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Volume 7 (1960)
- Issue 4 Pages 261-
- Issue 3 Pages 175-
- Issue 2 Pages 91-
- Issue 1 Pages 1-
Volume 7, Issue 1
Displaying 1-12 of 12 articles from this issue
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AKIRA YOKOYAMA, KATSUAKI ÔTA1960 Volume 7 Issue 1 Pages 1-7
Published: 1960
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESSThe mammary glands of rats which kept intact for 8 days after the removal of the litter on the 7th day of lactation, consisted only of islands of cell clusters which were remnants of ducts. An administration of oxytocin prevented the involutional change slightly which followed weaning. On the other hand, the relatively good preservation of the alveolar system, which seemed to be ascribed to the sucking stimuli, was observed in the rats which had hypothalamic lesions, and failed in rearing. In spite of the well preserved alveolar systems of the mammary gland in the rearing-failed lesioned rats, the values of the R. Q. were lower than unity.
The animals with hypothalamic lesions were subjected to the replacement with oxytocin. The more evident preservation of mammary secretory systems was observed than the rearing-failed lesioned animals without oxytocin replacement. The R. Q. of the mammary glands of the rats replaced with oxytocin remained in a high level.
It seems reasonable to infer that the histological integrity is maintained by prolactin secreted from the anterior pituitary through the suckling stimulus, and in order to maintain a high synthetic activity of the secretory cells, the removal of accumulated products in the alveoli is required in addition to the suckling stimulus.View full abstractDownload PDF (4517K) -
KIYOSHI YAMAMOTO1960 Volume 7 Issue 1 Pages 8-12
Published: 1960
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESSSome enzyme activities of the tadpole tail of Rana japonica were studied for the period of metamorphosis induced by thyroid feeding. The activity of succinic and glutamic dehydrogenases diminished prior to the onset of metamorphosis, while the activity of aspartic-α-ketoglutaric transaminase and protease did not show any significant fluctuation. With these observations as a basis, the mechanism of the resorption of the tail mass was discussed.View full abstractDownload PDF (489K) -
SUMIO SAITO, FRANCA TANI1960 Volume 7 Issue 1 Pages 13-18
Published: 1960
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESSCrude material extracted from urine of normal human subjects and from the hypothalamus of dogs was separated with paper chromatography and with zone electrophoresis.This material (TRF) has no ACTH-releasing, vasopressor, or oxytocic activity and very little antidiuretic property, and was active only on the thyroid.
It is suggested that the active substance (TRF) may be one of the chemically related peptides present in the hypothalamic-neurohypophysial region and transported to the adenohypophysis via portal or systemic circulation.View full abstractDownload PDF (1760K) -
SHIGEO OKINAKA, HIROSHI IBAYASHI, KENJI MOTOHASHI, TAKUO FUJITA, SHO Y ...1960 Volume 7 Issue 1 Pages 19-24
Published: 1960
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESSSecretion of 17-hydroxycorticosterone and corlicosterone from adrenal venous blood of a dog was investigated using Bush's benzene-methanol-water system of paper chromatography. Stimulation of splanchnic nerve resulted in a significant increase of 17-hydroxycorticosterone and decrease of corticosterone resulting in a marked increase of F/B ratio. This effect was abolished by hypophysectomy and restored by maintenance with ACTH. Stimulation of 17-hydroxylation in adrenal cortical hormone biosynthesis is suggested as the mechanism of splanchnic nerve action.View full abstractDownload PDF (598K) -
MOTOTAKA MURAKAMI, KYUICHI KURAKANE, RYOYU TAKEDA, MASAKAGE KIMURA, HI ...1960 Volume 7 Issue 1 Pages 25-33
Published: 1960
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESSThe adrenocortical function in patients with hypertension, myocardial infarction, and angina pectoris was investigated.
1) These patients had higher plasma levels of cortisol than normal sub jects, and after ACTH infusion, the plasma levels of cortisol rose higher than normal.
2) The increase of urinary 17-hydroxycorticosteroids was not always so marked as that of the plasma levels of cortisol, but after ACTH-Z injection, the excretion of 17-hydroxycorticosteroids increased much more than normal, indicating adrenocortical hyperactivity.
3) The excretion of 17-ketosteroids was found to be decreased in these patients.
4) The disappearance of exogenous cortisol from plasma lagged in these patients.
5) From these results, it was suggested that the elevation of plasma levels of cortisol in these patients is due in part to modified metabolism of cortisol.
6) Certain clinical evidences relevant to these data were discussed.View full abstractDownload PDF (701K) -
JIRO NAGAI1960 Volume 7 Issue 1 Pages 34-38
Published: 1960
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESSThe mammary growth in normal female mice treated with estrogen was compared with that in intact female mice as a side work of breeding experiment in mice with special reference to the sensitivity of mammary gland. Half of females produced from 18 parents were injected with a standard dose of estrogen and the other half were kept without any treatment until 35 days after birth.
