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Volume 29, Issue 4
Displaying 1-12 of 12 articles from this issue
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Hidemi Ohwada, Yutaka Hayashi1989 Volume 29 Issue 4 Pages 327-335
Published: August 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSurgical specimens of large cell carcinomas and small cell carcinomas (intermediate cell type, lymphocyte-like type) of the lung, which were classified by the histologic criteria of the Japanese Lung Cancer Society, were used in this study.
The longest and the shortest dimension, circumference, area, nucleus-cytoplasmic ratio, and roundness of cancer cells and nuclei were measured by a real time image processor (Nexus 6400).
Concerning the mean longest dimension of cancer cells, the cells of large cell carcinomas were 2 times larger than those of the lymphocyte-like type of small cell carcinomas and those of the intermediate cell type of small cell carcinomas were 1.5 times larger. The mean area of cells in large cell carcinoma was 3.38 times greater than that of the lymphocyte-like type of small cell carcinomas. Similar relationships were recognized concerning cell nuclei. The mean nucleus-cytoplasmic ratio in large cell carcinomas was the smallest among these three types of lung cancer.
There were considerable differences among large cell carcinoma, intermediate cell type, and lymphocyte-like type small cell carcinoma of the lung. These results lend support to the histologic criteria of the Japanese Lung Cancer Society.View full abstractDownload PDF (1108K) -
Tsuneko Sato, Yoshitake Ito, Hisashi Tauchi1989 Volume 29 Issue 4 Pages 337-342
Published: August 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe relationship between cancer growth, smoking habits, and lipid metabolism in the lung was studied morphometrically by examining autofluorescent granules (AFG) in the respiratory epithelia.
AFG in the human bronchial epithelia were significantly larger in amount in male lung cancer cases of adenocarcinoma than in male cases of squamous cell carcinoma, female adenocarcinoma and non-cancerous cases.
In male cases of adenocarcinoma, AFG were observed in larger amounts in heavy smokers. However, in the alveolar lining cells AFG were smaller in amount or irregular in appearance.
In the bronchial and bronchiolar cells in the lungs of suncus murinus, AFG similar to those in the lungs of human and rats were observed. AFG in bronchial, bronchiolar, and adenomatous hyperplastic foci of suncus fed 1%(butylated hydroxyanisole (BHA) for 14.5-18 months) were significantly larger in amount compared to those in control animals.
The relationship between the increase in amount of AFG in bronchial epitheliun in humans and suncus and active proliferation of their epithelia were discussed.View full abstractDownload PDF (3798K) -
Makoto Seki, Ken Nakagawa, Shigehiro Tsuchiya, Toshiki Matsubara, Iwao ...1989 Volume 29 Issue 4 Pages 343-350
Published: August 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSince 1972, 27 cases of pulmonary metastases from colorectal cancer were resected. The methods of pulmonary resection were reviewed from clinicopathological aspects concerning the metastatic lesions in the lung. In cases in which the lesions in the lung were larger than 3cm in diameter, secondary lymph node metastases were positive in 40% and micrometastases around the most prominent metastatic lesions were seen in 53%. On the other hand, lesions 3cm or less had no metastatic lymph nodes and micrometastasis was seen in only one case among 12 such cases. Consequently we concluded that partial resection was appropriate for lesions 3cm or less in size and lobectomy with lymph node dissection was necessary for lesions larger than 3cm.View full abstractDownload PDF (4087K) -
Ryoichi Nakai, Masaaki Kawahara, Kiyoyuki Furuse, Rokuro Arai, Nagahis ...1989 Volume 29 Issue 4 Pages 351-357
Published: August 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSerum sialyl stage-specific embryonic antigen-I (SLX) was determined in 197 lung cancer patient by monoclonal antibody (FH-6), and serum carcinoembryonic antigen (CEA), CA19-9 and CAl25 were also determined in the same samples at the same time. SLX was elevated (>38u/ml) in 54.0%(41 of 76) of adenocarcinomas of the lung, which was a significantly higher positive rate than in normal adult controls (6.3%, 3/48, p<0.01), non-cancerous lung disease (6.7%, 6/90, p<0.01), squamous cell carcinoma (15.8%, 10/63, p<0.01), and small cell carcinoma (27.3%, 9/33, p<0.05), and higher than the positive rate of CA19-9, CAl25 in adenocarcinoma (p<0.01 p<0.01 respectively). In adenocarcinoma, the serum level of SLX was related to the clinical stage and the positive rate in the case of CEA negative was higher than that of CA19-9 and CAl25. SLX had no relationship with CEA. In adenocarcinoma of the lung, the change of SLX level correlated with the effect of the therapy. It is concluded that SLX is useful in the monitoring of adenocarcinoma of the lung.View full abstractDownload PDF (660K) -
Kiyoshi Ohara, Shinji Sugahara, Tsuguo Yoshida, Toshiyuki Okumura, Hid ...1989 Volume 29 Issue 4 Pages 359-366
Published: August 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSRegression of metastatic brain tumors after irradiation was studied. Twenty-three patients with 80 metastatic tumors were irradiated by conventional fractionation (8-9 Gy/5 Fx/week, 17 patients with 54 tumors) or a hypofractionation (10Gy/1 Fx/week, 6 patients with 26 tumors). TDF (Time Dose Fractionation Factor) calculated from radiation doses was between 60 and 106 in the former fractionation, and 80 and 89 in the latter.
