Although many authors described the frequent development of the hyperplasia of the endometrium in association with hormonal disorders, further development into adenocarcinoma is still controversial. The present case showed a menstrual irregularity with the rather profuse flow, since menarche. At the first observation obesity, hirsutism with masculine distribution, faulty breast development, monophasic type of B. B. T., and endometrial figure of glandular hyperplasia with epidermoid metaplasia were noted. The follow-up of the subsequent course revealed ineffectiveness of repeated hormone treatment. Nine years later, endometrial biopsy revealed a complete change from the previous historogical findings following the episode of the largest bleeding in her history, suggesting a malignant change. With the diagnosis of adenoacanthoma, laparatomy was performed.

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The experiments on parabiotic rats, as here reported, confirm observations of other workers that dietry cholesterol is absorbed and deposited in the tissues of rats.They show moreover that in parabiotic pairs of animals cholesterol which is fed to one of the partners is carried evidently by the blood stream to the companion. This work supports the suggestion of Borgstroem et al.that dietary cholesterol is retained for a time and to a certain degree in the intestinal wall and subsequently in the liver before it is released into the circulation to be carried to other tissues in the body. When both partners are fed cholesterol an even distribution of this substance is found and both fed animals of a pair show the known effect of cholesterol feeding on the incorporation of radioactivity from injected acetate-1-C¹⁴, in a considerably decreased incorporation of C¹⁴ into the newly synthesized cholesterol of the liver. In other tissues there is however much less decrease of the incorporation into this substance. The experiments suggest that if there is any extrahepatic biosynthesis of cholesterol in the intact animal, it may be only of quite minor importance in the total picture. When only one of the partners of a pair is fed cholesterol, the synthesis-depressing effect is observed only in the partner which received the feeding while the companion shows a normal incorporation of the radioactive label. Even an amount of cholesterol which does not visibly increase the deposition of this material in the liver has a very definite depressing influence on the incorporation of C¹⁴ from acetate-1-C¹⁴ into liver cholesterol.

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A simple method for the collection of pure testicular venous blood (abbr. TV-blood) in the rat is presented. Testosterone and androstenedione were measured both in TV-blood and in the testis, using 88 adult rats with and without HCG pretreatment.
Testosterone was the major androgen elaborated by the adult rat testis. Following a short treatment with HCG, the level of testosterone was elevated about 8 times in TV-blood and concentration was doubled in the testis. Androstenedione after stimulation with HCG, increased to a detectable level in both TV-blood and the testis.

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Hormonal regulation of parafollicular cells (p-cells) was investigated cytologically in 60-days-old male rats of Wistar strain. In the normal control rats, p-cells were divided into 4 types by their cytological features, representing resting, two intermediate and secretory phase. The possible transformation between the pcells and the common follicular cells (c-cells) was suggested in the cytological observation on normal rats.Factors affecting the proliferation of p-cells were thyroxine, hypophysectomy, sialoadenectomy, adrenalectomy and posterior lobe hormone in descending sequence. The neoformation of follicles subsequent to the proliferation of p-cells appeared to be the compensatory response to the atrophy of common follicles. The hyperplasia of p-cells was in equilibrium with the synchronized atrophy of common follicles.Factors affecting the neoformation of follicles due to the hyperplasia of c-cells were TSH, goitrogen and TRF (thyrotrophin releasing factor of Shibusawa); in particular, the action of TRF is most prominent in proliferating potency. On the contrary, the p-cells were diminished in number or disappeared by the administration of the compounds. The neoformation of follicles in thyroid gland, therefore, inhered in two formulae, conditioned respectively on p-cells and c-cells. Electron microscopy was made on the proliferated p-cells in the hypophysectomized rats. The ultrastructure of p-cells may account for the possible secretory activity. An assumption was drawn in present investigation that the reversible transformation between p-cells and c-cells is controlled by TSH.

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To clarify the functional relation between the ovulation blocking-effect and the central depresant action of progesterone, electrophysiological studies were done, using unanesthetized curarized albino rats under artificial respiration, additionally using rabbits and cats, and the following results were obtained:
(1) After the administration of progesterone (10-20mg/kg), EEG of the hippocampus and neocortex showed sleep patterns, lasting 1 hr.
(2) Activation threshold of posterior hypothalamic stimulation upon the hippocampus and neocortex was markedly elevated after the administration of progesterone.
(3) The threshold voltage of desynchronizing the hippocampal regular slow waves by anterior hypothalamic stimulation remained almost unchanged.
(4) The threshold voltage of the recruiting response of the neocortex by stimulation of nucleus centrum medianum almost unchanged.
From these results it is concluded that progesterone seems to suppress the activity level of the posterior hypothalamus as well as that of the limbic-midbrain area (Nauta, 1958) by which the blockade of ovulation may take place.

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It now appears that the parapharyngeal method by Smith(1930)is the routine procedure for hypophysectomy in rats, But this method is rather complicated, requiring many instruments and much time.The following procedure, described by the present author(Koyama, 1929), is simple enough that anyone can perform it in a very short time and with the use of only a few instruments.

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