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Volume 20, Issue 3
Displaying 1-14 of 14 articles from this issue
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Katsutoshi Yoshimura, Nobuo Yamashita, Shichiro Ishikawa1980 Volume 20 Issue 3 Pages 217-223
Published: September 25, 1980
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSFrom records of prospectively investigated 1, 827 cases during 1967-69 and 2, 493 cases during 1972-74, the results of treatment of lung cancer patients between both periods were comared.
Distribution of stagings, operability and curative resectability of the treated patients was almost the same in both groups, whereas an incidence of over 65-year-old male patients and a number of small cell carcinoma was predominant significantly in the later group. From the results of comparative features in both periods, there existed several unfavourable points for prognosis in the later periods, however, the five year survival rate in curative resection group was 38.4% in the former and 52.9% in the latter, respectively. The difference between the results in both periods was significant (p<0.001).View full abstractDownload PDF (604K) -
Shoji Hattori, Harumichi Ikegami, Yoshihiro Hayata, Mitsuo Oota, Hisan ...1980 Volume 20 Issue 3 Pages 225-232
Published: September 25, 1980
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSMultimodality treatment was done for 373 inoperable patients with adenocarcinoma of the lung. Median survival time was longer for the stage I + II group than for the stage III and IV groups (p<0.0001). Marked responders survived longer than nonresponders, suggesting the necessity of local control by the intensive multimodality treatment. But, for the time being, the best response rates of 36% was obtained in our study group by the combination chemotherapy with adriamycin, methotrexate and 5-fluorouracil. The longest median survival time was 10.2 months for patients treated with mitomycin C, 5-fluorouracil, cytosine arabinoside (MFC) and then radiotherapy, even though the response rate was 27%. Radiotherapy might have played an important role for this longer survival time. The careful stratification, the use of common arm regimen and the use of internationally accepted criteria of response are strongly recommended for a future study.View full abstractDownload PDF (672K) -
I. Mori1980 Volume 20 Issue 3 Pages 233-242
Published: September 25, 1980
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThis study concerns cytotoxic effect of the peripheral lymphocyte from patients with lung cancer.
Microcytotoxicity test utilizing three cultured cell lines established from bronchogeneic carcinoma was carried out on 63 patients with lung cancer.
Peripheral lymphocytes of the patients showed significantly low cytotoxic effect in comparison to those of patients with benign lung disease and healthy individuals (p<0.01).
Cytotoxicity of the patients, also correlated with a development of the disease.
In conclusion, our method is available to predict the outcome of the patient with lung cancer despite using allogeneic cultured cells.View full abstractDownload PDF (936K) -
Michio Kono, Masao Sako, Kazuo Sakamoto, Shusaku Yokogawa, Yoshiki Tak ...1980 Volume 20 Issue 3 Pages 243-249
Published: September 25, 1980
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSFor improvement of the techinique of roentgenographic mass survey for the detection of lung cancer, we devised a new equipment of fluorographic tomography using Cancer mirror camera. Excellent tomograms were obtained by the equipment. It seems adequate to take three films for individual subject on mass survey, a P-A film, left lateral, and tomogram.
The tomogram was taken with the following exposure conditions. The focal plane was set at the center of the chest breadth and the moving angle of the X-ray tube was 20 degree. Overall exposure dose in three projections was about 0.6 R. Approximately 30 persons could be examined in an hour by this method.View full abstractDownload PDF (10100K) -
Correlation with Clinical Stages, Therapy, and PrognosisShuzo Sakai1980 Volume 20 Issue 3 Pages 251-259
Published: September 25, 1980
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSStudies were undertaken to evaluate cellular immunity in patients with lung cancer. Purified protein derivative (PPD) skin test, dinitrochlorobenzene (DNCB) skin reaction, blastogenic response to phytohaemagglutinin (PHA), and T cell counts were examined in one hundred thirty six cases of cancer of the lung. DNCB skin reaction and blastogenic response to PHA of lung cancer patients were significantly low in comparison to those of controls (p<0.05). PPD skin test and the number of T cells were gradually decreased in proportion to the advance of clinical stages. PPD skin reaction and blastogenic response to PHA were impaired immediately after irradiation therapy, however, they could be recovered within a few months. Survival rate of lung cancer patients tended to be declined as the clinical stages progressed. In patients with stage III disease, significant difference of survival rate was observed between the groups with no distant metastases (M0) and distant metastases (M 1), and well-PHA responded groups showed better prognosis.View full abstractDownload PDF (873K) -
Takehiko Fujisawa, Yutaka Yamaguchi, Hideki Kimura, Nobumasa Satoh, Ma ...1980 Volume 20 Issue 3 Pages 261-267
Published: September 25, 1980
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSFifty two primary, resected lung cancer patients were utilized in order to evaluate the possible clinical effect of Transfer factor obtained from “household contact” family members. Patients were randomized immediately after surgery and 26 patients received chemotherapy and TF, and 26 control patients received chemotherapy alone. Distribution of age, sex, histology, clinical stages and chemotherapeutic drugs was very similar in both groups.
