All issues
Volume 33, Issue 4
Displaying 1-22 of 22 articles from this issue
- |<
- <
- 1
- >
- >|
-
Dissemination with Regard to the Relationship between Cell Type, Growth Pattern and Surgical OutcomeHisami Yamakawa, Mitsutoshi Shiba, Kazuyoshi Sasaki, Suguru Hanzawa, K ...1993 Volume 33 Issue 4 Pages 461-469
Published: August 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSixteen bronchioloalveolar carcinomas (BAC) with aerogenous dissemination were studied with special reference to the relationship between cell type, growth pattern and surgical outcome. Eleven cases were classified as goblet cell type and 5 as bronchial surface cell (BS) type according to the criteria of Shimosato and Kodama. No pleural invasion was observed in any case and no lymph node involvement was observed except one with N2 disease of BS type. All type I BAC, whose tumors were localized within one segment, were alive and two type II BAC, whose tumor extents were limited within one lobe, were alive for 23 and 38 months after operation, respectively. Survival of the unresected two patients were 19 and 31 months, respectively. The prognosis of BAC, except for a few cases of BS type, was determined by intra-pulmonary tumor extent. Based on a comparison with the outcome of unresected cases, BAC limited to within one lobe should be surgically resecteView full abstractDownload PDF (9197K) -
Toyohiro Ishimatsu, Takashi Yoshimatsu, Kazuhito Dobashi, Yoshio Horiu ...1993 Volume 33 Issue 4 Pages 471-480
Published: August 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThis report analyzes the results in 87 patients with N2 non-small cell lung cancer who underwent surgical resection, from January 1979 through August 1989. Including operative death and hospital death, the 5-year survival rate was 14.1% for all resected patients and 25.5% for patients with relatively curative resection. No significant difference in survival was found between adenocarcinoma and squamous cell carcinoma. Concerning to T factor, the survival rate lowered and the MST (median survival time) shortened as the T stage progressed from T1 to T4. The survival of cN0 patients was significantly better than that of cN1 or cN2 patients. As for metastasis to N1 nodes, the survival of N1 negative case with skip lesions in the mediastinum was significantly superior to N1 positive case. In relation to the level of metastatic N2 nodes, the prognosis of patients with metastasis at only 1 level was significantly better than that of those with more than 2 levels. The location of the primary tumor has no influence on prognosis. Among 16 pN2 patients who survived longer than 3 years, there was no patient under 48 years of age or over 74 years of age. Good prognostic factors (curative resection, N1 negative, only 1 level metastasis to mediastinum) were significantly predominant in the long survivers, in whom 7 of 8 cases of cN2 disease were squamous cell carcinoma and underwent pneumonectomy.View full abstractDownload PDF (980K) -
Eiichi Akaogi, Kiyofumi Mitsui, Masataka Onizuka, Riichiro Morita, Shi ...1993 Volume 33 Issue 4 Pages 481-486
Published: August 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe relationship between histological features of superficial layers of the tumor and the degree of tumor extent of early squamous cell lung cancer was examined. In 33 lesions, the degree of keratinization was divided into the following 3 types; 1) well keratinized, keratinizing cancer cell composing 4 or more superficial layers of the tumor, 2) moderately keratinized, keratinizing cells composing only 1-3 superficial layers, 3) poorly keratinized, no or only a few keratinizing cells in the tumor tissue. Eight lesions well or moderately keratinized were covered with keratinizing cells with small pyknotic nuclei, of which the nuclear atypism were rather mild. These lesions tended to be misdiagnosed as benign atypia by sputum cytology. Of 18 well keratinized lesions, 14 were central type and 7 invaded beyond the cartilaginous layer. In 7 lesions with poor keratinization, 5 were superficial infiltrating type in growth pattern and 4 were more than 20mm in longitudinal length. These results indicate that the well keratinized type is likely to be centrally located and invade to a deep layer of the bronchus, and the poorly keratinized type is likely to extend superficially and widely in the bronchial wall.View full abstractDownload PDF (4416K) -
Hiroyoshi Ayabe, Masashi Muraoka, Akihiro Nakamura, Tsutomu Tagawa, No ...1993 Volume 33 Issue 4 Pages 487-493
Published: August 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe analyzed the results of 11 cases of hilar type early stage lung cancer treated surgically. There were 10 males and one female with a mean age of 63.5 years (range 55 to 68). The reasons why early lung cancer was detected were screening for early stage lung cancer by chest roentgenogram and cytologic sputum study in 6 patients, chest roentgenogram in follow-up study for coronary disease in one, and respiratory symptoms in 4. All patients had squamous cell carcinoma localized in the bronchial wall without regional lymph node metastasis. One of the 11 cases had multiple simultaneous early lung cancer (right main stem bronchus, right B9+10 and left B1+2). Operative procedures were carinal resection in 2 patients, bronchoplasty in one, lobectomy with bronchoplasty in 3, segmentectomy with bronchoplasty in 2, lobectomy in 2 and bronchoplasty combined with bilateral segmentectomies in one. Postoperative complications occurred in 5 patients (45%). However, there were no operative deaths or hospital deaths. Seven patients are alive without disease at 2, 3, 4, 19, 39, 48 and 50 months after operation. Four patients died of respiratory failure at 13, malignant lymphoma at 18, subsequent lung cancer at 36, and cerebral infarction at 147 months after resection.
