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Volume 27, Issue 7
Displaying 1-13 of 13 articles from this issue
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Hideo Kobayashi, Osamu Tanaka, Enjyo Hata, Kanae Fukushima, Teruo Ishi ...1987 Volume 27 Issue 7 Pages 731-737
Published: December 20, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSixty patients with lung cancer, including 35 operated cases and 4 autopsy cases, were studied by magnetic resonance imaging (MRI). Transverse and coronal imaging were performed by spin-echo sequence with electrocardiogram gating.
MRI clearly demonstrated the normal mediastinal and hilar structures. More than 90% of pulmonary vessels and lobar bronchi were identified. Seventy six percent of mediastinal and hilar lymph nodes shown on resected materials to be over than 1 cm in diameter were detected, as compared to 82% for hilar nodes alone. Staging for T factor, tumor size were fairly accurate but P factor was correctly diagnosed of 64%. In atelectasis, the pulmonary artery was presented as a linear structure, and this finding has not been reported yet.
Our experience suggests that MRI is useful for the diagnosis of atelectasis, vascular involvement, and hilar lymphadenopathy.View full abstractDownload PDF (5825K) -
Yutaka Mizushima, Hitoshi Hirata, Saburo Izumi, Kiyoshi Hoshino, Muneh ...1987 Volume 27 Issue 7 Pages 739-743
Published: December 20, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe values of serum CA19-9, CEA, NSE, SCC and TPA were measured simultaneously and the auxiliary value of each marker and the usefulness of combination assay in diagnosing primary lung cancer were studied in 40 cases of primary lung cancer and 70 cases of non-malignant pulmonary diseases. The positive rates of the above five tumor markers in lung cancer were all higher than those in benign diseases, and the accuracy rates of the markers ranged between 68.2% and 83.6%. Regarding the histologic type, the positive rate of SCC was higher in squamous cell carcinoma (Sq), while the other four markers were higher in adenocarcinoma (Ad) and in small cell carcinoma (Sm). In combination of two markers, a high positive rate was obtained by the combination of TPA and CEA or TPA and CA19-9. The highest positive rate was obtained in the combination of TAP + CA19-9 + CEA + SCC, namely 90% in lung cancer and 32.9% in benign diseases. The probability of lung cancer was 21.4% when only one marker was positive, 87.5% when two markers were positive, and 100% when four or more markers were positive. These results indicate that the number of positive tumor markers are important as auxiliary means to diagnose lung cancer. Since the outcome of the number of positive markers in Sq is less than in other histologic types, development of new tumor markers sensitive to it is necessary.View full abstractDownload PDF (575K) -
Kazufumi Imanaka, Yasumasa Kuroda, Akira Sano, Masashi Takahashi, Hiro ...1987 Volume 27 Issue 7 Pages 745-752
Published: December 20, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThis paper deals with bronchial artery infusion (BAI) using digital subtraction angiography (DSA) and with the therapeutic effect of our new regimen for lung cancer. The initially performed DS-aortography ensured the anatomical mapping of arteries related to the tumor. By referring to this map, selective DS-bronchial arteriography is effectively performed to evaluate metastatic lymph nodes as well as the primary tumor. In spite of the multiplicity and variants of the bronchial artery, the areas to be infused with the drugs were easily estimated.
Two different drugs were combined for BAI as follows:(1) Pepleomycin sulfate (30mg) and Carboquone (6mg) for squamous cell carcinoma, (2) Adriamycin (20-30mg) and Mitomycin C (10mg) for adenocarcinoma, small cell carcinoma and sometimes for large cell carcinoma, (3) Pepleomycin sulfate (30mg) and Mitomycin C (10mg) for adenocarcinoma and large cell carcinoma. We applied this regimen for lung cancer to 52 patients, and compared the therapeutic effect with that of 10 patients treated by a single drug BAI.
