Simple ulcer is one of the rare intestinal diseases, showing the recurrent and intractable chronic ulcerative lesions in the bowel. Its pathogenesis and etiology have remained to be elucidated, and the standard method for the treatment has not yet been established. Herein, we show the clinical analysis of 5 patients with simple ulcer in our clinic. In the first medical examination, all of 5 cases complained abdominal pain and bloody stool. Four of them complained diarrhea, intermittent bloody stool and painful oral aphtha. Endoscopical findings showed macroscopically deep and discreted ulcers in the ileocecal region in all patients. In two patients, recurrent and intractable deep and demarcated ulcers have appeared in the pharynx. The patients associated with deep pharyngeal ulcers may have an inclination to suffer from bowel perforation or recurrent bloody stool. In two cases with the lesions extending to the upper or middle ileum, the intestinal perforation have appeared, suggesting that the patients with ulcers extending to the upper or middle ileum from the ileocecal region may have a higher risk of perforation. For the introduction and maintenance of the remission stage, it is necessary to treat them by the nutrition therapy including total parenteral nutrition, elemental diet and/ or low residual diet, and drug administration such as salazosulfapyridine, 5-aminosalicylic acid and/or corticosteroid. Four with corticosteroid administration showed a healed or scarred ulcer, temporarily for one case. suggesting that steroid treatment should be efficacious for simple ulcer, only for short duration in any cases.
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