All issues
Volume 31, Issue 1
Displaying 1-18 of 18 articles from this issue
- |<
- <
- 1
- >
- >|
-
Ryuji Ieki, Shouji Kudo, Tatsuru Okamura, Masakiyo Hirayama, Takeshi U ...1991 Volume 31 Issue 1 Pages 1-6
Published: February 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe changes in ratios of various histological types of lung cancers were investigated in lung cancer patients treated in the past 13 years. The subjects were 955 patients confirmed to have lung cancers by histopathological diagnosis in this hospital from 1976 to 1988. The patients consisted of 711 males and 244 females. Patients with adenocarcinomas and squamous cell carcinomas consisted of 45% and 33%, respectively, of the subjects. Patients with lung cancers increased annually during the investigated period. With respect to the ratio of each histological type of lung cancers to the total number of lung cancers, that of squamous cell carcinoma decreased and that of adenocarcinoma increased during the investigation period. These tendencies resulted in the reversal of the ratios of squamous cell carcinomas and adenocarcinomas in 1981 that has continued since then. The changes in the ratios of these histological types of lung cancer were not ascribed to differences in sex or age. According to the registration of patients in the Lung Cancer TNM Committee of Japan until 1983, it was suggested that the ratio of adenocarcinoma has increased all over Japan. Conventionally, the incidence of squamous cell carcinomas was said to be higher than that of adenocarcinomas. However, it was suggested recently that the incidence of adenocarcinomas has exceeded that of squamous cell carcinomas.View full abstractDownload PDF (582K) -
Yoichi Nakanishi, Kenya Hiura, Osamu Katoh, Shigetaka Kuroki, Yosuke A ...1991 Volume 31 Issue 1 Pages 7-15
Published: February 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSAmong 41 patients with small cell lung cancer (SCLC), the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) was found in 12.2%(5 cases) of the patients. Plasma ADH level was elevated in four of the five patients with SIADH. High concentration of ADH-like immunoreactivity was detected in the supernatant of a cultivated cell line derived from the patient whose plasma ADH level was within the normal range. In these patients ectopic ADH production by tumor tissue was suggested. In four patients, plasma ADH levels were elevated before and after anti-cancer therapy. Serial determination of ADH showed that ADH is useful for monitoring the response to therapy and clinical course.
In 18 patients with SCLC, ACTH, glucagon, calcitonin, cortisol, 11OHCS, and somatomedin C (IGF-I) levels were determined by radioimmunoassay. Elevated levels of cortisol and 11OHCS were found in 26.7% and 100% of the patients, respectively. On the other hand, the ACTH, glucagon, calcitonin, and IGF-I levels were normal in most patients. It was suggested that increased levels of steroid hormones resulted from ectopic hormone production of cancer cells, although they were not related to the response to therapy or prognosis. Among these moieties evaluated, only ADH was useful as a tumor marker in SCLC patients.View full abstractDownload PDF (867K) -
Satoru Nozawa, Yoshiaki Nakajima, Sinobu Hatakeyama, Akihiko Nagai, Sa ...1991 Volume 31 Issue 1 Pages 17-24
Published: February 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA total of 102 patients with inoperable non-small cell lung cancer were randomly assigned to four regimens as follows ; CV: cisplatin (80mg/m2 on day 1) plus vindesine (3 mg/m2 on day 1, 8, 15), CVM: cisplatin plus vindesine (3mg/m2 on day 1, 8) and mitomycin C (8mg/m2 on day 1), CVI: cisplatin plus vindesine (3mg/m2 on day 1, 8) and ifosfamide (2g/m2 on day 1-3), CVA: cisplatin plus vindesine (3mg/m2 on day 1) and adriamycin (30mg/m2 on day 1). All therapy was repeated at 4-week intervals until progression of disease or unacceptable toxicity. The response rate among 80 evaluated patients were 17.4% for the CV group, 31.8% for the CVM group, 50.0% for the CVI group and 17.6% for the CVA group. The median survival times were 3lwks for the CV group, 50wks for the CVM group, 58wks for the CVI group and 50wks for the CVA group. There was significant difference in response rate and survival curves between the CV group and the CVI group. These results show that combination chemotherapy using cisplatin plus vindesine and ifosfamide is effective in non-small cell lung cancer.View full abstractDownload PDF (902K) -
Histological Effects of Long-term Inhalation Studies of Exhaust from the Diesel Engine on F-344 RatsYuki Takaki1991 Volume 31 Issue 1 Pages 25-39
Published: February 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTo investigate the carcinogenetic effect of diesel emissions, long term inhalation studies were carried out on Fischer-344 rats (SPF) using heavy duty (HD-series; 11 liter) and light duty (LD-series; 1.8 liter) diesel engine exhausts. In addition, an experiment of observe the influence of particles in the exhaust was carried out using heavy duty engine with particle-free exhaust. The pulmonary lesions were observed microscopically and morphometrically.
