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Volume 37, Issue 7
Displaying 1-15 of 15 articles from this issue
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Takashi Seto, Tomio Nakayama, Fumio Imamura, Shinichiro Nakamura, Yoko ...1997 Volume 37 Issue 7 Pages 961-966
Published: December 20, 1997
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSCytologic features of adenocarcinoma of the lung in relation to response to chemotherapy were studied. Twenty-six patients underwent more than 2 courses of intensive chemotherapy with cisplatin and vindesine. Among them, 9 patients showed partial response (PR), 11 patients showed no change (NC) and these were 6 cases of progressive disease (PD). Cellular characteristics of adenocarcinoma cells obtained directly from tumors were examined in terms of the size of cells and nuclei, nuclear shape, chromatin pattern, and nucleoli features. The adenocarcinoma cells which appeared more frequently in the PR group were characterized by a large, round nucleus with fine reticular chromatin evenly distributed. The adenocarcinoma cells which appeared more often in the NC group had a small irregular nucleus with sparse chromatin unevenly distributed and a solitary small nucleolus. Adenocarcinoma cells with coarse chromatin appeared more ofter in the PD group.
Cytologic characteristics of adenocarcinoma cells of the lung indicate the probable response to chemotherapy.View full abstractDownload PDF (3496K) -
Hiroyuki Suzuki, Takanori Kawaguchi, Koichi Fujiu, Ryuzo Kanno, Akio O ...1997 Volume 37 Issue 7 Pages 967-972
Published: December 20, 1997
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe attempted to establish the pattern of recurrence in primary lung adenocarcinoma with clinicopathologic variables based on data of 131 patients with completely resected primary lung adenocarcinoma. In univariate analysis, tumor size (more, or less, than 3 cm in diameter), p-T, p-N, pathological stage, differentiation, ly factor and v factor were chosen for prognostic predictors. p-N, ly factor and differentiation correlated with metastatic recurrence. Tumor size, ly factor and v factor correlated with local recurrence. In multivariate analysis, v factor and p-N were independent variables of local recurrence and metastatic recurrence, respectively. We conclude that node involvement and vascular invasion play central roles in lung adenocarcinoma recurrence.View full abstractDownload PDF (2980K) -
Akihisa Fujita, Hirotsugu Takabatake, Shigeru Tagaki, Kyuichirou Sekin ...1997 Volume 37 Issue 7 Pages 973-980
Published: December 20, 1997
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe evaluated the characteristics of 2-year survivors among 146 patients with stage IIIB or N adenocarcinoma of the lung admitted to our hospital from 1986-1994. Twentyfive patients were survived over 2 years. Univariate prognostic factor analysis for 2-year survivors identified a good performance status as significant. Two-year survivors showed a higher response rate and underwent repeated treatments. We evaluated the effect of chemotherapy on QOL in 2-year survivors by quality-adjusted survival analysis known as a Q-TWiST (Quality adjusted Time Without Symptoms and Toxicity) analysis. If ut was nearly O, namely toxicity due to chemotherapy was severe, mean QTWiST at 2 years of follow was approximately 70% of the value when healthy.View full abstractDownload PDF (808K) -
Resected Solitary Lung Nodules in Patients who had Previously Undergone Resection of Malignant TumorShoko Kawanami, Hideyuki Watanabe, Takatoshi Aoki, Kumi Hatanaka, Haji ...1997 Volume 37 Issue 7 Pages 981-989
Published: December 20, 1997
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe CT and clinical features of 28 surgically resected solitary lung nodules which developed in patients in whom malignant tumors had previously been recected were evaluated. Pulmonary metastasis was the most frequent diagnosis comprising 15 of 28 (53-6%). Overall, 23 of the 28 (82.1%) were malignant tumors including 6 lung cancers and 2 unclassifiable cases. There were 5 benign lesions. On CT, most metastases were spherical with a smooth margin, and only 2 were non-spherical shape, while 5 showed a moderately irregular margin. They were frequently located in lower lobes. Five of 6 lung cancers were non-spherical with markedly irregular margins. A solitary lung nodule developing in a patient with a history of a malignant tumor is most likely to be a metastasis if it is spherical shape with a smooth margin on CT. However, lung cancer and benign lesions can also develop, therefore surgical resection seems to be necessary when a clinical diagnosis is not possible.View full abstractDownload PDF (5539K) -
Hiroki Moriyama, Kazuhiko Kataoka, Motoki Matsuura, Noritomo Senoo, Yo ...1997 Volume 37 Issue 7 Pages 991-995
Published: December 20, 1997
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA rare case of endobronchial granular cell tumor, which developed as a mass at the orifice of B3a of the right upper lobe, was treated with right upper lobectomy. A 57-yearold man under observation after surgery for cecal cancer underwent fiberoptic bronchoscopy twice at a clinic to clarify an abnormal shadow on chest X-ray. No definitive diagnosis was established. He was referred to our department for further examination. Bronchoscopy performed at our department revealed a polypoid lesion which almost completely occluded the orifice of B3a of the right upper lobe. Because the abnormal shadow on chest X-ray appeared larger compared with previous films, right upper lobectomy was performed under a suspected diagnosis of malignant tumor. Although intraoperable frozen-section analysis suggested hamartoma, the excised specimen after formalin fixation was diagnosed as granular cell tumor because it showed positive staining for PAS and S-100 protein. Endobronchial granular cell tumor is a rare condition with only 34 reported cases in Japan. Although granular cell tumor is considered to originate from nerve cells and is histologically benign, this tumor has been treated surgically in most cases.View full abstractDownload PDF (5703K) -
