Gastric adenocarcinoma of the fundic gland type (chief cell predominant type, GA-FG-CCP) has recently been proposed as a new, rare variant of gastric adenocarcinoma. However, the endoscopic features of GA-FG-CCP have not been investigated in detail. The aim of this study was to elucidate the clinicopathological and endoscopic features of GA-FG-CCP, and describe tips for the endoscopic diagnosis of GA-FG-CCP.
The most common features of GA-FG-CCP on conventional endoscopy (CE) were 1) shape of a submucosal tumor, 2) whitish color, 3) dilated vessels with branching architecture, and 4) background mucosa without atrophic change. The endoscopic findings of GA-FG-CCP by magnifying endoscopy with narrow-band imaging (ME-NBI) did not meet the criteria for the usual type of gastric cancer. However, we detected the four most frequent features of GA-FG-CCP on ME-NBI as follows : 1) indistinct line of demarcation between the lesion and the surrounding mucosa, 2) dilatation of crypt opening, 3) dilatation of intervening part between the crypts, and 4) microvessels without distinct irregularity. These features were present due to the location of tumor origin and congestion by pressure from the tumor.
The endoscopic diagnosis of GA-FG-CCP could be made by recognizing these endoscopic features of GA-FG-CCP on CE and ME-NBI. In addition, to diagnose GA-FG-CCP correctly by pathological examination of biopsy specimens, these endoscopic features and clinicopathological features should be taken into consideration.
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