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Volume 36, Issue 1
Displaying 1-12 of 12 articles from this issue
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Goro Kimizuka, Masahiko Ishibashi, Hidemi Ohwada, Yutaka Hayashi, Hide ...1996 Volume 36 Issue 1 Pages 1-6
Published: February 20, 1996
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThirty seven lung cancers of young patients under 50 years old and 74 lung cancer patients aged older than 70 were analyzed histopathologically. The frequency of females was higher in the young group (40.5%) than the old group (27.0%). In the young group adenocarcinoma predominated, but epidermoid carcinoma was most comon in the old, with the differences bing significant. More large carcinomas with abundant stroma were found in the old group than the young. It was suggested that lung cancer of the young grew faster and had a more malignant character than that in the old group.View full abstractDownload PDF (2819K) -
Kazuya Fukuoka, Nobuhiko Tsukaguchi, Sumito Choh, Kaoru Hamada, Hideak ...1996 Volume 36 Issue 1 Pages 7-13
Published: February 20, 1996
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn order to elucidate the factors causing respiratory infections (RI) during anticancer chemotherapy, we prospectively analyzed the changes in pharyngeal bacterial floras and the host's defensive potential against infections in lung cancer patients receiving anticancer chemotherapy with the passage of time. Twenty of primary lung cancer patients receiving systemic chemotherapy were selected for this study and 32 treatment courses, including 15 treatment courses with RI (A) and 17 treatment courses without RI (B), could be evaluated.
In treatment course A, the changes in pharyngeal bacterial floras tended to demonstrate that pathogenic organisms were continuously isolated during, or newly isolated after anticancer chemotherapy. There were significant differences between the two treatment courses, in the frequency of patients with a poor performance status (PS) before anticancer chemotherapy, the nadirs of white blood cell counts and the changing pattern of pharyngeal bacterial floras. Multivariate analysis revealed that the changes in pharyngeal bacterial floras and PS before anticancer chemotherapy are important factors influencing susceptibility to RI during anticancer chemotherapy.
In conclusion, these results suggested that both the changes in pharyngeal bacterial floras and the deterioration of the host's defensive potential against infections might be responsible for the development of RI during anticancer chemotherapy against lung cancer.View full abstractDownload PDF (780K) -
Eiji Yatsuyanagi, Satosi Hirata, Hirosi Moriyama, Yasukazu Sugimoto, M ...1996 Volume 36 Issue 1 Pages 15-22
Published: February 20, 1996
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDNA ploidy pattern and the presence of blood or lymph vessel invasion (VI) were analyzed to evaluate the significance of these parameters as prognostic factors. Flow cytometric nuclear DNA content analysis and investigation of VI using paraffin-embedded specimens were performed on the materials obtained from 42 patients with pathological stage I non-small cell lung cancer: 14 patients with recurrence and 28 patients without recurrence. There was no statistically significant difference in clinical characteristics between patients with recurrence and those without recurrence. The proportion of VI in patients with recurrence (85.7%) was statistically higher than that of patients without recurrence (39.3%, p<0.05). Aneuploidy was found in 57.1% of the patients with recurrence and 35.7% of those without recurrence, but this difference was not statistically significant. The incidence of VI in patients with aneuploidy (77.8%) was statistically higher than that in patients with diploidy (37.5%, p<0.05). These results suggest that the DNA ploidy pattern closely correlates with VI, and these two parameters are important prognostic factors in patients with pathological stage I non-small cell lung cancer.View full abstractDownload PDF (877K) -
Masahiro Endo, Masahiko Kusumoto, Michio Kono1996 Volume 36 Issue 1 Pages 23-32
Published: February 20, 1996
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTo evaluate the effectiveness of MR imaging for diagnosing thymomas and differentiating non-invasive from invasive thymomas, MRI was performed in twenty-five patients with thymoma and the MR appearances were compared with the pathological findings.
The MR appearances of thymomas corresponded well with the pathological findings: intratumoral linear septae of low signal intensity were fibrous septae and nodular images were lobules with tumor cells, necrosis or hemorrhage. Coronal and sagittal images provided additional useful information concerning tumor extent.
