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Volume 31, Issue 2
Displaying 1-20 of 20 articles from this issue
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Tetsuhiro Shiota, Takaaki Konishi, Wataru Chiba, Yuji Yasuda, Yoshito ...1991 Volume 31 Issue 2 Pages 159-166
Published: April 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA total of 114 paraffin-embedded tumor specimens from resected stage I lung carcinomas were analyzed for cellular DNA content by flow cytometry. Of these 114 cases, 47 cases (41.2%) showed DNA diploidy and had a 5-year survival rate of 75.8%, 49 cases (43.0%) showed DNA aneuploidy with a 5-year survival rate of 61.2%, while the remaining 18 cases (15.8%) showed DNA multiploidy with 5-year survival rate of 22.5%. The patients with diploid tumors had significantly longer survival than cases oftumor with any other ploidy. In particular, the patient with mul tiploid tumors have poor prognosis.View full abstractDownload PDF (775K) -
that Received or did not Receive Anticancer TreatmentNobuhiko Nagata, Koichi Takayama, Tsuneo Ishibashi, Nobuaki Shigematsu ...1991 Volume 31 Issue 2 Pages 167-173
Published: April 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe reviewed the case records of 240 autopsy cases that died of lung cancer in Kyushu University Hospital from 1976 to 1987, of which 36 cases received no anticancer treatment and 204 did. Duration of illness and survival of cases receiving some anticancer treatment were significantly longer than those of cases who received no anticancer treatment. In the same treatment group, those who presented because of chest X-ray abnormality had a significantly longer survival than those who presented because of symptoms. On the other hand, the number of involved organs by the tumor at autopsy was significantly more in those who received some anticancer treatment than in those who did not. The background factors were not significantly different between the two groups, except for age. These results suggest that anticancer treatment extends survival in lung cancer patients, though the spread of the tumor tissue at autopsy is more extensive in the anticancer treatment group than in the no-treatment group.View full abstractDownload PDF (800K) -
Shuichi Yoneda, Kiyokazu Yoshida, Akira Yoshii, Yukio Noguchi, Mizuyos ...1991 Volume 31 Issue 2 Pages 175-182
Published: April 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSNinety-one patients with locally advanced non-small cell lung cancer were treated with cisplatin-containing chemotherapy which was combined before and after radiotherapy (50-70Gy). Because local failure occured in 23 out of 68 patients who had responded to the combined therapy, it was anticipated that surgical rescue may prolong survival.
Ten responders underwent thoracotomy. There were 4 with stage IIIA and 6 with stage III B, 8 squamous cell carcinomas, one large cell carcinoma and one adenosquamous carcinoma. Complete tumor resection was accomplished in all patients with 3 pneumonectomies and 7 lobectomies. Four patients had pathologically complete responses with no cancer cells detected in the resected specimen. Histological examination in one patient revealed that squamous cell carcinoma should be corrected to small cell carcinoma. The only one death was due to bleeding after the pneumonectomy. Subsequent CNS relapse developed in 2 other patients, both of whom are alive 28 and 18 months after surgery. The other 7 patients remain free of disease with a median follow up of 28 months (18-55 months).View full abstractDownload PDF (6019K) -
Hiroyuki Nishiyama, Kenro Takahashi, Mitsuyo Nishimura, Shinichi Yamas ...1991 Volume 31 Issue 2 Pages 183-191
Published: April 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSFrom 1972 to 1986, 596 patients with non-small cell carcinoma of the lung underwent pulmonary resection at Matsudo National Hospital. Of these, relatively curative resection was performed on 77 patients with N2 node metastasis. The 5-year survival rate of these 77 patients was 23.2%.
Concerning the histology and T factor, 14 of the 15 T1-patients had adenocarcioma and their 5-year survival rate was 29.5%, but the T2 and T3 cases of adenocarcinoma had poor prognosis and none survived for 5 years. On the other hand, most T3 and T4 patients had squamous cell carcinoma and their 5 -year survival rates were 31.3% and 33.3% respectively.
