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Volume 21 (1981)
- Issue 5 Pages 499-
- Issue 4 Pages 379-
- Issue 3 Pages 231-
- Issue 2 Pages 115-
- Issue 1 Pages 1-
Volume 21, Issue 2
Displaying 1-10 of 10 articles from this issue
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Kazushi Hayakawa1981 Volume 21 Issue 2 Pages 115-126
Published: June 10, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn vitro and in vivo experiments on CEA were made with a cell strain (C-1) which was derived from a cancer of the colon and established in the Department of Surgery, Tokyo Medical College, and serum levels of CEA were also evaluated in 140 patients with cancer of the lung.
The level of CEA was seen to be low both in vitro and in vivo at the time when the number of tumor cells or the weight of tumors was rapidly increasing and to be remarkably high at the time when the number of cells or the weight of tumors became slower in increase or tended to decrease.
When db-cAMP or MMC was added to cultures of C-1 cells, the growth of cells was inhibited and the level of CEA was remarkably high only in the db-cAMP group: A significantly high level of CEA was observed also in 3 kinds of other cell strains which were established from well differentiated adenocarcinoma. From the results stated above, it was seen that the inhibited growth and the differentiation of tumor cells had a close relation to a high level of CEA.
The weight of tumors increased in proportion to the level of CEA, but the level of CEA could not clinically be correlated with the volume of tumors, because the tumor did not metastasize to nude mice in vitro. On the other hand, the clinical course, the extent of lymphatic metastasis, the presence or absence of remote metastasis, and the presence or absence of tumor cells in the blood vessel of the lung were proportional to the blood level of CEA.
From these results, the blood level of CEA is considered to be dependent on the biological properties and the total amount of tumor cells in a carrier of cancer.View full abstractDownload PDF (3185K) -
Jutaro Ono1981 Volume 21 Issue 2 Pages 127-141
Published: June 10, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSEvaluation of the effectiveness of various therapeutic methods by cytophotometric quantitative analysis of cell nucleic Feulgen-DNA in advanced lung cancer cases was examined using bruched cell specimens.It was found that therapeutic effectiveness was reflected by changes in histogram patterns.It was concluded that this can be applied for the evaluation of therapeutic effects and that the -results cytochemically confirmed the validity of evaluation of therapeutic effects based on morphological examination.View full abstractDownload PDF (17172K) -
Kazuya Nakahara, Masazumi Maeda, Yasumasa Monden, Kazuya Nakaoka, Tsun ...1981 Volume 21 Issue 2 Pages 143-149
Published: June 10, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSForty cases of primary lung cancer were studied by 133 Xe-Radiospirometry. From the ventilation distribution (V%), volume distribution (V%) and perfusion distribution (Q%) to the involved hemithorax we produced a tentative nomogram to predict the number of obstructed subsegments on the assumption that 133 Xe distributed equally in each subsegment.
The number of subsegmental obstructions predicted with V %, V % or Q % correlated significantly with the bronchographically observed number of subsegmental obstructions, irrespective of the location of the lesion.
This nomogram was found to be useful to detect the extention of lung cancer, though there was a tendency to slightly overestimate lesions in the upper lobe and underestimate lesions in the lower lobe.View full abstractDownload PDF (702K) -
with a case of lung resection after radioactive iodine therapyS. Hitomi, K. Maezato, C. Reshad, K. Takahashi, I. Nagata, T. Okuda, Y ...1981 Volume 21 Issue 2 Pages 151-160
Published: June 10, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe report 23 cases of pulmonary metastasis of thyroid cancer, with special reference to the results of curative therapy. Of 16 cases with radioactive iodine (R.I.) uptake, 2 cases showed complete response to R.I. therapy, 13 cases showed curative effects, and only one case showed no effective. In one case, the pulmonary metastatic lesion was resected after R.I. Therapy, and efficacy was confirmed on hyalinization and other changes.
Pulmonary metastasis was more often seen in female patients, and prognosis was better in younger patients. No differences in the metastatic rate and prognosis between papillary adenocarcinoma and follicular adenocarcinoma were noticed.
