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Volume 88 (1986)
- Issue 6 Pages 403-
- Issue 5 Pages 331-
- Issue 4 Pages 255-
- Issue 3 Pages 173-
- Issue 2 Pages 65-
- Issue 1 Pages 1-
Volume 88, Issue 3
Displaying 1-10 of 10 articles from this issue
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Toshiji MIYAGAWA, Ryuichiro ANDO, Shinobu SAKURADA, Tsukasa SAKURADA, ...1986 Volume 88 Issue 3 Pages 173-178
Published: 1986
Released on J-STAGE: March 02, 2007
JOURNAL FREE ACCESSResponses induced by tooth pulp stimulation were studied in 27 gallamine immobilized adult cats. Single units were recorded from the amygdala using stainless steel microelectrodes. Of 57 amygdaloid neurons, 8 were responsive to only non-nociceptive (tap and/or hair bending) stimuli, 7 were responsive to both nociceptive (pinch) and non-nociceptive stimuli, 18 were responsive to nociceptive stimuli, non-nociceptive stimuli and tooth pulp stimulation, and the others did not respond to these stimuli. The neurons in the amygdala responsive to tooth pulp stimulation were localized in the nucleus amygdaloideus centralis (pars lateralis) [Acl], nucleus amygdaloideus centralis (pars medialis) [Acm] and nucleus amygdaloideus basalis (pars magnocellularis) [Abm]. The response induced by tooth pulp stimulation was depressed by morphine and reversed by naloxone. These results suggest that Acl, Acm and Abm in the amygdala may receive pain sensation evoked by tooth pulp stimulation. Moreover, there is a possibility that these nuclei may be related to the emotional component involved in nociceptive processing.View full abstractDownload PDF (4235K) -
Ikufumi YOSHITAKE, Kazuhiro KUBO, Nobuo IKEDA, Itsuo KODAMA, Junji TOY ...1986 Volume 88 Issue 3 Pages 179-187
Published: 1986
Released on J-STAGE: March 02, 2007
JOURNAL FREE ACCESSEffects of KW-3049 on electrophysiological properties of the heart were examined using Langendorff-perfused hearts and superfused sinus nodal tissues of rabbits and superfused guinea-pig ventricular muscles. In rabbit hearts, KW-3049 at concentrations above 10-7 M caused a dose-related prolongation of atrio-His bundle conduction time (AH), whereas His bundle-ventricular conduction time (HV) was unaffected. In spontaneously firing rabbit sinus nodal tissues, KW-3049 at concentrations above 10-8 M prolonged cycle length significantly. At 10-6 M, amplitude and the maximum upstroke velocity of sinus nodal action potential were decreased as well. In normally polarized guinea-pig ventricular muscles under 4 mM [K+]0, KW-3049 at concentrations above 10-6 M shortened the action potential duration without affecting the resting membrane potential and the maximum upstroke velocity of action potential (Vmax) . The Vmax of slow action potentials induced by isoproterenol at 10-7 M was inhibited significantly by additional application of KW-3049 at concentrations above 10-9 M. At above 10-8 M, the amplitude and duration of slow action potentials were reduced significantly. The potency of this slow action potential inhibition by KW-3049 was slightly less than that of nifedipine, while it was 10 to 100 times greater than that of verapamil. Spontaneous activity of ventricular muscles induced by BaCl2 at 1 mM was abolished completely at 16 min after application of KW-3049 at 10-7 M. These results suggest that KW-3049 may have a potent and selective inhibitory action on cardiac slow calcium channels.View full abstractDownload PDF (6597K) -
Yasuko ASHIDA, Kayoko OKAMOTO, Yoshitaka MAKI1986 Volume 88 Issue 3 Pages 189-194
Published: 1986
Released on J-STAGE: March 02, 2007
JOURNAL FREE ACCESSThe slow-reacting substance of anaphylaxis (SRS-A) is generated in lung fragments of the actively sensitized guinea pig by an antigen-antibody reaction. The SRS-A generation in lung fragments was inhibited by its quinonyl acid (QS), and quinonyl-alcohol (QSA) derivatives of ubiquinone from a concentration as low as 10-7 M. It was of interest that the C10 to C13 side chain length in the 6-position of ubiquinone provided the highest activity. These compounds showed no antagonistic activity towards the contractile response of guinea pig ileum to SRS-A, indicating that the compounds inhibit the biosynthesis of SRS-A.View full abstractDownload PDF (4237K) -
Masami SATO, Hiroshi ISHIKAWA, Takeshi NIHO, Masahiro MIZOTA1986 Volume 88 Issue 3 Pages 195-203
Published: 1986
Released on J-STAGE: March 02, 2007
