Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
Print ISSN : 0300-9173
Volume 28 , Issue 1
Showing 1-14 articles out of 14 articles from the selected issue
  • T. Ozawa
    1991 Volume 28 Issue 1 Pages 1-9
    Published: January 30, 1991
    Released: November 24, 2009
    JOURNALS FREE ACCESS
    Download PDF (1384K)
  • T. Tsumita
    1991 Volume 28 Issue 1 Pages 10-12
    Published: January 30, 1991
    Released: November 24, 2009
    JOURNALS FREE ACCESS
  • Akiko Kawamoto, Kazuyuki Shimada, Kozo Matsubayashi, Osamu Kuzume, Tai ...
    1991 Volume 28 Issue 1 Pages 13-17
    Published: January 30, 1991
    Released: November 24, 2009
    JOURNALS FREE ACCESS
    Evidence suggests that physical activity is related to lower coronary risk factors in middle-aged subjects, but to date data are lacking for older persons. A total of 32 healthy male subjects in their seventh decade (64±3 years) were divided into 2 groups based on maximal exercise tests (Bruce protocol). Group I consisted of 14 individuals who showed “excellent” work capacity (exercise duration of≥10min, 11±1min), and Group II 18 individuals with “fair” work capacity (7.5±1min). None of them showed ECG evidence of ischemia in these tests. As compared with Group II, Group I showed lower casual and 24 hour ambulatory blood pressure (136±21 vs 114±11mmHg for the average daily systolic pressure respectively), higher apo A-I levels (116±36vs 139±20mg/dl) and lower apo B/A-I ratios. There was no significant difference in triglycerides, total and HDL cholesterol or apo-B levels between these two groups. Body mass index and smoking habits were similar in Groups I and II. These results suggest that even in older persons, excellent physical fitness is related to lower cardiovascular risk factors.
    Download PDF (684K)
  • Hirohiko Sato, Kimunao Mizukawa, Norio Ogawa, Masato Asanuma, Haruhiko ...
    1991 Volume 28 Issue 1 Pages 18-23
    Published: January 30, 1991
    Released: November 24, 2009
    JOURNALS FREE ACCESS
    Changes in the distribution and densities of somatostatin receptors (SS-R) in young adult and aged rat brain and the effects of chronic administration of bifemelane hydrochloride (bifemelane) on these changes were studied by in vitro quantitative autoradiography of iodinated [Tyr11] SS-14. SS-R was highest in density in the amygdala, followed by the cingulate cortex, temporal cortex, frontal cortex, hippocampus and septal nucleus in the young adult rats. In contrast, SS-R binding was markedly reduced in the frontal cortex, temporal cortex, cingulate cortex, hippocampus, amygdala and septal nucleus of aged rats compared to young adult rats. However chronic administration of bifemelane significantly increased SS-R binding in the frontal cortex, temporal cortex, cingulate cortex, hippocampus and septal nucleus of aged rats without effects on young adult rats. This bifemelane-induced increase in SS-R is considered to have important implications in the mechanism of the therapeutic efficacy of bifemelane.
    Download PDF (1254K)
  • Kenji Kohtani
    1991 Volume 28 Issue 1 Pages 24-28
    Published: January 30, 1991
    Released: November 24, 2009
    JOURNALS FREE ACCESS
    Ultramicromeasuring studies were made on different sites of thyroxine-induced hypertrophic myocardium of rats of different ages (6 and 26 months of age). In the resting stage, the area ratio of mitochondria to myofibrils was significantly smaller in old rats and also in the apex. In rats receiving thyroxine, the ratio was not increased in the young rats, but was markedly increased in the old, reaching the value in the young rat, suggesting a decrease in the reserve power of the myocardial mitochondria in the old rats.
    Download PDF (657K)
  • Tomio Tsukazaki, Kizuku Kuramoto, Shuuji Oda, Seigo Ueda, Satoru Matsu ...
    1991 Volume 28 Issue 1 Pages 29-33
    Published: January 30, 1991
    Released: November 24, 2009
    JOURNALS FREE ACCESS
    A clinicopathological analysis of myocardial infarction with an onset of stroke-like symptoms was carried out on 30 autopsy cases at the Tokyo Metropolitan Geriatric Hospital. The cases were classified into four groups according to the types of brain lesions, I: embolism (n=17), II: thrombosis (n=9), III: bleeding (n=2), and IV: no remarkable focal lesion (n=2). Classification was made based on clinical findings, and pathological features. The characteristic clinical findings were conciousness disturbance, no elevation of blood pressure at the onset of stroke, hemiplegia and shock. However, the typical anginal chest pain was found in only 17% of cases. The underlying diseases and complications were hypertension, atrial fibrillation (Af), disseminated intravascular coagulation (DIC), renal failure, malignant neoplasma, and diabetes mellitus. The incidences of Af, DIC, mural thrombus, non-bacterial thrombotic endocarditis (NBTE) were significantly higher in the group with cerebral embolism than in the group with cerebral thrombosis. The coronary stenotic index was also smaller in the group with cerebral embolism. Therefore, the major etiology of cardio-cerebral apoplexy was a simultaneous embolism to the brain and heart due to Af, NBTE or, DIC.
