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Volume 83 (1984)
- Issue 6 Pages 479-
- Issue 5 Pages 373-
- Issue 4 Pages 269-
- Issue 3 Pages 193-
- Issue 2 Pages 93-
- Issue 1 Pages 1-
Volume 83, Issue 6
Displaying 1-5 of 5 articles from this issue
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Haruhiko SHINOZAKI, Kenji HIRATE, Michiko ISHIDA1984 Volume 83 Issue 6 Pages 479-483
Published: 1984
Released on J-STAGE: March 07, 2007
JOURNAL FREE ACCESSA method for analyzing drug-induced tremor in mice was developed using a power spectral analysis of the random current induced by the movement of a magnet attached to a mouse on a wire coil. The power spectral density function defined the frequency composition of the drug-induced tremor, and the mean square value of the data in any frequency range of concern was determined.View full abstractDownload PDF (2259K) -
Takemi FUKUDA, Tatsumi TSUMAGARI1984 Volume 83 Issue 6 Pages 485-496
Published: 1984
Released on J-STAGE: March 07, 2007
JOURNAL FREE ACCESSThe effects of neuroleptic drugs on self-stimulation behavior were investigated in rats with electrodes chronically implanted in the lateral hypothalamus. Except for sulpiride and carpipramine, the neuroleptic drugs chlorpromazine, thioridazine, perphenazine, haloperidol, floropipamide, pimozide, clocapramine and oxypertine all suppressed self-stimulation behavior dose-dependently. The anti-anxiety drugs chlordiazepoxide, diazepam, clotiazepam and etizolam facilitated this behavior. The antidepressant drugs imipramine and amitriptyline suppressed this behavior slightly at the dose of 40 mg/kg. The alpha-antagonist phenoxybenzamine also suppressed this behavior, but the slope of its dose-response curve was gentle compared with those of the neuroleptic drugs. The inhibition produced by the neuroleptic drugs is considered to be mediated primarily at the dopaminergic receptors. Turning behavior induced by methamphetamine in rats with unilateral 6-hydroxydopamine lesions of the caudate nucleus was used to assess the striatal dopaminergic blocking potency of the neuroleptic drugs. No correlation was found between the ED50 values for the turning behavior inhibition and the ED50 values for the self-stimulation behavior inhibition produced by these drugs, so the dopaminergic receptors in the striatum are apparently not involved in the mediation of self-stimulation behavior.View full abstractDownload PDF (6734K) -
Masao HISADOME, Kazuhiro GOTO, Michio TERASAWA, Yukinobu KADOBE, Chiyu ...1984 Volume 83 Issue 6 Pages 497-505
Published: 1984
Released on J-STAGE: March 07, 2007
JOURNAL FREE ACCESSThe production of spleen and thymus-rosette forming cells (RFC) in BALB/c mice 4 days after immunization with 5×103 sheep red blood cells (SRBC) was inhibited by traxanox at doses of 10-30 mg/kg, p.o. This agent (100 mg/kg, p.o.) suppressed the 19S hemagglutinin titer and elevated the 7S hemagglutinin titer. The transfer of spleen-RFC of thymus-RFC into syngeneic recipient mice 4 days after immunization with SRBC increased the production of spleen hemolytic plaque forming cells (HPFC). This increase was abolished by the transfer of spleenRFC obtained from mice treated with traxanox (30 mg/kg, p.o), but not by the transfer of spleen-RFC treated with anti-Lyt 2.2 antiserum and complement. The viability of the spleen-RFC in mice treated with traxanox was decreased by treatment with anti-Lyt 2.2 antiserum and complement. Traxanox (3-30 mg/kg, p.o) significantly increased the inhibition of HPFC, spleen-RFC and thymus-RFC production by Concanavalin A at a dose of 50 leg/ mouse. This agent (3-30 mg/kg, p.o) inhibited the production of HPFC, spleen-RFC and thymus-RFC in mice 4 days after the secondary immunization. These results suggest that traxanox may inhibit antibody production via the induction of Lyt 2.2 positive cells (suppressor T cells).View full abstractDownload PDF (4762K) -
Yasuto MORIMOTO, Takemi FUKUDA, Tatsumi TSUMAGARI1984 Volume 83 Issue 6 Pages 507-511
Published: 1984
Released on J-STAGE: March 07, 2007
JOURNAL FREE ACCESSThe cerebral protective action of nizofenone was compared with that of pentobarbital (PBT) in Mongolian gerbils in which an incomplete circle of Willis causes the development of ischemic damage in the cerebral hemispheres following common carotid arteries occlusion. The mean survival time following occlusion of both common carotid arteries which induced a mortality rate of 100% was 2.3 hr for the control group and 3.3 hr (P<0.05) and 4.1 hr (P<0.01) for the animals pretreated with nizofenone (10 mg/kg) and PBT (60 mg/kg), respectively. The mortality rate during a I month period following transient bilateral occlusion of the carotid arteries for 30 min was 100% for the control group and 41% (P<0.01) and 40% (P<0.01) for the animals pretreated with nizofenone (30 mg/kg) and PBT (60 mg/kg), respectively. No significant protective action was observed when administration of the drugs was carried out immediately after the onset of recirculation. These results suggest that nizofenone may be an effective cerebral protective agent.View full abstractDownload PDF (2434K) -
Shigeru OKUYAMA, Sanae HASHIMOTO, Fusao AMANUMA, Hironaka AIHARA1984 Volume 83 Issue 6 Pages 513-521
Published: 1984
Released on J-STAGE: March 07, 2007
JOURNAL FREE ACCESSWe attempted to develop an experimental model of chronic inflammatory pain in mice. The mice were injected intradermally at the base of the tail with various kinds of irritants (yeast, carrageenin, mustard and adjuvant). The pain threshold was measured by the pressure method every 60 min for 5 hr and once a day at the same time throughout the experimental period. The group of 10% yeast-injected mice exhibited the most intensive hyperalgesia. The analgesic effect of various types of analgesic drugs were studied, comparing the effects in normal mice and various kinds of irritants-induced hyperalgesia mice. It was demonstrated by observing ED50 values that nonsteroidal antiinflammatory drugs (NSAIDs), narcotic analgesic drugs and agonist/antagonist type of analgesic drugs were effective, but CNS-acting drugs were ineffective in yeast hyperalgesia mice. In comparison with yeast hyperalgesia mice, larger doses of analgesic drugs were required in normal mice and other irritants-treated mice. Especially, acidic NSAIDs were more effective in yeast hyperalgesia mice than normal mice. It was suggested that acidic NSAIDs specifically inhibit inflammatory pain. Moreover, yeast hyperalgesia mice are useful for the quantitative measurement of analgesic drugs.View full abstractDownload PDF (4129K)
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