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Volume 27, Issue 2
Displaying 1-14 of 14 articles from this issue
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Hiroshi Miyamoto, Yoshikazu Araya, Masami Ito, Hiroshi Isobe, Hirotosh ...1987 Volume 27 Issue 2 Pages 117-124
Published: April 25, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWhether serum selenium and vitamin E (tocopherol) and A (retinol) concentrations were related to familial factors or not was examined in healthy families of lung cancer patients.
Family members (115 sons and daughters of 55 patients with primary lung cancer) were found to have a trend towards lower serum selenium levels (0.116±S.D. 0.024μg/ml, p<0.1); particularly so in families of adenocarcinoma patients (0.111±0.019μg/ml, p<0.01) than that (0.122±0.014 μg/ml) of age and sex-ratio matched controls who did not have a familial history of cancer patients as far as second-degree relatives.
The serum vitamin E level (11.85±2.85μg/ml) was significantly lower in the families of adenocarcinoma patients than in the controls (13.92±2.99 μg/ml, p<0.01). There was no difference in serum vitamin A levels between families of lung cancer patients and the controls. Serum selenium and vitamin E and A levels were significantly lower (p<0.001) in lung cancer patients than in controls.
These data suggest that there are familial factors in serum selenium and vitamin E levels in primary lung cancer.View full abstractDownload PDF (824K) -
Hiroshi Isobe, Masami Ito, Toru Shimizu, Hirotoshi Dosaka, Yoshikazu A ...1987 Volume 27 Issue 2 Pages 125-132
Published: April 25, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe results of flow cytometric DNA content analysis, performed on 25 surgical specimens from patients with primary lung cancer (5 squamous cell carcinoma, 18 adenocarcinoma, 1 adenosquamous carcinoma, 1 carcinoid), were compared with clinical features and histological examinations. Sixty-eight percent of all the patients had abnormal DNA content (DNA aneuploidy). Comparing squamous cell carcinoma and adenocarcinoma, 100% and 61% of the tumors displayed DNA aneuploidy, respectively. Advanced stage tumors tended to show DNA aneuploidy. There was significant evidence that increased DNA index was associated with increased size of the primary tumor (p<0.05). Cell cycle analysis was possible in eight tumors. There was a significant increase in S-phase compartment size with in creasing DNA index (p<0.05). Flow cytometric DNA content analysis might be useful to estimate the degree of malignancy of lung cancer.View full abstractDownload PDF (3285K) -
Ken Kodama, Osamu Doi, Eiji Kurokawa, [in Japanese], Toshio Terasawa1987 Volume 27 Issue 2 Pages 133-140
Published: April 25, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe combined effects of hyperthermia (42.5°C, 1 hour) and CDDP on lung cancer cell lines were studied in tissue culture. The z ults indicated that combination of these methods was more cytotoxic than either treatment alone against established human lung cancer cell lines. Moreover, lethal effect was recognized when the CDDP concentration reached more than 10μg/ml.
Clinically, it was also demonstrated in our study that the free-Pt concentration was kept at more than 10μg/ml only two hours immediately after a bolus injection of CDDP (50-100mg) in the pleural cavity. Therefore, the optimal sequence for clinical utilization of combined local chemotherapy and hyperthermia was thought to be simultaneous treatment (within 2 hours).
We report the clinical data on 14 patients who had been treated with chemotherapy following radiofrequency hyperthermia (RFHT). Six of the eight patients who were treated by the above method for intrapleural residual disease after operation remain clinically free of disease at from 1-28 months later. Further, two patients with postoperative distant metastases and two others with inoperable local advanced lung cancer were treated with chemotherapy (selective arterial or intravenous) and RFHT. Autopsy findings on one of the latter two patients showed severe necrosis of the larger part of the tumor, including the heated field.
