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Volume 35, Issue 4
Displaying 1-16 of 16 articles from this issue
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1995 Volume 35 Issue 4 Pages 385-386
Published: August 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (2159K) -
Takefumi Komiya, Minoru Takada, Takasi Yana, Kaoru Matsui, Noriyuki Ma ...1995 Volume 35 Issue 4 Pages 387-392
Published: August 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTen cases of primary mediastinal malignant germ cell tumors were studied retrospectively. All but one were male and most of the patients suffered from chest pain or cough. While 3 patients who were classified as seminoma had normal serum tumor markers, seven non-seminomas had high levels of α-fetoprotein (AFP) or carcinoembryonic antigen (CEA). Of the 5 patients who initially received cisplatin-based combination chemotherapy, 3 attained a pathological complete response (CR) by thoracotomy.
Of the 5 patients whose tumors were initially resected, 4 received adjuvant cisplatincontaining chemotherapy.
In summary 7 of the 9 remain alive and disease-free. These results strongly suggest that combined modality treatment provides good results for patients with primary mediastinal malignant germ cell tumor.View full abstractDownload PDF (3758K) -
Naoko Iibachi1995 Volume 35 Issue 4 Pages 393-400
Published: August 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSerum erythropoietin (EPO) and hemoglobin (Hb) were measured in 354 untreated adult lung cancer patients. Changes in serum EPO, Hb and reticulocyte levels were measured in 45 patients during the first, second, third and fourth course of chemotherapy. The mean EPO and Hb levels were 28.5±18.9mU/ml and 12.7±1.88g/dl. A significant inverse correlation was found between EPO and Hb (r=0.386, p<0.0001). The meanEPO level in Stage IV was significantly higher than that in any other stage. The mean EPO level was higher in patients under 49 years of age. The EPO level increased after the initiation of the first course of chemotherapy and showed a peak value at 2 weeks of chemotherapy, then gradually fell to the initial level. The EPO levels at each week of the third course of chemotherapy were significantly higher than those during the first and second course of chemotherapy. The reticulocyte level decreased significantly at 1 week of chemotherapy and increased at 2 weeks of chemotherapy in each course. There was a linear correlation between the initial EPO level and peak EPO level. These findings suggest that recombinant human erythropoietin (rHuEPO) may be useful in the treatment of these patients.View full abstractDownload PDF (836K) -
Hideoki Yokouchi, Osamu Doi, Masahiko Higashiyama, Ken Kodama1995 Volume 35 Issue 4 Pages 401-406
Published: August 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe established an assay system to detect very small amounts of cancer cells among a large amount of peripheral blood mononuclear cells (PBMNC) through expression of keratin 19 gene specific for epithelial cells by RT-PCR.
Expressions of keratin 19 gene were not detected in normal PBMNC but were detected in a lung cancer cell line, CADO-LC4 diluted with 106 of normal PBMNC.
We applied this system for 21 resected cases of primary lung cancer (11 stage I cases, 2 stage II, 8 stage III) and detected keratin 19 expressions in PBMNC of 3 cases of stage I. There was no correlation between the keratin 19-positive rate and vascular invasion. The keratin 19-positive rate of squamous cell carcinoma was higher than that of adenocarcinoma (2/7 vs 1/14).
Whether circulating cancer cells reflect occult distant metastases or not should be determined based on the outcome after appropriate follow-up.View full abstractDownload PDF (4347K) -
Hiroshi Sakai, Syuichi Yoneda, Mizuyoshi Sakura, Kazuhiro Kimura, Sugu ...1995 Volume 35 Issue 4 Pages 407-415
Published: August 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTo evaluate therapeutic strategies against brain metastasis from lung cancer, 327cases clinically diagnosed to have metastasis to the brain out of a total of 1586 lung cancer cases treated since 1977 were examined, and single factor analysis of the survival rate from the onset of metastasis to the brain was conducted by prognostic factor and by therapeutic factor. Multivariate analysis was then performed to find the extent of contribution of the items demonstrating statistic significance to the survival rate by each factor, using Cox's proportional hazard model.