When recurrence rate was evaluated, recurrences were demonstrated in 4 of 26 TF recipients and 9 of 26 control patients. When the mode of recurrence was evaluated, 3 local recurrence and 6 hematogeneous distant metastases with or without local recurrences were demonstrated in 9 control patients, however, only local recurrence was demonstrated in all 4 TF recipients. Disease free interval of TF recipients was longer than that of control patients.
In conclusion, TF might suppress tumor growth, especially hematogeneous metastasis. TF may be beneficial to lung cancer patients as postoperative adjuvant immunochemotherapy.View full abstractDownload PDF (712K) -
Naganobu Hayashi1980 Volume 20 Issue 3 Pages 269-280
Published: September 25, 1980
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe author examined the relationship between tumor growth, histologic type, lymphatic metastasis and microscopic metastasis in 17 canine cases of peripheral type lung cancer induced experimentally by intrabronchial application of 20-methylcholanthrene.
The histologic type was adenocarcinoma in 8, adenosquamous cell carcinoma in 3 and squamous cell carcinoma in 6. Regarding lymphatic metastasis, there were 6 cases of NO, 2 of N1 and 9 N2 cases, 7 of which were adenocarcinoma. Microscopic metastasis was observed in 7. A close relationship was observed between the appearance of metastasis, N factor and tumor size. Microscopic metastasis were observed in the tumorbearing lobe and also other lobes of the same lung and lobes of the contralateral lung.
In the lymphatic vessels the tumor was seen to grow diffusely and disseminately. This indicates that lymph flow will be disturbed due to stenosis of the vessels, or dilatation of the lymphatic sinus will occur accompanied by reactive changes such as an increase of macrophages in the lymphatic wall. Lymph retroflux can also be anticipated. These phenomena are likely causes of micrometastasis in non-tumor bearing lobes.
Since microscopic metastasis cannot be diagnosed macroscopically or roentgenologically, the author suggests the importance of combined therapy with resection in operable cases of lung cancer.View full abstractDownload PDF (15945K) -
Nobuo Yamashita1980 Volume 20 Issue 3 Pages 281-285
Published: September 25, 1980
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThis paper described statistical analysis concerning routes of dissemination of smallcell and large-cell carcinoma of the lung based on 576 autopsy records. The analysis of average number of cases with metastasis at minor metastatic sites were carried out using occurrence or non-occurrence of major metastatic sites (lung and liver) as 2 X 2 factorial design.
The results were as follows;
1) The dissemination of large-cell carcinoma of the lung was influenced mainly by the presence of metastasis in the liver, whereas that of small-cell carcinoma was influenced by the presence of metastasis in the liver and the lung.
2) The frequencies of metastasis to the lung, intestines, kidney and spleen in large-cell carcinomas were significantly higher than those in small-cell carcinomas.
