaline (NA), CP+A, and CP+NA. The resuts were as follows:
1. S and CP did not affect capillary resistance, while both A and NA raised it twice with an intervening fall. The first rise with A was lost by combination with CP, whereas the first rise with NA was not lost by combination with CP. This fact implies strongly that A and NA act differently on the peripheral vascular system, and also that certain catabolites of A and NA might participate in the second rise in capillary resistance.
2. A increased uropepsin excretion, but NA decreased it. However, neither A nor NA had any influence upon plasma pepsinogen. CP checked and delayed the initial rise in uropepsin with A, but CP+NA increased it in contrast to the effect of NA administration alone. CP did not affect urinary pepinogen, while it greatly raised urine volume. Both A and NA apparently counteracted the diuretic action of CP, although A seemed more effective than NA in this measure.抄録全体を表示PDF形式でダウンロード (797K) -
AN APPLICATION OF THE DIMENSION METHODFUSAKO MIZUHARA, TERUKO KAMEI, TOMOKO FUJII1958 年 5 巻 4 号 p. 243-246
発行日: 1958年
公開日: 2011/01/25
ジャーナル フリーA comparative study on the difference of estrous cycle among 5 strains of mice was made In order to demonstrate numerically the nature of the various sexual cycles, so called “dimension method” was devised by authors. Through the use of this method, the CFW strain is shown to be the superior strain as shows few individual differences and a nearly normal estrous cycle. In addition norm of the sexual cycle in mice was obtained. It has 4.5 frequencies of estrus and 636.3 dimensions in three weeks.抄録全体を表示PDF形式でダウンロード (334K) -
SHIGERU AONUMA, TAKAO HAMA1958 年 5 巻 4 号 p. 247-250
発行日: 1958年
公開日: 2011/01/25
ジャーナル フリーFrom the bovine heart muscle, two distinguishable fractions were obtained lead acetate method. One of them had the action of retarding heart function, and another the action of promoting heart function.
Various biological tests on these fractions were carried out. Especially about the extraction of the principle which retarded heart function, the better result than that in the previous paper was obtained.抄録全体を表示PDF形式でダウンロード (2131K) -
SHIGERU AONUMA, TAKAO HAMA1958 年 5 巻 4 号 p. 251-255
発行日: 1958年
公開日: 2011/01/25
ジャーナル フリーThe substance of retarding heart function was isolated by the lead acetate method from bovine heart muscle and then purified by alumina column chromatography and charcol treatment. This aqueous solution was pH 5.4 to 5.6 and possessed the remarkable action of retarding heart function. This solution affected normal heart nearly according to doses by Yagi-Straub perfusion method. On other hand, different result was observed on the heart which was weakened with chloralhydrate, i. e., this substance had promoting action on heart pretreated with chloralhydrate. The heart sensitized by the preadministration a little amount of this substance received hardly the action of chloralhydrate. One per cent solution of this substance had a stronger uterus contracting activity than 0.2 I. U. per cc solution of oxytocin. As for the depressor action, it played as a vasodilator of peripheral blood-vessel. LD50 was 0.002985±0.0004342g per mouse body weight (g) at a fiducial probability of 0.95.抄録全体を表示PDF形式でダウンロード (6834K) -
STUDIES ON SUBMAXILLARY GLAND XIISHIGERU AONUMA, TAKAO HAMA, HIROKO HONDA, YOSOJI ITO, MASATO SHINODA1958 年 5 巻 4 号 p. 256-264
発行日: 1958年
公開日: 2011/01/25
ジャーナル フリーThe activities of S-Parotin in aqueous solution were relatively stable against acid and alkaline. In solid state, S-Parotin could be stored for 4 years at room temperature without any remarkable loss of the activity. The activities reversiblly denaturated by urea. Ca-decreasing activity received non-reversible denaturation by guanidine hydrochloride, but Leucocytes decreasing and then increasing activity did not receive any denaturation. From the results of S-Parotin treated with nitrous acid, formaldehyde, iodine, cysteine and thioglycollic acid, it could concluded that there is no particularly responsible radical for the display of activities and the free amino radical and the tyrosine phenyl radical are responsible.抄録全体を表示PDF形式でダウンロード (692K) -
