Haigan
Online ISSN : 1348-9992
Print ISSN : 0386-9628
ISSN-L : 0386-9628
Volume 19, Issue 3
Displaying 1-12 of 12 articles from this issue
  • Tomoya Murai
    1979 Volume 19 Issue 3 Pages 209-214
    Published: September 20, 1979
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    A study based on questionaires was carried out in 95 hospitals to obtain informations on patients with early lung cancer and longterm (over 5 years) survivors in Chugoku and Shikoku district.
    As a result of analysis, 56 patients with early lung cancer in 21 hospitals and 109 patients with over 5 years survivor in 18 hospitals were recognized.
    In 56 patients with early lung cancer, peripheral type and adenocarcinoma were dominated.
    In 109 patients with over 5 years survivor, there were 57 Stage I cases (52%), stage II cases 20 (18%) and 55 epidermoidcarcinomas (51%), therefore prognosis depending both to clinical staging and histological typing.
    In above survivors, 98 cases were resected and 11 cases were irradiated without resection. 25 cases survived over 10 years with maximum 16 years.
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  • Nobuo Kohmo
    1979 Volume 19 Issue 3 Pages 215-227
    Published: September 20, 1979
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    A cell line (DL-2) was established from a mongrel dog lung cancer induced experimentally by intrabronchial application of 20-methylcholanthrene. The specimen for tissue culture was obtained from metastatic paratracheal lymph nodes of dog lung cancer, and minced and explanted to Petri dishes. The nutrient medium, maintained at PH 7.2, consisted of RPMI-1640 medium and 20% fetal bovine serum. Cultivation was carried out in a CO2 incubator. After 90 days of primary culture the cell line was established. The histologic type of implanted lymph nodes was moderately differentiated adenocarcinoma. The author identified the cultured cells as tumor cells by comparing the histology of transplanted tumors in nude mice and chromosomal analysis. The cultured cells are now in the 148th passage, and cells from the 36th to 104th passages were in 11 adult mongrel dogs, 7 young and 6 newborn dogs. Implantation sites included the testes, lung, subcutaneous tissue and the submucosa of the main bronchus (this last by means of a transbroncho-fiberscopic catheter), and the amounts varied from 1 × 107 to 2.2 × 108 cells.
    In young dogs, from 24 hours to three months old, the tumor grew in the lung in three out of 7 and lymphatic metastasis occured in two.
    In newborn mongrel dogs less than the one day old, a tumor grew in the lung and the testis in one out of 6 impianted and lymphatic metastasis to the thorax and abdomen cocured. Tuomr cells were seen microscopically to the transplanted tissue in three although no tumor developed. A tumor invading the chest wall which developed in a young dog were transplanted to two young and two adult mongrel dogs intrapulmonary after homogenization. A tumor grew in the lung, and metastasis occured in the thoracic lymph nodes and bones in one young dog. The transplanted tumor revealed the same hystologic findings as the original lung cancer induced experimentally. Furthermore, features of bronchiolo-aiveolar carcinoma were seen in the tumor which grew in the lung of a young dog. Thus the DL-2 cell line may be said to be a transplantable cell line.
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  • Saburo Amino, Kimihiko Abe, Taisuke Komori, Kohji Kawana, Yoshikazu Oi ...
    1979 Volume 19 Issue 3 Pages 229-238
    Published: September 20, 1979
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    Today a variety of therapeutic modalities are available for the treatment of lung cancer. With the intention of contributing towards the improved prognosis of the disease the present study was undertaken to clarify the effects of combined surgical and irradiation therapy in terms of histological type, surgical stage, surgical procedure and type of radiotherapy, thereby providing information on which to base the establishment of therapeutic regimens.
    Combined irradiation and surgical therapy was observed to be effective in stage II and III cases of squamous cell carcinoma and in stage III cases of adenocarcinoma, thereby demonstrating the value of this technique in non-curative resection cases.
    In particular, the positive effectiveness of preoperative irradiation inadvanced cases involving adjacent organs (T3) and in cases of metastasis to mediastinal lymphnodes (n3) was demonstrated to be statistically significant.
    Although the number of intraoperative irradiation cases is to small to permit any firm conclusions, results do suggest the possibility that this might be a profitable method in cases of non-curative resection of adenocarcinoma, which otherwise tends to be more resistant to radiation therapy.
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  • Nobuyoshi Shimizu, Shin Matsumoto, Tetsuro Okazaki, Toyoji Wada, Kon M ...
