The effects of hot water extracts (HWEs) and distanninized fractions (DTFs) from 9 kinds of
Labiatae herbs on rat hepatic lipid peroxidation (LPO) and the activities of aminopyrine
N-demethylase (APD) and aniline hydroxylase (ANH) were examined in vitro. The APD activity was inhibited by the HWEs from 6 herbs, of which the effect of HWE from
Ogon was remarkable. The APD activity was increased by HWE from
Shisoshi. The inhibitory effect of the HWE from
Ogon was not different compared that of the DTF from
Ogon, whereas the APD activity was decreased in the DTF from
Shisoshi in comparison with that of the HWE. The ANH activity was inhibited by the HWEs from 7 herbs. Except in the case of
Kakho and
Shisoyo, the inhibitory effects of the HWEs were enhanced by these of the DTFs from the 7 herbs, of which the effect of DTF from
Ogon was remarkable. LPO was inhibited by the HWEs from 8 herbs. Especially, HWE from
Ogon strikingly inhibited LPO, and this effect was retained by the DTF from
Ogon. The present results suggested that
Ogon, which showed remarkable effects on LPO, and the activities of APD and ANH might also exert their effects in vivo.
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