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Volume 29, Issue 3
Displaying 1-14 of 14 articles from this issue
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1989 Volume 29 Issue 3 Pages 219-220
Published: June 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (145K) -
Shigeyuki Sasaki, Atsuo Ogasawara, Satoshi Yano, Junichi Ikeda, Shin H ...1989 Volume 29 Issue 3 Pages 221-228
Published: June 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDelayed skin reaction tests were carried out in 245 patients with primary lung cancer in the past 10 years, and the data obtained were analyzed in relation to their prognoses.
The survival rate of the group with PPD≥15 (mm) (group A) was significantly superior to the group with PPD<15 (mm) (group B) (p<0.05). Comparing respective stage cases, group A was superior to group B in survival in stage I cases (p<0.01).
The survival rate of the group with PHA≥30 (mm) (group C) was significantly superior to the group with PHA <30 (mm) (group D) (p<0.05). Group C was also superior to group D in survival in stage I (p<0.05) and stage II (p<0.05) cases.There was no significant correlation between the results of post-operative skin reaction (both PPD and PHA) and survival rate.View full abstractDownload PDF (869K) -
Akiharu Okamura1989 Volume 29 Issue 3 Pages 229-236
Published: June 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTo clarify the histogenesis of adenocarcinoma of the lung, 50 resected adenocarcinomas of the lung that did not undergo radiotherapy or intensive chemotherapy, of well-, moderately-and poorly-differentiated adenocarcinomas, bronchiolo-alveolar and largecell carcinomas were evaluated immunohistopathologically, using the avidin-biotin-peroxidase complex method, and histochemically, using PAS-Alcian blue (pH 2.5) staining.
Epithelial membrane antigen (EMA) was positive in all cases, cytokeratin (CK) in 45, secretory component (SC) in 37, lysozyme (LY) in 5, PAS in 42, Alcian blue (AB) in 27 cases. Diffusely positive results were obtained in 39 cases, 23 cases, 9 cases, 3 cases, 7 cases and 4 cases, respectively. According to the subclassification of adenocarcinoma, the overwhelming majority of well-differentiated adenocarcinomas were positive for all markers. In poorly-differentiated adenocarcinoma, although most cases were negative for AB and LY, almost all cases were positive for EMA and CK. Furthermore, 82 cases of adenocarcinomas demonstrated multiphenotypes, such as alveolar, non-ciliated bronchiolar, bronchial goblet cell, and mucous gland of bronchial gland types, in the same lesion. The multiphenotypes of the adenocarcinoma group indicated heterogeneity. In consequence, it might be reasonable that lung adenocarcinoma derives from pluripotential cancer cells rather than from a single indigenous cell corresponding to the normal pulmonary glandular epithelium.View full abstractDownload PDF (11296K) -
Adenocarcinoma with Special Reference to its PrognosisMitsutoshi Shiba, Yutaka Yamaguchi, Hisami Yamakawa, Toshihiko Iizasa, ...1989 Volume 29 Issue 3 Pages 237-245
Published: June 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn 21 resected cases of peripherally originating lung adenocarcinoma which were less than 2cm in tumor diameter, cytomorphometrical studies were performed and analyzed in relation to their postoperative stages (p-TNM) and postsurgical courses. The atypical and pleomorphic grades of the tumor cells were scored and measured by a digital micrometer. In addition, nuclear DNA content was also measured in cytology smears. Atypia and pleomorphia correlated well with the malignancy of the tumor, and higher scores and higher DNA content were related to more advanced stage and poorer postsurgical prognosis. These results indicate that cellular atypia and nuclear DNA content are good indicators of the biological malignancy of small peripheral lung adenocarcinoma.View full abstractDownload PDF (4011K) -
Yuji Mori, Masaki Mori, Hiroyuki Koba, Mitsuo Asakawa, Takuji Mori, Ak ...1989 Volume 29 Issue 3 Pages 247-252
Published: June 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTwelve patients with bronchiolo-alveolar carcinoma were analyzed by CT. Abnor mal shadows were classified into two groups, either pneumonia-like shadows or nodular shadows. Characteristically lucencies were observed within these abnormal shadows in 9 patients and were classified into two groups, according to the size and the density, as cavity or multiple air-density areas distributed irregularly within the shadows (irregular air-density areas).
