A methodological evaluation of 133Xe clearance technique for determination of regional cerebral blood flow (rCBF) was attempted with special regards to geometrical distribution of the inert radioisotope in the brain and its relation to the extracranial monitoring system. Results are summarized as follows:
1) According to size and shape of the collimator used, distributions of intracranial isosensitive points of
133Xe were found to be markedly varied. The tapered-type collimator with a small orifice had the most localized monitoring area compared to cylindrical- or open-type collimators.
2) Repeated determinations of rCBF at the same portion(temporal area)of the same patient using various kinds of collimator revealed that average rCBF (f) were correlated with each other to a certain extent (P<0.05), but that both fast (f
f) and slow (f
s) flow components showed no significant correlations. There was, however, such a tendency that values of weight fraction of fast flow perfusion area (w
f) measured by the tapered-type collimator were greater than those obtained by other types of collimators.
3) Each value of rCBF which was calculated by two compartmental analysis was well consistent with a corresponding rCBF value calculated by stochastic analysis using the same clearance curve of
133Xe. This was observed indifferent to kinds of diseases which patients were suffering from.
4) Comparisons of rCBF and average total cerebral blood flow (CBF, N
2O method) in the same individual revealed a statistically significant correlation between fast flow component (f
f) and CBF (r=0.511, P<0.01), suggesting that values of f
f were reflected to a certain extent in CBF. However, there found no such significant correlations between f and CBF, or between f
s and CBF.
5) A mean value of average rCBF in patients with cerebrovascular diseases (CVD) was significantly lower than that of other subjects without CVD (P<0.01), however, there were no significant differences in f
f and f
s between these two groups. The decrease in average rCBF in the CVD group was supposedly due to a statistically significant reduction of w
f as a whole in the CVD group (P<0.01).
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