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Volume 25, Issue 4
Displaying 1-12 of 12 articles from this issue
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Nobuyuki Mitani, [in Japanese], [in Japanese], [in Japanese], [in Japa ...1985 Volume 25 Issue 4 Pages 469-477
Published: June 30, 1985
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe clinical efficacy of OK-432 (Streptococcus pyogenes preparation), which is considered to be an immunopotentiator, was evaluated in a randomized controlled study on 117 patients with primary lung cancer. The results of the 51-months study indicated that OK-432 was effective for the treatment of surgically curative patients in stage I (P<0.1), in particular in adenocarcinoma cases (P<0.05).
No significant life prolongation, however, was observed following OK-432 immunotherapy in the relatively-curative resection stage III cancer patients, non-curatively resected cancer patients and the non-surgically treated cancer patients. Furthermore, the augmentation of delayed type skin reactivity (P.P.D., P.H. A. and Su-PS reactions) was studied in the patients. OK-432 therapy was found to augment skin reaction to Su-PS.View full abstractDownload PDF (1026K) -
Masaru Murakami, Hiromasa Fujita, Masato Nagata, Hideyuki Kawahara, Sh ...1985 Volume 25 Issue 4 Pages 479-486
Published: June 30, 1985
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSPre-and posttreatment CEA levels were measured in 52 surgical and 22 nonsurgical cases of lung cancer. Of these 37 patients (50.5%) showed elevated plasma CEA levels of more than 5.0ng/ml. The positive rate of the CEA value was not related to the histological type of lung cancer, but correlated well with stage of disease.
In 10 of 42 patients undergoing successful surgical resection CEA levels elevated transiently within four weeks after surgery and, except in two cases, decreased to a normal range within three months.
Prognosis of the patients whose preoperative CEA levels exceeded more than 2Ong/m1 was generally poor, but one patients lived for 26 months after operation and another is alive and clinically free of disease 19 months postoperatively with persistently elevated CEA values. Therefore it seems that the use of CEA to predict prognosis in patients with lung cancer is limited.View full abstractDownload PDF (725K) -
Shosaku Abe, Koichi Itabashi, Shiro Makimura, Tatsuo Nagai, Yasuhiro T ...1985 Volume 25 Issue 4 Pages 487-493
Published: June 30, 1985
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe relationship between the nuclear DNA contents of tumor cells obtained by brushing via bronchoscopy and the response to chemotherapy of 22 patients with small cell carcinoma of the lung was investigated. The nuclear DNA content was measured at 550 nm using a microspectrophotometer.
The DNA histogram pattern was classified into either “Type A”, containing a higher proportion of GoGI-phase cells, or “Type B”, containing a higher proportion of S and/or G2M-phase cells. All patients were treated by combination chemotherapy of Vincristin, Cyclophosphamide and Adriamycin.
Of the 8 patients who responded well to chemotherapy, 6 patients (75%) had the Type B histogram pattern, and 2 patients had the Type A histogram pattern.
Of the 14 patients who did not respond to chemotherapy, 11 patients (78.6%) were Type A and 3 patients were Type B. Small cell carcinoma with the Type A histogram pattern were regarded as poor responders whereas the cases with Type B were good responders.
These results indicated that the nuclear DNA content of small cell carcinoma may indicate the choice of drugs and help to evaluate the effect of chemotherapy.View full abstractDownload PDF (680K) -
Heiichi Yano1985 Volume 25 Issue 4 Pages 495-502
Published: June 30, 1985
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTwo monoclonal antibodies (MHPC-1, MHPC-2) with high reactivity with human lung cancer were produced by immunizing mice with crude plasma membranes prepared from the human lung cancer xenografts (giant cell carcinoma and adenocarcinoma).
The antigenic determinants recognized by these antibodies were shown to be carbohydrate chains without terminal sialic acids.
The reactivity of these antibodies was examined by inmmunohistochemical methods using Avidin-Biotin-Peroxidase Complex on formalin-fixed, paraffin-embedded sections of lung cancer and various normal tissues.