HIDEO MIZUNO, TATEKI CHIKAMUNE1958 年 5 巻 4 号 p. 265-272
発行日: 1958年
公開日: 2011/01/25
ジャーナル フリーThe effects of forced weaning on the respiratory activity of mammary slices in mice were investigated. The marked fall in oxygen consumption and R. Q. was observed after weaning. The fact that the non-removal of milk from the gland can be a factor responsible for such reduction of activity and further the possibility that the engorgement of milk might systemically inhibit the mammary activity were shown by the experiment using the technique of unilateral ligature of nipples. However, from the result of the renursing experiment, it was discussed that the lactogenic and mammogenic hormone (s) liberated from the anterior pituitary by the suckling stimulus might be effective for the maintenance of respiratory activity of the mammary gland. In conclusion, the removal of milk seems to play as well important role as the suckling stimulus for maintaining the mammary gland in the functional state.抄録全体を表示PDF形式でダウンロード (4335K) -
TAKUO FUJITA, JUN ISHII, KAZUO SHIZUME, AKITO NOGUCHI1958 年 5 巻 4 号 p. 273-276
発行日: 1958年
公開日: 2011/01/25
ジャーナル フリーCalcium tolerance test and calculation of “Parathyroid Index” was carried out on 8 hyperthyroid and 10 euthyroid subjects. Abnormal parathyroid response to hypercalcemia was observed in hyperthyroid subjects. Functional relationship between thyroid and parathyroid glands was briefly reviewed.抄録全体を表示PDF形式でダウンロード (373K) -
STUDIES ON THE SALIVARY GLAND HORMONES XXXVIYOSOJI ITO, YOUNG EUN KIM, SEIYU TANAKA1958 年 5 巻 4 号 p. 277-279
発行日: 1958年
公開日: 2011/01/25
ジャーナル フリーA Parotin-like substance, Saliva-Parotin-A, isolated from human saliva, was labeled with radioactive iodine. The biological activity of the radioiodinated Saliva-Parotin-A preparation was largely retained. Remarkably large amount of radioactivity was demonstrated in the kidney after the intravenous injection of I131-labeled Saliva-Parotin-A to rats. Only a small localization of radioactivity was found in the liver and spleen which were the main and characteristic sites of localization of radioactivity after the administration of the labeled Parotin to rats.抄録全体を表示PDF形式でダウンロード (246K) -
YOSOJI ITO, MASAAKI YAMAMOTO1958 年 5 巻 4 号 p. 280-288
発行日: 1958年
公開日: 2011/01/25
ジャーナル フリーBy the means of isoelectric precipitation, the crude U. P. which contains a constant potency of 2mg/kg was prepared from human urine, and this crude U. P. can be purified with ethanol fractionation to be a potential substance having two-fold activity and its recovery is almost 100%. According to the pattern of electrophoresis, this purified U. P. seemed to be a homogeneous but yet, it is considered that this substance may contain any other component, because further purifying effect was observed by ammonium sulfate fractionation. The further purification of purified U. P. by the method of ammonium sulfate fractionation is not yet enough, whereas some increase of the recovery of activity may be expected, so that the application of a more excellent purifying method must be sought for it.抄録全体を表示PDF形式でダウンロード (4901K) -
YOSOJI ITO, MASAAKI YAMAMOTO1958 年 5 巻 4 号 p. 289-297
発行日: 1958年
公開日: 2011/01/25
ジャーナル フリーU. P. was purified easily by alumina column chromatography to obtain the highly purified preparation in good yield. In human U. P., a preparation whose activity was 100γ per kg, was obtained with the yield of 1.0-1.2mg per 1. and in rabbit U. P., a preparation was obtained, whose estimated values were 100γ per kg as the activity, and 5-6mg per 1. as the yield. It was, however, observed that even with the most purified active preparation of human U. P., the chemical homogeneity was not obtained; slight contamination with any other component was observed with ultracentrifugical pattern. The isoelectric point of human U. P. was estimated as pH 2.3 by using buffer solution (μ=0.5), and acid-proteinlike properties were observed.抄録全体を表示PDF形式でダウンロード (4604K)
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