    1979 Volume 19 Issue 3 Pages 239-245
    Published: September 20, 1979
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    In 74 lung cancer patients, carcinoembryonic antigens were measured at preoperative and postoperative period using CIS RIA Kit. Thirty one cases out of 74 cases were positive, namely 41.9%. On histological types, adenocarcinoma is highly positive compared with other types, and those patients who had intrathoracic lymph node metastases were strongly CEA positive than those who had no metastasis. No positive CEA values were found in those patients who had tumors smaller than 3 cm in diameter. After the extirpation of tumors, CEA values lowered. But preoperative CEA positive patients had short survivals. Between PPD, SK/SD, Candida skin tests and CEA, significant correlation was found.
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  • Masayuki Niitsuma
    1979 Volume 19 Issue 3 Pages 247-260
    Published: September 20, 1979
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    To clarify immunological developments in the cancer host I monitored both cellular and humoral immune parameter changes in 225 lung cancer patients. Tuberculin reaction was used as the parameter of cellular immunity and serum complement levels, βIC/βIA globulin, βIE globulin, immunoglobulin IgG, IgAand IgM as parameters of humoral immunity. Tuberculin reaction decreased as the clinical stage advanced. These results reflect the diminished cellular immunity in these patients. Serum complement levels for all stages were high. Complement components were at normal levels. IgG levels for all stages were high while IgA and IgM levels were within normal ranges. Next I examined movements of several immune parameters according to therapeutic modality. Tuberculin reaction decreased in cases receiving radiotherapy and/or chemotherapy but on the other hand, it increased as a result of BCG-CWS non-specific immunotherapy. Other parameters showed no tendency to move. Examining movements of the parameters in relation to prognosis, tuberculin reaction increased in cases with good courses. On the other hand, in cases with poor courses the tuberculin reaction went down. Other parameters did not show any particular course-related tendency. I examined each cases according to a six-stage classification system of immune response which is based on the idea that the complement system compensates lower cellular immunity. With advance in clinical stage a definite counter-clockwise movement through higher stages was seen. Cases with good courses showed movement in a clockwise direction as did cases BCG -CWS non-specific immunotherapy. Cases with long survival moved to clockwise direction coming together in stage I or II in the six-stage classification. Cases which developed recurrences or metastasis moved in a counter-clockwise direction. These results show that the six-stage classification of immune response is a very useful and vaild method to observe and evaluate the host's immunity, to determine treatment and to estimate the prognosis in lung cancer patients. It was also seen that BCG-CWS non-spesific immunotherapy is effective in stimulating the immune response in lung cancer patients.
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  • Kyoichi Ogawa, Hiroyasu Terashi, Hisayuki Chihara, Noboru Ishii, Shozo ...
    1979 Volume 19 Issue 3 Pages 261-267
    Published: September 20, 1979
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    From April, 1966 through July, 1978, 15 intrapericardial dissection pneumonectomy (IPDP) and 18 combined lung and thoracic wall resection were performed among 91 cases with stage three lung cancer.
    IPDP was indicated for such cases as standard pneumonectomy seemed to be impossible. No operative death or major complication was encountered. The survival rate of IPDP was similar to that of standard pneumonectomy and higher than that of exploratory thoracotomy in the stage three lung cancer until 18 months following the operation. However, long-term survival beyond three years has not been obtained so far.
    Seven cases with combined lung and thoracic wall resection survived beyond 3 years and four beyond 5 years. In all of these cases no mediastinal lymph node metastasis (N2) or remote metastasis (M1) was seen, and a semi-curative operation could be performed.
    Consequently, we have concluded that IPDP improves the short-term survival rate in advanced lung cancer, and combined lung and thoracic wall resection can bring about good long-term survival rate when a semicurative operation is to be performed.
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  • Takeshi Hashimoto, Yukio Shimosato, Tetsuro Kodama, Tooru Kameya, Akir ...
    1979 Volume 19 Issue 3 Pages 269-276
    Published: September 20, 1979
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    Nineteen cases of surgically resected small size of squamous cell carcinoma of less than 3.0 cm. in diameter arising from the periphery of the lung were studied morphologically and prognostically. Some of them were difficult to differentiate both grossly and radiologically from peripheral adenocarcinomas, possessing pleural indentation and fibrotic foci in the center of the tumor as in adenocarcinoma. None of the cases extended through the elastic layer of the pleura, 16 out of 19 cases were free of lymph node metastases, and thus the prognosis was good in the majority of the patients. Prognostic significance of collagenization and hyalinization within tumor mass was not obvious in our cases of peripheral squamous cell carcinoma of the lung.