The tumor regression curves were obtained from the volume of each tumor measured on contrast enhanced CT. The tumor regression correlated well with the initial tumor volume. Smaller volume tumors showed greater regression. This trend was more remarkable in patients treated by hypofractionation than in those by conventional fractionation 4 and 6 weeks after starting the radiotherapy. Response rates (PR+CR) after 4, 6, 12 and 26weeks were 56%(45/80), 83%(40/48), 89%(24/27) and 90%(17/19). Complete response was observed in 6%, 15%, 59% and 74%, respectively. Eighty seven percent (14/16) of the tumors smaller than 103mm3 showed CR after 12 weeks. All the 14 CR tumors had been treated by the conventional fractionation.
Based on our results the brain metastases of non-small cell lung cancer were controled well by radiotherapy with doses below the brain tolerance dose level, especially in tumors smaller than 103mm3.View full abstractDownload PDF (3401K) -
Noriyoshi Nagamoto, Yasuki Saito, Shinichiro Ohta, Masami Sato, Keiji ...1989 Volume 29 Issue 4 Pages 367-375
Published: August 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThis study was based on 83 resected specimens of roentgenographically occult lung cancer. The bronchial trees were cut serially into 2-mm-thick blocks. Histologic sections prepared from all the serial blocks were examined by microscopy. The length of longitudinal extension was defined as the product of the thickness and the number of consecutive blocks involved by carcinoma from the most proximal to the most distal block. The depth of invasion into the bronchial wall from the luminal surface was measured with a micrometer. The maximal depth of transmural invasion was defined as the maximal value of the depth.
In the total of 92 lesions, including multifocal carcinoma, detected in the 83 specimens, the depth was plotted against the length to analyze the relationship between them. The plots visualized at least two different zones of tumor growth pattern within the bronchus: one was the creeping type zone, which showed marked superficial growth and the other was the penetrating type which showed marked downward growth. Thirty-one non-polypoid lesions 16 mm or longer (creeping type 25, penetrating type 6) were studied in terms of the histological patterns of longitudinal growth within the bronchial wall. Those of the creeping type were classified into the following three categories: standard superficial extension (17 lesions), intraepithelial extension (5), lymphatic extension (3). All of the penetrating type showed massive extension.
It was suggested that occult lung cancer has a propensity either for longitudinal growth along the bronchial lumen or for transmural growth through the bronchial wall at the time of occurrence, and, as it grows, it clearly exhibits differences in histological growth pattern, namely, carcinoma with the former propensity shows standard superficial, intraepithelial or lymphatic extension whereas the latter shows massive extension.View full abstractDownload PDF (9565K) -
Shinji Maebeya, Osamu Nishimura, Hideki Yokoi, Tatuya Shimizu, Hitosi ...1989 Volume 29 Issue 4 Pages 377-382
Published: August 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSNineteen patients with brain metastases of resected lung cancers were reviewed. The brain metastasis was diagnosed by means of brain CT scan after appearance of some symptoms. Patients with solitary brain metastasis and metastasis to no other organ survived significantly longer than those with multiple brain metastases or metastasis to other organs.
