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Predecessor
Volume 5, Issue 5
Displaying 1-6 of 6 articles from this issue
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Motohiro Momose, Akinori Takasawa, Bunya Imamura, Shinji Shimizu1968 Volume 5 Issue 5 Pages 367-374
Published: September 30, 1968
Released on J-STAGE: November 24, 2009
JOURNAL FREE ACCESSThe Numbers who consulted their health in periodic health check-up from March, 1956 to Dec., 1966 were 697 sasses, male and female numbers were respectively 647 and 50. The constitution of their ages peaked on the wrong side of fifty, next fourty and sixty. The authors investigated about various results of periodic health check-up concerning circulatory (A) and digestive organs (B).
(A) Results of circulatory sistem examination
Hypertension……21.4%
Abnormality of urine; protein positive…7.9%
sugar positive…6.9%
Examination of eye bottum; KW 0……48.9%
I……29.5%
II……21.6%
III, IV……0%
Abnormality of PSP test……29.8%
Abnormality of Fishbergs concentration test……17.4%
Abnormality of GTT……41.1%
Abnormality of serum total cholesterol value……12.0%
Abnomality of cardiothoracic ratio……13.4%
Abnomality of ECG; RV5>2.6mV……27.7%
ST-T abnomality……14.7%
(B) Results of digestive system examinatiom
Faecal parasiten eier positive……11.7%
(Eier of Metagonimus yokogawai……58.3%)
Acidity of gastric juice; anacidity……19.4%
hypoacidity……29.1%
normoacidity…31.4%
hyperacidity…21.1%
Abnormality BSP test……29.9%
Abnormality of X ray examination
Stomach……
susp cancer 0.3%, susp ulcer 1.7%, ulcer 1.0%, susp polyp 0.15%, polyp 0.15%
Duodenum……
susp ulcer 1.6%, ulcer 2.4%, diverticle 0.5%, deformity of bulbus 2.4%
Gall bladder……
susp, stone 0.6%, stone 1.9%, bad image 3.9%.
Large intestine……
cancer 0%, ulcer 0%.
In investigation of prognosis, percentage of answer were 81%, 17 cases died of circulatory diseases (brain: 9, heart: 7, kidney: 1), 7 cases died of digestive diseases (stomach cancer: 3, intestine cancer: 1, liver cancer: 1, liver cirrhosis: 1, pancreas cancer: 1), 4 cases died of other causes (mammary cancer: 1, brain tumor: 1, dotage: 1, traffic accident: 1). In the circulatory death, abnormality of GTT was most dominant in various examinations ECG abnormality was next. In the digestive death, a case of stomach cancer was already suspected at periodic health check-up, but others were indisputable. A case of liver cirrhosis indicated abnormality of BSP test at that time.View full abstractDownload PDF (762K) -
Follow-up Obseavation after Discontinuation of the DrugJun Igari, Yasuyuki Hayashi, Moriyasu Ushio, Motohiro Iwado1968 Volume 5 Issue 5 Pages 375-380
Published: September 30, 1968
Released on J-STAGE: November 24, 2009
JOURNAL FREE ACCESSIt was proved from our earlier studies that the anabolic steroid was to decrease the serum cholesterol level.
The purpose of this report is to show the changes of the serum cholesterol level after discontinuation of the drug.
Twenty atherosclerotic patients treated with anabolic steroid and 17 patients treated with placebo as acontrol were examined during a period of 1 year the administration of the drug discontinued.
The results were as follows:
(1) The cholesterol level returned after the discontinuation of the drug. However, the cholesterol level in the group rescieving the anabolic steroid was lower than that in the control group during 3 months after the discontinuation of the drug.
(2) In 1 case among 8 with the anabolic steroid, S-GOT, S-GPT and serum alkaline phosphatase activity showed significant increase within 2 months after the administration, but these values returned to the normal level after the discontinuation of the drug. In the other 7 cases. S-GOT and S-GPT showed within the normal level and serum alkaline phosphatase activity showed the upper limit of the normal level.
(3) The results of these findings, indicate that an intermittent administration of an anabolic steroid should be recommended, and is an effective method to decrease total serum cholesterol level.View full abstractDownload PDF (530K) -
Relationship between Cerebral Apoplexy and the Retinal Artery and Intra-cerebral Small ArteriesShigeo Shibata1968 Volume 5 Issue 5 Pages 381-391
Published: September 30, 1968
Released on J-STAGE: November 24, 2009
JOURNAL FREE ACCESSAlthough many histopathological studies on the retinal artery or the in tracerebral small artery have been found, there have been quite a few studies on the relationship between these two arteries. The purpose of the present paper was to elucidate the relationship between the retinal artery and the intracerebral small arteries. The materials and methods were already described in the first report of these series of study.
The results were as follows;
1) The thickening in the intima of the intracerebral small artery was often found in cases with the hypertrophy or collagenous fibrosis in the media of the retinal artery.
2) Histopathological findings that might correlate with cerebral apoplexy were collagenous fibrosis in the media of the retinal artery, and thickening in the intima and angionecrosis of the intracerebral small arteries, but not likely the thickening in the media of the retinal artery.
3) The fact a definite correlation between cerebral apoplexy and collagenous fibrosis in the media of the retinal arteries was demonstrated may be very important and usefull in prediction of cerebral apoplexy by the clinical findings of eyeground.
4) The pathological findings of the retinal arteries were less and more slight than those of the intracerebral small arteries.View full abstractDownload PDF (1498K) -
Relationship between Clinical Findings of Eyeground, Histopathology of Retinal Arteries, and Cerebral ApoplexyShigeo Shibata1968 Volume 5 Issue 5 Pages 392-401
Published: September 30, 1968
Released on J-STAGE: November 24, 2009
JOURNAL FREE ACCESSCorrelation between collagenous fibrosis in the media of the retinal arteries and cerebral apoplexy was presented in the second report of this series. If the correlations between clinical findings of the eyeground and pathological findings of the retinal arteries are, therefore, confirmed, the occurence of the cerebral apoplexy may be predicted. In the present study, the clinical findings of the eyeground were correlated with the histopathlogical findings of the retinal arteries and then with cerebral apoplexy.