Lung preserving procedures by tracheo-bronchoplasty are recommended for hilar type early stage lung cancer.View full abstractDownload PDF (782K) -
Noriyoshi Nagamoto, Yasuki Saito, Masami Sato, Motoyasu Sagawa, Keiji ...1993 Volume 33 Issue 4 Pages 495-499
Published: August 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA total of 149 patients with roentgenographically occult squamous cell carcinoma (ROSCC) were detected mainly by sputum cytology in mass screenings up to 1991. Resected specimens were cut serially into 2 mm-thick block from the margin of resection down to sub-subsegmental bronchi and microscopic sections prepared from the proximal surface of each serial block were investigated. The block which demonstrated the deepest invasion and the maximal area involved by carcinoma on a section was regarded as the portion of bronchus corresponding to the site of occurrence. The presence of carcinoma on a cross section prepared from a block was regarded as involvement ofthe corresponding 2-mm portion of the bronchus. We studied 65 ROSCCs of 16 mm or more in length from the proximal through the distal block involved by carcinoma. The length of proximal extension (LPE) was defined as 2m+1 (m=the number of consecutive blocks involved, counting from the most proximal block to the block just proximal to the site of occurrence). The length of distal extension (LDE) was defined as 2n-1 (n=the number of consecutive blocks involved, counting from the most distal block to the site of occurrence). Comparing LPE and LDE of a tumor, the greater is divided by the smaller to calculate the ratio of LPE to LDE (P/D ratio) or of LDE to LPE (D/P ratio). Of the 65 tumors, 29 (45%) had a P/D or D/P of 1.5 or less, 17 (26%) had a P/D of more than 1.5, and 19 (29%) had a D/P ratio of more than 1.5. These data suggest that an equal extension in the proximal and the distal extension was shown in about a half, the proximal greater than the distal extension in about a quarter, and the distal greater than the proximal extension in about a quarter of ROSCCs.View full abstractDownload PDF (558K) -
Cisplatin and Vindesine in Localized Inoperable Non-small Cell Lung CancerToru Rikimaru, Yasuyuki Tanaka, Yoichiro Ichikawa, Kotaro Oizumi, Kazu ...1993 Volume 33 Issue 4 Pages 501-505
Published: August 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDuring the period from February 1991 through October 1992, we conducted a pilot phase II trial of an “Alternating Radiotherapy and Chemotherapy” for 15 patients with localized inoperable non-small cell lung cancer. The combined regimen, consisting of ifosfamide 1.5g/m2 on days 1 through 3, cisplatin 80mg/m2 and vindesine 3mg/m2 on day 1, was given repeatedly every 4 weeks.
Patients were treated in a split course fashion with combination chemotherapy sandwiched between radiation therapy (total dose 60Gy). Of 15 evaluable patients, complete remission, partial remission and no change were obtained in 1, 13 and 1 patients respectively with an overall response rate of 93.3%. The median survival for all patients was 62 weeks.
Hematologic toxicity was severe and was judged to be dose limiting. It was, however, clinically manageable with colony stimulating factor.