We concluded that combined chemo-hyperthermotherapy has considerable value as an adjuvant therapy after operation for advanced lung cancer. Additional studies of the survival time of the treated group compared to the historical control group are planned.View full abstractDownload PDF (4757K) -
Akitoshi Tatsumi, Morihisa Kitano, Akira Fujio, Shoji Asakura, Teruo M ...1987 Volume 27 Issue 2 Pages 141-148
Published: April 25, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTwenty-three cases of double primary cancer involving lung cancer were experienced from June, 1969, to November, 1985.
The incidence was 3.8 per cent of all hospitalized cases of primary lung cancer. The patients included 19 males and 4 females, a ratio of 5 to 1. Their ages at the time of detection of the lung cancer ranged from 48 to 74 years with an average age of 62.8 years. Thirteen out of 23 cases of double cancer appeared synchronously. Of 20 patients who had pulmonary excision, 16 had lobectomies, one had a pneumonectomy and 3 had segmentectomies or wedge resections. The counterpart organs involved were the stomach in 7 cases, prostate and larynx in 3 cases each, rectum and uterus in 2 cases each and esophagus and pancreas in 1 case each. There were four multiple lung cancers. In respect to the histological type of lung cancer, 11 were adenocarcinoma, 9 were squamous cell carcinoma, 3 were small cell carcinoma and 3 were large cell carcinoma.
The incidence of double primary cancer tends to increase in time, and the prognosis of double primary cancer involving lung cancer will depend on the clinical course of the lung cancer. Nevertheless, limited resection for lung cancer can occasionally be recommended to conserve pulmonary function as much as possible. The possibility of a second primary cancer should be considered carefully whenever a solitary shadow appears on the chest roentgenogram of a patient who has been treated for another cancer before.View full abstractDownload PDF (873K) -
Chojiro Yamashita, Noriaki Tsubota, Ryuta Aogauchi, Koichi Yoshikawa, ...1987 Volume 27 Issue 2 Pages 149-154
Published: April 25, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSCT scan has been widely utilized recently to assess mediastinal lymph node metastasis of lung cancer. However, it has become obvious that there are occasional discrepancies between CT findings and operative or histological findings. We investigated CT images in 50 patients with lung cancer comparing operative findings with the histology of the mediastinal lymph node. As far as superior mediastinal (#1) to paraaortic (#6) lymph nodes are concerned, their enlargement was accurately predicted by CT scan, but it was less sensititive to the involvement of subcarinal (#7) lymph node, which had a false-positive rate of 18% and false negative of 16%. Paraesophageal (#8) to hilar (#10) lymph node enlargement was difficult to diagnose. Histologically demonstrated lymph node metastasis was frequently found in lymph nodes estimated to be greater than 10 mm in diameter on CT scan.View full abstractDownload PDF (2857K) -
Hiroyuki Nishiyama, Yutaka Nishiwaki, Tetsuro Kodama, Yasuyuki Sone, T ...1987 Volume 27 Issue 2 Pages 155-161
Published: April 25, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn 338 cases of surgically resected primary lung cancer from 1979 to 1984, preoperative evaluation of the T-factor and N-factor was performed in 2 groups, that is, one undergoing CT examination (CT (+)), the other was without CT examination (CT (-)).
The accuracy of the T-factor was 83.3% for the p-T1 cases, 73.2% for the p-T2 cases, 71.2% for the p-T3 cases, and 74.9% overall. In the p-T1 cases the accuracy of the CT (+) group was higher than the CT (-) group, on the contrary, in p-T2 cases the accuracy of the CT (-) was higher than the CT (+) group.
The main causes of mistaken evaluation of the T-factor were (1) error in measuring tumor diameter and (2) error in recognizing the presence or absence of invasion to adjacent organs. In the CT (+) group, there were fewer cases in which the T-factor was underestimated compared with the CT (-) group. On the other hand, there were more cases of overestimation.
The diagnostic accuracy of the N-factor was 75.5% for the p-NO cases, 41.7% for the p-N1 cases, 48.9% for the p-N2 cases, and 62.4% overall.
This was clearly inferior to the results for the T-factor.
In the CT (+) group the accuracy of evaluation of N1 was less than the CT (-) group, but that of N2 was markedly increased.
