A 74-year-old male was admitted to our hospital because of general fatigue. In his past history, he had chronic renal failure on HD and diabetes meritis. six yeare ago, he was pointed out to have an adenoma of the 4th portion of the duodenum, and followed up. Duodenography showed a sessile polypoid lesion of the 4th portion of the duodenum. Upper gastrointestinal endoscopy revealed a 40 × 30 mm polypoid lesion, suspected intramucosal lesion. The pathological finding was well differentiated adenocarcinoma. He was at poor risk, but we didn't choose endoscopic mucosal resection due to the location and size of the lesion. Partial resection of the duodenum was performed, which revealed intramucosal adenocarcinoma with adenoma component. After the operation, his condition was uneventful with no recurrence.
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