One hundred and four cases, which were fundoscopically examined the eyeground prior to death, were selected among materials used in previous two papers, and were used in the present study.
The narrowing, an increase in reflex, and the irregularity in caliber of the retinal artery, arteriovenous crossing, silver-wire artery, white thread artery, bleeding and white spot in the retina, and the slightly modified classifications by Keith-Wagener as well as Sheie were fundoscopically observed and were used in this investigation.
The results were as follows:
The narrowing of the retinal arteries and the retinal bleeding likely correlated with the medial hypertrophy of the retinal arteries.
An increase in reflex and narrowing of the retinal arteries, and arterio-venous crossing seemed to correlate with the medial collagenous fibrosis of the retinal arteries.
Incidences of cerebral apoplexy in each group of II a, II b, III of Keith-Wagener's classification, and II, III, and especially in grade IV of Scheie's classification for sclerois, and I, II, and III of Scheie's classification for hypertension were higher than those in other groups.
Fundoscopic findings which correlated with cerebral apoplexy were likely narrowing, increased reflex and irregularity in caliber of the retinal arteries, and arterio-venous crossing.
There was only a little correlation between the retinal bleeding and cerebral apoplexy. Therefore, the retinal bleeding is not so useful in prediction of cerebral apoplexy.View full abstractDownload PDF (1166K) -
Takenori Yamaguchi, Katsuharu Kimoto, Takaaki Mimatsu1968 Volume 5 Issue 5 Pages 402-409
Published: September 30, 1968
Released on J-STAGE: November 24, 2009
JOURNAL FREE ACCESSComparative histo-pathologic study was made in the vessels of thekidney, brain (basal ganglia), and retina utilizing 42 adult autopsy cases.
The grade of arteriolar hyalinization or so called angionecrosis and fibroelastic hyperplasia of the kindney and brain vessels was determined from negative through 3 plus considering the extent and severity of each respective finding. Retinal arteri olosclerosis was likewise graded from negative through 3 plus.
Eighty-one per cent of the cases showed a nearly equal degree-either equal or not differing by more than one grade-of hyalinization or so-called angionecrosis between the kidney and the brain. Cerebral angionecrosis was found in approximately 70% of the cases with arteriolar hyalinization in the kidney, but it occurred in only 10% of the cases without the renal change.
Fibroelastic hyperplasia of nearly equal degree of the renal and cerebral vessles was found in 88% of the cases and fibroelastic hyperplasia of the cerebral vessels was found in over 90% of the cases bearing the same change in the kidney.
The degree of retinal arteriolosclerosis was coincident with that of hyalinization or fibroelastic hyperplasia of renal arterioles in 71% and 76% of the cases, respectively. Fibroelastic hyperplasia in the kidney was always found in the cases with retinal arteriolosclerosis.
The association of retinal arteriolosclerosis with cerebral angionecrosis in nearly equal degree was found in 50%, and that of the former with fibroelastic hyperplasia of cerebral vessels in 67% of the cases. Cerebral angionecrosis was observed in only 50% and fibroelastic hyperplasia of the cerebral vessels in approximately 90% of the cases with retinal arteriolosclerosis. It can be presumed from these results that retinal arteriolosclerosis associated with fibroelastic hyperplasia of cerebral vessels but not of angionecrosis.
In summary, the overall, correlations of vascular changes were the best between kidney and the brain, followed by the kidney and the retina. The significance of these findings were discussed.View full abstractDownload PDF (1059K) -
Takuo Fujita, Noboru Handa, Kazutoshi Okano, Hajime Orimo, Michiyoshi ...1968 Volume 5 Issue 5 Pages 410-414
Published: September 30, 1968
Released on J-STAGE: November 24, 2009
JOURNAL FREE ACCESSA 75-year-old female with history of partial left nephrectomy due to nephrolithiasis at the age of 44 followed by extirpation of the remaining part of the left kidney at 69 developed cough, productive sputum and painful swelling of the left lower back with corresponding density in the left lower lung field in chest X-ray over a period of 1 year.
After admission thirst, polyuria, polydipsia, and constipation gradually appeared. Serum calcium was 13.8mg/dl, serum phosphorus 2.6mg/dl, serum alkaline phosphatase 2.8-4.4 Bessey units, % TRP 41.5%, and the Expected Time of Recovery of serum Ca following EDTA-Ca-Na2 infusion 1.5 hour.
Hemoglobin was 60% (Sahli), RBC 325×104, WBC 12, 300. ESR 74/hour, serum Na 144 mEq/l, K 3.6-3.2 mEq/l, and Cl 102-103 mEq/l. Parathyroid hormone-like calcium mobilizing activity in urine assayed by Munson's method was 47 USP units/24 hours (normal range 0-30). The hypercalcemia failed to respond to corticosteroid but normalized following oral administration of K2HPO4. Autopsy revealed squemous cell carcinoma of the left lung occupying almost the whole left lower lobe of the lung and infiltrating to the diaphragm and chest Wall involving the left 9th, 10th, and 11th rib.
All 4 parathyroid glands were normal in size. The tumor tissue extracted with phenol and purified through XE-64 column had parathyroid hormonelike calcium mobilizing activity corresponding to 28.6 USP units/g. Secretion of parathyroid hormone-like substance from the primary pulmonary cancer appears to be responsible for the clinical picture.View full abstractDownload PDF (1918K)
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