The results in tumor size reduction showed that the new regimen was superior to the previous one. These combinations of two drugs occasionally induced local toxic reactions, most of which were transient except one case of severe ulceration in the esophagus and two cases of hemoptysis. Thus, we may conclude that BAI with combined drugs using DSA can be expected to at least reduce tumor size.View full abstractDownload PDF (3859K) -
Seiji Hayashi, Masaaki Kawahara, Nagahisa Kodama, Kaoru Kubota, Masash ...1987 Volume 27 Issue 7 Pages 753-759
Published: December 20, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA single-arm trial of empiric antibiotic therapy in febrile (body temperature>38°C) primary lung cancer patients with granulocytopenia (WBCC<1000/mm3) was carried out. Twenty nine cases (33 episodes) were evaluated. Ticarcillin plus amikacin was administered to all the patients. In this phase, 48.5% of patients were improved. Patients that did not improve were then given ticarcillin plus cefazolin. The overall response rate was 90.9%(30 of 33 episodes). Three cases died due to septic shock caused by Pseudomonas aeruginosa, Candidiasis and resperatory failure, respectively. Adverse effects were minimal. Although more than two thirds of episodes were treated with cis-platinum as an anticancer agent, no synergistic adverse effects that seemed to be caused by amikacin were observed. Empiric antibiotic therapy combined with ticarcillin plus amikacin was effective for febrile primary lung cancer patients with granulocytopenia.View full abstractDownload PDF (878K) -
Takayuki Shirakusa, Takuo Kusano, Masayoshi Tsutsui, Masahiko Seki, Mi ...1987 Volume 27 Issue 7 Pages 761-768
Published: December 20, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSClinico-pathologic studies of metastatic lung tumor were performed in 38 cases. The overall cumulative 5-year survival rate was 40.4%. No statistical differences were found between unilateral lung metastatic lesion and bilateral lung lesions, or between solitary lung metastatic lesions and multiple metastatic lesions. All cases were subdivided into two types, the infiltrative type and non-infiltrative type. The prognosis of the former was poor compared to the latter. Lymph node dissection was carried out in 18 cases and four of them showed metastasis. We consider that lymph node dissection is important to increase curability by surgery.View full abstractDownload PDF (5853K) -
Eiichi Akaogi, Katsumi Yamabe, Hiroshi Tsukada, Naoya Funakoshi, Isao ...1987 Volume 27 Issue 7 Pages 769-778
Published: December 20, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSNine cases of radiologically occult squamous cell carcinoma of the bronchus detected by sputum cytology mass screeening for heavy smokers were examined.
Most of them had chronic obstructive pulmonary diseases and their pulmonary functions were very poor. Additionally, 2 cases had another synchronous early stage squamous cell carcinoma of the bronchus.
It was thought that limited operation should be performed as much as possible. The histology of the surgical margin of the bronchus should also be examined carefully at operation, because invasion of the cancer cells was sometimes more extensive than had been expected preoperatively based on the bronchoscopic findings.
Cases which showed only a small nodule are thought curatively treatable by non-surgical treatment.View full abstractDownload PDF (12553K) -
Junichi Ogawa, Masayuki Iwazaki, Hiroshi Inoue, Shirosaku Koide, Shiak ...1987 Volume 27 Issue 7 Pages 779-787
Published: December 20, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe A, B, H, Lewisa, CA19-9 and CEA reactivities were examined in postoperative lung cancer cases, employing monoclonal antibodies with an immunohistochemical method. There were no significant differences between fresh-frozen and paraffin-processed tissues in antigen detectability. In the same patient, reactivities of A and B antigen in the operative specimens decreased more in autopsy specimens than H antigen. In reference to antigen detectability and prognoses, patients who survived more than 4 years after the operation had higher rates of retention for blood proup antigens, while patients who died within 2 years after the operation had higher rates of total loss of blood group antigens with statistical significance. These results were also observed in stage 1 patients, adenocarcinomas and well-differentiated lung cancers. Lewisa, CA19-9 and CEA had no correlation with the prognoses. CA19-9 (sialylated Lewisa) was detected in almost the same areas where Lewisa was positive. In conclusion analysis of blood group antigens in lung cancers may be valuable for prediction of prognoses. especially in stage 1 patients, adenocarcinomas and well differentiated lung cancers.View full abstractDownload PDF (3590K) -
