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Volume 30, Issue 6
Displaying 1-19 of 19 articles from this issue
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Yoshitaka Uchiyama, Koji Kimino, Norio Yamaoka, Kohji Azuma, Shinji Ak ...1990 Volume 30 Issue 6 Pages 809-815
Published: October 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSAmong 366 cases of surgically resected lung cancer, 37 cases (10.1%) of double primary cancer involving lung cancer were encountered. Ages at the time detection of lung cancer ranged from 44 to 80 years with the average age being 67.7 years and for nondouble primary lung cancer 63.7 years. In double cancer cases, the most common site of the other primary cancer was the stomach (12 cases), followed by the lung (6 cases), breast (4 cases), larynx and bladder (3 cases each). The histological type of lung cancer was squamous cell carcinoma in 20 cases, adenocarcinoma in 13 cases, large cell carcinoma in 7 cases, small cell carcinoma, adenosquamous cell carcinoma and carcinoid tumor in one case each, including cases with multiple lung cancer. Secondary cancer in the case of primary lung cancer was found in the lung or gastrointestinal tract. The 5 year survival rate was 34.9% for double primary cancer and 35.2% for non-double primary cancer, these values being essentially the same. The interval following treatment of an initial primary cancer was within 6 years in all cases of prior lung cancer, and 5 more years in 13 cases of subsequent lung cancer (21 cases). Thus, it is necessary to consider the possibility of double cancer in cases of lung tumor in which first primary cancer was resected over 5 years ago. In regard to the prognosis of double primary cancer, lung cancer caused death in many cases. Thus, prognosis should improve if absolute or relatively curative resection are carried out.View full abstractDownload PDF (764K) -
Takashi Nakano, Noriaki Iwahashi, Juichiro Maeda, Shinsuke Tamura, Tos ...1990 Volume 30 Issue 6 Pages 817-826
Published: October 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSEleven patients with malignant pleural mesothelioma were studied to assess the efficacy of chemotherapy. Five of 11 patients were treated with combination chemotherapy consisting of cisplatin + doxorubicin + vindesine, 1 patient was treated with cisplatin + VP-16, 1 patient was treated with cyclophosphamide + vincristine + aclacinomycin, and the remaining 4 patients were treated with tagafur and/or OK432. Remission was not achieved in any patient. Of 7 patients treated with combination chemotherapy, 6 showed NC, and 1 showed PD, while the other 4 patients receiving no combination chemotherapy showed PD. All seven patients treated with chemotherapy showed a marked reduction of pleural effusion. The median survival of the 4 patients who received combination chemotherapy was 44 weeks, in contrast to 17 weeks for the 4 patients who did not undergo systemic chemotherapy. These results suggest that combination chemotherapy is not effective in malignant pleural mesothelioma, however, it may have a good therapeutic value in the treatment of pleural effusion.View full abstractDownload PDF (8969K) -
Junzo Shimizu, Yoh Watanabe, Makoto Oda, Yoshinobu Hayashi, Shinichiro ...1990 Volume 30 Issue 6 Pages 827-832
Published: October 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn this study, survival curves and background factors affecting prognosis of resected T4 lung cancer were reviewed. A total of 738 patients with primary lung cancer, including 75 cases of T4 lesion, were surgically treated at Kanazawa University Hospital from January 1973 through June 1989.
The cumulative 5-year survival rate after operation for all 67 cases of T4 lesion was 10.5%. Of these 67 cases, 28 cases which had curative operation showed no significant prolonged survival when compared to another 39 cases which resulted in non-curative operation.
The background factor which was most concerned with the survival rate was the N factor. The 5-year survival rates according to N factor were as follows: T4NO; 38.2%, T4N1; 6.3%, T4N2; 3.5%, T4N3; nil. There was significant difference of survival rates between T4NO and T4N2.
Three-year survival was obtained in 6 patients with invasion to the following: left atrium in 2 cases, carina in 2, superior vena cava in 1 and intra-pericardial pulmonary artery in 1. There was no prolonged survival in the cases of pleuritis carcinomatosa.
It is possible that aggressive surgical treatment may yield long survival in T4 cases having invasion to solitary structure, such as left atrium and carina. However, it seems that decision on operative indications for cases of pleuritis carcinomatosa requires considerable circumspection.View full abstractDownload PDF (586K) -
Tsuyoshi Hasegawa, Nobuyuki Katakami, Hiromi Tomioka, Miki Okazaki, Hi ...1990 Volume 30 Issue 6 Pages 833-840
Published: October 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSPrognoses of 95 consecutive patients of non-small cell lung cancer with brain metastases were evaluated. Three factors, therapy for brain metastases, general performance status (PS) and distant metastases to other organs had significant impact on survival. Among these 3 factors, PS was independent from the other 2 factors. Significant correlation was present, however, between therapy and other organ metastases, and few patients with brain and other distant metastases received aggressive treatment for brain metastases. Cranial irradiation had significant impact on survival even in those patients with brain and other distant metastases. Cranial irradiation also reduced death from brain metastases in responders.
