All issues
Volume 26, Issue 6
Displaying 1-15 of 15 articles from this issue
- |<
- <
- 1
- >
- >|
-
Noriyoshi Nagamoto, Yasuki Saito, Tadashi Imai, Hideichi Suda, Shinich ...1986 Volume 26 Issue 6 Pages 609-616
Published: October 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSForty patients with chest x-ray-negtive lung cancer underwent surgical resection in our hospital during the past 3 years. Thirty-five were discovered by mass screening and five in the outpatient clinic. Bronchoscopic localization of all lesions was accomplished. Serial block sectioning of the resected specimens of the 40 patients was performed and bifocal occult carcinoma was detected in 2 specimens. The lesions totaled 42 and they were all squamous cell carcinoma. Microscopic investigation was undertaken to study the location of the lesions in the bronchi and the depth of invasion into the bronchial wall.
Six carcinomas occurred in the right upper lobe, 3 in the right main bronchus and/or the truncus intermedius, 1 in the right middle lobe, 10 in the right lower lobe, 18 in the left upper lobe and 4 in the left lower lobe. Three carcinomas were located in order 0 bronchi, 3 in order I, 4 in order I-II, 17 in order II, 9 in order III and 6 in order IV. Thirteen of 15 carcinomas occurring in the subsegmental and sub-subsegmental bronchi were confined to the bronchial wall. A six-category microscopic classification was attempted on the basis of the depth of invasion (DI) into the structures of bronchial wall (DI0 to DI5); 6 lesions were judged to be carcinoma in situ (DI0), 4 were designated as suspicious of invasion (DI1), 7 as intramucosal invasion (DI2), 17 as extramuscular invasion (DI3), 5 as extracartilaginous invasion (DI4) and 3 as extrabronchial invasion (DI5).View full abstractDownload PDF (9853K) -
Shinichiro Ota, Katsuo Usuda, Keiji Kanma, Motoyasu Sagawa, Masami Sat ...1986 Volume 26 Issue 6 Pages 617-622
Published: October 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn mass surveys for detection of lung cancer, X-ray films are necessary to detect the peripherally located lung cancers.
Twenty cases of resected lung cancers were detected by such mass surveys during the past two years (1983-84), and these cases had been examined for more than the past three years. The tumor shadows were investigated retrospectively.
The mean tumor diameter of squamous cell carcinomas (4.0±1.2cm) was larger than that of adenocarcinomas (2.9±1.8cm). The greatest hindrance for tumor shadow detection was overlapping with normal components. The roentgenological patterns of the detectable initial shadows did not correlate with the histologic type. The configuration of the tumor margin, whether the tumor margin was well-defined or ill-defined, did not change with time. Tumor doubling time varied from 61 days to 4313 days. The mean tumor doubling time of adenocarcinomas (717 days) was longer than that of squamous cell carcinomas (394 days). Even in the same case, the tumor doubling time could vary greatly with differences in measurement periods.View full abstractDownload PDF (631K) -
Masakazu Hasegawa, Masao Sako, Shuji Adachi, Shozo Hirota, Shuhei Ohts ...1986 Volume 26 Issue 6 Pages 623-627
Published: October 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSConcentrated polysaccharide solution (PS) was utilized as a carrier of anti-cancer agents in order to prolong the effect of bronchial arterial infusion therapy. PS consists of dextran 40 (14%), sodium carboxymethyl cellulose (5%) and saline solution.
In this investigation, between 0.2 and 1 mg/kg Mitomycin C (MMC) was dissolved in PS.
Serologic and histologic data in experimental animals, normal dog lung and VX2 rabbit thigh carcinomas showed evidence of prolonged release of MMC from PS without any untoward reaction in normal tissue. Histologic examination in dogs showed that PS remained not only in the lung but also in the mediastinal lymph nodes.
Concerning the mechanism of the action of this agent, it was postulated that high molecular polysaccharide solution retains MMC for a certain period of time and, partly as a result of its high viscosity, reduces the velocity of blood flow, and adheres in some degree to the vascular intima, thereafter releasing MMC slowly.