Concerning the site of metastatic N2 nodes, the prognosis of patients with metastasis to the inferior mediastinal and the left aortic lymph nodes was better tnan that of those with metastatic superior mediastinal nodes.
In relation of the level of metastatic N2 nodes, the prognosis of patients with metastasis at only one level was better than that of those with metastasis to two levels of nodes or more in squamous cell carcinoma, but this tendency was not observed in patients with adenocarcinoma.
Concerning the growth type of metastatic N2 nodes, perinodal growth was rarely seen (21.1%), although it seemed to be slightly more common in squamous cell carcinoma, but the prognosis of these cases was poorer than that of cases with intranodal growth.View full abstractDownload PDF (958K) -
Trial of NIMC+Tegafur and MMC+UFT for Adenocarcinoma of the Lung-First StudyTakashi Teramatsu, [in Japanese], [in Japanese], [in Japanese], [in Ja ...1991 Volume 31 Issue 2 Pages 193-200
Published: April 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA joint study was carried out in western Japan by 30 institutions (Society of Adjuvant Chemotherapy for Lung Cancer Surgery in West Japan) to examine the survival period, disease-free period, and side effects of postoperative adjuvant chemotherapy.Absolutely or relatively curatively resected patients were randomized to a group treated with MMC+ Tegafur (Group A) or one treated with MMC+UFT (Group B) and results were compared. Of 224 patients 80.8% were eligible for this study.
No difference was observed in background factors, medication, 3-year survival rate, and 3-year disease-free rate between the two groups. The results were better in Group B in relatively curatively resected cases and Stage III patients, and significantly better in patients with N2 lesions than in Group A.View full abstractDownload PDF (880K) -
Eiichi Akaogi, Kiyofumi Mitsui, Masataka Onizuka, Akira Fujiwara, Hiro ...1991 Volume 31 Issue 2 Pages 201-206
Published: April 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe clinical features and outcome of 57 cases of lung cancer detected by sputum cytology mass screening from 1985 to 1988 were examined. Of these, 21 had an abnormal shadow on chest roentgenogram. However, 9 of them had not been detected at the initial roentgenological mass screening. Therefore, sputum cytology is useful for detection of the roentgenological false negative cases. Pulmonary resection was performed in 15 of the 21 cases and 14 cases are still alive. Roentgenological study of the chest could not reveal any abnormality in the remaining 36 cases. Furthermore, in 14 of these cases no bronchoscopical abnormalities were recognized. Surgical procedures were performed in 27 chest X--ray negative patients and a histological diagnosis of early squamous cell carcinoma of the lung was established in 23 of them. Four operated early lung cancer cases, in whom pulmonary function was severely restricted, died of pneumonia at 3 months to 3 years after operation. Therefore, operative procedures should be carefully selected in those cases with poor pulmonary function. On the other hand, resected cases of early cancer with normal respiratory function are all still alive at 1 to 5 years after operation.View full abstractDownload PDF (726K) -
Noboru Tanio, Mitsutaka Kadokura, Toshihiro Takaba1991 Volume 31 Issue 2 Pages 207-214
Published: April 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSFibronectins (FN) are large glycoproteins that make up the extracellular matrix, and have been implicated in a wide variety of cellular properties.Recently, much interest has been taken in the relation between FN and transformed cells, particularly to metastasis.We determined urinary FN fragment (UFN) by monoclonal antibodies (FN10, FN30) in 57 primary lung cancer patients (adenocarcinoma=28, squamous cell carcinoma=23, others=6).In addition, serum carcinoembryonic antigen (CEA), serum sialyl stage-specific embryonic antigen-I (SLX), and squamous cell carcinoma-related antigen (SCC) were also determined at the same time.