Our results indicate that there are several subgroups with different prognoses in patients of non-small cell lung cancer with brain metastases, therefore the most beneficial treatment modality should be selected for each group of patients.View full abstractDownload PDF (886K) -
Shuichi Watanabe, Satoshi Kitamura, Takeshi Yokoyama, Shiro Kira1990 Volume 30 Issue 6 Pages 841-847
Published: October 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA study of 140 autopsied male lung cancer patients in our institute showed that Double lung cancer was significantly more frequent in lung cancer cases accompanied by idiopathic interstitial pneumonia (IIP) in comparison with lung cancer patients accompanied by emphysema, miscellaneous lung diseases such as old lung tuberculosis, brochiectasis, bulla and asthma or without any background chest disease.
Furthermore, the location of the primary lesions were all in the peripheral lung field in IIP, even with the lung cancer of cell types of either squamous cell carcinoma or small cell cancer of which developement is usually in central air way.
These results suggest that IIP is a state of high risk for developement of the peripheral lung cancer.View full abstractDownload PDF (6342K) -
Masayuki Noguchi1990 Volume 30 Issue 6 Pages 849-856
Published: October 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSRecently monoclonal antibodies which recognize specific tumor-associated antigens have be used in clinical practice. The clinical usefulness of tumor associated antigens; SLX, CEA, CA19-9, CAl25, β2MG, SCC, and NSE in the sera of the 150 cases of cytologically or histologically confirmed primary lung cancer was evaluated. In adenocarcinoma of the lung more than 50% of the patients tested positive for the tumor-associated antigens TPA, CEA, CA125, and SLX. A statistically significant correlation was observed markers between the expression of SLX and CAl25, SLX and CEA, and TPA and CRP. Therefore, screening for either one of these pairs of tumor-associated antigens is sufficient. Statistically significant differences by the Wilcoxon signed rank test for SLX, SCC, β2MG, NSE, CEA and CA19-9 were observed in the serum for each histological type of lung cancer. Using the serum value of NSE and CEA it was possible to correctly diagnose small cell carcinoma and the non-small cell carcinoma 88.5% 107/121 by discriminant analysis. For these markers SLX, CA19-9, CEA, CAl25, β2MG statistically significant differences were also observed between the limited disease and the extensive disease.View full abstractDownload PDF (853K) -
Katsuo Usuda, Yasuki Saito, Satomi Takahashi, Keiji Kanma, Motoyasu Sa ...1990 Volume 30 Issue 6 Pages 857-861
Published: October 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe clinical properties of 139 cases of lung cancer detected during a radiologic screening program were analyzed using previous miniature radiographs. Most of the cases with tumor shadow present on chest miniature radiographs taken the previous year had a smaller growth rate and were in a relatively early stage. Seventy percent of these were stage I and II lung cancer cases. The mean size of nodular tumor shadows at detection was 30mm. Cases of adenocarcinoma were significantly more frequent than cases of other cell types in this group (p < 0.01). The four-year survival probability of these cases was 60%. Most of the cases with tumor shadow absent on chest miniature radiographs taken the previous year had a larger growth rate and were in a more advanced stage. Forty-eight percent of these were stage I and II lung cancer cases. The mean size of nodular tumor shadows at detection was 38mm, which was significantly larger than that of the former (p <0.01). Cases of squamous cell carcinoma were significantly more frequent than cases of other cell types in this group (p <0.01). The four-year survival probability of these cases was 25%, which was significantly smaller than that of the former.View full abstractDownload PDF (531K) -
Satomi Takahashi, Katsuo Usuda, Keiji Kanma, Motoyasu Sagawa, Masami S ...1990 Volume 30 Issue 6 Pages 863-870
Published: October 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA total of 398 primary lung cancers were detected during the 6-year period from 1982 to 1987. Of these 291 cases were detected by X-ray examinations in a total of 1, 088, 009 participants. Sputum cytology in the high-risk group (above 50 years of age with a cigarette index above 600) resulted in the detection of 131 cases.
Among the 398 patients with lung cancer, 278 cases underwent surgical resection (resected rate 69.8%) and 48.2 of all the detected lung cancers were postsurgical histopathological stage 0 or I.View full abstractDownload PDF (861K) -
Yasuki Fukuda, Katsuhiko Yamada, Akitaka Iwagaki, Tohru Urano, Shigeki ...1990 Volume 30 Issue 6 Pages 871-877
Published: October 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTo ninety five chest physicians and surgeons specializing in lung cancer, a questionnaire was sent as to how they classify metastasis of station 3 mediastinal lymph node (#3), some of which are located in the right half of the mediastinum.
