EXPERIMENTAL ANIMALS
Online ISSN : 1884-4170
Print ISSN : 0007-5124
ISSN-L : 0007-5124
Volume 10, Issue 3
Displaying 1-4 of 4 articles from this issue
  • [in Japanese]
    1961 Volume 10 Issue 3 Pages 69-74
    Published: May 30, 1961
    Released on J-STAGE: August 25, 2010
    JOURNAL FREE ACCESS
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  • 1. Epizootiologicol Observation
    Yoshio TAKAGAKI, Masayuki IWATA, Kosaku FUJIWARA, Yoshio TAJIMA
    1961 Volume 10 Issue 3 Pages 75-82_4
    Published: May 30, 1961
    Released on J-STAGE: August 25, 2010
    JOURNAL FREE ACCESS
    Since TYZZER described the disease in Japanese waltzing mice in 1917, it has been revealed that the infection is widespread among mouse colonies in Europe and the U. S. A.
    However, in Japan the Tyzzer's disease was first described recently by KANEKO et al. and IMAI and general aspects of the infection among Japanese mouse colonies are still unknown.
    In August 1960, authors observed an outbreak of the disease in mice of so-called dd strain derived from a farm. Pathological and bacteriological examinations were performed concerning to this outbreak and some other reproducing colonies were surveyed in order to detect the subclinical infection. The results obtained are summarized as follows:
    1. Acute or subacute disease observed in so-called dd mice, was identified with the Tyzzer's disease histopathologically. Characteristic necrosis of liver parenchyme was accompanied with intracellular configuration of bacilli. The disease seemed to run also in mild or chronic type (Table 1) .
    2. Culture of pathogenic organisms was not obtained by any media used for the isolation. It was noticed that Lactobacilli were isolated more frequently from infected livers than non-infected ones (Table 2) .
    3. Intravenous or intraperitoneal infection of mice with infected liver materials succeeded only when accompanied with cortisone acetate administration. (Fig. 1) .
    4. The survey performed in a certain prefecture revealed that 6 out of 10 reproducing mouse colonies were contaminated subclinically. Fifty-four out of 482 (11.2%) mice examined showed positive liver lesions (Table 3) .
    5. It was suggested that environmental conditions could be related to the infection of the disease (Fig. 1, Fig. 4) .
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  • Masanobu FUKUI, Sawako MATSUZAKI, Hiroshi TANAKA, Tatsuji NOMURA, Hide ...
    1961 Volume 10 Issue 3 Pages 83-90_4
    Published: May 30, 1961
    Released on J-STAGE: August 25, 2010
    JOURNAL FREE ACCESS
    Surveys on myobiasis and Myocoptiasis of albino mice were conducted during the spring-summer season of 1960. Various techniques for detecting parasitic mites were compared in their efficiency, such as follows: Scotch-tape methcd, TERAMURA's mice-hanging method, Scab-warming method and hair-warming method.
    The efficiencies of the first and the second methods did not appear highly practical, since the mites, especially myobid mites, did not come off from dead host. On the contrary, the hair-warming technique was considered to be the most effective for the detection of myobid and listropholid mites.
    Out of total 121 albino mice (dd strain), 77 mice were parasitized with Myobia musculi or Radfordia affinis. In another experimental animal farm, the mice showed a high parasitic incidence with listropholid mites, Myocoptes musculinus.
    Most of the mice parasitized with myobid mites were suffering from a chronic dermatitis. Dermatitis was observed on head, neck and back. The myobid mites were found in the sites of the dermatitis.
    In the case of myocoptic mange, the hair of the whole body surface became rough and the mites were detected in any part of skin lesion.
    The parasitic incidence of mites onto mice was considered to be decreased in summer than in spring.
    Pathological and microbiological tests have proved that no case of dermatitis is attributable to the infection caused by pathogenic microbes, although the following microbes were isolated: Micrococcus, gram positive or negative rod, Cephalosporium sp., Monosporium sp., Aspergillus fumigatus and Aspergillus sp.
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  • Takayoshi INO, Sadao ISHIGAKI, Akira MORI
    1961 Volume 10 Issue 3 Pages 91-96
    Published: May 30, 1961
    Released on J-STAGE: August 25, 2010
    JOURNAL FREE ACCESS
    Blood characters, such as, erythrocyte number, leukocyte number, hemoglobin content, serum protein percentage, leukocyte diagnosis and liver dehydrogenase activity were determined among the W1 and W2 subline and their reciprocal hybrids, W1 (_??_) ×W2 ( _??_) and W2 (_??_) ×W1 ( _??_) .
    There were significant genetic differences among the two lines and hybrids in factors affecting erythrocyte number, leukocyte number and hemoglobin content. Erythrocyte number was 867 in W1, 777 in W2, 878 in W1×W2 and 786 in W2×W1 (ten thousand) . Leukocyte number was 5, 871 in W1, 7, 750 in W2, 6, 356 in W1×W2 and 7, 242 in W2×W1. Hemoglobin content was 16.49 in W1, 16.06 in W2, 16.40 in W1×W2 and 15.10 in W2×W1 (g/dl) . The values of erythrocyte number, leukocyte number and hemoglobin content in F1 from mother showing high values were higher as compared with those in F1 from mother showing low values. The results might indicate that there are certain maternal effects for the blood characters of hybrids mice.
    Intensity of heterosis was concluded by the calculation of potence ratio in F1 with the following results. Erythrocyte number, showed higher value in W1×W2 than in W1, W2, showing intense heterosis, and hemoglobin content lower value in W2×W1 than in W1, W2. Other characters in F1 showed intermediate value of W1 and W2.
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