The single factor analysis indicated significant difference in the performance status (PS) upon discovery of metastasis to the brain, control status of the primary lesion, metastasis to organs other than the brain, resection of the metastatic lesion, cerebral irradiation and dose, and the time metastasis appeared. The factors demonstrated to be significant by multivariate analysis were PS upon discovery of metastasis to the brain, cerebral irradiation, resection of the metastatic lesion, control status of the primary lesion and metastasis to organs other than the brain, in order of greater contribution to the survival rate. In non-small cell carcinoma cases, longer survival of patients was observed when cerebral surgery and radiological treatment were conbined, but the surgery did not achieve better result in small cell carcinoma cases.
If the conditions of PS and primary lesion control and extracerebral metastasis are favorable, aggressive multidisciplinary treatment is recommended for longer survival with emphasis on radiotherapy and cerebral surgery if possible in patients with non-small cell carcinoma and emphasis on radiotherapy in patients with small cell carcinoma.View full abstractDownload PDF (829K) -
A Prospective Randomized Trial Comparing Granisetron with Granisetron Plus Moderate-Dose MethylprednisoloneMasafumi Yoshizawa, Mamoru Chida, Masahiko Ichioka, Naoko Tojo, Naoyuk ...1995 Volume 35 Issue 4 Pages 417-423
Published: August 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe conducted a prospective randomized trial comparing granisetron (G) and granisetron plus moderate-dose methylprednisolone (GM) in controlling nausea and vomiting induced by chemotherapy in patients with non-small cell lung cancer. In patients treated with G (n=25), 12 (48%) were completely free from nausea and vomiting, during 24 hours after administration of cisplatin.In the GM group (n=24), 12 patients (50%) had neither nausea nor emesis.Eighteen patients (72%) in the G group, and 18 (75%) in the GM group did not vomit at all.
We conclude that granisetron alone is effective in preventing acute anusea and vomiting induced by cisplatin. Addition of moderate-dose methylprednisolone to granisetron does not augment the number of patients completely free from nausea and vomiting during 24 hours after cisplatin administration, although it attenuates the symptoms of female patients during the first six hours.View full abstractDownload PDF (882K) -
Tomohiko Ikeya, Shigeki Sugiyama, Takurou Misaki1995 Volume 35 Issue 4 Pages 425-435
Published: August 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSElectron microscopic morphometry was studied in a total of 46 cases of adenocarcinoma of the lung. The adenocarcinoma cell nuclear area (NA) and the perimeter (NP), and the nuclear dense area (NDA) were measured by graphic analysis system with computer. Further, the NDA-NA ratios (NNR) and the nuclear form factors (NFF) were calculated. Five parameters were generated from each pulmonary adenocarcinoma and statistically examined with clinical and pathological findings of each patient. As a result, NDA and NNR were revealed to be significant by related to all clinical and pathological findings examined in this study. NA and NP were significantly correlated with the histological grade of differentiation and the observation of lymph node metastasis. However, no significant correlation with prognosis was detected in NA, NP and NFF. The significance of electron microscopic morphometry was shown, because NDA and NNR were revealed to be prognostic indicators for pulmonary adenocarcinoma patients.View full abstractDownload PDF (4656K) -
Kouzo Yamada, Fumihiro Oshita, Teruaki Yoshioka, Ikuo Nomura, Kazumasa ...1995 Volume 35 Issue 4 Pages 437-443
Published: August 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTo facilitate the accurate diagnosis of pleural dissemination of lung cancer, weevaluated the use of thin-slice computed tomography (CT). Conventional CT and thinslice CT images of 100 patients with lung cancer who underwent thoracotomy were retrospectively reviewed. The conventional CT and thin-slice CT images were examined by an extended scale (window level:-600, window width: 1900) using highresolution images.