Hayato Inoue, Ken Nakagawa, Shigehiro Tsuchiya, Sakae Okumura, Kazunor ...1997 Volume 37 Issue 7 Pages 997-1002
Published: December 20, 1997
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTo elucidate growth patterns of early small cell lung cancer (SCLC), we describe a 52-year-old male case, a moderate smoker, with a small SCLC that occurred peripherally and was resected surgically. The tumor was found by an annual X-ray check up and was located in the right B2biα bronchus, and radiologically showed longitudinal growth along the bronchus. Surgical materials resected after induction therapy also demonstrated subepithelial and longitudinal spread of viable tumor cells despite remarkable decrease in size after the chemotherapy. This case provides solid evidence for subepithelial and longitudinal growth along the bronchus, which has been believed to be characteristic of SCLC.View full abstractDownload PDF (9612K) -
Metastasis Presenting as Thin-walled CavitiesMomoko Mitani, Takashi Seto, Hiroshi Semba, Yuji Fukai, Syunji Yoshima ...1997 Volume 37 Issue 7 Pages 1003-1008
Published: December 20, 1997
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA tumor on the flexural side of the left leg of a 30 year-old male was removed under the diagnosis of epitheloid sarcoma. Six years later his left leg was amputated for recurrence. In second case is a 45 year-old female, a tumor of the flexural side of her left arm was removed and found to be epitheloid sarcoma. Fourteen months after the operaion, she was admitted because of bloody sputum and the chest abnormal shadow. Their chest X-ray films and chest CT film showed multiple thin-walled cavities, which were proved pulmonary metastasis of epitheloid sarcoma by biopsy of their inner wall. The pathogenesis of cavitation is suspected to be related to tumor growth, central necrosis and drainage of the necrotic material from the bronchus. We assumed that thinning of the cavity wall is due to a check valve mechanism.View full abstractDownload PDF (9047K) -
Minoru Fukuda, Mikio Oka, Kenji Terashi, Fumihiko Narasaki, Seiji Naga ...1997 Volume 37 Issue 7 Pages 1009-1015
Published: December 20, 1997
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSAn 81-year-old man was admitted to our hospital and complaining of cough and dyspnea. Chest X-ray and CT showed a consolidation in right S8 and S9, hilar and mediastinal lymph node swelling, and emphysema. Small-cell lung carcinoma (SCLC) was diagnosed by cytological examination of sputum and bronchial washing from theright B9a. The clinical stage was evaluated for extensive disease (T4N2M0). Because of his age and renal dysfunction, four cycles of combination chemotherapy with etoposide (75mg/m2, days 1-3) plus carboplatin (target AUC=5, day 1) using the Chatelut formula were performed. The total tumor volume was reduced to 30% and a partial response was achieved. Actual carboplatin AUC at the first cycle was 4.42mg.min/ml, which was slightly lower than the target AUC. Manageable bone marrow suppression in combination with G-CSF and less toxicity including renal injury, nausea/vomiting, and appetite loss were observed. This regimen is potentially feasible and effective for elderly or renal function-impaired patients with SCLC.View full abstractDownload PDF (5948K) -
Kazuhiko Shibata, Kazuyoshi Kanamori, Yuzo Yoshimi, Sogo Iioka, Masaki ...1997 Volume 37 Issue 7 Pages 1017-1022
Published: December 20, 1997
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 69-year-old man was admitted to our hospital because of massive pericardial effusion, which was diagnosed as malignant by pericardocentesis and pericardial biopsy. He underwent surgical pericardial drainage with topical installation of cytocidal drugs. Subsequent three cycles of systemic chemotherapy consisted of cisplatin, vindesine and mitomycin C resulted in partial response. The disease did not progress until the primary nodule enlarged three years later. No recurrence of lymph node metastases and pericardial effusion or emergence of other organ metastases were seen. He underwent left upper lobectomy as salvage surgery. Histologically, the tumor was diagnosed as poorly-differentiated adenocarcinoma composed of malignant cells with morphological similarity to those found in the biopsy specimen of the pericardium three years previously. No tumor cells were found in the dissected mediastinal lymph nodes and in the re-biopsied pericardium.View full abstractDownload PDF (10486K) -
Dong Ran Shen, Hideki Kimura, Naomichi Iwai, Naoyoshi Yamamoto, Shinic ...1997 Volume 37 Issue 7 Pages 1023-1028
Published: December 20, 1997
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 26-year-old man was admitted to our hospital with abnormal shadows in both lungs after resection of synovial sarcoma of his left arm. Anti-cancer chemotherapy and resection of the metastatic lung tumors were performed but pulmonary metastases recurred repeatedly. After the fourth thoracotomy, adoptive immunotherapy with IL-2 and LAK cells was added to the treatment. From February 1994 to April 1997, a total of 3 thoracotomies and 18 courses of IL-2, LAK therapy combined with chemotherapy were performed. The patient is in good condition 4 years after the initiation of the therapy. He suffered slight fever, trepidation and shaking chills soon after the transfer of IL-2 and LAK cells but he recovered within one or two days. The extention of recurrence interval and decrease of the number of metastatic foci were attributed to the effect of immunotherapy.View full abstractDownload PDF (7920K) -
Hiroyuki Tanaka, Hideo Kobayashi, Souichiro Kano, Naokazu Nagata, Shin ...1997 Volume 37 Issue 7 Pages 1029-1034
Published: December 20, 1997
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSCase 1 was a 45-year-old man who was admitted with mass in the right upper lobe.Percutaneous tumor biopsy revealed adenocarcinoma. Four months later, a metastatic tumor appeared on the right tonsil. After resection of the tonsil he was given irradiation. Although the metastatic tonsil tumor disappeared he died after 22 months.