These results indicate that this alternating radiotherapy and chemotherapy is feasible for localized non-small cell lung cancer and warrants further clinical trials.View full abstractDownload PDF (580K) -
Yoshio Hamashima, Gengo Saitoh, Syougo Iwata, Toshio Ichiwata, Hitoshi ...1993 Volume 33 Issue 4 Pages 507-515
Published: August 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSUsing an IgG type monoclonal RF (IgGmRF) which was established by fusion of mouse myeloma cells (P3-NS1/1-Ag4-1; NS-1) with splenocytes from MRL / MP-lpr/1 pr mice, we measured the serum levels of immune complexes (circulating immune complexes, CIC) in 146 patients with primary lung cancer according to their clinical and pathological stages. We compared results with those obtained by the Clq procedure, and obtained the following results: 48.6% of cases were CIC positive by the IgGmRF procedure, revealing a higher rate than by the Clq procedure. The CIC levels determined by the IgGmRF procedure were 6.0±2.6μg/ml in stages I and II compared to4.4±2.5μg/ml in stages III and N. The CIC levels decreased significantly in stages III and N compared to stages I and II. In contrast with this, the CIC levels measured by the Clq procedure tended to increase in proportion to the progression of the disease. When it came to pathological classification, the CIC levels by the IgGmRF procedure in large cell carcinoma showed slightly lower levels than those in squamous cell carcinoma, adenocarcinoma or small cell carcinoma. There was a correlation between CICs measured by IgGmRF and Clq procedures. Furthermore, in the gel filtrated fraction from serum which showed a high CIC concentration, a difference of the response in their CIC levels was recognized using the IgGmRF and Clq procedures.View full abstractDownload PDF (907K) -
Toshihiko Sakamoto, Noriaki Tsubota, Masahiro Yoshimura, Maki Kubota, ...1993 Volume 33 Issue 4 Pages 517-523
Published: August 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTo assess the characteristics of small (≤8cm3) non-small cell lung cancer, DNA ploidy was investigated by means of flow cytometry using paraffin-embedded specimens from 62 patients. Of the 62 cases, 24 (39%) showed DNA aneuploidy and 38 had DNA diploidy. DNA ploidy was not associated with pathological stage, nodal status, pleural invasion, pulmonary metastasis, lymphatic invasion, vascular invasion, histological type, or grade of differentiation. The 5-year-survival rate was 67% in cases of DNA diploidy and 40% in those of DNA aneuploidy, but the difference was not significant. In 37 stage I cases and in 48 cases resected curatively, there were no statistical significant differences in the 5-year-survival according to DNA ploidy. But in 23 cases resected curatively in which no lymphatic or vascular invasion was proved microscopically, cases of DNA aneuploidy had a significantly lower 5-year-survival rate (44%) than cases of DNA diploidy (93%) (p<0.05). These results suggest that DNA ploidy is an independent prognostic factor and that DNA aneuploidy possesses occult malignancy.View full abstractDownload PDF (663K) -
Noritoshi Lee, Kiyotoshi Inoue, Hiroaki Kinoshita1993 Volume 33 Issue 4 Pages 525-532
Published: August 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSAnthracosis may affect the detectability of hilar and mediastinal lymph nodes by endoscopic ultrasonography (EUS). The authors examined 50 patients with bronchogenic carcinoma (who later underwent surgery) using an electronic ultrasonicfiberscope with a linear array (EPB-503-FS, Machida-Toshiba). A total of 513 hilar and mediastinal nodes (54 metastatic) removed in surgery were examined under a microscope. Non-metastatic nodes were larger and detected more readily when anthracosis of those nodes was severe or diffuse than when it was mild or localized. The size and detectability of metastatic nodes were unaffected by the severity and distribution of anthracosis. Ultrasonographic findings of detected nodes were classified into six types according to their internal echo patterns. We studied the relationships between the severity and distribution of anthracosis and the homogeneity or echogenicity of the ultrasonograms. As to the severity of anthracosis, there were no such relationships. However, in nodes of the three types that were rarely metastatic, the distribution of anthracosis affected echogenicity: lymph nodes in which anthracosis was diffuse were more hypoechoic than those in which it was localized. The internal echo patterns of metastatic nodes were not affected by the severity or distribution of anthracosis in the nodes, and their non-homogeneous internal echoes seemed to arise from the metastatic tissue itself.View full abstractDownload PDF (4088K) -
Kiminori Fujimoto1993 Volume 33 Issue 4 Pages 533-542
Published: August 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe longest transverse diameter (LTD) and shortest transverse diameter (STD) of 3855 resected mediastinal lymph nodes (3695 non-metastatic and 160 metastatic) obtained from 206 patients with non-small cell bronchogenic carcinoma were measured. Node measurement was performed using microscopic HE specimens, after classification of the region according to the node mapping of the Japan Lung Cancer Society. For revising the sizes of these nodes measured by HE specimens, decreasing rates of LTD and STD were respectively obtained from the other 58 resected nodes in which the LTD and STD were compared immediately after resection and those after preparing HE specimens. Comparison with non-metastatic and metastatic nodes were perfomed based on the revised diameters. The difference in LTD and STD between non-metastatic nodes and metastatic nodes was statistically significant (p<0.001 for both). To obtain a guideline for diagnosis of non-rnatastatic from metastatic lymph nodes based on size, the regional maximum standards of the LTD and STD of non-metastatic nodes were calculated. The STD showed a smaller variation and appeared to be a more useful parameter than the LTD. A standard maximum for normal STD for nodes in each region of the mediastinum was proposed as follows: 12mm for nodes in #7; 10mm for nodes in #1, #3, #4, #5 and #8; 8 mm for nodes in other regions.