MHPC-1 (1gM, κ) produced by immunizing mouse with giant cell carcinoma, bound mainly to human non-small cell lung cancer. It also reacted with restricted areas of some small cell lung cancer, but it did not react with typical oat cell type cells. MHPC-2 (1gM, κ) obtained by immunizing mouse with adenocarcinoma bound not only to non-small cell lung cancer but also to small cell lung cancer. The antigen of this antibody was detected in the pleural fluid of a patient with adenocarcinoma of the lung.
These antibodies might be useful in serological and cytological diagnosis of cancer.View full abstractDownload PDF (7853K) -
with Special Reference to Cases Initially Overlooked or MisdiagnosedTakehito Katoh, Shugaku Oh, Michio Kanai, Toshiki Matsubara, Ken Nakag ...1985 Volume 25 Issue 4 Pages 503-511
Published: June 30, 1985
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn 80 cases of lung cancer the shadows on X-ray films were either overlooked or diagnosed as benign diseases for over six months prior to definitive diagnosis during the period from 1970 through 1983 at the Cancer Institute Hospital in Tokyo. We described these as “follow-up” cases and discussed how a correct diagnosis was eventually obtained.
There was little change in the incidence of follow-up cases during the periods of 1970-75, 76-80, 81-83, despite advances in diagnostic technology during that time.
A retrospective X-ray study of the overlooked or misdiagnosed tumor shadows indicated that careful attention must be paid to peripheral shadows smaller than 2 cm. on the X-ray film, because lung cancers of this size were most frequently overlooked or misdiagnosed.
The detection rate of cancer cells by bronchoscopy has become very high even for small peripheral lung cancers-96% at the Cancer Institute Hospital. Only 5% of follow-up cases, however, underwent initial bronchoscopy. This suggests that if bronchoscopy had been applied to all of the follow-up cases, they might not have been overlooked or misdiagnosed. This enphasizes the importance of making a definitive cytological or histological diagnosis by bronchoscopy for all abnormal X-ray shadows.
In the study of tumor doubling time, it was noticed that lung cancers with a slow growth rate that were sometimes followed up for a long time because of the slow increase in size of the tumor shadows showed relatively good prognosis.View full abstractDownload PDF (860K) -
Noriyuki Sagara1985 Volume 25 Issue 4 Pages 513-521
Published: June 30, 1985
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSCEA was first reported in 1965 as a colon cancer-specific antigen by Gold & Freedman. However a number of studies thereafter have revealed that CEA exists not only in malignant tumors and that there are partly crossreacting substances in the normal lung, spleen, feces, and meconium, as well.
Burtin, von Kleist, and Matsuoka immunochemically analyzed CEA and these CEA analogues in normal tissues, and tried to differentiate CEA specific antigen determinant from others.
Although attention has been paid to the possible existence of some CEA with organ specificity, a lack of appropriate specimens, except for metastatic liver foci of colon cancers, has hampered further studies. The author tried to separate and purify CEA from a human lung cancer cell line (HLC-1) which secretes a large amount of substances with CEA activity into culture media.
CEA from HLC-1 [HLC-1 (CEA)] showed a fused precipitin line between colon cancer CEA but did not crossreact with NCA-1, NCA-2. The physicochemical properties of HLC-1 (CEA) were similar to colon cancer CEA in terms of amino acid composition, but differed in molecular weight (HLC-1 (CEA) =27×104 daltons), pI (HLC-1 (CEA) =4.4) and monosaccharide analysis (sialic acid was not detected).
HLC-1 (CEA) showed uniform physicochemical properties as did CEA-S, pH3/CEA, and is probably related to lung cancer-specific CEA.View full abstractDownload PDF (4468K) -
I. Characterization of Monoclonal Antibodies against a Human Lung Adenocarcinoma Cell Line, ABC-1Shigeru Haisa1985 Volume 25 Issue 4 Pages 523-534
Published: June 30, 1985
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSFour monoclonal antibodies (LA-1, LA-2, LA-3 and LA-4) were produced by fusion of mouse NS-1 myeloma cells with mouse spleen cells immunized with a human lung adenocarcinoma cell line, ABC-1. Membrane immunofluorescence tests and hemaggulutination assays revealed that LA-1 and LA-3 reacted specifically with a blood group, H-antigen. Both antibodies were completely absorbed by 0 type red cells; however, the antibody reactivities against lung adenocarcinoma cells were different. LA-2 and LA-3 reacted to fresh lung adenocarcinoma cells from pleural effusion of 5/7 and 7/7 patients, whereas LA-1 was unreactive with those cells. An immunohistochemical study showed that LA-3 sharply stained primary and metastatic lung adenocarcinoma tissues, but faintly stained normal lung tissues. LA-4 reacted only with ABC-1 cells.