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  • Yosei Katayama, Tetsuo Ueno, Koshi Maruyama, Kinya Sawada, Yasuo Seki
    1979 Volume 19 Issue 3 Pages 277-284
    Published: September 20, 1979
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    A 71-year-old female was admitted to our hospital because of hemoptysis and an abnormal shadow in her chest X-ray film. Bronchoscopic examination revealed a tumorous growth at the B6 bronchus of the left lung. Thoracotomy was performed, and a specimen was collected from the tumorous lesion of the left lung. Tumorous lesions of the left lung and pleura were irradiated with a single dose of 3, 000 rads. Histological examination of the specimen revealed anaplastic-carcinoma consisted of spindle-shaped cells growing in sarcomatoid pattern. She died approximately 8 months after the clinical onset. Autopsy revealed a hemorrhagic tumor in the lower lobe of the left lung, measuring 5 cm in diameter, markedly necrotized probably due to irradiation. Widespread metastases were found in other organs. On histological examination, pleomorphic multinucleated giant cells with occasional “cytophagocytosis” were frequently observed in tumorous lesions of both the lung and other organs. In some areas tumor cells assumed spindle shape and grew in sarcomatoid pattern. Electron microscopic examination of tumor cells showed well-developed r-ER and mitochondria, and Golgi apparatus. In some tumor cells numerous lysosomes were observed. Interdigitation of the plasma membrane was remarkable. Although formation of tight junction was occasionally encountered, desmosome was not detected.
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  • Hiroshi Mikami, Ikuhiro Tsuneta, Kiyonobu Kimura, Shosaku Abe, Yutaka ...
    1979 Volume 19 Issue 3 Pages 285-289
    Published: September 20, 1979
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    A case of chromate worker with pulmonary carcinoma was reported. The concentration of chromium in the resected lung tissue was as remarkably high as 26μg/g wet weight. The primary lesion of pulmonary carcinoma was in the peripheral region of the lung and the histological examination revealed adenocarcinoma. In the past reports in Japan concerning pulmonary carcinoma among chromate workers, we could not find any case with adenocarcinoma any case with pulmonary carcinoma in the peripheral region either. It is considered that the differentiation between spontaneous pulmonary carcinoma and pulmonary carcinomas due to chromate in hation is difficult.
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  • Fumio Shirai, [in Japanese], [in Japanese], [in Japanese], [in Japanes ...
    1979 Volume 19 Issue 3 Pages 291-298
    Published: September 20, 1979
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    A 51-year-old male, exposed to asbestos for 27 years, was admitted to the hospital because of dyspnea. The characteristic findings of the chest roentgenogram were a tumorous shadow in the left lower lung field and a shadow suspected extensive pleural thickening all over the left lung, in addition to the findings of asbestosis, grade 2. It was diagnosed as a poorly differentiated adenocarcinoma of the lung by means of cytology of the sputum and needle biopsy of the lung.
    After conservative treatment of approximately one month's duration, he died of pneumonia.
    Autopsy confirmed the diagnosis of poorly differentiated adenocarcinoma of the lung arising from the periphery of the left lower lobe associated with moderate asbestosis. The shadow suggested of pleural thickening in the roentgenogram was proved as additional lymphangitis carcinomatosa to the tough fibrous adhesion of the pleura. Distant metastasis was seen to the pancreas, the right adrenal and the right kidney.
    The clinico-pathological features of asbestos-related lung cancer and the problem of asbestos pollution were discussed.
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  • H. Homma, M. Tamura, M. Washizaki, H. Kudo, A. Yamanaka, T. Taki, N. K ...
    1979 Volume 19 Issue 3 Pages 299-307
    Published: September 20, 1979
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    A 54-year old woman was hospitalized with chief complaints of loss of consciousness and vomiting. Physical examination, chest X-ray findings and radiographic bone survey established the diagnosis of lung cancer with metastases to the leptomeninges, the left pleura, and the vertebrae. At autopsy, a primary lesion of adenocarcinoma was identified in the L. U. L., and metastatic involvement was confirmed in the meninges of the spinal cord, the brain, the left pleura and the vertebrae. Microscopic sections of the nerve root of the spinal cord revealed infiltrations of tumor cells into the vertebral veins. According to the result of our study on 191 autopsied cases of lung cancer, the incidence of meningeal metastasis is about one tenth on the incidence brain metastasis, suggesting that the route to the meninges is different from that to the brain. From the fact that one or two of all of either vertebral, peritoneal or pleural metastasis were found in cases with menigeal metastasis and from the fact that there were infiltrations of tumor cells into the vertebral veins, it is emphasized that the importance of the vertebral vein as a metastatic route to the meninges can not be too much stressed.
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  • 1979 Volume 19 Issue 3 Pages 309-322
    Published: September 20, 1979
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
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