The changes of serum triglyceride (TG) during a day were investigated in diabetic patients. The results were as follows; 1) TG was lowest at am 7.00 and rose to the peak value at pm 2.00. 2) The maxium value of TG during a day was highly correlated with the value at am 7.00. 3) No significant correlation existed between the changes of TG and glucose. 4) The increase of TG was high in obese, and low in lean patients. 5) When insulin was administered to the patients, the increase of TG was higher than when insulin was not administered. 6) By filtering the serum through the membrane (pore size 0.1μ), the exogenous TG was excluded and the only endogenous TG was determined. By this method, it was confirmed that the endogenous TG changes during a day paralleling the changes of tota TG.
Recent evidences indicate that the plasma enzyme lecithincholesterol acyltransferase (LCAT) can convert circulating free cholesterol to esterified cholesterol. The present study was performed to evaluate the significance of the plasma LCAT activity in hyperlipidemic patients with arteriosclerosis (cholesterol 258±55mg/dl, triglyceride 192±81mg/dl) and lanolin-induced hyperlipidemic rabbits (cholesterol 1045±346mg/dl). Plasma LCAT activity was assayed by measurement of the ability of plasma to esterify 14C-labelled free cholesterol. This activity (μg of cholesterol esterified per ml plasma per hour) was 19.0±3.1μg in control subjects, 15.8±3.3μg in normolipidemic subjects with arteriosclerosis (cholesterol 185±16mg/dl, triglyceride 121±22mg/dl) and 18.8±3.6μg in hyperlipidemic subjects with arteriosclerosis. In arteriosclerotic subjects with and without hyperlipidemia, the LCAT activity was significantly correlated with the plasma concentration of triglyceride (r=0.8447, p<0.001), the percentage of pre β lipoprotein (r=0.7908, p<0.01) and obesity index (r=0.6101, p<0.05). Plasma LCAT activity in lanolin-induced hyperlipidemic rabbits was higher than in normolipidemic rabbits. These findings suggest that the plasma LCAT may play a important role on lipid transport in response to plasma lipid concentration.
In order to clarify the underlying causes of convulsive seizures in the aged, the patients who experienced onset of seizures after the age of 40 were analysed with the following results. 1) Cerebral infarction was the most important cause of convulsive seizures in the aged. 2) The incidence of seizures in cerebral infarction was 6% in autopsy cases and 2% in all cases with cerebral infarction. 3) Seizures due to cerebral infarction occurred in some cases at or before the time of stroke (early seizure), while in others several months after the stroke (late seizure). In the latter, the average latent period between stroke and onset of convulsion was 6 months. 4) In all cases with seizures following cerebral infarction, lesions of the cerebral cortex were found either clinically or pathologically. All cases examined by carotid arteriography revealed obstruction of the internal carotid artery or the middle cerebral artery, and the cases with right hemiplegia were all accompanied by motor aphasia. 5) Approximately one-third of patients with reccurrent convulsive seizures were found to have cerebral tumors. The incidence of seizures in cerebral tumor was as high as 30%. 6) Of the patients with cerebral hemorrhage, 10% had seizures. All of these cases showed seizures at the time of stroke and died within a few days indicating unfavorable prognosis of seizures following cerebral hemorrhage.