However, there were many cases overestimated because of swollen lymph nodes without metastasis in squamous cell carcinoma cases, and no improvement was noted in the diagnostic accuracy of the N-factor in the CT (+) group.
The diagnostic accuracy of the CT (+) group was not neccesarily markedly better than the CT (-) group, in terms of either the T-factor or N-factor.View full abstractDownload PDF (831K) -
Minoru Takeuchi, Takateru Izumi, Yusaku Matui, Sonoko Nagai, Yoshiyuki ...1987 Volume 27 Issue 2 Pages 163-171
Published: April 25, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSNatural killer (NK) cell activity was examined in patients with lung cancer and in healthy controls, employing K562 cells as target cells, using 51Cr release assay, and by analysis of Leu-7 positive (Leu-7+) cells and Leu-11 positive (Leu-11+) cells of mononuclear cells employing monoclonal antibodies (Leu-7, Leu-11) using an Ortho Spectrum III.
NK cell activity in patients with lung cancer was significantly lower (p<0.01) than that in the healthy control group (E/T-100). The NK cell activity in patients with lung cancer in clinical stage IV tended to be lower than that in clinical stage III.
The NK cells in lung cancer cases and healthy controls were responsive to α-interferon (α-IFN) and interleukin-2 (IL-2).
The percentage of Leu-7+ cells in patients with lung cancer revealed no change, but the percentage of Leu-11+ cells in lung cancer case increased to significantly higher (p<0.05) levels than the levels found in the healthy controls.
The percentage of Leu-7+ cells and Leu-11+ cells did not correlate with the NK cell activity in patients with lung cancer or in healthy controls.
These results suggest that overall NK cell activity was depressed, but the function of NK cells themselves was not depressed, and the results also suggest that the percentage of Leu-11+ cells losing NK cell activity increases in patients with lung cancer.View full abstractDownload PDF (891K) -
Haruhiko Nakamura, Kenkichi Oho, Osamu Taira, Tomiaki Shou, Ryuta Amem ...1987 Volume 27 Issue 2 Pages 173-180
Published: April 25, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSFour cases judged endoscopically to be early stage central type squamous cell carcinoma of the lung and one case of carcinoid were treated by endoscopic Nd-YAG laser, because of poor pulmonary function or refusal of operation. All patients are alive and apparently diseasefree at from 5 to 22 months after treatment, except one case that died from non-malignant disease.
Endoscopic Nd-YAG laser treatment avoids the burden of invasive surgery and is considered to be extremely effective in cases of early stage lesions when the option of thoracotomy is not available.View full abstractDownload PDF (7766K) -
Akira Hayashibe, Yutaka Nishiwaki, Tetsuro Kodama, Yoshiyuki Nishiyama ...1987 Volume 27 Issue 2 Pages 181-187
Published: April 25, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe experienced two cases of mediastinal malignant germ cell tumors which were resectable following cisplatin, vinblastine and bleomycin (PVB) combination chemotherapy. The first case was a 30 year-old man with a complaint of susceptibility to fatigue and shoulder stiffness The second case was a 37 year-old man who complained of bloody sputum and left chest pain. At admission, the serum alpha-fetoprotein was markedly elevated (5000 and 200 ng/ml) in both cases and serum human chorionic gonadotoropin was also elevated (36 ng/ml) in the second case.
After two courses of modified PVB chemotherapy, the serum tumor markers were normalized in both cases.
The markedly decreased mediastinal tumor masses were then resected. Viable tumor cells were not present in the resected tumors. Both patients are free of disease at present, 6 and 27 months after the initial treatment.