Ninety-one of these patients were recognized postoperatively as having no tumor dissemination on the pleural surface. Of the remainder, nine patients had tumor dissemination on the pleural surface of the chest wall or in the interlobar fissures. For the 91 patients without pleural dissemination, preoperative thin-slice CT images clearly showed a semicircular high-attenuation line in the interlobar fissures. As for the nine patients with pleural dissemination, preoperative thin-slice CT images of five patients (56%) clearly showed the presence of multiple small nodular lesions, while no surface irregularity in the interlobar fissures was visible on the conventional CT images.
Our results may suggest that thin-slice CT images could play a significant clinical role in the early detection of pleural dissemination by demonstrating multiple small nodular lesions of the interlobar fissures.View full abstractDownload PDF (4722K) -
Manabu Date, Katashi Satoh, Hideharu Nakano, Junpei Nakagawa, Hitoshi ...1995 Volume 35 Issue 4 Pages 445-452
Published: August 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 57-year-old man was sent to our hospital because of right back pain.Chest X-ray showed a massive pleural effusion on the right side. Diagnostic imaging and further examination of the pleural effusion disclosed no evidence of malignancy.After 4 months, computed tomography of the chest disclosed the increase of the right pleural thickening.The patient underwent CT-guided pleural biopsy under a diagnosis of malignant pleural mesothelioma, and the specimen was diagnosed as poorly differentiated adenocarcinoma on the basis of histochemical staining. At the same time, a tumor appeared in his right submandibular region, and the aspiration cytology of the tumor was similar to the pleural tumor.The patient underwent panpleuropneumonectomy with combined resection of the submandibular tumor, and the histological examinations of both submandibular and pleural lesions revealed adenoid cystic carcinoma.View full abstractDownload PDF (7917K) -
Akihiro Hayashi, Shinjiro Mori, Shinzo Takamori, Yoshinori Nagamatsu, ...1995 Volume 35 Issue 4 Pages 453-458
Published: August 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe report a case of a primary lung cancer which showed markedly elevated serum alpha-fetoprotein (AFP) levels. A 54-year-old man with a chief complaint of cough and a lesion on chest roentgenogram, was admitted to our department for further examinations and possible surgery. Both chest roentgenogram and chest CT demonstrated a dense mass in the upper lobe of the left lung located near the bifurcation of B1+2 and B3a+b.A bronchofiberscopic examination showed slight stenosis of the orifice of B1+2c but could not detect the tumor. Bronchofiberscopic transbronchial biopsy and curetting were performed, but no malignant cells were identified either pathologically or cytologically.The serum level of AFP was markedly high at 15, 210ng/ml, but all other tumor markers, including CEA, SCC, CA19-9, and HCG, were within the normal range. There was no detectable lesion in the liver, testes, mediastinum, stomach, or any other organ.Upper lobectomy of the left lung was performed under the diagnosis of primary lung cancer.Microscopic examination of the resected tumor confirmed anaplastic large cell carcinoma.These findings were considered to resemble so-called “hepatoid adenocarcinoma” .Immunohistochemical staining using anti-AFP antibody revealed prominent AFP granules in the cytoplasm of the tumor cells. By one month after operation the serum AFP levels had decreased to within the normal range. There has been no evidence of any tumor recurrence or metastasis, and serum AFP level has remained within the normal range for one year since operation.View full abstractDownload PDF (9045K) -
Kazuhiko Kataoka, Noritomo Seno, Motoki Matsuura, Masao Doi, Teruomi M ...1995 Volume 35 Issue 4 Pages 459-463
Published: August 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA case of cystic thymoma, that is, thymoma undergoing cystic degeneration of extent degree was experienced.A 75-year-old female was found to have an abnormal shadow on a chest X-ray film. CT scans and MRI films revealed a cystic lesion 8 cm in diameter in the left anterior mediastinum. Thymic cyst was suggested and operation was performed. Median sternotomy revealed a cystic lesion originating from the left lobe of the thymus.The lesion was extirpated with the left lobe of the thymus.The contents of the lesion were brown fluid and some soft brown elevated lesions attached to the inner wall. Pathologically, these elevated lesions were diagnosed as thymoma of the epithelial type, but many of the tumor cells were necrotic. Cystic wall lacked epithelial lining.Therefore, this lesion was diagnosed as a cystic thymoma.