JOURNAL FREE ACCESSWe investigated the effect of urinastatin on energy metabolism disorder during shock. Intravenous administration of urinastatin at the dose of 50, 000 U/kg ameliorated the decrease in total adenine nucleotide (TA) levels and in energy charge (EC) of liver and pancreas during traumatic-shock induced by the Noble-Collip drum method in rats. Urinastatin, at a concentration of 3, 000 U/ml, suppressed the decrease in EC of rat liver slices exposed to the medium including 10% serum obtained from traumatic-shock rats. Aprotinin showed a similar effect. Depression in respiratory activity of liver mitochondria exposed to the shock rat serum was also ameliorated by 1, 000 U/ml of urinastatin, but aprotinin failed to reverse this depression. In the isolated rat livers perfused with normal rat serum, urinastatin at the concentration of 3, 000 U/ml did not affect ATP and TA levels and EC. These results suggest that, unlike aprotinin, urinastatin ameliorates the depression of energy metabolism in liver during shock without affecting normal energy metabolism, probably by antagonizing the actions of depressant factors released into blood during the shock state and by protecting against the decrease in the adenine nucleotide pool.View full abstractDownload PDF (6121K) -
(3) Damaging effects on the gastrointestinal tractNaohiko ONO, Yasundo YAMASAKI, Noriyuki YAMAMOTO, Akihiko SUNAMI, Hide ...1986 Volume 88 Issue 3 Pages 205-213
Published: 1986
Released on J-STAGE: March 02, 2007
JOURNAL FREE ACCESSDamaging effects on the gastrointestinal tract of proglumetacin maleate (PGM), a new indomethacin (IND) derivative, were examined in comparison with those of IND. Gastric and small intestinal lesions were maximum 4 and 24 hr after a single oral administration of PGM, respectively. Ulcerogenic effects of PGM on the gastric mucosa were approximately 1 /7 and 1/10 times as potent as those of IND on a molar ratio 4 hr after single oral dosing to fasting and feeding rats, respectively. PGM was also less active on the small intestinal mucosa 24 hr after single oral dosing. After repeated dosing for 7 days, ulcerogenic effects of PGM were about 1/3 and 1/2 times more potent than those of IND on the gastric and the small intestinal mucosa, respectively. The weak ulcerogenicity of PGM appears to be due to the fact that it has little direct action on the gastrointestinal mucosa. On the other hand, protective effects of PGM on diarrhea induced by arachidonic acid in mice were about 1/2 times as potent as those of IND in both 1 and 4hr pretreatments. So PGM must have less inhibitory effects on prostaglandin biosynthesis in the intestine than IND. PGM is a safer drug than IND because it has less damaging effect on the gastrointestinal mucosa. Therefore, it may be much more useful for the treatment of chronic inflammatory disorders like rheumatoid arthritis.View full abstractDownload PDF (6128K) -
Junzo ISHIGURO, Masahiro MIZOTA, Masami SATO, Hideyuki FUNATO, Hiroyuk ...1986 Volume 88 Issue 3 Pages 215-222
Published: 1986
Released on J-STAGE: March 02, 2007
JOURNAL FREE ACCESSThe pharmacokinetics of intracoronary administered urokinase was investigated in anesthetized open-chest dogs, together with its effect on the cardiovascular system, and the influence of urokinase in isolated guinea-pig heart was also examined. After intracoronary administration of 20, 000IU/kg of 125I-urokinase, radioactivity in plasma was eliminated biexpomentially with half-lives of 6.8 min and 4.4 hr. At 4 hr after the administration of 125I-urokinase, 32% of the total radioactivity remained in the TCA-insoluble fraction of plasma, and only 0.13% of the administered radioactivity was excreted as a TCA-insoluble fraction in the urine, suggesting that the administered urokinase may be metabolized for the most part into low molecular weight compounds. In hemodynamic measurements, we observed some decrease in cardiac function which was thought to be attributable to bleeding from the incision of open-chest surgery, probably caused by the fibrinolytic activity of urokinase, and urokinase, up to the dose of 2, 000, 000IU/kg (approximately 100 times of therapeutic dose), did not appear to show any direct action on the cardiovascular system. This result was supported by the fact that urokinase (10, 000 ?? 1, 000, 000 IU/heart) did not have any effects on contractile force, heart rate and coronary flow in isolated guinea-pig heart. From these results, we confirmed that the pharmacokinetics of intracoronary administered urokinase was essentially the same as that of intravenously administered urokinase and that intracoronary administered urokinase showed virtually no direct effect on the cardiovascular system.View full abstractDownload PDF (6480K) -
Hiroyuki KOHNO, Yoshiyuki SEYAMA, Saburo YAMASHITA, Hajime ARAMAKI, Ha ...1986 Volume 88 Issue 3 Pages 223-228
Published: 1986
Released on J-STAGE: March 02, 2007
JOURNAL FREE ACCESSThe effect of iodine-enriched egg (IE-egg) on nasal allergy was investigated using an experimental allergic model. In addition, the effect of IE-egg was investigated using patients with yearly nasal allergy. (1) IE-egg could suppress the leakage of pontamine sky blue dye in the experimental allergic model. (2) β-Glucuronidase activity in the perfusate was suppressed with the ingestion of IE-egg. (3) The symptoms of the patients with yearly nasal allergy were mitigated by the ingestion of IE-egg. (4) β-Glucuronidase activity in the pituita of nasal allergic patients tended to be decreased.View full abstractDownload PDF (4183K) -