Case 2 was a 61-year-old man who had been admitted with left gingival tumor. Chest roentgenogram showed a mass in the left hilum. He was given a diagnosis of large cell carcinoma of lung with gingival metastasis. After 30-Gy irradiation the gingival tumor disappeared. Because the primary lesion progressed he died after 4 months.
Case 3 was a 40-year-old man, admitted with a mass in the right upper lobe, in whom transbronchial biopsy revealed large cell carcinoma. One month later, a gingival tumor appeared and biopsy revealed it to be a metastatic tumor. After 60-Gy irradiation the gingival tumor disappeared. However liver and adrenal metastasis developed in the patient and he died after 4 months.View full abstractDownload PDF (9089K) -
Hirohisa Inaba, Shinichiroh Ohta, Toshihiko Nishimura, Kazuya Takamoch ...1997 Volume 37 Issue 7 Pages 1035-1040
Published: December 20, 1997
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESS67-year-old man with a past history of total gastrectomy for gastric cancer and right nephrectomy for renal pelvic cancer was admitted to our hospital because of left chest abnormal shadows. His chest X-ray film revealed a tumor shadow with pleural indentation in left S3 and another nodular shadow adjacent to the aortic arch in the left upper lung field. The tumor in left S3 was diagnosed as primary lung cancer, but the nodule in the para-aortic region could not be diagnosed. Left upper lobectomy and resection of the nodule with mediastinal pleura and adventitia of the aorta was performed. Histopathological diagnosis of this nodule was malignant fibrous histiocytoma which had originated in the mediastinum and invaded the left lung. Malignant fibrous histiocytoma originating from the mediastinum is very rare.View full abstractDownload PDF (6208K) -
Yuji Morita, Shin Teramoto, Kaoru Nishiyama, Akihiro Imada, Michio Hir ...1997 Volume 37 Issue 7 Pages 1041-1045
Published: December 20, 1997
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe report a rare case of malignant pleural mesothelioma in which tumor cells were detected in sputum. A 67-year-old man was admitted for evaluation of irregular pleural thickening on chest films. Productive cough and right chest pain had gradually increased. Tumor cells which resembled adenocarcinoma cells were detected in sputum. Malignant mesothelioma of the pleura (epithelial type) was diagnosed based on electron microscopic findings and special and immunohistochemical stainings of specimens obtained by percutaneous pleural biopsy.View full abstractDownload PDF (6094K) -
Makoto Sawafuji, Haruhisa Matsuguma, Kohei Yokoi, George Imura, Naoto ...1997 Volume 37 Issue 7 Pages 1047-1051
Published: December 20, 1997
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe report a case of long-term survival of an adolescent patient with primary lung adenocarcinoma accompanied by mediastinal lymph node metastasis. A 15-year-old girl was referred to our hospital because an abnormal shadow had been detected on her annual screening chest X-ray film. Chest CT showed a mass in the left S8 area of the lung without hilar or mediastinal lymphadenopathy. Cytologic examination of the specimen obtained by fiberoptic bronchoscopy revealed adenocarcinoma. Left lower lobectomy with mediastinal lymph node dissection was performed in August, 1989. Pathologic examination of the resected specimen demonstrated moderately differentiated adenocarcinoma of tubular type (acinar adenocarcinoma) of the lung and metastasis in a subcarinal lymph node. No postoperative adjuvant therapy was administered. She is currently well 8 years after operation. According to our review of the literature in Japan, this is the first long-term survival of adolescent patient with primary lung cancer associated with mediastinal lymph node involvement.View full abstractDownload PDF (3484K) -
1997 Volume 37 Issue 7 Pages 1052-1064
Published: December 20, 1997
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (1912K)
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