Results obtained are as follows:
1. No difference was found in body weight between treated and intact female mice on both 20 days and 35 days after birth.
2. Differences of mammary gland area and uterine weight were found between two groups.
3. Variance of mammary gland area in treated mice seemed to be smaller than that in intact mice. The fact might be caused by the decrease of relative variation of amount of estrogen acting on the mammary gland.View full abstractDownload PDF (494K) -
L. S. RAMASWAMI, A. B. LAKSHMAN1960 Volume 7 Issue 1 Pages 39-44
Published: 1960
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESSDownload PDF (575K) -
HISAAKI IWASAWA1960 Volume 7 Issue 1 Pages 45-52
Published: 1960
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESSUsing the adult frogs collected from various places of Japan as materials, form, size and position of the thyroid glands were observed. Specific difference in the thyroid gland was clearly found in all species examined, although local variation was also conspicuous in every species, though in lesser degree. Therefore introduction of the thyroid gland as one of characters in anuran classification seems to be useful in practice at least in certain cases.View full abstractDownload PDF (6272K) -
KYUTARO MAEKAWA1960 Volume 7 Issue 1 Pages 53-56
Published: 1960
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESSImmature ovaries transplanted to the spleen of gonadectomized immature rats of both sexes underwent an accelerated development within 15 days producing follicles of varying sizes and corpora lutea. This suggests that a minute amount of androgen or estrogen secreted by the gonad in immature animals is effective in exerting a regulatory influence on the hypophyseal gonadotrophic function.
Injections of minute doses of estrogen or androgen which were incapable of exerting any noticeable effects on the growth of sexual accessories (2.0μg daily of testosterone propionate or 0.03μg daily of estrone) were effective in inhibiting the above-mentioned postcastrational rise of gonadotrophic activity of the hypophysis in immature rats, as evidenced by the behavior of intrasplenic ovarian transplants.
It seems probable that a hormonal interrelationship between the anterior lobe of hypophysis and the gonad, like that demonstrated in mature rats, is in play in immature animals, at the blood levels of gonadal hormones and gonadotrophins much lower than those in mature animals.View full abstractDownload PDF (413K) -
S. AONUMA: STUDIES ON HEART VIITAKAO HAMA1960 Volume 7 Issue 1 Pages 57-60
Published: 1960
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESSThe influences of ubichinone-(50), ATP, AMP, carnosine and the active substance of inhibiting heart function isolated by author on 32P-incorporation into chick myocardium by injecting in abdomen of male chick 2 days after hatching were investigated. Administration of ubichinone-(50), ATP, AMP, or carnosine (1mg per chick) did not show any influence significantly, but 1mg per chick of the active substance decreased 32P-incorporation significantly with P less than 0.05. Furthermore a linear regression of log dose-response curve of the active substance was recognized in the range of 2γ to 500γ per chick.View full abstractDownload PDF (379K) -
JUN SERIZAWA1960 Volume 7 Issue 1 Pages 61-75
Published: 1960
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESS(1) Examinations were made to see if the sensitivity of the levator ani muscle, seminal vesicle, and prostate gland to androgen would differ by castration alone and by castration followed by adrenalectomy, using adult and immature rats. The sensitivity of the seminal vesicle and prostate in both adult and immature rats was higher in the Castrated-Adrenalectomized Group than in the Castrated Group. The levator ani muscle of adult rats showed increased sensitivity by castration and adrenalectomy but no difference was observed in immature rats.
(2) In the case of adult rats kept alive for 10 days after castration and adrenalectomy, sensitivity of the levator ani muscle, seminal vesicle, and prostate to androgen was higher than in merely Castrated Group, same as that immediately after adrenalectomy.
(3) The anabolic/androgenic ratio of immature rats showed higher value in the Castrated-Adrenalectomized Group than in the merely Castrated Group.
(4) A single administration of the androgen increased sensitivity of each of these organs than by continued administration of divided doses.
(5) Sensitivity of androgen to each organ in immature rats decreased in order of the prostate, seminal vesicle, and levator ani muscle, and this order was seminal vesicle, prostate, and levator ani muscle in the case of adult rats.View full abstractDownload PDF (1202K) -
MASAAKI YAMAMOTO1960 Volume 7 Issue 1 Pages 76-84
Published: 1960
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESSThe terminal amino acid residues were analyzed for α-and β-uroparotin, and for modified a-uroparotin following partial removal of sialic acid. The isoelectric point of uroparotin was shifted to a higher pH by the removal of sialic acid, suggesting that its acid isoelectric point was probably due to a sialic acid component.
N-terminal amino acids of uroparotin were the two of aspartic acid and threonine, and C-terminal amino acids were either a single of phenylalanine or the two of phenylalanine and methionine, and no difference between α-andβ-type was found out. Furthermore, the modified uroparotin has also given the identical terminal amino acids. Simultaneously, the modified uroparotin was found to be more susceptible to the carboxypeptidase than native uroparotin.View full abstractDownload PDF (883K)
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