Haigan
Online ISSN : 1348-9992
Print ISSN : 0386-9628
ISSN-L : 0386-9628
Volume 38, Issue 4
Displaying 1-9 of 9 articles from this issue
  • [in Japanese], [in Japanese]
    1998 Volume 38 Issue 4 Pages 297-300
    Published: August 20, 1998
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
  • Takashi Niimi
    1998 Volume 38 Issue 4 Pages 301-307
    Published: August 20, 1998
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    Interleukin 12 (IL-12) plays a critical role in the promotion of T helper 1 phenotype lymphocytes. It has also been considered to be important for development of the antitumor immune response. I therefore investigated the production of IL-12 by peripheral blood mononuclear cells (PBMCs) on stimulus with lipopolysaccharide (LPS) and interferon-γ(IFN-γ) or phytohemagglutinin (PHA). Levels of IL-12 were determined by an enzyme-linked assay method in 11 patients with advanced non-small cell lung cancer and 11 healthy controls. There were no significant differences in IL-12 production stimulated by LPS+IFN-γ in lung cancer patients and healthy controls. However, the production of IL-12 stimulated with PHA in the lung cancer cases was significantly lower than that in healthy controls (P<0.05). IL-12 production was not dependent on tumor histological type, clinical stage or performance status. The results obtained in this study suggest a decrease in IL-12 production in lung cancer patients associated with lymphocyte dysfunction.
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  • Hajime Maeda, Osamu Kuwahara, Takashi Mori, Satoru Yamamoto, Noboru Ya ...
    1998 Volume 38 Issue 4 Pages 309-316
    Published: August 20, 1998
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    Thirty eight cases of thymic carcinoma were treated in National Chest Hospitals between 1986 and 1995. These cases included 22 squamous cell carcinomas and 7 undifferentiated carcinomas. We then analyzed these 2 histologic types retrospectively and investigated the relationship between treatment and prognosis. We applied Masaoka's clinical staging for thymoma. Squamous cell carcinoma consisted of 1 Stage I case, 6 Stage II cases, 7 Stage III cases, 3 Stage N a cases, and 5 Stage N b cases. In undifferentiated carcinoma, there were 3 Stage III cases, 1 Stage N a case, and 3 Stage N b cases. On interim analysis, the five year survival was 52% in squamous cell carcinomas and 35% in undifferentiated carcinomas. In stage I and II cases, it was considered that good prognosis would be expected following surgery and postoperative radiation therapy. In stage III or more advanced cases, it was suggested that induction therapy by concurrent chemoradiation followed by surgery would contribute to improvement of the results in treatment for thymic carcinoma.
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  • Koji Hayashi, Kanae Fukushima, Yuzo Sagara, Yuji Siraishi, Akira Hebis ...
    1998 Volume 38 Issue 4 Pages 317-321
    Published: August 20, 1998
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    We studied the incidence of unsuspected lung cancers in patients who were admitted from October 1995 to March 1997 for evaluation of pulmonary emphysema.
    The 162 subjects patients with pulmonary emphysema, all underwent the 6 minute walking test (6MD).
    Lung cancers (5 squamous, 2 adeno, and 1 large cell carcinomas) were found in 8 patients (4. 9%). All were smokers (smoking index: 470-1, 840) and had severe obstructive impairments. Of the 8 patients 5 underwent surgery (2 lobectomies, 3 wedge resections).
    Our experience suggests that the incidence of unsuspected lung cancer is high in patients with pulmonary emphysema who are admitted for volume reduction surgery. For this reason, pre.operative evaluation of these patients must include sputum cytology and complete radiological examinations. To preserve pulmonary functions and QOL, limited resection under VATS is preferable in these patients.
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  • Akihisa Fujita, Takao Sohda, Hirotsugu Takabatake, Shigeru Tagaki, Kyu ...
    1998 Volume 38 Issue 4 Pages 323-334
    Published: August 20, 1998
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    A quality-adjusted survival analysis allows one to make treatment comparisons that incorporate differences in QOL associated with various health states. In this analysis, we define as health states the periods of time patients spend: a) in hospital for chemotherapy (toxicity; TOX): b) on an outpatient basis (TWiST: Time without Symptom and Toxicity), and in hospital for conservative therapy (relapse; REL). Utility coefficients to reflect the value of these health states were expressed as ut, uw and ur. If uw were 1 and ut and ur were plotted less than 1, utTOX+uwTWiST+urREL could be a quality-adjusted value relative to TWiST (CI-TWiST). One hundred ninety-six patients with a stage IIIB and N non-small cell lung cancer were included in 1986-96. One hundred seven patients were given a cisplatin-containing regimen in 1986-93, 38 patients received CIC-regimen (CDDP + IFO + CPT-11+ G-CSF) in 1994-96 and other 51 patients were treated with supportive care only. In the two years following start to treatment, the prognostic factors for Q-TWiST were investigated employing an automatic interaction detection. Chemotherapy contributed to Q-TWiST with the arbitrary utility coefficient values of ut>ur. CIC-regimen was a significant factor with the arbitrary utility co-efficient values of ut≥0.8 and ur≤0.7. CIC-regimen contributed to QOL marginally.
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  • Shuji Sato, Jun Asakura, Jun Hirano, Hideyuki Suzuki, Tadashi Akiba, Y ...
    1998 Volume 38 Issue 4 Pages 335-340
    Published: August 20, 1998
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    A 52-year-old man with a complaint of cough and sputum was referred to our hospital because of an abnormal shadow in the left upper lung field on chest X-ray films. The serum CEA level was 352.9 ng/ml. Cytological examination of a needle biopsy specimen revealed non-small cell carcinoma. The clinical stage was stage IIIB (T3N3αM0). The patient underwent surgery after induction chemotherapy. Left upper lobectomy and bilateral mediastinal dissection was performed via median sternotomy and an anterolateral incision. Histopathological examination demonstrated large cell carcinoma without lymph node metastasis (ypT3N0M0). The patient received 50 Gy of irradiation to the superior mediastinum because the surgical margin was histologically positive. After these treatments, the serum CEA level returned to normal. No recurrence has been detected and the serum CEA level has remained normal for 28 months postoperatively.
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  • Yoshinobu Hattori, Kouji Negi, Yasunori Kobayashi, Tooru Yamamoto, Shu ...
    1998 Volume 38 Issue 4 Pages 341-345
    Published: August 20, 1998
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    A 68-year-old woman underwent left upper lobectomy on September 25, 1990 because of primary left upper lobe lung cancer. The resected specimen demonstrated well differentiated adenocarcinoma and pathological stage I (pT1NOMO). Adjuvant chemotherapy (VP-16, CDDP) performed. Dyspnea appeared around July 1991. Chest CT and bronchofiberscopy revealed stenosis the left main bronchus but no tumor recurrence. A chest X-ray film on February 22, 1994 showed an abnormal shadow in the left upper lung field. Chest CT demonstrated a tumor in the left S6 and the result of CTguided needle biopsy suggested metastasis. She had no distant metastasis. Left completion pneumonectomy was performed on April 26, 1994. Clockwise torsion of the left main bronchus around the longitudinal axis at an angle of 90° was found. Histological study demonstrated two recurrent lung cancers. Postoperatively, she had no dyspnea and her performance status was Hugh-Jones grade 2. She died of systemic metastasis 3 years and 7 months after the left completion pneumonectomy.
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  • 1998 Volume 38 Issue 4 Pages 347-394
    Published: August 20, 1998
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
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  • 1998 Volume 38 Issue 4 Pages 395-402
    Published: August 20, 1998
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
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