To quantify the anthracosis and pulmonary epithelial proliferations, these regions were measured by a digital image analyzing system (ZEISS, IBAS-2000). Various degrees of carbon phagocytized by macrophages or deposition in the lungs were observed in the LD and HD series and this phenomenon increased with elevation of the particle concentration in each series. Anthracosis showed a statistically significant difference in degree among each experimental group in all series. The degree of hyperplasia of type II alveolar cells and of bronchiolar epithelium depended on the particle concentration. There was a statistically significant difference in hyperplasia among each experimental group in all series, excluding between the groups of 1.0mg/m3 and 1.8mg/m3 in the HD-series, and the groups of 0.1mg/m3 and 0.4mg/m3 in the LD-series. In the particle influence test, there was no difference in the histological changes of the lung from those of the control group. Therefore, the relationship between anthracosis and hyperplasia was suggested.
In the present study, the dose-dependency of incidence of primary lung tumors, including adenomas and carcinomas, was not noted in the LD series, and this tendency was noted only in the 3.7mg/m3 group in the HD series.View full abstractDownload PDF (17979K) -
Yahiro Kotake, Takahiro Okada, Kiyohiko In, Hirofumi Sueki, Meinoshin ...1991 Volume 31 Issue 1 Pages 41-46
Published: February 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSBased on 27 cases of multiple primary lung cancer which were treated in the Department of Surgery, Osaka Prefectural Habikino Hospital, the diagnosis and treatment of the disease was discussed. The criteria for diagnosis in our hospital is as follows:
In addition to the definition of Warren and Gates, or Martini and Melamed, our diagnostic criteria include histopathological findings of early stage, degree of differentiation, subtype, cell structure, vascular or lymphatic invasion, degree of scar formation and number of lesions in a lobe.
The 5-year survival rate in the 16 cases of synchronous type, all of which were surgically treated, was 33.3%, and in the other 11 metachronous type cases the results were varied but, 4 cases survived longer than 3 years.
These results were encouraging and suggested that our diagnostic criteria are justified.View full abstractDownload PDF (617K) -
Kazuo Shibata, Yousuke Yamakawa, Takasi Torii, Tutomu Mizuno, Akira Ma ...1991 Volume 31 Issue 1 Pages 47-52
Published: February 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSNine patients with synchronous multiple primary lung cancer were reported. They consisted of 8 men and 1 woman with a mean age of 67.4 years (rang 45 to 83 years). Of them, 7 patients had ipsilateral masses and 2 had bilateral masses. The incidence of synchronous multiple primary lung cancer among all resected lung cancers was 2.2%. There was some difficulty in differentiating synchronous lung cancer from metastatic lesions by using only conventional criteria. Even in case of bilateral disease, good results can be expected by successful management by combining surgery with systemic chemotherapy and transbronchoscopic procedures.View full abstractDownload PDF (702K) -
Akihisa Akamune, Masashi Kawamura, Shinichi Inatsuki, Hikaru Koito, Ma ...1991 Volume 31 Issue 1 Pages 53-60
Published: February 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSNineteen patients with lung cancer detected by the development of recurrent nerve paralysis were reviewed on the basis of conventional radiography, tomography and CT.