The LTD and STD of metastatic nodes (n= 120) of adenocarcinomas were statistically shorter than those (n=33) of squamous cell carcinomas (LTD: p<0.01; STD: p<0.005). The LTD and STD of metastatic nodes (n=120) of adenocarcinomas were statistically longer than those (n=3695) of non-metastatic nodes (Both LTD and STD: p<0.001).View full abstractDownload PDF (1185K) -
Hyung Eun Yoon, Kazuya Nakahara, Yoshitaka Fujii, Akihide Matumura, Ry ...1993 Volume 33 Issue 4 Pages 543-547
Published: August 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSix patients with superior vena cava (SVC) syndrome due to unresectable lung cancer underwent bypass operation with ringed GoreTex grafts. There were 2 cases each of adenocarcinoma and large cell carcinoma, and 1 case each of squamous cell carcinoma and small cell carcinoma. Three patients had chemotherapy, with or without irradiation, for SVC obstruction before operation. The other three patients had no treatment for SVC obstruction before bypass. All patients obtained symptomatic relief immediately after bypass without any serious postoperative complications. By obtaining a good performance status, all cases were able to receive sufficient postoperative adjuvant therapy. Only one patient developed recurrence of SVC syndrome due to lymph node metastases. It was concluded that bypass operation with ringed PTFE graft should be considered as one therapeutical modality for SVC syndrome caused by unresectable lung cancer.View full abstractDownload PDF (2797K) -
Naoyuki Toyota, Akira Naito, Masayuki Kagemoto, Masao Doi, Teruomi Miy ...1993 Volume 33 Issue 4 Pages 549-554
Published: August 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSAn expandable metallic stent developed for dilatation of stenosis or obstruction of ductal lumina was applied in 6 patients with tracheal or bronchial stenosis by primary or metastatic lung cancer. All patients had airway stenosis, and dyspnea or hypovolume of the diseased lung field. Placement of the expandable metallic stents improved respiratory function in one case, and maintained the bronchus patent in the other cases.
In conclusion, expandable metallic stents for airway stenosis are useful, especially in emergency cases.View full abstractDownload PDF (8474K) -
Takashi Eto, Harumi Suzuki, Atsuro Honda, Yasuyuki Nagashima1993 Volume 33 Issue 4 Pages 555-561
Published: August 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA total of 204 cases of type 2 peripheral adenocarcinoma of the lung (type 2), which characteristically formed central fibrotic foci (CF) of marked elastosis, were studied histologically and morphometrically. In CF, there were two types of elastosis, converging with air space collapse without tumor growth and forming elastotic framework (EFW) including various tumor growth. The latter could be further divided into two types, type 1-like EFW with thickened elastotic stroma and open air spaces lining stratified tumor cells, mostly in the periphery of CF, and collagenized EFW with air spaces replaced by collagen fibers and scanty tumor growth.