In conclusion, we consider polysaccharide solution has potential as a transporter of and-cancer agents for prolonged release in bronchial arterial infusion therapy.View full abstractDownload PDF (5753K) -
Satoshi Tanigawa, Sakae Sekiya, Yoshiaki Koya, Takashi Yoshinobu, Masa ...1986 Volume 26 Issue 6 Pages 629-636
Published: October 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe values of carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA) were measured in 115 cases of primary lung cancer, and compared in terms of clinical parameters. The sensitivity rate of CEA for lung cancer was 60% and of TPA was 82.6%. Moreover sensitivity was higher (88.7%) when CEA was used together with TPA. Regarding the histological type, cases both CEA-positive and with high TPA values were frequent in adenocarcinoma. Regarding the relationship between tumor growth and TPA and CEA, e.g. clinical stage, TNM-factor and performance status (P.S.), TPA was more closely related to tumor growth than CEA. TPA was related logarithmically to CEA (γ=0.432, p<0.01).View full abstractDownload PDF (825K) -
Tadaaki Sakai, Takaaki Ikeda, Koji Kikuchi, Tetsushi Suito, Masahisa F ...1986 Volume 26 Issue 6 Pages 637-641
Published: October 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSPanpleuropneumonectomy was performed in nine carcinomatous pleuritis due to lung cancers. They were five males and four females with an average of 58.8±11.4 years. The histological types were eight adenocarcinomas and one adenoid cystic carcinoma. Intrapleural instillation of OK432 (an immunomodulator prepared by SU strain of a-streptococcus) was applied to all patient pre-intra-and postoperatively. Other adjuvant therapies consisted of radiation (1), chemotherapy (6) and combination of radiation and chemotherapy (1). The cumulative survival was 40.4% at one year and 26.9% at two years with a median survival of nine months. Those in whom the cytology of pleural effusion turned negative preoperatively by the instillation of OK432 and patients with well differentiated adenocarcinoma showed relatively good survival.View full abstractDownload PDF (2854K) -
Comparison between Removed Lymph Nodes and CT in Four AreasNobuyuki Mitani, [in Japanese], [in Japanese], [in Japanese], [in Japa ...1986 Volume 26 Issue 6 Pages 643-649
Published: October 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe authors evaluated the CT diagnosis of mediastinal lymph node metastasis in four sections of the mediastinum (58 cases, 151 parts).The reliability of CT diagnosis was as follows; Sesitivity 61.9%, specificity 86.9%, and accuracy 82.8%. CT often resulted in underestimation in adenocarcinoma, and the true positive rate was lower in the upper section of the superior mediastinum than in other parts.
We analyzed the lymph node size, number and range of metastasis. The length of the lymph node was shorter than 10 mm in many cases; 90.3% in metastasis-negative, 52.2% in metastasispositive.
In lymph node metastasis, the length and also the range of cancer varied from section to section. Each part contained not only positive metastasis but also metastasis-negative lymph node.
We, therefore, suggest that these factors influence the diagnosis even in true positive cases.View full abstractDownload PDF (762K) -
II. Characterization of Monoclonal Antibodies against a Human Lung Oat Cell Type Small Cell Cancer Cell Line, SBC-3Shigeru Haisa1986 Volume 26 Issue 6 Pages 651-664
Published: October 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSFive monoclonal antibodies (LSO-2, LSO-3, LSO-4, LSO-5 and LSO-6 Mo-Abs) were produced by the fusion of mouse NS-1 myeloma cells with mouse spleen cells immunized with an oat cell type small cell lung cancer (SCLC) cell line, SBC-3. Reactivities of the Mo-Abs were analyzed using an indirect membrane immunofluorescence test or an indirect immunoperoxidase technique against culture cell lines, normal hematopoietic cells, various tumor cells and normal or malignant tissues.