3) The frequencies of metastasis to the pancreas and bones in the small-cell carcinomas were significantly higher than those in the large-cell carcinomas.View full abstractDownload PDF (432K) -
T. Shirakusa, R. Motonaga, T. Doki, T. Aritomi, T. Koga1980 Volume 20 Issue 3 Pages 287-292
Published: September 25, 1980
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe biopsied method with Tru-cut needles for anterior mediastinal tumors were stated. Three cases with the anterior mediastinal tumors were diagnosed histologically by Tru-cut needle biopsy. One case is seminoma originated in thymus and two cases are thymic epidermoid carcinoma. Comparing to other needles, Tru-cut needle is more useful in the following points including 1) the specimen is usually obtained plentifully and 2) this needle is disposable and the biopsied technique is not complicated.View full abstractDownload PDF (10022K) -
Yasunari NAKATA, Mikio KATAOKA, Jiro YAMASHITA, Toshio SATO, Norio NOD ...1980 Volume 20 Issue 3 Pages 293-300
Published: September 25, 1980
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSFunction of peripheral blood monocyte in 59 untreated patients with bronchogenic carcinoma was studied and compared to that of normal controls. The total leukocyte count was determined with a Coulter counter, whereas the differential was determined on the basis of 500 cells counted. The absolute monocyte count was found by applying the percent of monocytes in the differential to the total leukocyte count. The mean absolute number of monocytes was 294±176/cmm in patients with bronchogenic carcinoma and 299±144/cmm in controls. However, there was no significant difference between these two groups. Furthermore monocyte number, clinical stage and histological type also failed to demonstrate any significant correlations among them.
Lysosomal enzyme activity of monocyte was histochemically determined by ability of staining to beta-galactosidase. The mean percentage of positive monocytes was 23.1±12.1 in patients with bronchogenic carcinoma and 33.7±12.1 in controls, which showed significant difference between these two groups.
Monocyte chemotactic response was measured in vitro by Boyden's millipore technique using zymosan activated human serum as chemoattractant. It was significantly reduced in bronchogenic carcinoma (19.4±7.0) to compare with that of controls (34.8±8.0). In addition, combination chemotherapy further reduced the monocyte chemotactic response rate.
Ability of monocytes to phagocytose complement fixing zymosan was also significantly lowered in patients with bronchogenic carcinoma.
These data suggested that neoplasm affect monocyte function which can possiblydestruct malignant cells immunologically.View full abstractDownload PDF (858K) -
S. Abe, Y. Ohsaki, K. Kimura, Y. Tsuneta, H. Mikami, M. Murao1980 Volume 20 Issue 3 Pages 301-307
Published: September 25, 1980
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe studied relationship between chromium compounds produced during manufacturing process and exposure period or latent period (Period from the onest of exposure to the occurrence of lung cancer) or chromate workers.
Chromate workers with lung cancer were mainly exposed to soluble hexa-valent chromium compounds.
Concerning cell type of lung cancer, rate of exposure period of squamous cell and small cell carcinoma patients to soluble hexa-valent chromium compounds was 55.4 and 100 per cent of total working period, respectively.
On the contrary, the exposure period of non-carcinoma patients was 18.4 per cent of total working period which was significantly short in comparison to those of patients occurring carcinomas.
The latent period of small cell carcinoma patients was 173.4 months of mean value.
This value was significantly shorter than that of squamous cell carcinoma patients. (334.4 months of mean value).
Small cell carcinoma patients were exclusively engaged in the manufacturing process of heavily polluted place.
Based on our studies, it was concluded that the carcinogenicity could be soluble hexa-valent chromium compounds.
Furthermore, the longer and heavier exposure to soluble hexa-valent chromium compounds, the higher occurrence of small cell carcinoma.View full abstractDownload PDF (680K) -
N. Yamamoto, [in Japanese], [in Japanese], [in Japanese], [in Japanese ...1980 Volume 20 Issue 3 Pages 309-315
Published: September 25, 1980
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 35-year-old male was found to have a giant mediastinal tumor (1340g) protruding into the right thoracic cavity. He had ventricular septal defect and multiple pulmonary artery aneurysms in addition. After complete excision of this tumor, it was diagnosed as a thymic carcinoid on the basis of histological examinations, which revealed rosette formation of tumor cells and argyrophil granules within these cells. There was no clinical evidence of carcinoid syndrome before surgery, and the patient has been well for 1 year after surgery. This is the 1 lth case ever reported in Japan and the clinical entity was reviewed based on the literature previously published.View full abstractDownload PDF (11349K) -
1980 Volume 20 Issue 3 Pages 317-320
Published: September 25, 1980
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (413K) -
1980 Volume 20 Issue 3 Pages 321-329
Published: September 25, 1980
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (1164K)
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