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Volume 28, Issue 1
Displaying 1-15 of 15 articles from this issue
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Kenji Sawamura, Yong-Eun Lee, Keiichi Suemasu, Naoto Miyazawa, Yutaka ...1988 Volume 28 Issue 1 Pages 1-9
Published: February 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThis report analyzes the results of surgical resection on non-small cell lung cancer with mediastinal lymph node involvement. The subjects consisted of 146 adenocarcinomas and 85 squamous cell carcinomas, which underwent complete resection with complete mediastinal lymph node dissection and were proved to be N2 postoperatively. No significant difference in survival was found between adenocarcinoma and squamous cell carcinoma. The survival of T1 cases was significantly superior (P<0.001) to T2 or T3 cases.
As to mediastinal lymph node involvement, metastasis to the highest mediastinal lymph node or to more than 3 levels of mediastinal lymph nodes were poor prognostic factors in N2 disease. The tumor size correlated well with the survival in adenocarcinoma. Local recurrence was observed more frequently in squamous cell carcinoma (30.6%) than in adenocarcinoma (19.2%).View full abstractDownload PDF (860K) -
Takayoshi Tashiro, Jun Goto, Hideaki Shigeno, Yoichiro Goto, Yoshinobu ...1988 Volume 28 Issue 1 Pages 11-17
Published: February 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe 19-9 monoclonal antibody, prepared by Koprowski et al., reacts with a carbohydrate antigenic determinant (CA 19-9) which has been identified as a sialylated lacto-Nfucopentaose II. CA19-9 has been known to be a useful tumor marker for gastrointestinal carcinoma, especially pancreatic cancer.
The authors investigated the significance of this antigen for lung cancer. We measured serum CA 19-9 concentration in 56 patients with lung cancer by a forward sandwich type radioimmunometric assay (cut-off value 37 U/ml), and immunostained the antigen in 32 lung cancer tissue by an immunoperoxidase assay.
The positive rate of serum CA 19-9 concentration was 16%, lower than that of carcinoembryonic antigen (CEA). The concentration of the antigen was markedly increased in patients with bronchial gland type adenocarcinoma, and strongly stained in cancer tissue.View full abstractDownload PDF (3269K) -
Kiyoshi Konno, Masakichi Motomiya, Kotaro Oizumi, Masahiro Sato, Fusak ...1988 Volume 28 Issue 1 Pages 19-28
Published: February 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA randomized controlled study was conducted to investigate the effects of PSK in the treatment of small cell carcinoma of the lung (SCC). A total of 109 cases were given standard chemotherapy consisting of 1mg Vincristine, 200-400mg Cyclophosphamide, and 2-4mg Mitomycin-C weekly for 4 to 8 weeks, with or without radiotherapy. To the group allocated to PSK, 3g/day of PSK was orally administered along with the above treatment. Of 93 eligible cases, 46 were PSK and 47 were control group. Response rates for PSK and control were 45% and 46%, respectively. The median duration of response for PSK (25w) was significantly longer than that for controls (13w), although survival rates for PSK and control groups were not significantly different. A tendency towards better survial in the PSK group was observed in cases responsive to chemo-and radiotherapy, with a higher pretreatment lymphocyte count and with good performance status (0-1). Changes of lymphocytes, PS score, erythrocyte sedimentation rates, A/G ratio etc were persistently beneficial for patients in the PSK group. The frequency and severity of side effects oriented to the standard chemotherapy and radiotherapy were not different between the both groups.
It was concluded that immunotherapy with PSK would be beneficial in the treatment of SCC when used in cases responsive to basic treatment, particularly in the patients with good prognostic factors.View full abstractDownload PDF (1127K) -
Atsushi Takise1988 Volume 28 Issue 1 Pages 29-35
Published: February 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSerum levels of neuron-specific enolase (NSE) and squamous cell carcinoma-related antigen (SCC antigen) were measured by radioimmunoassay in 20 normal controls, 16 patients with non-malignant pulmonary diseases and 65 patients with primary lung cancer. The mean values of these markers in the primary lung cancer group were significantly higher than those in normal controls and non-malignant pulmonary diseases. The positive rates of serum NSE and SCC antigen in all lung cancer cases were 32.3% and 24.6%, respectively.
Serum NSE level was significantly higher in small cell carcinoma as compared to other histologic types and increased in proportion as the stage advanced. Serum NSE level also correlated well with the response to chemotherapy. Serum SCC antigen level was significantly higher in squamous cell carcinoma as compared to other histologic types and increased in proportion as the stage advanced.
It is concluded that NSE and SCC antigen are very useful markers of lung cancer for diagnosis and treatment.View full abstractDownload PDF (769K) -
Akira Kurita1988 Volume 28 Issue 1 Pages 37-47
Published: February 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSOne hundred and eighty-three cases of lung cancer, which were resected in our department over the period between 1972 and 1981, were examined histopathologically. Using formalin-fixed materials, three levels of the tumor mass and adjacent areas were analyzed. The regional lymph nodes were also examined at the plane of greatest extent. Several factors were assessed in the 3-year survivor group and non-survivor group, and the conclusions were as follows.
