Subsequent to our studies on blood coagulation, fibrinolysis and lipids reported in Part 1, as a link in the studies of lipid metabolism, blood coagulation, and fibrinolytic systems we investigated the platelet functions with special reference to the adhesiveness and aggregation of platelets in various arteriosclerotic diseases. As a result we find that in various arteriosclerotic diseases an acceleration of the adhesiveness and aggregation of platelets can be generally recognized, but there can be seen no correlation of such an acceleration to the total lipid, the total cholesterol, triglyceride, and phospholipid in the blood. On the other hand, in the disease known as hyperlipidemia there can be observed a direct correlation of the platelet aggregation to the contents of triglyceride and phospholipid in the blood, but no correlation bettween the adhesiveness of platelet and the amount of lipid fraction in the blood. It is a well-known fact that arteriosclerosis occurs quite frequently in diabetes. In our scrupulous investigations of the lipid metabolism, sugar metabolism and the platelet function in diabetes we have observed a direct correlation between the blood sugar content and the platelet adhesiveness in diabetes with normal lipid blood, while an inverse correlation between the aggregation and the blood sugar content in hyperlipemic diabetes. Even admitting that the lipid metabolism and the sugar metabilism are in an inseparable relationship, we seem to discover a very interesting phenomenon when we compare these two metabolisms with the platelet function as well as consider their effects on the treatment of diseases.
Lymphosarcoma cell leukemia is an establiched clinical entity which is characterized by the presence of numerous abnormal lymphoid cells in the peripheral blood, together with the clinical signs simular to that of lymphosarcoma. We report here an autopsied case of lymphosarcoma cell leukemia in the elderly characterized by an extensive infiltration of the tumor in the skelton. A 68 years old man was admitted to the Department of Geriatrics, Faculty of Medicine, University of Tokyo, with the chief complaints of generalized lymphadenopathy and general malaise. Examination revealed a leukocytosis with 34.5% of abnormal lymphoid cells in the peripheral blood, completely destroyed lymph-node structure with the proliferation of abnormal reticulum-like cells and proliferation of lymphoid cells in the bone marrow. It appeared that the lymph-node was the primary site of affection and was the origin of abnormal lymphoid cells in the peripheral blood. Particularly interesting in this case was the finding of an extensive infiltration of the tumor in the entire skelton, demonstrating numerous punched out lesions of the long bones, flat bones and the skull.