In order to evaluate distinctive features on thyroid function tests in elderly hyperthyroid. patients (EHP), basal metabolic rate (BMR), thyroid uptake of
131I, the serum concentrations of triiodothyronine (T
3) and thyroxine (T
4) and the value of T
3-uptake were measured and free thyroxine index (FT
4I) and T
3/T
4 ratio (ng/μg) were calculated in 24 untreated hyperthyroid patients, caused by Graves' disease, over the age of 61. The results were compared to 34 untreated hyperthyroid patients, caused by Graves' disease, under the age of 39. In 24 EHP, 3 had congestive heart failure, 2 had diabetes mellitus and each one of 2 had myasthenia gravis and gastric ulcer, and anyone of 34 young hyperthyroid patients (YHP) had not other systemic illness. The serum concentrations of T
3 and T
4 and FT
4I were significantly lower in EHP without any other systemic illnesses than in YHP, however there was no difference in T
3/T
4 ratio between both groups. Although there were no significant differences in the serum T
4 concentration and FT
4I between in 7 EHP with other systemic illnesses and 17 EHP without any other systemic illnesses, the serum T
3 concentration and T
3/T
4 ratio were significantly lower in EHP with other systemic illnesses than in EHP without any other systemic illnesses and in YHP. The pattern of T4 toxicosis, which is characterized by a normal T
3 and an elevated T
4 level, was shown in 2 of 7 EHP with other systemic illnesses and was not shown at all in 17 EHP without any other systemic illnesses and in 34 YHP. Our present data suggests that serum concentrations of T
3 and T
4 in EHP is significantly decreased in comparison with YHP, farther- more peripheral conversion of T
4 to T
3 in EHP may be decreased in the presence of other nonthyroidal illnesses not by aging.
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