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Volume 85 (1985)
- Issue 6 Pages 415-
- Issue 5 Pages 305-
- Issue 4 Pages 209-
- Issue 3 Pages 111-
- Issue 2 Pages 59-
- Issue 1 Pages 1-
Volume 85, Issue 2
Displaying 1-5 of 5 articles from this issue
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Masao HISADOME, Kazuhiro GOTO1985 Volume 85 Issue 2 Pages 59-70
Published: 1985
Released on J-STAGE: March 02, 2007
JOURNAL FREE ACCESSC57BL/6 mice, lower responders to sheep red blood cells (SRBC), were intraperitoneally immunized with 5×108SRBC on day 0. Traxanox (10 and 30 mg/kg) administered orally on days 0 and 1 potentiated the production of spleen- and thymus-rosette forming cells (RFC) assessed on day 7. The production of hemolytic plaque forming cells (HPFC) to SRBC in the spleen of the syngeneic recipient mice assessed on day 4 was inhibited by the transfer of spleen-RFC obtained from the vehicle-treated donor mice, but not by that obtained from the traxanox (30 mg/kg)-treated donor mice. The same results were obtained in the thymectomized-recipient mice. The activity of the spleen-RFC obtained from the vehicle-treated donor mice was abolished by treatment with anti-Thy 1.2 or antiLyt 2.2 antibody and complement. On the other hand, the activity of the spleen-RFC obtained from the traxanox-treated donor mice was abolished by treatment with anti-Lyt 1.2 antiserum and complement. Traxanox (3 and 30 mg/kg) also caused the induction of the Thy 1.2-positive RFC in the spleen of the thymectomized mice. These results suggest that traxanox has a capacity to potentiate the immune responses to SR-BC in C57BL/6 mice by the induction of Lyt 1.2-positive cells (helper T cells).View full abstractDownload PDF (9042K) -
(I) Effects on experimental amnesia in miceKoretake ANAMI, Yoshinobu YAMAMOTO, Michihide SETOGUCHI1985 Volume 85 Issue 2 Pages 71-77
Published: 1985
Released on J-STAGE: March 02, 2007
JOURNAL FREE ACCESSThe effects of sufoxazine on various experimental amnesia models were studied using passive avoidance behavior in mice. Sufoxazine had no influence on learning and memory in intact mice. Sufoxazine, administered either immediately after CO2 exposure or 30 min prior to the acquisition trial, improved CO2 induced amnesia. It also improved both electroconvulsive shock (ECS) induced amnesia (administered immediately after the amnestic treatment) and scopolamine induced amnesia (administered immediately after the acquisition trial). The antidepressant drugs, imipramine and desipramine had no ameliorative activity in any of these experimental amnesiamodels. These results suggest that sufoxazine improves amnesia experimentally induced by various methods.View full abstractDownload PDF (4691K) -
Toshiki WATANABE, Kunio MATSUHASHI, Satoshi TAKAYAMA1985 Volume 85 Issue 2 Pages 79-90
Published: 1985
Released on J-STAGE: March 02, 2007
JOURNAL FREE ACCESSThe drugs used were methamphetamine, reserpine, norepinephrine, epinephrine, propranolol, chlorpromazine, haloperidol, pilocarpine and atropine. Each drug except for reserpine (days 7-13 and 14-19 of gestation) was administered subcutaneously to dams from day 7 to 19 of gestation. The body weight gain of dams receiving reserpine (days 7-13) and haloperidol was inhibited during the gestation period. Two out of 9 dams receiving methamphetamine died on day 21 of gestation period; However, no effect was observed in dams given other drugs. The body weight gain of pups was inhibited in methamphetamine and haloperidol treated groups. The mortality of pups was comparable in all groups. The behavioral development of the righting reflex, cliff drop avoidance and negative geotaxis of pups given reserpine (days 7-13), norepinephrine, chlorpromazine and haloperidol was significantly retarded in comparison with that of control pups. The spontaneous motor activity of pups measured by Animex was increased in reserpine (days 7-13) and epinephrine treated groups and decreased in the chlorpromazine treated group on day 28 postpartum, but comparable in all groups on day 56 postpartum. The conditioned avoidance responses using the shuttle box revealed deficits of avoidance learning of pups in the reserpine (days 7-13), norepinephrine and atropine treated groups. These findings suggest that the prenatal exposure to drugs acting on the autonomic nervous system may produce adverse effects on the behavioral development of pups; However, the adverse effects were more apparent by postnatal exposure than by prenatal exposure.View full abstractDownload PDF (8801K) -
Hajime INOUE, Noritaka YOSHIKAWA, Eiko ONISHI, Yoshiyuki SEYAMA, Sabur ...1985 Volume 85 Issue 2 Pages 91-95
Published: 1985
Released on J-STAGE: March 02, 2007
JOURNAL FREE ACCESSExperimental allergy was induced in animals: asthma, a Type I allergy, was induced in guinea pigs by sensitizing them with α-amylase (inhalation), and experimental allergic encephalomyelitis (EAE), a Type IV allergy, was induced in rats. Pulmonary, brain and serum lysosomal enzyme activities were measured in normal and allergic conditions. β-Glucuronidase (β-G) and arylsulfatase (AS) activities were determined by the fluorescent technique. During the asthmatic attack, pulmonary lysosomal enzyme activities were not different from that in the normal state in guinea pigs. However, brain lysosomal enzyme activities were elevated markedly on the 1 st day of EAE induction. Brain β-G activity was elevated on the 2nd day, and AS activity had a tendency to be increased. On the other hand, serum lysosomal enzyme activity was not altered significantly. In the experimental allergy, lysosomal enzyme activity was altered in Type IV, but not in Type I.View full abstractDownload PDF (3800K) -
Hidemi ISHII, Masaaki KUBOKI, Minoru OHKURA, Sayuri HIRAISHI, Jiro TSU ...1985 Volume 85 Issue 2 Pages 97-110
Published: 1985
Released on J-STAGE: March 02, 2007
JOURNAL FREE ACCESSTopically applied thrombin was known to be effective in hemostasis of local bleeding, but complications of shock, anaphylaxis or disseminated intravascular coagulation (DIC) have been reported recently in rare cases. In this experiment, the possibility of DIC was examined by intraperitoneal injection of topical thrombin (Parke-Davis) to rabbits with liver cirrhosis or acute liver damages induced by CCl4. No significant changes in the coagulation parameters were found in the groups of liver cirrhosis or the untreated control, but the injection of thrombin induced decreases of platelet count and fibrinogen and prolongation of prothrombin time and partial thromboplastin time in the groups of acute liver damages, 24 or 48 hr after CCl4 injection. When the “junk” prepared from the topical thrombin was injected to the 48 hr-damage group, no change was noted in these parameters. It was concluded that DIC could be induced by the intraperitoneal injection of topical thrombin only in cases of acute liver damages, where the increased permeability of peritoneum was postulated. However, such an immediate or marked change in coagulation was not found in our experiment as encountered in the clinical cases, which suggested the involvement of the anaphylactic reaction to the topical application of thrombin in the development of DIC in these clinical cases.View full abstractDownload PDF (16588K)
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