Eight patients with solitary metastasis were treated with surgical resection and 9 with solitary or multiple were with radiotherapy and chemotherapy. Median survival time was 14 months in the surgical group and 3 months in the radiotherapy group. In some patients with solitary brain metastasis the surgical treatment may be recommended.View full abstractDownload PDF (661K) -
Hideaki Itoh, Akira Watanabe, Takio Ooka1989 Volume 29 Issue 4 Pages 383-389
Published: August 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA case of small cell carcinoma of the left lower lung with osteoplastic bone metastasis in a 62-year-old man was reported. Before treatment, bone roentgenograms were normal, except one bone scan showed multiple uptake. After 4 courses of chemotherapy, osteoplastic bone changes were detected in roentgenograms. At that time a bone scan demonstrated multiple cold lesions, corresponding to osteoplasic bone lesions. At autopsy, spongy bone of the vertebra was partially replaced by compact bone, and marked trabecular new-bone formation was seen around the tumor cell nests and fibrotic tissue. We considered that these osteoplastic bone changes might be due to the influence of some local factors in the agents healing process of necrotizing metastatic cancers caused by chemotherapeutic agents.View full abstractDownload PDF (8755K) -
Kazuya Fukuoka, Hitoshi Katada, Hiromichi Kitada, Nobuhiro Narita, Mas ...1989 Volume 29 Issue 4 Pages 391-396
Published: August 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 80-year-old male had complained of cough and general fatigue. The chest roentogenogram showed a mass shadow in right S3. Fiberoptic bronchoscopy revealed a white necrotic polypoid tumor obstructing the orifice of right B3. Right upper lobectomy and lymph node dissection was performed. Histological examination of the resected specimen showed that the tumor was composed of mesenchymal chondrosarcoma and moderately differentiated squamous cell carcinoma. Since these two were separate, this case was considered double lung carcinoma. In spite of postoperative chemotherapy, he died of metastatic brain tumor, pneumonia and DIC after six months. Autopsy revealed multiple skin neurofibromatous lesions, and that the mesenchymal chondrosarcoma did not originate from bones or soft tissue. Metastases to the cerebrum, small intestine and mesenteric lymph nodes were recognized. We reported a rare double lung carcinoma associated with multiple neurofibromatosis.View full abstractDownload PDF (9049K) -
Satoshi Yano, Takeshi Okayasu, Masato Hashimoto, Tatsuzo Tanabe, Miri ...1989 Volume 29 Issue 4 Pages 397-402
Published: August 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSPulmonary carcinosarcoma is a rare tumor first described by Kika in 1908. About 70 cases have been reported in the literature in detail. The chest X-ray film in a 68-yearold man showed a mass shadow in the right upper lung field. The mass grew rapidly; squamous cell carcinoma was diagnosed by both transbronchial brushing cytology and transcutaneous needle biopsy. Right upper lobectomy with 3rd rib resection was performed and the histological findings showed pulmonary carcinosarcoma. This case is unusual because it presented multiple carcinomatous elements (undifferentiated carcinoma, squamous cell carcinoma, and adenocarcinoma) and sarcomatous elements (chondrosarcoma, rhabdomyosarcoma, and fibrosarcoma). Clinically this case is of the solid peripheral parenchymal type with poor prognosis. After a 12 month follow-up, there is no evidence whatever of recurrence.View full abstractDownload PDF (9397K) -
Kazuo Shibata, Yousuke Yamakawa, Manabu Kobayashi, Osamu Tanamura, Hid ...1989 Volume 29 Issue 4 Pages 403-407
Published: August 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTwo cases of lung cancer, histologically large cell carcinoma and squamous cell carcinoma associated with dermatomyositis were reported. In one case serum LDH, GOT and GPT level were high, and the LE test and antinuclear antibody were staining positive. In the other case there were abnormalities in the serum T -cell subset. In each case, dermatomyositis was well controlled by the resection of lung cancer or by the systemic chemotherapy which made the tumor shrink in size, without any steroid therapy. Primarily the presence of an autoimmune mechanism was suggested in the relationship between lung cancer and dermatomyositis.View full abstractDownload PDF (7554K) -
1989 Volume 29 Issue 4 Pages 409-431
Published: August 20, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (3585K)
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