Invasive thymomas tend to have irregular margins, larger size, more cranio-caudal extent and internodular differences in signal intensity (IDSI) on MR images than noninvasive thymomas. Among them, IDSI is the best differential diagnostic finding to determine invasiveness.
Gd-DTPA enhanced MRI in thymomas showed intratumoral linear septae and necrotic lesions more clearly than the plain Tl-weighted image.View full abstractDownload PDF (12501K) -
Hideaki Yamasawa, Yoshiki Ishii, Satoshi Kitamura1996 Volume 36 Issue 1 Pages 33-40
Published: February 20, 1996
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSLiver metastases were studied clinically in 533 patients with primary lung cancer. Liver metastases were detected in 63 patients (11.8%), in 40 of whom they were detected on initial staging. In 23 patients, liver metastases were newly detected after initial staging. According to the histological type, the metastatic rate in patients with small cell carcinoma was significantly high compared to that in patients with adenocarcinoma or squamous cell carcinoma. A significant correlation between incidence of liver metastasis and clinical N factor was found. Most metastatic lesions in the liver showed multiple metastases in bilateral lobes of the liver. When liver metastases were detected, other metastatic organs were seen in 58 patients (92.1%). In patients who received initial chemotherapy, there was no difference in the response rate for the chemotherapy at the metastatic site and the primary site. The median survival period of patients who had liver metastases was 4.5 months.View full abstractDownload PDF (752K) -
Shinji Koyama, Shigeki Sugiyama, Yoshinori Doki, Takurou Misaki, Kazuh ...1996 Volume 36 Issue 1 Pages 41-47
Published: February 20, 1996
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSHyperleukocytosis was accompanied with lung cancer possessing cellular biological diversity. Giant cell carcinoma of the lung was found in a 68-year-old man. The tumor, with a doubling time of one month, was removed by right middle and lower bilobectomy with mediastinal lymph node dissection. Five months after the operation, recurrence was found in the right hemithorax and mediastinum, and accompanying hyperleukocytosis (the number of leukocytes was 63, 180/mm3, of which neutrophils were more than 95%). Furthermore, fever, anemia, thrombocytosis, hypoproteinemia, and high values of CRP, LDH, and ALP were detected. No malignant cells were found in the bone marrow. As the tumor developed in size and metastasized to the contralateral lung, the number of leukocytes increased to 169, 700/mm3 two weeks later, when the patient died of the cancer. A high concentration of G-CSF in the blood was measured (0.66ng/ml). However, immuno-histochemical examination of the resected tumor with antirecombinant human G-CSF antibody did not reveal G-CSF in the tumor cell itself. The tumor might produce some kind of granulocyte poietic factor different from G-CSF, which was responsible for hyperleukocytosis in this case.View full abstractDownload PDF (10700K) -
Takuji Kiryu, Eisuke Matsui, Mayumi Enya, Hiroaki Hoshi, Satoshi Sakai ...1996 Volume 36 Issue 1 Pages 49-53
Published: February 20, 1996
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 47-years-old man had undergone resection for multiple chondromatous hamartoma of the lung 18 years previously. After the first operation he had an asymptomatic course. An abnormal chest shadow was pointed out in July, 1994, when he was examined by his family doctor for an upper respiratory irifection and he was referred to our department. The chest CT showed a large mass with an irregular surface based on the right chest wall and a nodule in the middle lobe, and the transcutaneous biopsy from the mass revealed hyperplasia of cartilage, identical to the findings of the previously resected chondromatous hamartoma. Multiple chondromatous hamartoma of the lung is a rare disease, and only 15 cases have been reported in the world. Three main characteristics of this disease are as follows: the age of onset is relatively young (mean age of onset is 34.3 years old); the recurrence rate is very high (6 of 15 cases, 40%) and the period between first onset and recurrence is very long (the mean period of all recurrence cases is 12.7 years); young females are often complicated by gastric leiomyogenic neoplasms, especially gastric leiomyoblastoma, and extraadrenal paragangliomas. These three diseases, including chondromatous hamartoma of the lung, are described as “Carney syndrome”.View full abstractDownload PDF (6066K) -