In stage I adenocarcinoma cases with a mitotic index of <0.005 showed better prognosis. In Stage I squamous cell carcinoma the group without blood vessel invasion had a significantly better prognosis and those with a tumor size ≤5 cm and mitotic index <0.016 with intense inflammatory cell infiltration also indicated a better prognosis. In Stage III adenocarcinoma the necrosis negative group demonstrated significantly better prognosis as did the tumor size <3 cm group. In stage III squamous cell carcinoma no predictive factors were recognized.View full abstractDownload PDF (8247K) -
Tesshi Yamada, Ryuuta Amemiya, Atsushi Uehara, Masayuki Niitsuma, Nobu ...1988 Volume 28 Issue 1 Pages 49-55
Published: February 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSPercutaneous aspiration biopsy using the modified Menghini needle (SURE CUT) was carried out for histological diagnosis of 54 patients with thoracic diseases (lung 37 cases, mediastinum 2 cases, thoracic wall 11 cases, supraclavicular lymph node 4 cases). Biopsied specimens obtained by this method preserve the structure of tumor histology well. This method provided not only a high diagnostic accuracy in malignant diseases but also evaluation of prognostic factors such as local extent, interstitial fibrosis and histological subtypes of the tomor. There was no serious complication in this series but there were 2 cases of pneumothorax and 2 cases of hemosputum.View full abstractDownload PDF (10208K) -
Kazuya Suzuki, Tomohiro Horiguchi, Yasuyuki Nagashima, Ryutaro Moriyam ...1988 Volume 28 Issue 1 Pages 57-64
Published: February 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe performed limited operation in 24 cases, simple lobectomy in 46, and standard resection in 213 cases for the treatment of lung cancer. The following results were obtained.
Limited operation and simple lobectomy without standard lymph node dissection were mainly selected for aged patients with various complications, but the occurrence rate of postoperative complications was relatively low.
Five-year survival rates of stage Ia patients who underwent limited operation and simple lobectomy were 93.7% and 67.7% which were acceptable in comparison with that of standard resection (76.5%). On the other hand, the survival rates after these operations were significantly lower than that of standard resection in patients with stage Ib, II or III disease.
The presence or absence of blood vessel and/or lymph vessel invasion as seen microscopically in the surgical specimen was found to bear a close relationship to the survival rate. Routine examination for the evidence of there invasions may be useful in order to evaluate the prognosis especially in operations without standard lymph node dissection.View full abstractDownload PDF (3218K) -
Koji Kimino, Hiroyoshi Ayabe, Katsunobu Kawahara, Kiyoto Shinkai, Yuta ...1988 Volume 28 Issue 1 Pages 65-73
Published: February 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn this paper, we reviewed the surgical management of postoperative intra-or extrathoracic recurrence of primary lung cancer. Most recurrent cases of primary lung cancer were found in the terminal stage or with multiple metastasis. However, due to an increase in numbers of resected primary lung cancer cases, solitary recurrent cases with no evidence of distant metastasis have been revealingly seen. Of 514 cases with resected primary lung cancer, 14 cases underwent reoperation for intrathoracic recurrence and 11 were reoperated for extrathoracic metastasis. In 12 of the former cases pulmonary metastasis had observed while in the other 2 cases were bronchial stump recurrence. Reoperated cases of extrathoracic metastasis evaluated 4 of brain metastasis, 3 of intestinal metastasis and 2 each of adrenal and bone metastasis. Concerning the histological distribution, 19 cases were adenocarcinoma and 6 were squamous cell carcinoma. All reoperated specimens showed same cell type as in the first resected specimens. According to the TNM (UICC) classification, 85.7% of intrathoracic cases were stage I as opposed to 36.3% of extrathoracic cases. The average interval from the first operation to reoperation and average survival time after reoperation was 35.4 months and 22.1 months in intrathoracic cases, but only 8.9 months and 4.6 months in extrathoracic cases.View full abstractDownload PDF (989K) -
Naohisa Tsunoda, Ken Saito, Rokurou Matsuoka1988 Volume 28 Issue 1 Pages 75-85
Published: February 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSAmong 209 consecutive autopsy cases of primary lung cancer in Jichi Medical School, 11 cases died of massive hemoptysis. All cases were male and heavy smokers. The primary focus was around the lung hilum in all cases. Ten cases were squamous cell carcinoma and one was large cell carcinoma.
Cavity formation was demonstrated after radiotherapy in all cases. All cavities communicated with main bronchi. In 8 cases, cavitation and associated infection caused complete destruction of the segmental bronchi as well as segmental pulmonary arteries, which were already obstructed or markedly stenotic.
The lethal bleeding points were identified in 10 cases. All of the ruptured vessels were patent large pulmonary arteries running along the hilar portion of the cavities. Cancer cell infiltration into the ruptured arterial wall was observed in only one case. Purulent phlegmonous inflammation of the arterial wall was the histological feature of remaining 9 cases. Bacterial colonies were attached to the ruptured arterial walls in all cases.