Noboru YAMADA, Kazuo TAKAHASHI, Kanou ENDOH, Yasuhiro ARAI1986 Volume 88 Issue 3 Pages 229-237
Published: 1986
Released on J-STAGE: March 02, 2007
JOURNAL FREE ACCESSThe effects of a new anti-allergic agent, MY-5116: isoamyl 5, 6-dihydro-7, 8-dimethyl-4, 5-dioxo-4H-pyrano [3, 2-c] quinoline-2-carboxylate, and its main metabolite, MY-1250: 5, 6-dihydro-7, 8-dimethyl-4, 5-dioxo-4H-pyrano [3, 2-c] quinoline-2-carboxylic acid, on 48 hr homologous PCA (PCA) in rats and the release of histamine and SRS from rat peritoneal exudate cells (PEC) induced by IgE antibody in comparison with other anti-allergic agents were investigated. Also, the effects of MY-5116 and MY-1250 on antagonistic action against histamine and LTD4 were studied. MY-5116, tranilast and ketotifen inhibited PCA at oral doses of more than 3 mg/kg, 300 mg/kg and 0.3 mg/kg, respectively. MY-1250, DSCG and tranilast inhibited significantly the release of histamine from PEC induced by the antigen-antibody reaction in a dose-dependent manner, and the values of IC50 were 4.9 × 10-8, 4.8 × 10-6 and 4.6 × 10-6 g/ml, respectively. Ketotifen inhibited significantly the release of histamine at a concentration of 10-5 g/ml, but it accelerated significantly the release of histamine from PEC at a concentration of 10-4 g/ml. MY-1250 and tranilast suppressed the release of SRS from PEC induced by the antigen-antibody reaction. The values of IC50 of MY-1250 and tranilast were 1.5 × 10-6 and 2.1 × 10-6g/ml, respectively. MY-1250 suppressed slightly the release of SRS from PEC induced by A23187. MY-5116 showed no effect on the increase of vascular permeability induced by histamine, bradykinin and serotonin in rats. MY-5116 and MY-1250 showed no antagonistic action on the bronchial contraction and the contraction of isolated ileum and trachea induced by LTD4 in guinea pigs. Theses results suggest that the MY-5116 and MY-1250 do not have antagonistic action against chemical mediators, and the anti-allergic action of MY-5116 is based on the inhibitory effect of MY-1250, the main active metabolite of MY-5116, on the release of chemical mediators.View full abstractDownload PDF (7870K) -
Hitoshi INABA, Katsuaki KATO, Nobuo OHZAWA, Kazuo NAKAYAMA1986 Volume 88 Issue 3 Pages 239-244
Published: 1986
Released on J-STAGE: March 02, 2007
JOURNAL FREE ACCESSEffect of urinary enzyme inhibitor urinastatin (MTI) on disseminated intravascular coagulation (DIC) was investigated. The prolongation of PTT and increase in FDP in endotoxin-induced DIC in rats were restored by the intravenous infusion of MTI. The reduction in platelet counts, decrease in fibrinogen level and prolongation of PT were partially suppressed by the drug. Furthermore, in vitro addition of MTI prevented the decrease in r and k values and increase in ma and mε values in the thromboelastogram of whole blood in endotoxin-induced DIC in rabbits. It is suggested that MTI might prevent DIC in vivo and in vitro through the inhibition of Factor XII activity and through the prevention of thromboplastin release caused by endotoxin.View full abstractDownload PDF (4995K) -
Kazuo TAKAHASHI, Kanou ENDOH, Noboru YAMADA, Shuichiro KADOWAKI, Yasuh ...1986 Volume 88 Issue 3 Pages 245-254
Published: 1986
Released on J-STAGE: March 02, 2007
JOURNAL FREE ACCESSThe effects of a new anti-allergic agent, MY-5116: isoamyl 5, 6-dihydro-7, 8-dimethyl-4, 5-dioxo-4H-pyrano [3, 2-c] quinoline-2-carboxylate, on experimental animal models of type I ?? type IV allergic reactions and the formation of IgE antibody were investigated. MY-5116 administered intraperitoneally at doses of 30 and 100 mg/kg suppressed significantly the homologous PCA in guinea pigs. MY-5116 administered intraperitoneally at the dose of 100 mg/kg also suppressed significantly the heterologous PCA in guinea pigs. MY-1250, the main active metabolite of MY-5116, showed no suppression on the Schultz-Dale reaction in guinea pigs, and MY-5116 showed no inhibition on the active systemic anaphylaxis in mice (type I). MY-5116 showed no inhibition on the reversed cutaneous anaphylaxis in rats (type II), the Forssman reaction in guinea pigs (type II), the Arthus reaction in mice (type III) and the delayed type hypersensitivity in mice (type IV). MY-5116 showed no suppression on the formation of IgE antibody in C3H/He and BALB/c mice and rats. From these results, it is concluded that MY-5116 selectively suppresses the experimental models of type I allergic reaction.View full abstractDownload PDF (7948K)
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