All issues
Volume 14 (1974)
- Issue 4 Pages 251-
- Issue 3 Pages 139-
- Issue 2 Pages 67-
- Issue 1 Pages 1-
Volume 14, Issue 1
Displaying 1-7 of 7 articles from this issue
- |<
- <
- 1
- >
- >|
-
Hidemi Ohwada, Hideo Katsuki, Yutaka Hayashi1974 Volume 14 Issue 1 Pages 1-11
Published: March 25, 1974
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSIn order to estimate the useful method for the induction of the local pulmonary fibrosis and to analyse the relationship between the local pulmonary fibrosis and carcinogenesis, this experiment was performed 72 Wister rats were divided into the following 3 groups.
Group C: 22 rats received the single intravenous injection of hexachlorotetrafluorobutane (HCTFB).
Group A: 15 rats received the single intravenous injection of HCTFB, followed 67 days after by the subcutaneous injection of 4-nitroquinoline71-oxide (4 NQO). The subcutaneous injection of 4NQO was repeated weekly until the total dose of 4NQO reached 10 mg (20 times).
Group B: 35 rats received the single injection of HCTFB intravenously. These rats were given the subcutaneous injection of 4NQO simultaneously once a week until the total dose of 4NQO reached 10 mg (20 times).
All rats died or were killed were necropsied and examined histologically. The following results were obtained.
The local pulmonary fibrosis accompanied with elastosis was induced at a high rate by the single intravenous injection of HCTFB. The fact that the local pulmonary fibrosis invariably occured by the intravenous injection of HCTFB indicates that it is an advantageous method for studying the experimental carcinogenesis of the scar cancer.
Atypical epithelial hyperplasia was often observed around the site of the local pulmonary fibrosis, also there was one case of pulmonary cancer in the both group A and B respectively. There was obvious fibrosis accompanied with elastosis in the central portion of these two cases of pulmonary cancer.
It seems to us that there is intimate relationship between the local pulmonary fibrosis and carcinogenesis.View full abstractDownload PDF (3979K) -
Tsuneko SATO, Kikuko ASAI, Hisashi TAUCHI1974 Volume 14 Issue 1 Pages 13-19
Published: March 25, 1974
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSAutopsy (146 males, 56 females) and surgical resecting materials (100 males, 40females) of primary lung cancer were investigated on the relationship among thecancer histology, sex, site of primary growth and smoking habitus.
Two different pathogenetic factors on the primary lung cancer were suggested.
One type of the lung cancer seems to be characterized by histological picture of squamous cell carcinoma, originating mainly from central portion of the bronchus, and by frequent appearance in the male cases with smoking habitus of higher grade.
Another type seems to be characterized by adenocarcinomatous picture, originating from peripheral bronchus, and frequent appearance in the females without smoking habitus.
The exogenous or endogenous factor on the etiology of the primary lung, cancer was discussed with special reference to the cancer histology.View full abstractDownload PDF (598K) -
Shinichiro Mitani1974 Volume 14 Issue 1 Pages 21-29
Published: March 25, 1974
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSSystemic observation of mucus gland in the bronchial tree has been done in present report by methods of photomicroscopy and electronmicroscopy. Specimens were obtained from autopsied and surgical resected lungs. 258 trees and 1, 331 specimens from bronchial trees were observed from the first (lobar), the second (segmental), the third (subsegmental), the fourth, the fifth, the sixth, the seventh, the eighth, and to the nineth bronchus. The same morphological pattern of mucus gland was observed in the bronchial wall from the first to fourth bronchus. One type of mucus gland was found between bronchial mucosa and cartilage, and the other was between cartilage and cartilage. The former type of mucus gland disappeared in the fifth and sixth bronchus. The combination of mucus gland and cartilage was observed 78.5% of the fifth bronchus, but only 11.3% of sixth bronchus. There were no existence of mucus gland and cartilage in the wall of the seventh, eighth, and the nineth bronchus. Histogenetically, benign and malignant tumors of mucus gland origin could be developed from the first to sixth bronchus and not be from the seventh, eighth, and the nineth bronchus. Carcinoid and oat-cell carcinoma could be originated from the both side of mucus gland and bronchial mucosa, which was revealed the co-existence of Kultschitzky cell by the electronmicroscopic observation.View full abstractDownload PDF (4303K) -
Kimito Matsumura, Hideo Katsuki, [in Japanese], [in Japanese], [in Jap ...1974 Volume 14 Issue 1 Pages 31-42
Published: March 25, 1974
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSA technic of percutaneous needle biopsy has proved extremly useful in primary lung cancer, especially small peripheral lesions. Also it can provide a diagnosis in metastatic lung tumors, mediastimal tumors or even benign tumors of the lung.
Our newly designed needle is a diameter of 0.6mm or 0.45mm, for the smaller the needle size, the less traumatic is the effect on the pulmonary tissues. A positive diagnosis was obtained in 102 of the 130 lung cancer patients (78%). No serious complications were encountered in 249 biopsy procedure. Therefore, this method is recommended as a routine means of diagnosing pulmonary lesions, together with bronchoscopy.View full abstractDownload PDF (3435K) -
Lung Cancers with Involvement of the Thoracic Wall and Pancoast's Syndrome. (Result of Radiotherapy)Toshio Kato, Nobuo Koike, Hideo Niibe, Yuko Murakami, Yoshihiko Suzuki ...1974 Volume 14 Issue 1 Pages 43-53
Published: March 25, 1974
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSLung Cancers with involvement of the thoracic wall and Pancoast's syndrome were analyzed. The former comprised 3.5% (12/345), and the latter 2.3% (8/345), of lung cancers seen in our department from 1959 to 1972, respectively. Of the 7 patients with thoracic wall involvement, irradiated more than 5, 000 rads, one was alive without disease at 41 months, and another died of concurrent disease at 7months. The remainning 5 patients died of cancer at a range from 2 to 15months. (Survival time: 6.0±5.2months) None of 5 patients irradiated palliatively survived more than 3 months. One patient with Pancoast's syndrome died of cancer at 36 months after presurgical irradiation and lobectomy, and another died without palliation at 3 months after 5-Fu. administration. All 6 patients with Pancoast's syndrome, irradiated more than 5, 000 rads, died of cancer at a range from 4 to 10months. (Survival time: 6.3 ±2.4months) Of the total group, palliative effects (relief of pain, etc.) were noted almost in all patients after radiotherapy. Policy and result of treatment of these two types of lung cancer in the literature were reviewed and discussed.View full abstractDownload PDF (1231K) -
1974 Volume 14 Issue 1 Pages 55-59
Published: March 25, 1974
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSDownload PDF (461K) -
1974 Volume 14 Issue 1 Pages 61-64
Published: March 25, 1974
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSDownload PDF (554K)
- |<
- <
- 1
- >
- >|