Kenji Okada, Yasumasa Kani1987 Volume 27 Issue 7 Pages 789-792
Published: December 20, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSPsammoma bodies were present with adenocarcinoma cells in the sputum of a seventysix-year old male. A diagnosis of papillary adenocarcinoma was established by transbronchial biopsy. No psammoma bodies were present in the biopsy specimen. Psammoma bodies in the sputum specimen have been rarely reported in the literature.View full abstractDownload PDF (3243K) -
Yasuhiro Koyama, Hitoshi Katada, Kiyoshi Nishikawa, Masayoshi Sawaki, ...1987 Volume 27 Issue 7 Pages 793-798
Published: December 20, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe chest X-ray film in a 71-year-old man showed a mass in the right upper lung field. Squamous cell carcinoma of the lung (T3N2Mx) was diagnosed by transcutaneous needle lung biopsy and other methods. Minor response to chemotherapy plus radiotherapy was obtained. One month later, edema of the face and the upper limbs, and dyspnea appeared. These symptoms decreased following radiation therapy, one month later, however, these symptoms increased again, and bilateral chylothorax appeared. Venogram showed the obstruction of the superior vena cava. After drainage of pleural effusion, pleurodosis and radiation therapy yielded no more effect and the patient died. This was a rare case of a lung cancer associated with both superior vena cava syndrome and bilateral chylothorax.View full abstractDownload PDF (6910K) -
Sadatoshi Noge, Makoto Miyoshi, Kozo Kumagai, Tomoyuki Nobe, Nobuyuki ...1987 Volume 27 Issue 7 Pages 799-804
Published: December 20, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 57-year male patient suffered severe tracheal stenosis due to adenoid cystic carcinoma. A 5 mm diameter bronchoscope could not be passed through the trachea. Surgical resection was very difficult, because the CT scan showed that the length of stenosis was at least 5 cm.
After the patient received 40 Gy external beam irradiation, a 5 mm diameter catheter could be passed through his trachea for intraluminal radiotherapy. A cobalt-60 source was fed into the catheter by a remote afterloader. A dose of 3 Gy at 1 cm from the source was delivered weekly for 7 weeks. After intraluminal radiotherapy, his trachea opened stillmore. Intraluminal radiotherapy involves no danger to the spinal cord or vital mediastinal structures, because the dose decreases remarkably at a short distance from the source. And further, the patient received 20.8 Gy external beam irradiation. The combination of external and intraluminal radiotherapy produced an 80% opening of the trachea with few side effects.
Intraluminal radiotherapy can be useful method to boost the total tumor dose in unresectable tracheal tumors.View full abstractDownload PDF (9383K) -
Satoshi Tanigawa, Yoshifumi Yamaguchi, Masayuki Masutani, Hiroto Hayas ...1987 Volume 27 Issue 7 Pages 805-810
Published: December 20, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 74 year-old man, who had received therapy for chronic obstructive pulmonary disease, was admitted to our hospital because of a tumor shadow in right S8 on chest X-ray films. Bronchofiberscopically a polypoid tumor was seen at the orifice of right B6.
Right middle and lower lobectomy with mediastinal lymph node dissection was performed. Histological examination of the resected lung and lymph nodes revealed non-caseated epithelioid cell granulomas in the lung and all lymph nodes. From the a clinical. findings and laboratory data, we concluded these granulomas represented sarcoidlike reaction with lung cancer.
Histologically the tumor in right S8 was moderately differentiated squamous cell carcinoma, but the tumor in right B6 was poorly differentiated squamous cell carcinoma. Because the two tumors were in different regions and had slightly different histology, this case was considered primary double lung cancer. However as they had similar in histology, it was difficult to say definitely whether it was double lung cancer or metastatic cancer.View full abstractDownload PDF (7728K) -
1987 Volume 27 Issue 7 Pages 811-815
Published: December 20, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (765K) -
1987 Volume 27 Issue 7 Pages 815-819
Published: December 20, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (910K)
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