It is well known that the bone mineral content in male is significantly higher than that in female in all over the age. In addition, the loss of bone mineral after age 50 is significantly greater in females than in males.
Little informations about quantitative and qualitative difference in bone mineral content between male and female were available.
In order to clarify the difference in the loss of bone mineral with aging between male and female, we have examined the bone mineral status in 407 elderly subjects (201 males and 206 females; aged over 60) lived in Yoikuin home for aged. The bone mineral status was measured by the method of microdensitometry developed by Inoue
et al. This method could measure metacarpal index (MCI) and maximal calcified rate in metacarpal cortex (ΔGSmax).
MCI and ΔGSmax in the male subjects were significantly (p<0.01) higher than those in females. MCI and ΔGSmax were decreased with aging in both sexes. In male subjects, loss of ΔGSmax with aging was greater than that of MCI with aging. On the other hand, the loss of MCI with aging was predominant when compared with that of ΔGSmax in the females.
Subsequently, we have calculated the correlation coefficients between MCI and ΔGSmax, and other physical and chemical parameters in both sexes. In the male, MCI was significantly correlated with age (p<0.05), serum calcium levels (p<0.01) and serum Al-P activity (p<0.01) and ΔGSmax was significantly correlated with age (p<0.05), body height (p<0.01), body weight (p<0.01), blood pressure (p<0.01), power of grasping (p<0.05), serum uric acid levels (p<0.05) and serum Al-P activity (p<0.01).
In the female, MCI was significantly correlated with age (p<0.01), thickness of skin (p<0.01), power of grasping (p<0.05) and serum Al-P activity (p<0.05), and ΔGSmax was significantly correlated with age (p<0.01), body height (p<0.01), body weight (p<0.01), thickness of skin (p<0.01), power of grasping (p<0.01), serum total protein levels (p<0.05) and serum Al-P activity (p<0.01).
Thus the bone mineral content was qualitatively and quantitatively different between aged males and females. This sexual difference in bone mineral content in the aged might be explained by the difference in hormonal enviroment and by physical status.
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