The UFN levels were high in each histologic type of lung cancer, and the more advanced the stage of the patient, the higher were the UFN levels and positive rate, especially in recurrence (100%).UFN was elevated (>200U/mg·Cr.) in 57.9%(33 of 57) of all patients in this study, which shows a higher positive rate than that of other serum tumor marker.The positive rate of UFN in stage I patients was not high (36.4%), however, combined measurement of UFN and CEA in the same patients yielded a high rate (72.7%).
It is concluded that the measurement of UFN is useful in the postoperative monitoring of lung caner patients, and combined assay of UFN and CEA or another tumor marker shows a high positive rate in screening tests for early stage lung cancer.View full abstractDownload PDF (898K) -
Yasuyuki Kurihara, Yasuo Nakajima, Hiroshi Niimi, Akihiko Hara, Yoshik ...1991 Volume 31 Issue 2 Pages 215-219
Published: April 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe prognosis of 26 cases of pathological stage III non-small cell lung carcinoma were examined in relation to CT findings of mediastinal lymph nodes.
Cases were classified into three groups based on CT findings Group A: false negative, less than 1cm in diameter, Group B: true positive with a well-defined margin, and Group C: true positive with infiltration to adjacent fat tissue.
Group C had the worst prognosis, compared with Groups A and B (p<0.05). Group A had a relatively good prognosis. There was no significant difference between Group A (false negative) and pathological T3NO, 1 (true negative).
It is important to evaluate not only the size of mediastinal lymph nodes but also their shape. Radiological negative findings indicate good prognosis, no matter whether it is true or false.View full abstractDownload PDF (2705K) -
Toshiro Yonei1991 Volume 31 Issue 2 Pages 221-227
Published: April 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSCisplatin (CDDP) has proven to be useful in combination with etoposide (ETP) in small-cell lung cancer (SCLC). Recently, platinum analogs, carboplatin (CBDCA) and 254-S, have been developed and are attractive candidates for combinations with ETP. The in vitro combination effcts of these platinum compounds and ETP were evaluated in a search for synergistic pairs. Fractional cytotoxicity (FC) was determined in vitro by colony assay using a human SCLC cell line. The median-effect plot was applied to quantify the combination effect of concurrent treatment of these drug pairs. A synergistic effect was reproducibly observed for combination of CDDP and ETP at fixed molar ratio of 1: 1. The combination effect of CBDCA and ETP (molar ratio 5: 2) was almost additive and was inferior to that of CDDP and ETP. On the contrary, for combination of 254-S and ETP (molar ratio 2: 1), antagonistic effect was observed at low concentrations, whereas marked synergism was obtained at higher concentrations. This synergistic effect was equal to the combination effect of CDDP and ETP at FC of 0.9 and even superior at a FC of more than 0.9. These data suggested the efficacy of 254-S in the treatment of SCLC.View full abstractDownload PDF (802K) -
Toyohiko Tsurumi, Junichi Ogawa, Hiroshi Inoue, Akira Shohtsu1991 Volume 31 Issue 2 Pages 229-234
Published: April 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe changes in the proportion of killer T lymphocyte (Tk) and NKcell activity of regional lymph nodes were studied in 38 lung cancer patients, according to tumor progressi on.
The proportion of Tk was significantly lower in N2 cases than NO or Ni cases. When the lymph nodes examined were restricted to the non-metastatic nodes of NO or N1 cases, the proportion of Tk was also significantly lower in cases in which the tumor had invaded to adjacent tissues or showed aneuploid pattern on DNA histograms. These results suggest that the proportion of Tk in lymph nodes is useful for predicting immunological and defensive response against the malignant extent of the tumor.
The NK cell activity, however, did not correlate with various malignant factors, such as metastasis, tumor invasion and DNA ploidy pattern.View full abstractDownload PDF (654K) -
Kiyohide Taniguchi, Hitoshi Kawaguchi, Noriyuki Tsubota, Kiyomi Nii, K ...1991 Volume 31 Issue 2 Pages 235-240
Published: April 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 65-year-old male was diagnosed as having adenocarcinoma of the lung extensivelyinfiltrating the mediastinum at exploratory thoracotomy. After five cycles of neoadjuvant chemotherapy (MVP; MMC+VDS+CDDP) with recombinant humangranulocyte colony-stimulating factor (rhG-CSF), complete response was achieved.Subsequently, left upper lobectomy was able to be performed. Postoperative histological studies showed no malignant cells in all sections examined.
