Fundamental Toxicological Sciences
Online ISSN : 2189-115X
ISSN-L : 2189-115X
8 巻 , 5 号
選択された号の論文の4件中1~4を表示しています
Original Article
  • Noriko Suzuki-Kemuriyama, Akari Abe, Sae Nakane, Kinuko Uno, Shuji Oga ...
    2021 年 8 巻 5 号 p. 135-145
    発行日: 2021年
    公開日: 2021/10/20
    ジャーナル フリー

    Nonalcoholic steatohepatitis (NASH) is an aggressive form of nonalcoholic fatty liver disease that presents with steatosis, inflammation, and fibrosis and can progress to cirrhosis and cancer. Thus, methods for controlling this lifestyle-related disease are urgently needed. An extract of Siraitia grosvenorii (Luo-Han-Guo) (luohanguo extract (LE)) is widely used as a sweetener; its major bioactive constituents, mogrosides, have shown anti-oxidative and anti-inflammatory properties, exerting multiple pharmacological effects in various disorders. In the present study, we investigated the effects of LE on NASH induced in mice fed a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet without trans fatty acids (CDAA-HF- T(−)). Mice were fed with CDAA-HF- T(−) and drinking water containing LE at concentrations of 0%, 0.2%, 0.6%, and 2% for 28 weeks. Our results showed that LE was not toxic under the experimental conditions evaluated. In the liver of mice fed CDAA-HF- T(−), LE did not affect steatosis or early phase events from macrophage recruitment to hepatocyte death but inhibited late phase events, the progression of inflammation, and fibrosis (mechanisms independent of transforming growth factor-β signaling). Sweeteners with beneficial biological functions, such as LE, may be useful for controlling lifestyle-related diseases, such as NASH, and promoting human health.

Original Article
  • Kaito Yamashiro, Atsushi Hirata, Ryosuke Ota, Fumihiko Ogata, Takehiro ...
    2021 年 8 巻 5 号 p. 147-155
    発行日: 2021年
    公開日: 2021/10/20
    ジャーナル フリー

    Liposomal amphotericin B (L-AMB) causes renal dysfunction and hypokalemia, but little is known about the relationship between serum electrolyte levels before or after administration and renal dysfunction. The changes in serum electrolyte levels before and after administration in patients with L-AMB-induced renal dysfunction were examined. This study included 87 patients administered L-AMB at Kindai University Nara Hospital. The number of patients with G1 (serum creatinine (Scr) levels (mg/dL) > 1.07–1.605 in male and > 0.79–1.185 in female) and G2 (Scr level > 1.605–3.21 in male and > 1.185–2.37 in female) was 25 (28.7%) and 14 (16.1%), respectively. Multivariable logistic regression analysis revealed the onset of G2 was significantly associated with baseline estimated glomerular filtration rate (eGFR), odds ratio (OR): 0.99, 95% confidential interval (95% CI): 0.95–1.02 and, baseline serum potassium levels, OR: 3.50, 95% CI: 1.16–12.06. Serum potassium levels were significantly higher in the G2 group than in the G0 group (Scr levels < 1.07 in male and < 0.79 in female) during the study period. These results indicated the changes in serum potassium levels are associated with renal dysfunction. Monitoring of serum potassium levels before and after administration may contribute to the evaluation of renal dysfunction in patients receiving L-AMB.

Toxicomics Report
Original Article
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