Accordingly, the major direct cause of lethal massive hemoptysis was considered to be the infection of the cancer cavity.View full abstractDownload PDF (14039K) -
Katsuaki Yoshida, Shojiro Morinaga, Akihiko Gemma, Yukio Shimosato, Ry ...1988 Volume 28 Issue 1 Pages 87-92
Published: February 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA rare case of adenocarcinoma of the lung with stromal ossification is reported. The patient was a 49-year-old man. X-ray films of the chest revealed a mass shadow with calcification in the right lower lobe. Right lower lobectomy and lymph node dissection were performed. Microscopically, a firm solid tumor measuring 3.5×3.0×3.0 cm, was located in the peripheral portion of right S6. The histology of the tumor was moderately differentiated tubular adenocarcinoma composed of cuboidal or low columnar cells. Tumor stroma with abundant collagen was the site of bone formation with mature osteoblasts and osteocytes. About 5 years after surgery, recurrence of the tumor was observed in the right truncus intermedius, right middle lobe and left pulmonary hilar lymph nodes. Right upper and middle lobectomy and biopsies of the tumor in the left parietal pleura was performed, because tumor dissemination was observed in the left thoracic wall. The histology of the recurrent tumor was the same as the primary tumor and bone formation was also noted in a tumor of the right middle lobe. We suggest that some factors produced by the tumor cells might induce osseous metaplasia of fibroblast in the tumor stroma.View full abstractDownload PDF (6487K) -
Jun Araki, Naomi Ito, Masamoto Nakano, Takehiro Nakata, Kenji Matsuo1988 Volume 28 Issue 1 Pages 93-98
Published: February 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThis paper reports a case of pulmonary carcinosarcoma in the upper division bronchus. The tumor was removed surgically and found to measure 7.8×4.0×3.5 cm. Histologically, it consisted of two components, carcinoma and sarcoma. The epithelial component consisted of squamous cell carcinoma and adenocarcinoma. The sarcomatous cellular component showed fibrosarcomatous, chondrosarcomatous and rhabdomyosarcomatous differentiation. In some areas the tumor resembled pulmonary blastoma. The patient died postoperatively due to the development of a brain metastatic lesion resembling fibrosarcoma. Reports of pulmonary carcinosarcoma with pulmonary blastoma are very rare. The histogenesis of pulmonary carcinosarcoma is discussed with reference to the literature.View full abstractDownload PDF (9745K) -
Junichi Hiratsuka, Shuji Adachi, Yoshinari Imajo, Kyuhei Gose, Michio ...1988 Volume 28 Issue 1 Pages 99-105
Published: February 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThree cases of Hodgkin's disease with pulmonary involvement are presented. They showed three different roentgenographic patterns, one having a discrete pulmonary nodule, another exhibiting poorly defined linear densities radiating from bilateral hili associated with Kerley's B line and the third displaying multiple hazy, ill-defined nodules.
In our cases, it was difficult to differentiate pulmonary involvement due to Hodgkin's disease from lung cancer, tuberculosis and pneumonia on chest X-ray films because there was no specific sign in the radiographic evidence of the pulmonary lesions. However, early and accurate diagnosis of pulmonary involvement by TBLB or CT-guided needle biopsy is very important in the selection of therapeutic procedure.View full abstractDownload PDF (9941K) -
Samon Miyata, Teiji Nakagawa, Shoji Maeda, Atsuo Miwa, Masanobu Kitaga ...1988 Volume 28 Issue 1 Pages 107-111
Published: February 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA rare case of lung cancer with central calcification recognized on chest CT was reported.
A 62 year-old woman was found to have a pulmonary nodule (4 cm) with an irregular margin in the right upper lung field on chest X-ray film. Central calcification in the nodule was not detected on plain film and tomogram, but was evident on chest CT. The possibility of lung cancer was not excluded because the lesion was large and had an irregular margin, so the patient underwent right upper lobectomy.
Microscopic examination revealed a well-differentiated papillary adenocarcinoma and foci of bone formation was recognized in the central fibrotic zone of the tumor, which was considered not to be a preexisting calcified scar but dystrophic calcification.View full abstractDownload PDF (6197K) -
Isao Yamawaki, Syuji Yasui, Masahiko Kawakami, Kimio Konno, Takao Taki ...1988 Volume 28 Issue 1 Pages 113-118
Published: February 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSMucoepidermoid carcinoma of the bronchus is a very rare tumor. This paper describes one case including pathological findings. An 18-year-old female was admitted to our hospital complaining of cough, sputum and fever. On fiberoptic bronchoscopy, a tumor mass which almost completely occluded the orifice of right B6 bronchus was noted and biopsied. After right middle and lower bilobectomy, surgical specimens were prepared for pathological studies. Under light microscopy, the tumor including well differentiated squamous cell areas and mucusproducing glandular structures was observed. Electron microscopy revealed that some cells contained secretory granules, and/or tonofibrils. By immunohistochemistry, secretory component was demonstrated in mucus-producing glandular epithelium.View full abstractDownload PDF (7014K) -
1988 Volume 28 Issue 1 Pages 119-145
Published: February 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (3911K)
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