Mo-Abs LSO-3 (IgG2b), LSO-5 (IgG2a) and LSO-6 (IgG2a) seemed to recognize similar protein antigens (M.W. 98K) on SBC-3 cells by immunoprecipitation and SDS-PAGE analysis. Mo-Ab LSO-5 reacted exclusively with oat cell type SCLC cells and leukemia cells of null-ALL, pre-T-ALL, AML, AMMoL and CML-BC, but not with non-SCLC cells (squamous cell carcinoma, adenocarcinoma or large cell carcinoma), carcinomas derived from other organs as well as normal hematopietic cells. Normal lung alveolar epithelium, glomerulus and tubules of normal kidney and the stromal tissues of some normal organs also reacted faintly with LSO-5. The reactivity of LSO-5 was apparently different from that of BA-3 (anti-common ALL antigen Mo-Ab).
Mo-Ab LSO-4 (IgG2a) reacted preferentially with oat cell type SCLC cells and non-lymphocytic leukemia cells, but not with a variety of other normal or malignant cells. Immunoprecipitation and SDS-PAGE analysis revealed that LSO-4 recognized a glycoprotein antigen (M.W. 78K) on SBC-3 cells.
When SBC-3 cells were cultured with LSO-4 or LSO-5 Mo-Ab, LSO-4 reactive antigen (LSO-4 Ag) partially modulated, but LSO-5 Ag did not. LSO-3, -4, -5, -6 Mo-Abs exhibited complement dependent cytotoxic activity, but Mo-Ab LSO-2 (IgG1) did not.
These results indicate that LSO-4 and LSO-5 Mo-Abs reacted with unique common antigens shared by oat cell type SCLC cells and leukemia cells. These antibodies appear to be of potential diagnostic and therapeutic use.View full abstractDownload PDF (7668K) -
Masaki Hirota, Kiyoyasu Fukushima, Kazuhito Hiratani, Junnichi Kadota, ...1986 Volume 26 Issue 6 Pages 665-672
Published: October 25, 1986
Released on J-STAGE: September 13, 2011
JOURNAL FREE ACCESSThree monoclonal antibodies, CLEX5, CSLEX1, TT3, were produced by immunizing mice with human cancers. The CSLEX1 antibody had previously been confirmed to be directed to the sialylated form of Lewisx (sialylated Lewisx), but the chemical structures of epitopes of the others have not been completely clarified.
These antibodies were IgM and cytotoxic to the promyelocytic leukemia cell line HL-60. The cytotoxicity inhibition assay to detect the antigens in patients' sera has been performed using the antibodies. From the studies on antigen frequencies and specificities, the CSLEX1 antibody was found to be most useful for antigen detection by this method. The positive rate for sialylated Lewis' was 49.4% in patients with lung cancer and 46.4% for all cancer patients, wheras 7.0% for those with benign diseases and 6.1% for healthy controls. From the results together with the simplicity of this procedure, sialylated Lewisx would be a useful tumor marker for detection by cytotoxicity inhibition assay.View full abstractDownload PDF (931K) -
Takeshi Honma, Shuichi Yoneda, Masayuki Nakata, Taiki Fukuda, Yukio No ...1986 Volume 26 Issue 6 Pages 673-679
Published: October 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSRelapse patterns in patients with lung cancer who achieved complete response (CR) and partial response (PR) after induction chemotherapy followed by radiotherapy were evaluated. The numbers of CR and PR were 23 and 21 in 44 patients with small cell carcinoma and 10 and 29 in 39 patients with non-small cell carcinoma respectively.
Six of 19 (23%) relapsed cases in complete responders with small cell carcinoma failed initially in the brain and the bone. In partial responders with small cell carcinoma, relapses in the brain, the chest and lymph node were the common sites of failure.
In complete responders with non-small cell carcinoma, the most common site of recurrence was the chest in the field of radiation (5 of 8, or 63%). In partial responders the common relapse sites were the chest in the field of radiation (48%), outside the radiotherapy field (16%) and the bone (16%).
Ninety-five percent of patients with small cell carcinoma and 94% of patients with non-small cell carcinoma relapsed within 1 year.
In patients with small cell carcinoma, the median duration of response for complete responders was 17 months and 2 months for partial responders. The median duration of response for the complete responders was significantly longer than that of the partial responders, both in small cell carcinoma and non-small cell carcinoma.View full abstractDownload PDF (783K) -
Hironobu Iwasaki, Noritaka Hiramoto, Jyun Sono, Keisuke Hanioka, Sunao ...1986 Volume 26 Issue 6 Pages 681-686
Published: October 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA case of a 15 year-old girl with bronchogenic carcinoma was reported. She was found to have an abnormal density in the right middle lobe in the chest X-ray by mass examination.