    Download PDF (691K)
  • Keiko Miya, Shigeto Morimoto, Keisuke Fukuo, Shunji Imanaka, Tsunehito ...
    1991 Volume 28 Issue 1 Pages 34-39
    Published: January 30, 1991
    Released: November 24, 2009
    JOURNALS FREE ACCESS
    Calcium (Ca)-related factors were evaluated as possible related factors to senile dementia in 60 elderly female subjects(mean age±SD: 79±7 years). These subjects were classified by their score on Hasegawa's Dementia Screening Scale, into a non-dementia group (score 22-32.5, n=18) and a dementia group (0-21.5, n=42), and the latter group was further classified by ischemic score into Alzheimer-type dementia (n=22) and vascular-type dementia (n=20). There was no significant difference in the mean values of age or serum creatinine among the three groups. In the Alzheimer-type dementia group, the mean serum level of Ca was significantly lower, and the serum level of parathyroid hormone (PTH) and urinary Ca were significantly higher than those in the non-dementia group, respectively. In the group of vascular-type dementia, the mean serum level of calcitonin (CT) was slightly, but not significantly, lower than that in the non-dementia group. The score for cognitive subjects negatively correlated significantly with the values of serum PTH (r=-0.49, p<0.05) and urinary Ca excretion (r=-0.38, p<0.05), respectively, and positively correlated significantly with that of serum 1, 25-dihydroxyvitamin D [1, 25(OH)2D] (r=0.31, p<0.05), in the combined group of non-dementia and Alzheimer-type dementia, and positively correlated significantly with the serum CT level (r=0.40, p<0.05) in the combined group of non-dementia and vascular-type dementia. These results suggest that Ca-regulating hormones PTH, CT and 1, 25-(OH)2D are important in different ways for the cognitive state in senile dementia.
    Download PDF (802K)
  • Yasuyoshi Ouchi, Kenzo Terashita, Tetsuro Nakamura, Kazuhide Yamaoki, ...
    1991 Volume 28 Issue 1 Pages 40-45
    Published: January 30, 1991
    Released: November 24, 2009
    JOURNALS FREE ACCESS
    This study was conducted to investigate the relationship between aortic pulse wave velocity (PWV) and coronary atherosclerosis. We measured PWV in 105 subjects (84 males and 21 females; age 59±0.5) who received coronary angiographic examination (CAG). PWV was measured by simultaneous recording of pulse waves from the left carotid and the left femoral arteries, electrocardiogram and phonocardiogram. The subjects were classified into 4 groups according to the number of major coronary arteries having stenosis, that is, N group with normal CAG, 1 vessel disease (VD) group, 2VD group and 3VD group. The PWV value was significantly greater only in 3VD group(n=10, age 63±3.6, PWV 10.0 ±0.88m/sec) than that in N group (n=18, age 53±2.0, PWV 8.0±0.34m/sec). No significant difference was observed between PWV value in N group and that in all patients with coronary artery stenosis (n=87, age 60± 2.0, PWV 8.9±0.2m/sec). To further investigate the relationship between PWV values and CAG findings, we used a CAG score which means the sum of the points assigned to each coronary artery segment (American Heart Association) according to the severity of stenosis (0, 1, 2, 3, and 4 for normal, less than 49% stenosis, 50 to 74% stenosis, 75 to 99% stenosis, and complete occlusion, respectively). The PWV values significantly correlated with the CAG score and also with age by a simple regression analysis. Multivariate analysis, however, revealed that PWV values did no longer correlate with CAG score. PWV values still significantly correlated with age. These results indicate that PWV might not be an excellent clinical index of coronary artery stenosis.