Yasuto Akiyama, Seiya Saito, Suguru Kimura, Yoshiyuki Fujii1996 Volume 36 Issue 1 Pages 55-60
Published: February 20, 1996
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 65-year-old man was presented with pneumonia. Chest CT scan showed an 8mm nodule in the right upper lobe. The serum CEA level was 24.2ng/ml. One year later the nodule had increased in size to 2cm and the serum CEA level had become remarkably high, 147ng/ml. Cytological examination of the needle biopsy specimen revealed adenocarcinoma of the lung (cT1N0M0). Cellular immunity tests showed suppressed lymphocyte blastogenetic reaction (PHA) and natural killer (NK) cell activity. In April 1995 right upper lobectomy was performed (pT1N0M0). After resection the serum CEA level returned to normal in 59 days and immunological parameters also returned to a normal range. It was suggested that the high level of serum CEA was not a poorprognostic factor in the present case.View full abstractDownload PDF (5262K) -
Naoko Sakamoto, Kouji Takeda, Kikuo Nakano, Takehiko Hiramoto, Masanob ...1996 Volume 36 Issue 1 Pages 61-66
Published: February 20, 1996
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 50-year old man was admitted for evaluation of an abnormal shadow on his chest X-ray film, consisting of a mass containing an air-bronchogram. Transbronchial lung biopsy revealed interstitial infiltration of small lymphocytes.
Right lower lobectomy was performed on the suspicion of primary pulmonary lymphoma or pseudolymphoma. Conventional immunoperoxidase staining (PAP) showed monoclonal proliferation of B lymphocytes. Flow cytometry revealed that CD19- and CD20-positive lymphocytes were prominent, and that IgM was the most common surface marker. A diagnosis of small lymphocytic lymphoma, B-cell type, were made. Southern blot analysis showed clonal rearrangement of the light chain and heavy chain of the immunoglobulin gene, which supported the diagnosis.View full abstractDownload PDF (7822K) -
Tomonori Nakasone, Koji Kimino, Yuichi Inoue1996 Volume 36 Issue 1 Pages 67-74
Published: February 20, 1996
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSNine patients with lung cancer contiguous to emphysematous bullae were treated from 1989 to 1994. Four of the nine patients were followed upfor periods of from 26 to 98 months. Eight patients were diagnosed with lung cancer preoperatively and all nine had lobectomies. All cases were adenocarcinoma and 6 of the 9 were stage I. Five patients had well-differentiated adenocarcinoma. Four of the nine patients are alive 17 -69 months after operation. Periodic chest X-ray and CT scan examinations are useful for the early detection of lung cancer contiguous to emphysematous bullae. TBLB, TCB and finally open lung biopsy should be considered when a suspicious shadow is seen.
Prognosis appears excellent if curative operation can be performed.View full abstractDownload PDF (8079K) -
Kiyoshi Takenaka, Akira Murata, Yutaka Kokubo, Arata Azuma, Masahiko S ...1996 Volume 36 Issue 1 Pages 75-80
Published: February 20, 1996
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 69-year-old man was referred to our institution for examination and treatment of right-sided chest pain, swelling of the right chest wall and shortness of breath on exertion. He had a past history of artificial pneumothorax due to pulmonary tuberculosis at the age of 27.
The computed tomography image of the chest showed a tumor mass with prominent necrosis at the mediastinal site of chronic tuberculous pyothorax. There was a similar lesion in the right chest wall. Biopsy specimen of the subcutaneous mass in the right chest wall yielded a definitive diagnosis of non-Hodgkin's lymphoma (diffuse large cell, B-cell type).
We detected Epstein-Barr virus (EBV) gene products in malignant lymphoma cells. EBV-encoded nuclear antigen 2 (EBNA2) and latent membrane protein 1 (LMP1) were not detected by immunocytochemistry but EBV-encoded small RNA1 (EBER1) was detected on lymphoma cells by in situ hybridization.
We therefore suggest that there can be the causal relation between EBV and pyothorax-associated malignant lymphoma.View full abstractDownload PDF (8298K) -
1996 Volume 36 Issue 1 Pages 81-88
Published: February 20, 1996
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (1093K)
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