Right middle lobectomy confirmed the diagnosis of well-differentiated tubular adenocarcinoma probably originating from the broncial gland. The stage was p-T2N1M0, stagell.
Bronchogenic carcinoma in children is extremely rare and its prognosis is usually poor, but long term survival can be expected in surgically treated cases. Early detection and early resection are particularly required.View full abstractDownload PDF (6586K) -
Takahiko Yoshimoto, Tetsuya Kurimoto, Kyong-Hee Kim, Sayoko Tsuji, Nao ...1986 Volume 26 Issue 6 Pages 687-692
Published: October 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 64 year-old man complained of chest pain, cough and occasional hemosputum. His cigarette index was 1075. The chest roetgenogram showed a large tumor-like shadow in the right hilum. Sputum cytology and bronchoscopic biopsy of the tumor in the right truncus intermedius showed small cell carcinoma. A radiographic examination of the upper gastrointestinal tract was made because the stool was positive for blood and anemia was progressing. A large ulcerated mass on the greater curvature and a non-ulcerated mass on the lesser curvature of the stomach were found. Gastroscopic biopsy of the ulcerated mass showed small cell carcinoma identical to the bronchoscopic biopsy. The patient was treated with chemotherapy with complete respnse, but he died 26 months later from widespread liver metastasis.
Clinically apparent gastric metastases from carcinoma of the lung are extremely rare.View full abstractDownload PDF (6417K) -
Hideo Masuda, Toshiro Ogata, Keiichi Kikuchi, Keigo Takagi, Toshiaki K ...1986 Volume 26 Issue 6 Pages 693-698
Published: October 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe diagnosis of primary mediastinal choriocarcinoma is acceptable only when the primary site in the germinal organ has been ruled out. It appears mostly in young male patients and its prognosis is usually very poor. Recently, we operated on a 29-year old man with a rapidly growing mediastinal tumor. The patient died 9 months postoperatively while on adjuvant chemotherapy and irradiation. Autopsy disclosed no primary focus in the serially cut sections of the testes, but metastases in the lung, liver, brain and kidney were found. Titer of β-hCG reached a very high level of 1100 ng/ml in the tumor. It was thus histologically diagnosed as a primary mediastinal choriocarcinoma.View full abstractDownload PDF (6539K) -
Akira Yamanaka, Kentaro Takahashi, Hirofumi Kato, Yoshio Okada, Hideto ...1986 Volume 26 Issue 6 Pages 699-705
Published: October 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThis reports a case of malignant fibrous histiocytoma (MFH) of the chest wall. A 57 year-old man complained of right chest pain and swelling. After irradiation, panpleuro-pneumonectomy and chest wall resection were performed. The tumor was adjacent to the empyema wall, and extended into the thoracic wall. The resected specimen weighed 1525g.
Histologically, the tumor tissue was composed of both fibroblastic and histiocyticelements showing a storiform pattern. Using the immunoperoxidase method, the tumor cells were strongly positive for ferritin, which is thought to be a marker for histiocytic cells.View full abstractDownload PDF (8701K) -
Keisaku Sugiyama, Ken Shimizu, Hisahiko Ota, Jun Takeda, Takeshi Matsu ...1986 Volume 26 Issue 6 Pages 707-712
Published: October 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA case of double primary lung cancer was presented. Transbronchialung biopsy revealed large cell carcinoma in the right lung and oat-cell (small cell) carcinoma in the left lung of a 75 yearold male. The left lung tumor was accompanied by syndrome of inappropriate secretion of ADH (SIADH). Radiotherapy and chemotherapy reduced the size of left lung tumor, and SIADH disappeared. Autopsy showed adenocarcinoma in the right lung. The incidence of double primary lung cancer, especially adenocarcinoma and small cell carcinoma, was discussed.View full abstractDownload PDF (6988K) -
1986 Volume 26 Issue 6 Pages 713-723
Published: October 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (1641K)
- |<
- <
- 1
- >
- >|