We conclude that neoadjuvant chemotherapy with rhG-CSF enables more rapid delivery of full-dose cycles of anticancer agents, and that dose-intensitive chemotherapy is suitable for advanced non-small cell lung cancer.View full abstractDownload PDF (8051K) -
Masahiko Higashiyama, Osamu Doi, Ken Kodama, Ryuhei Tateishi1991 Volume 31 Issue 2 Pages 241-246
Published: April 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA case of sclerosing hemangioma of the lung in a 13-year-old male is presented. He was admitted because of a solitary coin lesion, 2cm in diameter, in S4 of the right lung on chest X-ray in a screening test for entrance into a junior high school. Partial resection of the middle lobe was performed, and the lesion was histologically diagnosed as sclerosing hemangioma.
Sclerosing hemangioma of the lung commonly occurs in middle-aged women. Only13 cases younger than age 20, including our case, have been reported in Japan so far. The features of the other cases are reviewed and discussed.View full abstractDownload PDF (6795K) -
Hideo Mashimoto, Naohumi Suyama, Jun Araki, Sadahiro Asai, Hiroyuki Mi ...1991 Volume 31 Issue 2 Pages 247-252
Published: April 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 63-year-old man was admitted to our hospital because a pulmonary mass with a 10-year history had enlarged rapidly in recent years. Chest X-ray film on admission showed a large mass shadow in the right upper lobe. Bronchofiberscopy revealed apolypoid tumor with a smooth surface completely occluding right B2. Right pneumonectomy was carried out as the histological findings of the biopsied specimen strongly suggested mucus-producing adenocarcinoma. Macroscopically, this well-circumscribed tumor contained abundant mucus. Microscopically, mucus-filled cyst walls consisted of mucus-secreting columnar cells. The pathological findings of the tumor resembled the mucinous cystadenocarcinoma originating in the ovary. Ultrastructure of the tumor showed a basal body in the cytoplasm. The tumor cells were weakly positive for lysozyme and negative for lactoferrin. These facts suggested that this tumor was derived from goblet cells rather than the bronchial gland.View full abstractDownload PDF (8878K) -
Toshiki Hirata, Takashi Yamada, Kazuyuki Yagi, Jin-ichiro Akiyama, Yos ...1991 Volume 31 Issue 2 Pages 253-258
Published: April 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSAlthough the correlation of pulmonary infarction and lung cancer has been oftendiscussed, clinical features of pulmomary infarction associated with lung cancer has rarely been reported. We report a case of pulmonary infarction secondary to lung cancer (poorly differentiated squamous cell carcinoma) clinically diagnosed before the surgical procedure. In this case, the decrease of blood flow caused both by compression by the tumor and by hypertrophy of the wall of pulmonary vessels was thought to have produced thrombi, which finally resulted in pulmonary infarction.
As most cases of pulmonary infarction secondary to lung cancer were not diagnosedbefore the surgical procedure or autopsy, it is important to examine the proximal portion of pulmonary infarction and the peripheral portion of bronchogenic carcinoma by arterio-graphy, scintigraphy and bronchofiberscopy.View full abstractDownload PDF (9828K) -
Motoyasu Sagawa, Yasuki Saito, Chiaki Endo, Satomi Takahashi, Katsuo U ...1991 Volume 31 Issue 2 Pages 259-263
Published: April 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn sputum-positive cases, it is important to discriminate radiographically occult lung cancer from carcinoma of the upper respiratory tract. In this article, two cases of early carcinoma of the upper respiratory tract detected by sputum cytology in a mass screening are reported. A method of detecting the location of cancer in patients with positive sputum cytology who have neither abnormal chest x-ray findings nor abnormal bronchoscopic findings is discussed.
