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Volume 16 (1976)
- Issue 4 Pages 299-
- Issue 3 Pages 173-
- Issue 2 Pages 91-
- Issue 1 Pages 1-
Volume 16, Issue 2
Displaying 1-7 of 7 articles from this issue
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Kikuko Asai1976 Volume 16 Issue 2 Pages 91-100
Published: June 25, 1976
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSSurgically resected lungs with the primary lung cancer (100 males, 40 females) and with other pulmonary disease (28 males, 21 females) were histologically investigated with special references to the relationship between squamous metaplasia orbasal cell hyperplasia of bronchial epithelium and histological types of the carcinoma, sex, preoperative radiotherapy and subepithelial inflammatory cell infiltration.
The grade of squamous metaplasia in the lung cancer cases was not related tothe histological types of the cases.
The grade of basal cell hyperplasia was related to the grade of inflammatory cellinfiltration in the subepithelial layer. However, the grade of squamous metaplasia inbronchial epithelium was not directly associated with inflammatory cell infiltrationin the subepithelial layer.
The squamous metaplasia was more extentively observed in the aged group (morethan 60 years) than in the younger group, but the smoking habit exhibited moremarked effect on the developement of the squamous metaplasia.
Among the cases with the similar smoking habits, however, the primary lung cancercases showed more remarkable squamous metaplasia than in the non-lung cancer cases.
The influences of preoperative radiotherapy on the developement of squamousmetaplasia in the bronchial epithelium was not recognized in the cases of epidermoid cancer investigated in this study.View full abstractDownload PDF (1138K) -
Soji Ishikawa, Kenji Komatsu, Keizo Tomiki, Shigeki Ishihara1976 Volume 16 Issue 2 Pages 101-110
Published: June 25, 1976
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSFrom 1956 through 1975, 237 patients underwent the treatments of primarycarcinoma of the lung at the department of thoracic surgery.
The resection of primary carcinoma in eighty three of these patients wereperformed and exploratory thoracotomy in fourty six cases.
Fifty of eighty three resected cases and twenty four of exploratory thoractomycases belonged to the stage III. Saying in conclusion, there were two patients livingover five years in the resected group but none in exploratory thoracotomy group.
Average survival time were 24.4 months in resected group but 9.5 months in ofexploratory thoracotomy group.
Two patients who underwent block resection of chest wall died less than threemonths after the operation but on the other hand, three patients who did notreceive the block resection lived over one year.
This investigation suggests that the resection for the stage RE of the bronchogeniccarcinoma may be able to curative procedure if the radiation therapy and chemotherapy after resection are given carefully to the invasive areas.View full abstractDownload PDF (2422K) -
In relation to lymphangitic spreadHisanosuke Matsumoto1976 Volume 16 Issue 2 Pages 111-127
Published: June 25, 1976
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSChest X-ray findings of 147 cases of pulmonary metastases were studied andradiographically divided into three types. Furthermore, the extirpated lungs in 20 caseswere studied for evaluating the radio-pathologic correlations soft X-ray films ofthe specimen were compared with the macrosection.Radiographic classification of the pulmonary metastases; Type I: Nodular shadowsalone, Type II: Strand and linear markings without nodular shadows, Type III: Mixedtype of Type I and Type II-Nodular shadows associated with strand and linearmarkings.
The lesion circumscribed by the capsule showed an expansive growing and wasconsidered to occur by embolic extension. Radiographically, the lesions showedsharply defined, smooth nodular shadows.The lesion with lymphangitic spread by way of the peribronchial and perivascularlymphatics showed and linear markings on a chest X-ray film. Invasive growing ofthe lesions had more or less lymphagitic spread and, on a chest X-ray film, could beseen as ill defined nodular shadows with or without strand and linear markings.
In this investigation, about 47 % of the case with strand and linear markings wereassociated with hilar enlargement, but more frequently (in 91 %) associated withnodular shadows. The fact may suggest a possibility that the lymphangitic spread mustbe occur secondarily as result of the hematogenous metastases.