When a cystic lesion is seen in the anterior mediastinum, thymic cyst, pericardial cyst and cystic teratoma must be considered for differential diagnosis, but the possibility of a cystic thymoma, as in this case, should be considered.View full abstractDownload PDF (6513K) -
Kousuke Kashiwabara, Hiroyuki Nakamura, Hisanaga Yagyu, Tosirou Kiguch ...1995 Volume 35 Issue 4 Pages 465-470
Published: August 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 63-year-old male was diagnosed as having small cell carcinoma (c-T4N3M0) and complete remission was achieved by 2 courses of chemotherapy with a carboplatinetoposide regimen.After 5 months, he relapsed and was treated with carboplatin (300mg/m2, on day 1), etoposide (100mg/m2, on days 1, 2, 3) and vincristine (1.0mg/m2, on day 1).Subendocardial myocardial infarction, paraplegia and cortical blindness developed 10 days after vincristine treatment.ECG showed ST-segment elevation in V4 to V6 and echocardiography revealed decreased motion of the anterior wall.The paraplegia was accompanied by lost of deep sensation and dysuria leading to a cordal infarction at the Th12, diagnosed by MRI.The cortical blindness may have been due to a cerebral infarction in the posterior cerebral artery, but brain CT and MRI results were normal. The cortical blindness abated within about 1 month. The onset of these symptoms was synchronous, suggesting that the myocardial infarction, paraplegia and cortical blindness were associated with vincristine treatment.View full abstractDownload PDF (4799K) -
Mitsuharu Kokubo, Tsuneo Tanaka, Kenitiro Tateyama, Motoyuki Katayama, ...1995 Volume 35 Issue 4 Pages 471-475
Published: August 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 60-year-old woman was found to have an abnormal shadow in the lung which was diagnosed as pseudolymphoma in 1988.She underwent left lingular segmentectomy in 1994 due to marked enlargement of the lesion.The histologic examination of surgical materials disclosed the lesion to be low-grade B-cell lymphoma of the MALT type.The immunohistologic findings of CD5-, CD10-, IgD-and IgM+were compatible with those of MALT lymphoma.MALT lymphoma of the lung is not a rare disease, but invasion to the pericardial adipose tissue is rare.View full abstractDownload PDF (5545K) -
Takefumi Komiya, Yoko Kusunoki, Takashi Yana, Minoru Takada, Katsuhiro ...1995 Volume 35 Issue 4 Pages 477-481
Published: August 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESS -
Yoshiharu Ohno, Masahiko Kusumoto, Masahiro Endo, Eiichiro Itouji, Mic ...1995 Volume 35 Issue 4 Pages 485-490
Published: August 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 38-year-old female was admitted because of discomfort and right chest pain.An anterior mediastinal mass was determined on chest X-ray and CT.On the MR image, the tumor showed expansive extension and necrosis, showing a high signal intensity on the T2-weighted image.Necrosis was not enhanced by Gd-DTPA.CT guided needle biopsy was performed and the tumor was diagnosed pathologically to be a diffuse large cell lymphoma with sclerosis.On immunohistochemical examination, the cells positively stained with leukocyte common antigen (LCA) and L-26.Chemotherapy combined with radiation therapy obtained a complete response.Almost all cases of this disease are treated surgically because it is difficult to diagnose it preoperatively.It was considered that the percutaneous needle biopsy can be useful for diagnosis of this disease, and that chemo-radiation therapy is effective.View full abstractDownload PDF (9564K) -
1995 Volume 35 Issue 4 Pages 491-508
Published: August 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (2560K)
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