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Volume 13 (1973)
- Issue 4 Pages 303-
- Issue 3 Pages 145-
- Issue 2 Pages 67-
- Issue 1 Pages 1-
Volume 13, Issue 2
Displaying 1-6 of 6 articles from this issue
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Tsutomu Takahashi1973 Volume 13 Issue 2 Pages 67-71
Published: June 25, 1973
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSIncipient growth sites of tumor cells intravenously transplanted in the lungs were investigated in animals. Three strains of ascites hepatoma (AH 66F, AH 272 and AH 601) and ACl/N rat transplantable breast cancer were used. Ascites hepatoma was transplanted into the tail vein of Donryu rat and transplantable rat breast cancer into the one of ACl/N rat. These rats were sacrificed 24-72 hours after tumor inoculation. The identification of different types of pulmonary blood vessels was made by micropaque (aquous barium sulfate) injection. The following results were obtained by histological examination of removed lungs.
The tissue spaces adjacent to pulmonary venules afforded the initial growth of AH66F. Both the inside and outside, or the inside of pulmonary arterioles afforded the one of transplantable rat breast cancer. Tumor embolus within capillaries or proliferation of tumor cells in the outside of capillaries was observed in the lungs of animals transplanted with AH272 or AH6O1.
The above results will mean that initial pulmonary metastasis might be formed not only by the growth of tumor cells embolized in arterioles or capillaries but also by the growth of tumor cells extravasated from venules.View full abstractDownload PDF (3678K) -
The Development of Carcinoma and Fibrosis in Lung of Rabbits Treated with N-methyl-N-nitrosourethaneT. Itano, T. Nakazi, R. Takimoto, T. Matsuki, T. Kagawa1973 Volume 13 Issue 2 Pages 73-81
Published: June 25, 1973
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSThe authors reported the development of the pulmonary fibrosis and the pulmonary carcinoma after the continous intravenous administration of N-methyl-N nitrosourethane (MNU) in the rabbits.
1. Rabbits were injected with MNU for 10 months (1mg/kg of body weight, 6 times monthly). Three of the 7 rabbits, which survived for 255 to 453 days had the development of pulmonary carcinomas. They were the subpleural rice-sized or soy-bean sized grey tumors without the infiltration or matastasis. Histologically, they were adenocarcinoma or squamous cell carcinoma.
2. Thirty-four of 36 rabbits which survived over 3 months after the administration of MNU for 4 to 10 months (1-2mg/kg of body weight, 4 to 6 times monthly) had the development of the typical diffuse interstitial fibrosis in the lung. Histologically, the developmental process of the pulmonary fibrosis through the stage of acute interstitial pneumonitis and of chronic interstitial pneumonitis was demonstrated.
3. As the histogenesis of the pulmonary carcinoma induced by MNU in rabbits, the epithelial cells in the fibrotic lesion was presumed to change into caricinoma through the glandular or squamous cells metaplasia and then the atypical proliferation.
4. In the ear of rabbits injected, 3 papillomas and 1 squamous cell carcinoma were demonstrated, although no development of tumors was observed in the liver, spleen, kidney and the other organs.View full abstractDownload PDF (7080K) -
Naoto Miyazawa1973 Volume 13 Issue 2 Pages 83-100
Published: June 25, 1973
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESShe newly developed flexible bronchofiberscope has enabled us to visualize lesions situated in smaller bronchi which could not be seen by usual rigid bronchoscope. Consequently, endoscopic findings of lung cancers became complicated. To make these findings practicable and simple, we made comparative studies between the bronchoscopic findings and pathological findings of affected bronchi.
We studied 100 cases of primary lung cancer, which were examined by a bronchoscope and then resected surgically during 2 years time from March 1970 to March 1972. The bronchi involved by lung cancers were grossly divided into 3 types, i.e. polypoid type, exposed type and conically obstructed type, of which histological characteristics were presented.
As a result, detailed bronchoscopic observation of the lesions and exact locations of the lesions will reveal the histological types of lung cancers with a fairly high accuracy.View full abstractDownload PDF (17663K) -
Toshio Kato, Nobuo Koike, Hideo Niibe, Kimiko Yamashina, Koji Sakaino, ...1973 Volume 13 Issue 2 Pages 101-110
Published: June 25, 1973
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSSixteen lung cancer patients in stage I, irradiated curatively (higher than 5, 000 rads) were analysed.
Average age was 66.5 years old, which was 8 years older than the patients operated on. Eighty per cent of patients were inoperable owing to their poor conditions or complicating diseases. Details of follow-up study were tabulated and discussed briefly.
Treatment results were as follows. Crude survival rate was 85.6% for 1 year, 60.0% for 2 year, 55.5% for 3 year, 33.3% for 4 year and 11.1% for 5 year respectively. Mean survival time was 27.5±18.4months.
If we compare these results with those of operation in 52 patients at Cancer Center Hospital, survival rates up to 3 years were quite identical, then marked decreases appeared in our series for 4 and 5 years. The reduction in long term survivors might be mainly attributable to the difference of average age in two groups, presumably 8 years.
At the moment, anaplastic cancers should be treated by radiotherapy, both epidermoid carcinomas and adenocarcinomas by surgery, provided the curative operation to be possible.View full abstractDownload PDF (1397K) -
1973 Volume 13 Issue 2 Pages 111-114
Published: June 25, 1973
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSDownload PDF (447K) -
1973 Volume 13 Issue 2 Pages 115-127
Published: June 25, 1973
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSDownload PDF (2111K)
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