In cases of primary lung cancer in the left lung, 39% of respondents classified a part of #3 metastasis as N3: contralateral mediastinal lymph node metastasis, and the other 61% classified it as N2: ipsilateral mediastinal lymph node metastasis. In cases of primary lung cancer in the right lung, however, most of them classified all #3 metastasis as N2.
It has been revealed that there are different opinions about nodal staging of #3 metastasis. Recently, in the official journal of the Japan Lung Cancer Society, vol.29 (3), standardized criteria concerning staging of #3 was published. The authors hope that these criteria will become incepted and, based on the standardized staging system of the General Rule for Clinical and Pathological Record of Lung Cancer, more precise clinical analyses of lung cancer will be carried out.View full abstractDownload PDF (760K) -
Hidemi Ohwada, Tamiko Kamei, Yutaka Hayashi, Yutaka Yamaguchi1990 Volume 30 Issue 6 Pages 879-884
Published: October 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA total of 311 cases of resected non-small cell lung cancers were classified by histological type, subtype, and grade of differentiation according to the histological criteria of the Japan Lung Cancer Society in order to compare histological findings with postoperative 3-, and 5-year survival rates of these patients.
Three-, and five-year survival rates of these patients decreased in the order of adenocarcinoma (51.0% and 39.7% respectively), epidermoid carcinoma (46.9% and 35.7%) and large cell carcinoma (20.8% and 20.8%). In patients receiving surgical resection of adenocarcinoma or epidermoid carcinoma of the lung, the survival rates were as follows. In cases of papillary adenocarcinoma, the 5-year survival rate was 100% in well-differentiated, 40.2% in moderately-differentiated, 0% in poorly differentiated cases, and 50% in the bronchiolo-alveolar type. In cases of epidermoid carcinoma, the 5-year survival rate was 66.7% in well-differentiated, 39.1% in moderately-differentiated, and 30.9% in poorly differentiated cases. As mentioned above, the survival rates were influenced by the grade of differentiation.
These results suggest that the postoperative survival rate of patients with lung cancer may be predicted by the histological classification according to the criteria of the Japan Lung Cancer Society.View full abstractDownload PDF (700K) -
Discrimination of Cross-contaminated Cancer CellsMotoyasu Sagawa, Yasuki Saito, Satomi Takahashi, Katsuo Usuda, Keiji K ...1990 Volume 30 Issue 6 Pages 885-892
Published: October 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWhen bronchoscopy combined with brushing cytology is used for the diagnosis of double roentgenographically occult lung cancers, it is important to ascertain whether the cancer cells in the cytological specimens originated from the bronchus examined or inadvertently from another unidentified bronchus. This problem was studied by cytological analysis of five patients with synchronous double roentgenographically occult lung cancers.
As a result of the examination, it was evident that: 1) Cancer cells with Orange-G stained cytoplasm which appeared in a single cell sporadically should be considered to have originated from another carcinoma. 2) Cancer cells with Orange-G stained cytoplasm which appeared in a cluster or characterized by degeneration should be considered to have originated from an unknown location. To determine the origin of such cells, we must compare the specimens with those obtained from another bronchus. 3) Clusters of cancer cells without degeneration and with Light-Green stained cytoplasm should be considered to have originated from the bronchus examined.View full abstractDownload PDF (5722K) -
Fumikazu Sakai, Shusuke Sone, Shun Imai, Youichi Okazaki, Yutaka Imai, ...1990 Volume 30 Issue 6 Pages 893-901
Published: October 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe applied flexible surface coils for the MR imaging of the pulmonary apex and thoracic inlet, and obtained an improvement of the image quality, permitting detailed imaging analysis of these regions. The soft tissue planes on the pulmonary apex, brachial plexus and the subclavian vessels were clearly shown. The ability of MRI to obtain coronal and sagittal images seemed to enhance the capability of MRI to precisely evaluate the thoracic inlet.View full abstractDownload PDF (15853K) -
Nobuko Kawamura, Kennichi Jingu, Makoto Miyoshi, Junnichi Ohmagari, Ko ...1990 Volume 30 Issue 6 Pages 903-911
Published: October 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe evaluated long-term administration of Tegafur, OK-432 and PSK after radiotherapy for non-resectable non-small cell lung cancer.
In our hospital 162 patients received radiotherapy between 1979 and 1986. Among those who were discharged after the first admission, 38 were completey followed up by us and 86 were not. These two groups were somewhat different in regard to patient characteristics and survival times.