In comparison with primary lung cancer, solitary metastatic lesion frequentlyshowed sharply defined and smooth shadow and less frequently had the secondary changes such as atelectasis and obstructive pneumonia.View full abstractDownload PDF (19452K) -
[in Japanese], [in Japanese], [in Japanese]1976 Volume 16 Issue 2 Pages 129-140
Published: June 25, 1976
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSDuring the five years period since May, 1969 through December, 1974 at NationalCancer Center Hospital. We have studied 111 cases with primary lung cancer whichwere treated with combination of external radiation and bronchial arterial infusionof chemotherapeutic agents. The survival rate was examined in these cases from thepoint of view of radiation treatment with several comments added.
The over-all survival at three years was 10 (14.9%) out of 67 cases. Histologically, the cases with squamous cell carcinoma revealed 3 (9.4 %) survivors at three yearsout of 32 cases, those with adenocarcinoma 4 (23.5%) of 17 cases those with undifferentiated large cell carcinoma 2 (50%) of 4 cases and those with undifferentiated smallcell carcinoma 1 (7.1%) of 14 cases. Viewing from the stage of the disease, the threeyear survival was 2 (66.7%) out of 3 cases with Stage I, 3 (37.5%) out of 8 cases withStage II and 5 (8.9%) out of 56 cases with Stage III.
From the point of radiation treatment, one of the advantages of this combinationwas that the extent of the cancer in the lung and the mecfiastinum was well demonstrated by the bronchial-arteriography. This was important to decide the field forradiation treatment. The second advantage of this technique was that the tumor dose ofradiation could be reduced by adding local administration of anti-cancer drugs throughthe bronchial artery. This meant that we could decrease radiation dose to the vital organs of the lung and the heart.View full abstractDownload PDF (11584K) -
(2) The results in case of MMC, 5-FU and PSPKeisuke Sagawa1976 Volume 16 Issue 2 Pages 141-151
Published: June 25, 1976
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSIn addition to the result of Bleomycin which was previously reported, sequentialchanges of concentration of Mitomycin (MMC), 5-Fluorouracil (5-FU) and Phenolsulfonphthalein (PSP) in the blood and pleural fluid on intrapleural instillation and onintravenous injection were studied with dogs in which pleural effusion was artificiallyinduced with instillation of saline into the pleural space.
On intrapleural instillations, the anticancer drug of the low molecular weight suchas 5-FU, showed clearly more rapid decay of the concentration and shorter half lifein the pleural fluid than those of the drug of the heavy molecular weight. The concentration of the drug escaped from the pleural space was maintained relatively longerin the blood than that injected into the vein because of the slow transfer from thepleural space into the vascular system. Based on the conparative study of the half life ofthe decay curve in the pleural fluid between BLM, MMC, 5-FU and PSP, it is suggestedthat BLM may directly move into the vascular system from the pleural space, though ithas the heaviest molecular weight (1400) among them.
Individual decay curve in the blood on intravenous injections was composed fromtwo compartments. A initial fast compartment was followed by a secondary slow compartment. The durg of the low molecular weight showed more rapid decay in the slowcompartment than that of the heavy molecular weight. The transfer of the drug intothe pleural space from the vascular space was also depended on the size of the molecularweight of the drug. The drug of the low molecular weight moved faster into the pleuralspace than that of the heavy molecular weight.
These findings suggest that an appropriate selection of the drugs and of the siteof instillation of the drug are important in the proper treatment of lung cancer patients suffered from metastatic pleural effusion.View full abstractDownload PDF (1271K) -
1976 Volume 16 Issue 2 Pages 153-155
Published: June 25, 1976
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSDownload PDF (352K) -
1976 Volume 16 Issue 2 Pages 157-171
Published: June 25, 1976
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSDownload PDF (3739K)
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