Left recurrent nerve paralysis was caused by AP window masses in 14 of the 19 patients and by preaortic lesions in 3. In one patient, left recurrent nerve paralysis was caused by an aortic aneurysm. Right recurrent nerve paralysis was caused by a paratracheal mass in only one patient.
In 10 patients, the paralysis was caused by direct invasion of the primary lung tumor into the nerve, in 8 patients by metastases to the mediastinal lymph nodes, and in one patient by an aortic aneurysm.
CT was superior to conventional radiography and tomography in the detection of mediastinal lesions responsible for causing the paralysis. Therefore, CT can play an important role in the assessment of patients with recurrent nerve paralysis.View full abstractDownload PDF (9164K) -
Atsushi Watanabe, Kaoru Shimokata, Fumio Nomura, Hideo Saka, Yoshitsug ...1991 Volume 31 Issue 1 Pages 61-67
Published: February 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSEleven cases of inoperable non-small cell lung cancer were treated with hyperfractionated radiotherapy combined with chemotherapy. Hyperfractionated radiotherapy consisted of 1.6 Gy per fraction, 2 fractions a day with 6 hours between fractions, 5 days a week for a total of 60.8 Gy. After 38.4 Gy of irradiation to the primary tumor, hilar, and mediastinal lymph nodes, an additional 22.4 Gy was given to primary lesion. Chemotherapy consisted of cisplatin, 80 mg/m2 day 1, mitomycin C, 10 mg/m2 day 1, and vinblastine, 5mg/m2, days 1 and 15. At least 2 courses were administered. The combination of radiotherapy and chemotherapy was sequential. Of 6 patients in whom hyperfractionated radiotherapy was performed first, 5 achieved PR. Of 5 patients in whom chemotherapy was performed first, 2 achieved PR. Median survival time was 300 days. Nine of the eleven patients experienced esophagitis, but in all patients this was controlled easily by oral antacids and/or H2 blockers. In regard to radiation pneumonitis, fibrosis occurred in seven of nine cases, but they did not require corticosteroids. Levels of hematological toxicity were similar to previous reports, but were somewhat severe in cases receiving chemotherapy after irradiation. We conclude that hyperfractionated radiotherapy combined with chemotherapy including cisplatin is safe, but further evaluation to determine optimal dose and combination methods is necessary.View full abstractDownload PDF (806K) -
Yutaka Kawano, Hideki Kimura, Yutaka Yamaguchi1991 Volume 31 Issue 1 Pages 69-75
Published: February 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSAn in vitro sensitivity test based on cytomorphological changes of nuclei was performed in 187 lung cancer cases. Forty-eight non-small cell lung cancer cases were divided into two subgroups: the positive group which showed positive results in anticancer agents sensitivity tests, and the negative group which received anticancer agents but in which the sensitivity test was negative for any of the agents. The two year survival rate and percent tumor-free survival of the positive group were superior to those of the negative group according to statistical analysis. It is suggested that in vitro sensitivity tests using cytomorphological changes of nuclei is useful for the selection of effective anticancer agents for adjuvant chemotherapy in lung cancer cases.View full abstractDownload PDF (865K) -
Nariaki Takahashi, Tatsuya Hirota, Masaaki Motohashi, Kou Ohshima, Yas ...1991 Volume 31 Issue 1 Pages 77-83
Published: February 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSerum levels of carcinoembryonic antigen (CEA), sialyl stage-specific antign; SSEA-1 (SLX), carbohydrate antigen 19-9 (CA19-9), tissue polypeptide antigen (TPA), squamous cell carcinoma antigen (SCC), neuron specific enolase (NSE), and NCC-ST-439 were measured in 85 patients with lung cancer and the diagnostic value of each marker was investigated.