Image analysis of elastic fibers revealed no difference in amounts between the type 1-like and collagenized EFW. These findings suggested that the collagenized EFW was made by collagen fibers in the air space with tumor growth of type 1-like EFW. It was concluded that in the early stage of type 2, stromal elastosis in the alveolar walls growing tumor formed a characteristic network (type 1 tumor) and with tumor invasion or growth, the stromal network was destroyed, followed by organization with collagen fibers or peripheral collapse, resulting in formation of the CF.View full abstractDownload PDF (11765K) -
Keisuke Tomii, Takekuni Iwata, Kazukiyo Oida, Fumihiro Tanaka, Morihis ...1993 Volume 33 Issue 4 Pages 563-568
Published: August 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 55-year-old man was admitted to our hospital because of fever and dry cough. His chest roetgenogram revealed a tumor shadow in the right upper lobe. His laboratory data showed marked leukocytosis (34, 500/μl), granulocytosis (32, 900/μl), thrombocytosis (5, 470, 000/μl) and increased CRP (12.7mg/dl). Right upper lobectomy was performed on a diagnosis of giant cell type lung cancer (T2NOMO stage I). Serum GCSF was 194pg/ml (normal <30) before the operation and 36pg/ml after that. He died 7 months after admission. Serum G-CSF level had been changing parallel to the total mass of the tumor and finally it increased to 13, 112pg/ml. The cytoplasm of primary tumor cells stained positively with gout anti-recombinant human G-CSF polyclonal antibody by the PAP method. This finding, supported by the course of serum G-CSF levels, indicated production of G-CSF by the tumor cells.
We think the PAP method with anti-rhG-CSF polyclonal antibody is a clinically useful tool for localization of G-CSF in cases in which its production by tumor is suspected.View full abstractDownload PDF (3366K) -
Hiraku Ichiki, Mamoru Yano, Kazushi Nishitani, Michihiro Shishido, Kaz ...1993 Volume 33 Issue 4 Pages 569-573
Published: August 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 64-year-old man with primary lung cancer and hypertrophic pulmonary osteoarthropathy (HPO) is reported. He complained of bilateral ankle pain and swelling of the lower extremities. Bone scintigraphy showed increased uptake in the both lower legs. The histological diagnosis was adenocarcinoma and a right upper lobectomy was performed. The pain and swelling rapidly disappeared within one week after operation and bone scintigraphy was normal one month after operation. On admission, serum estrone and estradiol levels were elevated but became normalized after operation. These data suggest that the elevated serum estrone and estradiol levels due to lung cancer were contributing factors in HPO.View full abstractDownload PDF (5006K) -
Takashi Sekine, Khaled Reshad, Fumuhiro Tanaka1993 Volume 33 Issue 4 Pages 575-578
Published: August 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 43- year-old woman was admitted due to a coin lesion detected on a chest x-ra.Despite detailed examinations including tomography, computed tomography and bronchofiberscopy, we could not obtain a definitive diagnosis. The open lung biopsy revealed a carcinoid tumor located at the apical lesion of the right lower lobe. Althoug carcinoid tumors often accompany other carcinomas, none was found on further postoperative examinations.View full abstractDownload PDF (5219K) -
Susumu Nakao, Osamu Takahara, Naoki Takahasi1993 Volume 33 Issue 4 Pages 579-584
Published: August 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe patient was a 48-year-old female without any complaints. She was sent to ourhospital for further examination of multiple nodular shadows on chest X-ray detected by a local doctor 2 years previously. Histological examination of the open lung biopsy specimen revealed a myxomatous polypoid lesion covered with tumor cells invadingvessels, alveoli and bronchioles. Immunohistochemically factor VIII-related antigen (VIIIRAG) was positive in tumor cells. The tumor was diagnosed as epithelioid hemangioendothelioma (EH). A microscopic specimen of a tumor resected from soft tissue in the left lower extremity 3 years previously was reexamined and was diagnosed as the same tumor. Further, retrograde evaluation of the chest X-ray taken 5 years previously revealed 3 small nodular shadows in the right lung field. Therefore, it is impossible to say the tumor arose primarily in the limb. As the incidence of EH is predominant in women and as the existence of estrogen receptor has been suggested, tamoxifen (estrogen receptor blocker) has been given to the patient for 3 years, but the tumor shadow is unchanged.View full abstractDownload PDF (6986K) -
Hitoshi Kodama, Toshikazu Hirai, Keiichi Endoh, Yasuo Morishita1993 Volume 33 Issue 4 Pages 585-589