The lucencies as mentioned above may be specific CT findings of bronchioloalveolar carcinnma.View full abstractDownload PDF (8082K) -
Toshiyuki Takahashi, Atsuo Ogasawara, Satoshi Yano, Junichi Ikeda, Mak ...1989 Volume 29 Issue 3 Pages 253-262
Published: June 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA total of 38 surgically resected benign lung tumors and tumor-like lesions of the lung were analysed. Of these 14 were hamartomas, 7 were sclerosing haemangiomas, 3 were inflammatory pseudotumors, 2 benign pleural mesotheliomas, 2 leiomyomas, and there was 1 case each of neurofibroma, chondroma, and benign clear cell tumor, and the remaining 7 were other tumor-like lesions. We classified our cases in accordance with “The World Health Organization Histological Typing of Lung Tumors” (1982).
Preoperative clinical diagnoses were benign tumors (including tuberculosis) in 27 cases and malignancy in 11. However, a histological diagnosis of benign tumors was obtained preoperatively in only two cases.
When surgical operations are performed for benign tumors and tumor-like lesions of the lung, we consider that minimal resection procedures must be done, in order to preserve respiratory function.View full abstractDownload PDF (12565K) -
Hideyuki Watanabe, Hajime Nakata, Hiroshi Yoshimatsu1989 Volume 29 Issue 3 Pages 263-269
Published: June 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSCT diagnosis was evaluated in 20 cases of malignant anterior mediastinal tumor in comparison with 18 cases of benign tumor. Most malignant tumors had a distorted shape and irregular margin, and a differential diagnosis between benign and malignant tumor was possible in most cases. The diagnosis of a specific malignant tumor in individual case was difficult, but in certain cases characteristic findings made the differential diagnosis possible. In malignant thymomas, there was a relatively good correlation between CT and operative findings cancerning tumor invasion to adjacent pleura and vessels. We conclude that the diagnostic accuracy of CT is useful in diagnosing anterior mediastinal tumors.View full abstractDownload PDF (5410K) -
Junichi Oda, Shinichi Akita, Katsumi Shimada, Kouichirou Okamoto, Kuni ...1989 Volume 29 Issue 3 Pages 271-278
Published: June 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn Niigata City radiological mass screening for lung cancer using miniature chest X-ray film which was originally aimed at the early detection of pulmonary tuberculosis has been performed from 1983. In total, 186, 981 examinations were performed by this method in five years (1983-1987), and 87 cases of lung cancer were detected in this period (detection rate, 46.5/100, 000).
Comparative reading with previous films (first using only the previous year's film) was introduced to improve the accuracy of the screening system. In the first two years (1983 and 1984), however, some cases missed in the process of the comparative reading were detected on the subsequent investigation. Actually, 67, 304 examinations wereperformed in this period, and 32 cases of lung cancer were detected (detection rate, 47.5/100, 000). Twelve cases of lung cancer were detected out of 2, 021 persons who had heenexcluded based on the results of the comparative reading. Subsequent investigations showed 9 of the 12 to be “missed cases”, all of which were adenocarcinomas. Careful double reading and comparative reading using several previous films from more than 2years previously were considered to be useful in avoiding overlooking cases in mass screening.View full abstractDownload PDF (5382K) -
Kohei Yokoi, Naoto Miyazawa, Kiyoshi Mori, Keigo Tominaga, Keiko Suzuk ...1989 Volume 29 Issue 3 Pages 279-285
Published: June 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 49-year-old man was admitted for complaints of dysphagia and dyspnea. On the physical examination, a left supraclavicular lymphadenopathy and no abnormality in the testes were noted. Chest radiography revealed a huge anterior mediastinal mass (22 cm×20 cm) extending to both pulmonary hili. Needle biopsy demonstrated seminoma.
Four courses of the chemotherapy, consisted of cisplatin, bleomycin, and either vinblastine or etoposide, were given. The pretreatment serum level of LDH was 956U/L and that of β-HCG was 12ng/ml, both of which returned to the normal range after the first course of chemotherapy. Following four courses of therapy, the residual mass (4 cm×3 cm) was surgically explored. The resected specimen contained no viable tumor cells.