The positive rates of CEA and TPA in the serum of patients with lung cancer were higher than those of other tumor markers, and combination assay of CEA and TPA was valuable in diagnosing lung cancer.
The markers showed a histological specificity; SLX and NCC-ST-439 to adenocarcinoma, SCC to squamous cell carcinoma, and NSE to small cell carcinoma.
The NSE and NCC-ST-439 levels tended to increase as the clinical stage advanced.View full abstractDownload PDF (757K) -
Toshiro Yonei1991 Volume 31 Issue 1 Pages 85-93
Published: February 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe antitumor activity of four newly developed platinum analogs, carboplatin, 254-S, DWA2114R, and NK121, was compared with that of cisplatin in five human lung cancer cell lines and nineteen specimens from lung cancer patients. The antitumor activity was evaluated by the ratio of maximum tolerated dose of the drug examined/70% lethal dose determined by colony assay. Regarding this ratio as the ordered metric scale of antitumor activity, cisplatin was most potent, followed by 254-S, and carboplatin. Carboplatin, DWA2114R and NK121 were less potent than cisplatin or 254-S, and there were no significant differences among them in degree of antitumor activity. In addition, cross-resistance patterns to these five platinums were investigated using an adriamycin-resistant small cell lung cancer subline, SBC-3/ADM. The SBC-3/ADM cells were 1.7 to 4.0-fold more resistant to cisplatin, carboplatin, NK121, and DWA2114 R, than the parent line, SBC-3, whereas the cells were 2.0-fold more sensitive to 254-S. These data suggest the usefulness of 254-S in the treatment of lung cancer.View full abstractDownload PDF (936K) -
Tetsuji Soga, Tsutomu Fukuroi, Mutsumasa Yanabu, Shosaku Nomura, Seibu ...1991 Volume 31 Issue 1 Pages 95-103
Published: February 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSFlow cytometry was used to measure concentrations of adhesive proteins on the surface membrane of platelets (platelet-associated fibrinogen: PA-Fbg, PA-fibronectin: PA-FN, and PA-thrombospondin: PA-TSP), plasma TSP (platelet-bindig TSP: PB-TSP) and platelet size in 18 patients with lung cancer (8 adenocarcinomas, and 10 squamous cell carcinomas) and normal controls. Results were correlated with histologic type and clinical stage.
PA-Fbg, PA-FN and PA-TSP were elevated in the lung cancer group compared to the healthy control group. In adenocarcinoma cases, PA-Fbg and PA-FN concentrations were highest in stage IIIB, but PA-TSP was approximately equal in all stages. Among squamous cell carcinoma cases, PA-Fbg and PA-FN were highest in stage IIIA, while PA-TSP was highest in stage IIIB. Moreover, PB-TSP was significantly higher in squamous cell carcinoma (p<0.01) than in adenocarcinoma. In both histologic types, the ratio of large platelets increased in accordance with advance in stage.
These results suggest that the number of activated platelet increases in lung cancer, and that this increase affects vessel walls either by tumor invasion or by shear stress caused by stenosis. TSP of non-platelet origin is increased in squamous cell carcinoma, and especially in stage IV a decrease of adhesive protein may increase consumption and accelerate production of platelets.View full abstractDownload PDF (937K) -
Takeshi Hatta, Noriaki Tsubota, Masahiro Yanagawa, Kayoko Oobayashi, Y ...1991 Volume 31 Issue 1 Pages 105-108
Published: February 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 44-year-old woman was introduced to our hospital because of an abnormal shadow on a chest X-ray. A CTscan of the chest revealed a tumor shadow in the middle mediastinum. The size of the resected tumor was 5×5×3.5cm. The cutsurface of the tumor was solid and yellowish white. Histopathologically the tumor was diagnosed fibrous histiocytoma.