Case 1 was a 65-year-old man with positive sputum cytology examined by chestx-ray, chest CT, bronchofiberscopy, nose x-ray, nose CT, and laryngofiberscopy. None of the examinations revealed abnormal findings. However, in a random biopsy of the epipharynx, squamous cell carcinoma was found. Case 2 was a 64-year-old man with positive sputum cytology examined by almost the same methods as in case 1. Mucosal thickness was detected in the left maxillary sinus by nose CT. Aspiration cytology of the left maxillary sinus revealed squamous cell carcinoma.
Early stage carcinomas of the epipharynx and maxillary sinus are very difficult to diagnose. It was concluded that nose CT and biopsy of the epipharynx should be performed in cases with positive sputum cytology who have neither abnormal chest x-ray findings nor abnormal bronchoscopic findings.View full abstractDownload PDF (3339K) -
Michiko Koike, Ken Nakagawa, Toshiki Matsubara, Yuichi Ishikawa, Siu-Y ...1991 Volume 31 Issue 2 Pages 265-273
Published: April 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 66 year-old male was admitted to our hospital under a diagnosis of lung cancer by sputum cytology. Chest roentgenogram showed a mass in the right upper lobe, and emphysematous bullae in the right lower lobe. At first, the former appeared malignant, but a series of chest X-ray examinations during the previous 7 years, CT-scan and transbronchial lung biopsy led us to the diagnosis of lung cancer contiguous to bullae in the latter region. Right lower lobectomy was carried out. Pathological examination revealed well differentiated papillary adenocarcinoma, spreading widely on the surface of bullae and infiltrating into the bulla wall without mass formation. The staging was pT 2 N 2 M 0, pStage III A.
We discussed the method of diagnosis of lung cancer adjacent to bullae by a review of 5 cases in our hospital and 30 cases reported in Japan. We emphasize the possibility that lung cancer can arise in association with emphysematous bullae and the necessity of the intensive examinations for the early accurate diagnosis of such lung cancers.View full abstractDownload PDF (9531K) -
Shinichiro Okada, Shunsuke Kobayashi, Hirohisa Inaba, Shigefumi Fujimu ...1991 Volume 31 Issue 2 Pages 275-278
Published: April 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSRecurrence of tumor was suspected by sputum cytological examination in a 71-year old male who had undergone right upper lobectomy of the lung two years ago on a diagnosis of small cell lung cancer. Bronchoscopic biopsy showed metastasis of small cell lung cancer to the trachea. The patient was treated with combination chemotherapy Vincristine and Cyclophosphamide followed by 40 Gy Lineac irradiation. Complete remission was achieved. Biopsy following therapy revealed no viable tumor cells. The above facts emphasize that it is important to periodically examine sputum cytology and bronchoscopic findings in cases suspicious of lung cancer.View full abstractDownload PDF (5440K) -
Hiroshi Saito, Kiyohide Kitagawa, Teruo Yamahana, Shinji Masuda, Masan ...1991 Volume 31 Issue 2 Pages 279-283
Published: April 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 35 year-old man was admitted to our hospital for treatment of cancer of the right lung. Bone scintigraphy showed a large solitary accumulation that seemed to be a metastatic lesion in the occipito-temporal area. Right upper lobectomy of the lung and removal of the right occipital bone were performed. Histological findings showed adenocarcinoma of the lung and osteosclerosis of the occipital bone but no cancermetastasis.
The significance of a solitary accumulation on bone scintigraphy in patients with lung cancer was discussed with paticular reference to preoperative diagnosis.View full abstractDownload PDF (7670K) -
1991 Volume 31 Issue 2 Pages 285-298
Published: April 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (1961K) -
1991 Volume 31 Issue 2 Pages 299-305
Published: April 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (1003K)
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