Comparative study has been made histologically and micrometrically on the senile changes of the kidney between Caucasians and Japanese, and there were noticed some interesting differences in the course of ageing process of the kidney between both races
1) The weight of the kidney was larger in the Caucasians than the Japanese, and the decrease of the weight with advancing age was more marked in the Japanese.
2) Arteriosclerotic changes of the arteries of middle and smaller caliber in the kidney increased in grade with age, and the increase was more marked and appeared earlier in the Japanese, but arteriolosclerosis was not increased in grade parallel with advancing age in both races.
3) Fibrosis and hyalinization of the renal medullae tended to increase with advancing age, more markedly in the Japanese.
4) Glomeruli of the kidney were larger in size in the Caucasians than the Japanese, and decreased in size with age only in the Japanese.
5) The cell number in the glomerular tuft was slightly fewer in the Japanese, and decreased with age in both races.
6) The renal parenchymal cells were considered to be larger in size in the Caucasians than the Japanese. The decrease in cell number with age began earlier in the Japanese.
7) The nuclei of the renal epithelial cells were also larger in size in the Caucasians, but there was observed no significant decrease with age in both races.
8) The senile changes of the kidney were not necessarily related to the arteriosclerotic changes, and were also considered to be essentially same between two races. The process of senile changes in the kidney has been discussed with special consideration to the difference between two races.
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