It is rare for fibrous histiocytoma to develop in the mediastinum. We found that there were only 3 reported cases of fibrous histiocytoma arising in the mediastinum during the past ten years in Japan.View full abstractDownload PDF (4533K) -
Kenzo Hiroshima, Hirotaka Takizawa, Takesaburo Ogata, Tatsuo Iijima, H ...1991 Volume 31 Issue 1 Pages 109-117
Published: February 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTwo cases showed multiple coin lesions on chest X-ray. Case 1, a 61-year-old woman, had multiple lung nodules which were detected 18 years after hysterectomy for leiomyoma. The lesions were composed of monotonous smooth muscle cells and intermingled with glandular structures of bronchiolar appearance. There was no morphologic evidence of malignancy in these components. Cases 2, a 45-year-old woman, was under therapy for uterine leiomyosarcoma for 2 years. The tumor cells of the lung were apparently similar to those in case 1 but were more pleomorphic and hyperchromatic. Multinucleated bizarre cells were also found. Most lesions of case 2 included no glandular structures except for a tiny lesion less than 2 mm. Concerning those morphologic feature the lesions of case 1 differ from those of case 2, which are considered to be metastatic from uterine leiomyosarcoma. We diagnosed case 1 as benign metastasizing leiomyoma.View full abstractDownload PDF (6993K) -
Chinaru Yamamoto, Hitoshi Katada, Hirofumi Ako, Nobuhiro Narita, Takas ...1991 Volume 31 Issue 1 Pages 119-124
Published: February 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 32-year-old woman was admitted to our hospital with a history of a productive cough for eight months. The chest X-ray film demonstrated an abscess-like cavitary lesion with an air fluid level, in the right lower lung field. Without any improvement of massive sputum production (up to 500ml per day) and of chest X-ray findings by antibiotics, right lower lobectomy was done. Histopathological findings of the resected lung specimen revealed bronchiolo-alveolar carcinoma associated with lipoid pneumonia around it.
A cavitary lesion resembling lung abscess on chest X-ray findings is extremely rare in cases with limited-type bronchiolo-alveolar carcinoma.View full abstractDownload PDF (1197K) -
Mitsuo Nakayama, Hiroaki Nomori, Shizuka Kaseda, Tsuneo Ishihara, Mich ...1991 Volume 31 Issue 1 Pages 125-130
Published: February 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 59-year-old male was diagnosed as having squamous cell carcinoma in the right upper lobe by transbronchial biopsy. He underwent thoracotomy, but because of pleural dissemination the chest was closed. The histology of the biopsied pleural lesions was squamous cell carcinoma. He was treated with combination chemotherapy, however, he died 8 months after the operation. Although the serum level of β-hCG was within the normal range in the early course of disease, it increased to 90.4ng/ml in the end stage. Autopsy disclosed that the lung tumor consisted of squamous cell carcinoma with choriocarcinomatous component, and metastatic lesions in the liver, pancreas and kidney showed characteristic patterns of choriocarcinoma. No other possible primary sites were found. Primary choriocarcinoma of the lung is rare, and hypotheses for its histogenesis were briefly discussed.View full abstractDownload PDF (7099K) -
Takahisa Tomono, Kei Hagiwara, Masahiko Fujii, Nobuhiko Takizawa1991 Volume 31 Issue 1 Pages 131-136
Published: February 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 54-year-old male presented with cough and sputum. Clinical examination and chest X-ray films revealed no significant abnormal findings. He had had cough and sputum for two years and he was a heavy smoker. Bronchoscopic findings showed a solitary polypoid lesion located at the bifurcation of right B4 and B5, but no other findings. Biopsy of the polypoid lesion resected it completely. Pathological findings revealed papillary growth of epithelium with a fibrous stalk, but no malignant cells. We followed this case up for six years, but no subsequent changes were recognized bronchoscopically.View full abstractDownload PDF (5591K) -
1991 Volume 31 Issue 1 Pages 137-154
Published: February 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (2505K)
- |<
- <
- 1
- >
- >|