Studies were made on the sex, age, tissue type, onset of pulmonary metastasis, therapy, and prognosis.View full abstractDownload PDF (12527K) -
Keigo Takagi1981 Volume 21 Issue 2 Pages 161-175
Published: June 10, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe mechanism of the spread of pleural carcinomatosis was studied pathologically. Materials used were 14 panpleuropneumonectomied cases, which consisted of 12 cases of primary adenocarcinoma of the lung, and one case each of malignant thymoma and malignant diffuse epithelial mesothelioma. In the early stage of dissemination, malignant cells were implanted on the pleural surface from the primary tumor and grew as small nodules mainly in the submesothelial layer. All the small nodules examined were covered by a thin layer of fibrous tissue. In cases of severe pleural dissemination, these small nodules grew in size and became adherent each other to produce remarkable pleural thickening. Upon further progression, extrapleural invasion and lymphatic vessel permeation were observed. Mediastinal lymph node metastases were positive in 10 out of 11 cases. However, 3 cases with a slight degree of dissemination had no metastases either in the hilum or intrapulmonary lymph nodes, indicating that subpleural lymphatics were connected directly to the mediastinal lymph nodes.
Pleural carcinomatosis should be treated not only for desquamated cancer cells in the pleural cavity but also for subpleural cancer tissue. Panpleuropneumonectomy is considered to be an effective treatment for the early stage of pleural dissemination of lung cancer, malignant thymoma, and malignant mesothelioma.View full abstractDownload PDF (18427K) -
Shiroo Yamazaki, Kohji Kikuchi, Takashi Suzuki, Shimao Fukai, Kohichi ...1981 Volume 21 Issue 2 Pages 177-185
Published: June 10, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe records of 130 consecutive cases undergoing resection for lung cancer at Keio and Tokai University Hospital from 1975 to 1980 were studied to define the characteristics of perioperative cardiovascular function of the aged patient. In our series the incidence of preoperative arterial hypertension and abnormal electrocardiogram was significantly higher in patients aged 60 or more than those under that age. In the older age group (60 or more) the patients with arterial hypertension also showed a significantly higher percentage of abnormal electrocardiograms than those with normal arterial pressure. The incidence of postoperative arrhythmia was also significantly higher in patients over the age of 60.
In the older group, two of the three patients who had a past history of angina pectoris died of acute myocardial infarction, and four in which old myocardial infarction had been diagnosed by preoperative electrocardiography suffered no severe postoperative cardiovascular complications.View full abstractDownload PDF (963K) -
Hideki Kimura, Kimiichi Uno, Takehiko Fujisawa, Yutaka Yamaguchi1981 Volume 21 Issue 2 Pages 187-197
Published: June 10, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSPeripheral blood lymphocytes from primary lung cancer patients or lymphocyte donors were collected by a blood processor M-30 (Haemonetics Co. USA), labeled with 99m Tc 04- (pertecnetate), and inoculatated into the bronchial artery of the patients. One to twenty hours after inoculation, scintigraphy was performed by a Gammacamera (GCA-401-5; Toshiba).
As early as one hour after the inoculation, accumulation of 99m Tc-labeled lymphocytes in tumor and regional lymph nodes was observed. The affinity of autologus lymphocytes to tumor and lymph nodes was higher than that of allogeneic ones. When 99mTc-labeled red blood cells were inoculated into the bronchial artery of the same patients, accumulation of red blood cells in tumors and regional lymph nodes was absent, indicating the immunological mechanisms of accumulation by lymphocytes. From 1 hour to 20 hours after inoculation, the distribution of lymphocytes was stable except for the increased accumulation of lymphocytes in liver and spleen at 20 hours.
In conclusion, 99m Tc-labeled lymphocytes infused via the bronchial arteries of patients with primary lung cancer accumulated in primary tumors and regional lymph nodes. This lymphocyte-scintigraphy appeared to be valuable for diagnosis of pulmonary malignancies.View full abstractDownload PDF (19870K) -
Hideo Nabeshima, Nobuhiro Okamoto, Osamu Doi, Toshio Terasawa, Ryuhei ...1981 Volume 21 Issue 2 Pages 199-206
Published: June 10, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThree cases of differentiated papillary adenocarcinoma otiginating in the large bronchi of the 2nd to 6th orders and proliferating in a medial direction intraluminally along the bronchial surface are presented.
Light microscopically, these tumors were composed of cuboidal cells but free of fibrotic foci, scars and psammoma bodyies.
Electron microscopically endoplasmic reticulum, abundunt mitochondria and oval granules of the varying sizes with varying electron densities were noted, in 2 of the cases. But no mucous granules were observed.
Histogenetically, the 3 cases seemed to have originated in the bronchial surface epithelium.View full abstractDownload PDF (16493K) -
1981 Volume 21 Issue 2 Pages 207-210
Published: June 10, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (359K) -
1981 Volume 21 Issue 2 Pages 211-228
Published: June 10, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (2551K)
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