It was considered that cisplatin-based chemotherapy was the initial treatment of choice for patients with advanced primary mediastinal seminoma.View full abstractDownload PDF (8359K) -
Kaoru Yamaguchi, Sakae Homma, Takashi Dambara, Hidetoshi Shiotsu, Yosh ...1989 Volume 29 Issue 3 Pages 287-291
Published: June 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 76-year-old male, initially complained of radiating pain to the right upper limb. His symptom gradually progressed and neurological abnormalities such as palsy of olfactory, optic and trigeminal nerves, hearing impairment of the right side and Horner's sign appeared successively in the following two years. Chest x-ray film on admission revealed radiopacity in the apical portion of the right lung.
Malignant cells (adenocarcinoma) were detected with ultrasonically guided needle aspiration through the chest wall. Neurological signs were compatible with meningitis carcinomatos there were no abnormalities in the cerebro-spinal fluid. Although he was treated with irradiation therapy for the Pancoast-type tumor, he died of subarachnoidal hemorrhage. Autopsy showed that the moderately differentiated adenocarcinoma lesion of the right lung extended to superior sulcus and the upper thoracic vertebrae and directly invaded to the meningeal space without metastasis. Meningitis carcinomatosa is relatively rare in comparison with brain metastasis in patients of lung cancer, but played a major role in the clinical course of this patient.View full abstractDownload PDF (8614K) -
Yuji Tou, Makoto Isobe, Jinryou Takeda, Teruo Kakegawa1989 Volume 29 Issue 3 Pages 293-298
Published: June 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA large mass with marked calcification in the left anterior chest wall was observed on P-A and lateral chest X-ray films, CT scan, and also on an ultrasonogram in a 67-yearold female patient, who had left anterior chest discomfort.
Needle aspiration did not yield a definitive diagnosis, with cytology giving a class III diagnosis. The tumor was resected through left thoracotomy. Histologically, it was diagnosed as Castleman's disease of the hyaline-vascular type.
A total of 191 cases of Castleman's disease have been reported in Japan, most of which occurred in the mediastinum or hilum. Chest wall Castleman's disease has been reported in only 2 cases.
In the present case, marked calcification was clearly demonstrated throughout most of the tumor and this was the second reported case with marked calcification.View full abstractDownload PDF (6419K) -
Masahiko Taguchi, Hirosi Okitsu, Jun Naito, Kanji Nagai, Kenkichi Oho, ...1989 Volume 29 Issue 3 Pages 299-304
Published: June 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSAn abnormal shadow was detected in the upper right lung field in a 58-year-old male in a mass survey. Transbronchial biopsy specimens showed large cell carcinoma. Onadmission, the serum AFP level was 2700ng/ml.No hepatic examinations revealed abnormal findings.A standard right upper lobectomy was performed.After the operation the serum AFP level decreased gradually to within the normal range. Histological findings of the resected tumor showed large cell carcinoma resembling hepatocellular carcinoma. In addition, the tumor produced AFP, which was demonstrated by immunohistochemical staining with a polyclonal antibody against AFP.View full abstractDownload PDF (5448K) -
Masaaki Kawahara, Kiyoyuki Furuse, Takashi Mori, Akihiko Ichimiya, Gen ...1989 Volume 29 Issue 3 Pages 305-310
Published: June 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTwo cases of radiologically occult cancer of the peripheral lung are presented. Case 1 was a 60-year-old man. Conventional plain chest X-ray film was negative, but a nodule in the right lung S2b was found by CT (computed tomography). The diagnosis of adenocarcinoma was confirmed by transbronchial lung biopsy. The patient was operated upon for stage I lung cancer (size: 1.5×1.4cm). Case 2 was a 66-year-old female. Examinations including plain chest x-ray film, tomogram and CT were noncontributory to the localization of the tumor. Sputum cytology was positive for adenocarcinoma. Although the tumor was bronchoscopically invisible, a diagnosis of adenocarcinoma was made by brushing through B8b. Postoperative stage was III A (size: 1.3×2.6cm). The features of plain chest X-ray film and other imaging methods for the detection of lung cancer were commented on.View full abstractDownload PDF (9241K) -
1989 Volume 29 Issue 3 Pages 311-323
Published: June 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (1879K)
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