EXPERIMENTAL ANIMALS
Online ISSN : 1884-4170
Print ISSN : 0007-5124
ISSN-L : 0007-5124
Volume 26, Issue 3
Displaying 1-13 of 13 articles from this issue
  • Hiroshi IWAI, Toshio ITOH, Seigo SHUMIYA
    1977 Volume 26 Issue 3 Pages 205-212
    Published: 1977
    Released on J-STAGE: August 25, 2010
    JOURNAL FREE ACCESS
    An epizootic of Sendai virus infection occurred in a mouse breeder colony with respiratory signs, mortality, retarded growth in young and prolonged gestation period in adults. Thereafter, the infection persisted in this colony without any clinical signs and with 90 to 100% antibody positivity in adults. Weanlings had maternal antibodies and no pneumonic lesions. Antibodies were hardly detected in 6-week-old mice with high incidence of red hepatization or congestion in their lungs, but mice over 8 weeks of age had antibody without the lesions. After isolating weanlings and pregnant mice with antibodies from the infected colony, the isolated weanlings and offspring from the isolated dams became negative for Sendai virus antibodies.
    Download PDF (705K)
  • Junichi KUROIWA, Tomonori IMAMICHI
    1977 Volume 26 Issue 3 Pages 213-222
    Published: 1977
    Released on J-STAGE: August 25, 2010
    JOURNAL FREE ACCESS
    The paper deals with observations on growth and reproduction of the chinchilla in recent 4 years started from 1966 at this laboratory. There were large variations in age of vaginal opening (less than 71 days-308 days) with an average of 173.2±57.6 days in 45 females. The average length of 100 oestrus cycles in 24 females was 35.7±7.9 (15-62) days. The mean period of 5 gestations in 5 females was 110.4 (108-112) days. Eighty-one out of 123 litters were born between March and August during 3 years, and parturition never occurs in December. The most suitable season for reproduction of chinchillas may be from January to April, and a summer anoestrous seems to be present in August to early September as reported by Weir. The litter size ranged from 1 to 4 with a mode of 2 (46.3%) and an average of 1.90±0.76. More male kids were produced at birth at this laboratory, and sex ratio was 133.7 (98 females and 131 males) . In 1973, 37 chinchillas gave birth to 71 kids with an average litter size of 1.92, and 59 of them were successfully weaned (1.59 per litter) . Of these kids, 50 (1.35 per litter) attained 240 days of age (adulthood) . Among 91 subjected to investigation for causes of death, 23 (25.3%) were dead during newborn period, and 9 and 5 adults were dead of malocclusion (9.9%) and the prolapse of rectum respectively.
    Download PDF (4317K)
  • Kazuhiko MATSUMOTO, Hiroshi KUBOTA, Yoshiro KOBAYASHI, Kazuo HAYANO
    1977 Volume 26 Issue 3 Pages 223-229
    Published: 1977
    Released on J-STAGE: August 25, 2010
    JOURNAL FREE ACCESS
    Biochemical properties of alkaline phosphatase (ALP) from placenta were compared between man, dog, cat, rabbit and cattle. 1) Optimum pH of the enzyme was essentially identical through the species of the animals but the inhibition by L-phenylalanine was clearly demonstrable with human ALP but little with that of other animals. 2) ALP of human placenta was not inactivated by heating at 65°C for 15 min, but one of the other animals was thermolabile. Such thermostability of human placental ALP almost disappeared after treatment with EDTA, suggesting that the divalent metal ions were required for the thermostability. 3) Activities of placental ALP were inhibited by cationsurfactants in human and rat but not in the other animals, while the inhibition by DOC-Na, an anion-surfactant, was seen only in human. 4) The affinity to β-glycerophosphae of placental ALP was seen only in human.
    Download PDF (644K)
  • Nobuo GOTO, Kenkichi IMAMURA, Kenichiro SAKAMOTO
    1977 Volume 26 Issue 3 Pages 231-238
    Published: 1977
    Released on J-STAGE: August 25, 2010
    JOURNAL FREE ACCESS
    A mouse mutation brachypodism was detected in an inbred strain of mouse (NC) maintained by National Institute of Animal Health (Ministry of Agriculture) . An attempt was made in this paper to reveal the mode of inheritance and the pattern of growth of this mutant. 1. From the results of crossing tests, it might be concluded that an autosomal recessive gene (brp, linkage group V) was responsible for the occurrence of the brachypodism. 2. Body weights of brachypod mice (brp/brp) were smaller than those of normal mice (+/brp) from the delivery, and this tendency was remarkable with age.