It was considered that PVB chemotherapy with surgical resection was extremely effective approach for the treatment of malignant germ cell tumor of the mediastinum.View full abstractDownload PDF (8345K) -
Takeshi Hatta, Masahide Matsubara, Noriaki Tsubota, Kayoko Oobayashi, ...1987 Volume 27 Issue 2 Pages 189-193
Published: April 25, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 49-year-old man presented with bloody sputum starting in June 1984. Chest X-ray examinations revealed giant bullae in bilateral upper lung fields with a small tumorous shadow in one of them on the left side. Sputum and brushing cytology were negative for malignant cells. Chest X-ray film taken six months later showed enlargement of the shadow, which was most suggestive of neoplasm. Left upper lobectomy was carried out in December 1984. As a lung cancer developing in a bulla was found, the hilar and mediastinal lymph nodes were resected. The histological diagnosis was large cell carcinoma. The pathological staging was T1 N0 M0, stage Ia. The postoperative course was uneventful and the patient's condition is good at 16 months after operation.View full abstractDownload PDF (6080K) -
Osamu Sakamoto, Hisato Yamasaki, Yasuo Shimokawa, Katsumasa Tokunaga, ...1987 Volume 27 Issue 2 Pages 195-200
Published: April 25, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 72 year-old man was admitted to our hospital on 14 September 1984, complaining of dry cough and weight loss. Chest X-ray film revealed a large mass shadow on the right middle lung field. Trans-bronchial brushing and biopsy specimens showed large cell carcinoma.
Serum AFP level was elevated to 37, 400 ng/ml, but laboratory data of liver function showed no abnormality. He died after 4 months in spite of chemotherapy and irradiation.
Findings of the autopsy revealed a destroyed tumor mass, probably as a result of therapy and pleuritis carcinomatosa, there was no metastasis in the liver or other organs. The immunoenzyme labelling technique using ABC (Avidin-biotin complex) method showed AFP in the lung cancer cells. We concluded that these findings suggest that AFP was produced in the tumor tissue.View full abstractDownload PDF (4091K) -
Motoji Sawabe, Eiju Tsuchiya, Tsutomu Kasuga, Shugaku Oh, Toshiki Mats ...1987 Volume 27 Issue 2 Pages 201-206
Published: April 25, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 65 year-old man, who had smoked 40 cigarettes a day for 45 years, was admitted with complaints of increasing cough and right lower chest pain. Chest X-ray film showed a nodular shadow in the right lower lung field and brochofiberscopy detected a 2 mm other mass in the right lower lobe bronchus. Under a diagnosis of double lung cancer, right middle and lower lobectomy was performed. The patient died of respiratory failure 5 months after the initial diagnosis. The resected lung lobes were found to have three cancers: peripheral adenosquamous carcinoma, hilar early squamous cell carcinoma and an incidentally found microscopic adenocarcinoma. This microscopic cancer arose from the segmental bronchus of right B6 and measured 7 mm in diameter, however, macroscopically, no tumor was recognized. Histologically, the carcinoma was composed of cuboidal or columnar cells, some of which formed mucin, and equally replaced the bronchical epithelium and underlying bronchial gland. Histological diagnosis was tubular adenocarcinoma in situ. This in situ cancer was considered as the most early stage of adenocarcinoma of large bronchi.View full abstractDownload PDF (6527K) -
Akitoshi Kinoshita, Kenji Kawano, Mikio Oka, Akimitsu Tomonaga, Tetsur ...1987 Volume 27 Issue 2 Pages 207-212
Published: April 25, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 74 year-old woman, who had been treated for uveitis and glaucoma for seven years, was referred for evaluation of a nodular shadow on chest radiogragh.
Since the abnormal shadow in the right upper lobe increased gradually, she was referred to our hospital. After a diagnosis of primary lung cancer was made, right upper lobectomy was performed on 12th July, 1984. Histopathological findings of the resected lung showed the coexistence of adenocarcinoma and non-caseous epitheloid cell granuloma in the area of cancer, and the presence of diffuse non-caseous granulomas in the non-cancerous region.
The serum ACE level was elevated, and the percentage of T-cell and OKT4/OKT8 ratio increased in bronchial alveolar lavage of the left lung at eight month after operation. Primary lung cancer (adenocarcinoma) of the right upper lobe associated with sarcoidosis was diagnosed.View full abstractDownload PDF (6220K) -
1987 Volume 27 Issue 2 Pages 213-221
Published: April 25, 1987
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (1323K)
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