These findings indicate that LA-2 is reactive exclusively with lung adenocarcinoma-associated antigen (M. W. 54, 000), whereas most lung adenocarcinoma strongly expresses a kind of H-antigen. These antibodies, especially LA-2 IgG1 antibody, appear to be of potential diagnostic and therapeutic use.View full abstractDownload PDF (7287K) -
Tetsuji Yamada, Kenji Omura, Hatsuro Yashiki, Sinya Murakami, Yasuo Ha ...1985 Volume 25 Issue 4 Pages 535-541
Published: June 30, 1985
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSCirculating immune complex was investigated in 107 patients with lung cancer and other lung diseases. The positive rate of immune complex in patients with lung cancer was 69%, higher than that in other diseases. Serum immune complex levels increased in according with the progress of disease, but no relationship with histological findings was observed. The antigens, isolated from immune complex by ion-exchange chromatography in the presence of 8M urea, were assayed by indirect enzyme-linked immunosorbent assay. Specific antigens of lung, kidney and spleen were isolated from immune complex but tumor-associated antigen of lung cancer was not detected.
From these results, it was suggested that the effects of treatment and prognosis could be predicted by pre-and post-operative immune complex levels but that this parameter is not useful for early diagnosis.View full abstractDownload PDF (623K) -
Syouji Nakamori, Ken Kodama, Eiji Kurokawa, Osamu Doi, Toshio Terasawa ...1985 Volume 25 Issue 4 Pages 543-548
Published: June 30, 1985
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSRight middle-lower lobectomy and mediastinal lymph node dissection were performed for a case of central type early stage lung cancer. Tumor extended very closely to the line of incision margin of the resected specimen, appearing as carcinoma in situ. To inprove curativity, postoperative radiation therapy was performed with 'Co high dose-rate endobronchial radiation by a remote afterloading system. A total dose of 40Gy was administered to the target area without any severe side effects. The patient is healthy and has no evidence of metastasis.
This procedure is considered to be an effective treatment for postoperative lung cancer with possible residual malignancy.View full abstractDownload PDF (10755K) -
Shinpei Yoshii, Tatsuhiko Hirono, Teruaki Koike, Akira Yamaguchi, Tsun ...1985 Volume 25 Issue 4 Pages 549-554
Published: June 30, 1985
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA case of “collision” lung cancer was reported.An abnormal shadow was pointed out in left S6 in a 70-year-old man.One month later, a second tumor-shadow appeared near the first coin lesion and the two tumor-shadows had developed into a fused tumor during the period of followup. Specimens from percutaneous biopsy showed class V Papanicolaou. Left lower lobectomy with mediastinal lymph node dissection was performed.
From the features of chest roentogenographs and post-operative histology, this tumor was considered to be a case of collision of small cell and squamous cell carcinoma.View full abstractDownload PDF (8545K) -
Akio Mitsuoka, Hiromi Wada, Motohiko Ito1985 Volume 25 Issue 4 Pages 555-558
Published: June 30, 1985
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA case of pulmonary blastoma lacking sarcomatous features (pulmonary endodermal tumor resembling fetal lung) is reported. This type of tumor was first described by Kradin et al. as recently as 1982.
Histologically, this tumor resembles fetal lung as does pulmonary blastoma. However, the tumor included only epithelial component with much less atypia, and the characteristics were consistent with those of pulmonary endodermal tumor but not with typical pulmonary blastoma.
Clinically, a 39-year-old male patient underwent right upper lobectomy of the lung and has shown a good course for more than 6 years. Such a clinical course is also consistent with that of the originally reported case of pulmonary endodermal tumor.View full abstractDownload PDF (3365K) -
1985 Volume 25 Issue 4 Pages 559-579
Published: June 30, 1985
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (2996K)
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