Published: August 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 75-year-old woman was admitted because of an abnormal lung shadow. Chest X-P films showed a poorly defined tumor shadow with an air bronchogram. Pseudolymphoma was suspected from the results of transbronchial lung biopsy and right upperlobectomy was performed. The pathological findings showed proliferative centrocytelike cells forming lymphoepithelial lesion, plasma cells and follicles, suggesting diffuse intermediate-sized cell type malignant lymphoma derived from bronchus-associated lymphoid tissue. Investigation of cytoplasmic immunoglobulins revealed monoclonality to Ig G and λ in the proliferative cells, confirming the diagnosis. We reported the present case because of the extreme rarity of the disease.View full abstractDownload PDF (5981K) -
Jun Araki, Hideo Mashimoto, Sadahiro Asai, Hiroyuki Minarni, Hiroshi S ...1993 Volume 33 Issue 4 Pages 591-597
Published: August 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 59-year-old man was admitted to our hospital because of general malaise and cough. The chest X-ray film disclosed a mass shadow with infiltration in the left lower lung field. The laboratory data showed marked leukocytosis (32, 000/μl) without any evidence of infection. The serum level of G-CSF (298pg/ml) was high by enzymeimmunoassay. A clinical diagnosis of lung cancer (squamous cell carcinoma, stage III A) was made and left pneumonectomy was performed. The level of G-CSF was high not only in the extract of tumor tissue obtained at operation but also in the supernatants of cultured tumor cells. An immunoperoxidase staining method using specific monoclonal antibodies against rh G-CSF showed positive staining in the tumor cells of the surgicalspecimen. After the operation, white blood cell counts and the level of serum G-CSF soon returned to normal. The patient has been in good health for two years after surgery without any evidence of recurrence.View full abstractDownload PDF (8406K) -
Mizuto Otsuji, Yutaka Yamaguchi, Toshitaka Ogawa, Masayuki Baba, Hidem ...1993 Volume 33 Issue 4 Pages 599-604
Published: August 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA relatively rare case of lung cancer combined with multiple myeloma (M.M.) is reported. The patient was a 72-year-old female. Upon receiving preoperative examinations for cataract, a tumor-like shadow was pointed out in the right middle lung field on her chest X-ray film. Transbronchial aspiration biopsy was performed and diagnosed as primary adenocarcinoma of the lung. Haematological examination showed anemia, hypoalbuminemia, and a relative increase of blood protein. Immunoelectrophoresis showed specific increase in the M-component of the κ type IgA. Furthermore, bone marrow puncture revealed the proliferation of myeloma cells and was diagnosed M.M.A right middle lobectomy with mediastinal lymphadenectomy was performed. After surgery, chemotherapy was performed additionally to treat the M.M. with VCMP (Vindesine, Cyclophosphamide, Melphalan and Predonisone). One year has passed since the operation and there has been no sign of recurrence.View full abstractDownload PDF (6317K) -
Hiroyuki Nakamura, Kousuke Kashiwabara, Yuuji Fukai, Hiroshi Semba, At ...1993 Volume 33 Issue 4 Pages 605-610
Published: August 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSynchronous multiple lung cancers have been reported by numerous investigators. However, there have been few reports on such cases of early stage lung cancer. Werecently encountered two cases of early synchronous multiple cancers within a single lung lobe. Case 1 was a 73-year-old male who complained primarily of hemoptysis. On chest X-ray films, a nodular shadow (later diagnosed as adenocarcinoma) was visible in the left S1+2. Bronchoscopy revealed a nodular tumor (later diagnosed as squamous cellcarcinomas) in the orifice of the lingular bronchus. This patient underwent left upper lobectomy (P-T1N0MO for both adenocarcinoma and squamous cell carcinomas). This case was diagnosed as early synchronous multiple lung cancers of different histological types (central and peripheral) affecting the same lung lobe. Case 2 was a 57-year-old male whose chief complaint was coughing. On chest X-ray films, an egg shell-like calcification of the hilar lymph nodes was visible (the patient, who had been working with stone for 40 years, and had been diagnosed as having silicosis). At the same time, two nodular shadows (later diagnosed as adenocarcinomas) were visible in the left upper lung field. This patient underwent left upper lobectomy (P-T1NOMO for both tumors). In this case, the two tumors were not contiguous, and their cell morphology and mucusproducing activity were different. Based on these findings, this case was diagnosed as early synchronous multiple lung cancers of the same histological type affecting the same lung field.View full abstractDownload PDF (9577K) -
1993 Volume 33 Issue 4 Pages 611-617
Published: August 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (925K)
- |<
- <
- 1
- >
- >|