In the former group, we examined the effect of long-term mild chemoimmunotherapy by multivariate analysis using Cox's proportional hazard model. This revealed that those who were given Tegafur and OK-432 showed better prognosis even after adjustment for several factors.View full abstractDownload PDF (799K) -
Masami Sato, Yasuki Saito, Katuo Usuda, Satomi Takahashi, Keiji Kanma, ...1990 Volume 30 Issue 6 Pages 913-919
Published: October 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe performed clinical studies on pulmonary metastasis in 49 out of 1246 cases of resected lung cancer.
Pulmonary metastasis was significantly more frequent in females than in males, in cases of adenocarcinoma than in cases of squamous cell carcinoma, in cases of pT4 than in cases of pT1, pT2 and pT3, and in cases of pN2 than in cases of pN0 and pN1.
In cases of non-small cell lung cancer in which all tumors including pulmonary metastasis were resected, solitary pulmonary metastasis cases and pm, i.e. metastasis limited to one lobe cases had excellent prognosis.
Further examination of non-small cell cancer patients who underwent total resection, revealed that those with pN0 and pN1 had a better prognosis than those with pN2.
Based on the above findings, it is concluded that in cases of solitary pulmonary metastasis and pm, if there is no mediastinal node involvement, surgical resection is recommended. In these patients, good prognosis can be expected. Although it is very difficult to distinguish multiple primary lung cancer from pulmonary metastasis, it dose not matter if pm, patients or soliotary pm patients with no mediastinal node involvement are diagnosed as having multiple primary lung cancer.View full abstractDownload PDF (746K) -
Kenji Ikeda, Akio Nakashima, Hiroshi Fujita, Akihiko Ikeda, Mitsuhiro ...1990 Volume 30 Issue 6 Pages 921-927
Published: October 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTwo operated cases of small bowel metastases from primary lung cancer were presented. Both were poorly differentiated large cell carcinoma
One had GI bleeding and intussuception caused by multiple polypoid metastatic tumors. He died 8 days after the small bowel resection. The other one died approximately 20 weeks after the small bowel resection because of perforation due to cancer metastasis.
A total of 40 cases were reported in the literature till 1989 in Japan. The prognosis in cases of small bowel metastases from primary lung cancer were extremely poor and the 20-week survival of case 2 was comparatively longView full abstractDownload PDF (9989K) -
Masayuki Shinoda, Shunzo Hatooka, Iwao Takagi, Motokazu Suyama, Kazuo ...1990 Volume 30 Issue 6 Pages 929-934
Published: October 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA rare case of adenoid cystic carcinoma which originated in the peripheral lung was reported.
An abnormal shadow was pointed out on the chest X-ray examination of a 46-yearold woman in August, 1988. A round tumor measuring 3.5×3.1cm was present in the right lower lobe. She was healthy and asymptomatic. Right lower lobectomy with mediastinal lymph node dissection was performed on September 28, 1988.
The surgically resected specimen of the tumor revealed the typical histology of adenoid cystic carcinoma. A gross study suggested that the tumor might have been derived from the fifth or sixth order peripheral bronchi. The tumor doubling time of the present case was estimated as about 667 days, based on radiological evaluation.
In the Japanese literature, to our knowledge, there are only 5 cases of peripheral typeof adenoid cystic carcinoma of the lung, including our case.View full abstractDownload PDF (6528K) -
Haruhito Kamei, Taisuke Ohnoshi, Shunkichi Hiraki, Hiroshi Ueoka, Tuyo ...1990 Volume 30 Issue 6 Pages 935-940
Published: October 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSMetastases to the hand in patients with malignant disease are to be reported extremely rare. In this paper, four patients with lung cancer who developed metastasis to the hand are reported. The involved tissue was bone alone in one, soft tissue alone in two and both bone and soft tissue in one. Local pain and swelling were the most common symptoms of these lesions, and it was often mistaken for an inflammatory process. All the patients died within six months after the detection of these lesions. Metastases to the hand are a part of systemic metastases indicating a poor prognosis.View full abstractDownload PDF (6462K) -
Hiroshi Sakai, Fuminao Suzuki, Akira Yoshii, Syuuichi Yoneda, Yukio No ...1990 Volume 30 Issue 6 Pages 941-945
Published: October 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 5×4 cm round mass with destruction of the 10th vertebral body was observed in the right posterior mediastinum on chest X-ray films at the time of routine medical examination in a 16-year-old girl. Ultrasound-guided needle biopsy was performed, and a diagnosis of giant cell tumor was made. The tumor was resected and fibral bone graft was performed. Giant cell tumors classically occur in the epiphysis of long bones. Involvement of thoracic vertebra is extremely rare. Reviewing the literature, we could find only 11 cases occurring in the vertebral body and 2 cases with a mediastinal tumorlike appearance in Japan.View full abstractDownload PDF (6728K) -
1990 Volume 30 Issue 6 Pages 947-959
Published: October 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (1797K)
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