    Download PDF (3496K)
  • Yasuhiko KANO, Toru SAWASAKI, Tokuyoshi OYAMA
    1977 Volume 26 Issue 3 Pages 239-246
    Published: 1977
    Released on J-STAGE: August 25, 2010
    JOURNAL FREE ACCESS
    Practical inf ormations of miniature “Shiba” goats, that have since long been bred for meat consumption in Kyushu District of Japan, were provided for using as laboratory animals. Nine years ago, some pairs of the goats, were introduced to Stock Farm of Tokyo University from a National Institute. Thereafter, they were successfully bred and increased in number and were distributed to many labolatories for researches. The “Shiba” goat is white coloured, horned, and much smaller in size while sharing common characteristics with full size goats. The handling is much easier with less amount of food consumption. The body weight are 24 to 28 kg and 15 to 22 kg in males and females, respectively. They are obedient and have a strong resistance to diseases, including cerebral nematodiasis. The productive characteristics are as follows: 1) Continuous breeder, 2) Age at the first parturition: 13 months, 3) Gestation period: 5 months, 4) Litter size: 1.84, 5) Rate of raising: nearly all, 6) Delivery interval: 8 months, 7) No intersexality. Hematological data were also demonstrated.
    Download PDF (615K)
  • Akiko KOGA, Shuichi KIMURA
    1977 Volume 26 Issue 3 Pages 247-253
    Published: 1977
    Released on J-STAGE: August 25, 2010
    JOURNAL FREE ACCESS
    To see the influence of a restricted diet and a meal feeding for the growing Wistar rats were subjected to three types of feeding patterns, free access feeding, three meals and one meal per day. The animals of each feeding pattern group were fed either unrestricted and restricted amount of diet. The restricted group received only 60% weight of the diet taken by the unrestricted groups. The growth of the animals having free access to the restricted amount of diet was almost similar to that of those having received the restricted amount of diet three meals per day rather than to the group fed the unrestricted diet once per day. The former group seemed to be a “nibbler type” rather than a “meal feeder type”.
    Download PDF (518K)
  • A. LEONARD, Gh. DEKNUDT, M. WILLOCX
    1977 Volume 26 Issue 3 Pages 255-257
    Published: 1977
    Released on J-STAGE: August 25, 2010
    JOURNAL FREE ACCESS
    Inherited anophthalmia was observed in the progeny of a female rat irradiated with 50 R of X-irradiation at 17 days of age. Observations on the inheritance of the condition indicated that this anophthalmia can be considered as the result of polygenic factors with incomplete penetrance.
    Download PDF (1457K)
  • Toru URANO, Kazuyoshi MAEJIMA, Osamu OKADA, Shinichi TAKASHINA, Seigo ...
    1977 Volume 26 Issue 3 Pages 259-262
    Published: 1977
    Released on J-STAGE: August 25, 2010
    JOURNAL FREE ACCESS
    Pseudo monas aeruginosa infection in laboratory mice was successfully eradicated by oral treatment of gentamicin, 1.0 g per liter of drinking water for 3 days.
    Download PDF (297K)
  • Shigeyuki YOKOIYAMA, Kimio MIZUNO, Kôsaku FUJIWARA
    1977 Volume 26 Issue 3 Pages 263-266
    Published: 1977
    Released on J-STAGE: August 25, 2010
    JOURNAL FREE ACCESS
  • Hiroshi IWAI, Toshio ITOH
    1977 Volume 26 Issue 3 Pages 267-271
    Published: 1977
    Released on J-STAGE: August 25, 2010
    JOURNAL FREE ACCESS
    Retired rats of SD strain from three breeder colonies (A, B and C) were monthly monitored for CF antibody to Tyzzer's organism for 2 to 6 years. In colony A, antibody-positive rats were found at frequencies ranging from 5 to 100% with a single peak during about one year without any detectable signs of apparent disease. However, in colony B, in spite of the outbreak of the disease, antibodypositive animals were only sporadically detected during about 4 years after the outbreak. Thereafter, in this colony, the antibody was not demonstrated in all animals examined for 2 years, and susceptibility to the disease of 3-week-old rats was the same as that of ones from non-infected colony. Cortisone test did not suggest the infection. In colny C, no antibody-positive rats were detected for 3 years.
    Download PDF (470K)
  • Senichi ODA, Kyoji KONDO
    1977 Volume 26 Issue 3 Pages 273-280
    Published: 1977
    Released on J-STAGE: August 25, 2010
    JOURNAL FREE ACCESS
    Download PDF (2270K)
  • 1977 Volume 26 Issue 3 Pages 281-291
    Published: 1977
    Released on J-STAGE: August 25, 2010
    JOURNAL FREE ACCESS
    Download PDF (5939K)
  • 1977 Volume 26 Issue 3 Pages e1
    Published: 1977
    Released on J-STAGE: August 25, 2010
    JOURNAL FREE ACCESS
    Download PDF (20K)
feedback
Top