    Download PDF (738K)
  • Noboru Koike
    1991 Volume 28 Issue 1 Pages 46-51
    Published: January 30, 1991
    Released: November 24, 2009
    JOURNALS FREE ACCESS
    During the last 10 years, 162 aged cases (60yrs. to 96yrs., average 75.7yrs.) that had positive effusion cytology were confirmed to have malignancy on autopsy. The effusion cytology of samples from aged patients made the first clinical diagnosis of malignancy in 46% of the cases studied, and this frequency increased with increasing age. The effusion cytology results from aged patients with malignancy were observed to have the following characteristic pathology profiles; (a). In pleural effusion: The primary organ of cancer was mostly the lung. However the histological cell types varied from predominantly adenocarcinoma to small cell carcinomas, squamous cell carcinomas etc. (b). In ascitic effusion: The primary organ of cancer varied and included the stomach, gallbladder, pancreas and ovaries. In these cases, however, the histological cell type was predominantly adenocarcinoma.
    Download PDF (772K)
  • Masayuki Ogiwara, Kyuzo Aoki, Koichi Miyagawa, Takaaki Nobuta, Tatsuji ...
    1991 Volume 28 Issue 1 Pages 52-57
    Published: January 30, 1991
    Released: November 24, 2009
    JOURNALS FREE ACCESS
    Sixty-four elderly autopsy cases with acute myocardial infarction (AMI) were investigated in Nagoya Koseiin Geriatric Hospital. First AMI was observed in 35 cases, and recurrent AMI in 29. The primary causes of death were cardiac rupture and congestive heart failure in the first AMI and the recurrent AMI, respectively. The most frequent ECG findings before AMI were ischemic ST-T change (57%) and Q-QS abnormality (41%) on the first and recurrent AMI, respectively. The ECG findings were normal in 6 (21%) of 29 recurrent MI cases. There was a tendency towards Q-QS abnormality in large size old MI, but not in small size MI. In 29 cases with recurrent AMI, the positional relationship between the old MI and the AMI was classified into 3 groups of different area, same area, and different and same area according to the Maccarie classification. The frequency in our cases was similar in the 3 groups. Ten cases with different area were further classified into 3 groups, i.e. opposite, adjacent, and opposite and adjacent. Opposite cases consisted of 4 (40%) cases, while opposite and adjacent consisted of 6 (60%). It is suggested that the recurrent AMI is more likely to be fatal when AMI occurs opposite to a previous lesion rather than adjacent to an old lesion.
    Download PDF (731K)
  • Satoshi Kuboi, Kozui Kida, Tomoko Mizuuchi, Satoru Jinno, Hideki Katsu ...
    1991 Volume 28 Issue 1 Pages 58-62
    Published: January 30, 1991
    Released: November 24, 2009
    JOURNALS FREE ACCESS
    A case of repeated episodes of hypoventilatory respiratory failure accompanied with primary hypothyroidism was reported. A 76-year-old woman was admitted to our hospital due to both disturbance of consciousness and respiratory failure. A diagnosis of primary hypothyroidism complicated with hypoventilatory respiratory failure deterioration due to respiratory infection was made. Supplemental therapy of thyroid hormones improved her general condition, but respiratory failure recurred after interruption of a replacement drug. Cases of unexplained respiratory failure should be differentiated from respiratory failure induced by hypothyroidism.
    Download PDF (1128K)
  • Kazuomi Kario, Takefumi Matsuo, Kazukiyo Nakao
    1991 Volume 28 Issue 1 Pages 63-68
    Published: January 30, 1991
    Released: November 24, 2009
    JOURNALS FREE ACCESS
    A 74-year-old female with hereditary xanthinuria and xanthine stones is reported. She has a family history of consanguineous parents and a past history of right side nephrectomy due to a xanthine renal stone and vesicolithotomy of 3 bladder stones approximately 5×4×4 cm in size at the age of 58 and 71, respectively. Her young brother exhibited a slightly elevated urinary excretion of oxypurines. Laboratory examination showed a low serum level (0.3mg/dl) and urinary excretion (1.56mg/day) of uric acid, and high plasma and urine levels of oxypurines. No xanthine oxidase activity was detectably in duodenal mucosa by biopsy specimen obtained by duodenofiberscopy. Now she has another stone approximately 5×4×4cm in her bladder. There have been are few elderly cases of hereditary xanthinuria with recurrent giant urolithiasis.
    Download PDF (1713K)
  • 1991 Volume 28 Issue 1 Pages 69-108
    Published: January 30, 1991
    Released: November 24, 2009
    JOURNALS FREE ACCESS
    Download PDF (6505K)
  • 1991 Volume 28 Issue 1 Pages 109-121
    Published: January 30, 1991
    Released: November 24, 2009
    JOURNALS FREE ACCESS
    Download PDF (1931K)
feedback
Top