All issues
Volume 39, Issue 2
Displaying 1-15 of 15 articles from this issue
- |<
- <
- 1
- >
- >|
-
[in Japanese], [in Japanese]1999 Volume 39 Issue 2 Pages 111-115
Published: April 20, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (525K) -
Katsuhiro Ueda, Keiichi Mikasa, Kaoru Hamada, Masahiro Sakamoto, Mitsu ...1999 Volume 39 Issue 2 Pages 117-124
Published: April 20, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSStudies have showen that 14-membered ring macrolides have various actions, in addition to antibacterial effects, in the long-term treatment of chronic lower respiratory tract infections. We reported that long-term treatment using clarithromycin (CAM), a 14-membered ring macrolide, was beneficial for patients with unresectable non smallcell lung cancer. In this study, we investigated the effects of CAM treatment on the expressions of cytokine mRNA in spleen cells of Lewis lung carcinoma cells in mice. Lewis lung carcinoma cells were injected into female C57BL/6 mice. Oral administration of CAM at a dose of 10mg/kg was given once a day. Mice were divided to four groups according to whether tumor was injected or not, or whether mice were treated by CAM or not. Spleen cells were examined by RT-PCR after 14 days treatment. In the case of non-tumor bearing mice, there was no difference in expression of cytokine mRNA between mice treated or not treated with CAM. However, in the case of tumor-bearing mice, expressions of IL-4, IL-12p40, IFN-γ mRNA increased and those of IL-6 mRNA decreased in CAM-treated mice compared to mice not treated with CAM. These results suggest that CAM might regulate the cytokine network in the tumor-bearing state.View full abstractDownload PDF (792K) -
Chimaengul Wushur, Yoshiro Ebihara, Harubumi Kato, Yuichi Ichinose, Ke ...1999 Volume 39 Issue 2 Pages 125-135
Published: April 20, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn order to know whether atypical adenomatous hyperplasia (AAH) is a precursor or early stage of well differentiated adenocarcinoma (WDA), we compared the histology of AAH and well differentiated adenocarcinomas morphologically. Materials consisted of 135 lesions of either AAH and WDA collected from 41 resected lung specimens at Tokyo Medical University Hospital between 1995 and 1997. AAH lesions were classified into lowgrade AAH (AAH-L), moderate-grade AAH (AAH-M), and high-grade AAH (AAH-H) histologically, and the nuclear DNA ploidy patterns, and the expressions of p53, Ki-67 and cyclin D1 were analyzed with an image cytometer and immunohistochemistry using monoclonal antibodies. Nuclear-DNA ploidy analyses revealed that 81.8% of WDAs were aneuploid, as were 66.7%, 31% and 24.3% cases of high, moderate and low AAHs respectively. Expression of p53, Ki-67, and cyclin D1 increased as the grade of AAHs increased, and was highest of all in carcinomas. All four parameters showed a tendency towards more aggressiveness in the low and moderate degrees of carcinoma-associated AAH than those of isolated AAH. These results suggest that AAHs could be a precursor lesion of WDA. In addition, there seem to be differences at the genetic level between isolated AAHs and carcinoma-associated AAHs even if they have the same degree of morphological abnormality.View full abstractDownload PDF (8660K) -
Takeshi Yamanda, Masahisa Miyazawa, Ryoichi Kondo, Emi Machida, Kazuo ...1999 Volume 39 Issue 2 Pages 137-143
Published: April 20, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe examined the clinicopathological findings of 40 cases of small peripheral lung tumors in which primary lung cancer were suspected and in which thoracoscopic excisional biopsy (wedge resection) was performed. The mean tumor diameter was 11.9 mm (5-30mm). Preoperative needle localizations were performed in 10 patients under computerized tomographic guidance. A conversion to open thoracotomy was needed in 4 patients, including 2 cases in which wedge resection was needed for a sufficient tumor margin (>20mm). The histologic diagnoses of the resected specimens revealed 27 primary lung cancers (25 adenocarcinomas, 1 squamous cell carcinoma and 1 small cell carcinoma), 3 atypical adenomatous hyperplasias, 2 hamartomas, 6 inflammatory lesions and 2 intrapulmonary lymphnodes. The mean tumor diameter of the 27 lung cancer lesions was 10.9mm (ranged from 3 to 22mm), and 18 of the 27 cases were very small, 10mm or less in diameter, lesions. After a definitive diagnosis of primary lung cancer was obtained, lobectomy and mediastinal dissections were performed in 18 patients, and segmentectomy and mediastinal dissection in 1 patient. In 8 patients, additional pulmonary resection was not performed. All 27 patients of primary lung cancer have survived without recurrence in the 18-month median follow-up period. Early detection by spiral computed tomography and thoracoscopic excisional biopsy (wedge resection) for diagnosis and treatment are thought to be useful to improve the prognosis of primary lung cancer.View full abstractDownload PDF (814K) -
Takamitsu Maehara, Michihiko Tajiri, Naoki Ishiwa, Makoto Ishibashi, F ...1999 Volume 39 Issue 2 Pages 145-151
Published: April 20, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSFifty-nine cases of surgically resected small peripheral lung adenocarcinoma, 2 cm or less in diameter, were reviewed using Noguchi's classification, and the correlation between thin-section CT images and the clinicopathological features was examined. All type A and B adenocarcinomas (n=21) had no recurrence, and 89% were the air-containing type by thin-section CT images. Increasing numbers of type C or type D adenocarcinoma and lymphnode metastasis were detected with tumor sizes of 1. 5 cm or more. Based on these results, a prospective study was started. VATS wedge resection was performed for adenocarcinoma to identify the air-containing type on thin-section CT with tumor sizes of 1. 5 cm or less. The findings were confirmed by frozen section diagnosis. VATS lobectomy was performed for solid type adenocarcinoma. Twenty-seven adenocarcinomas, 1.5 cm or less in diameter, were examined. Nineteen cases were the aircontaining type, and limited operation was performed in 14 of these cases (74%), showing type A or B adenocarcinoma and no recurrence. Limited operation was converted to VATS lobectomy in 5 cases because frozen section diagnosis indicated type C or the surgical margin was insufficient. Eight cases were the solid type, and revealed type C, D or F. Moreover, lymphnode involvement and recurrent malignant effusion were each found in one case. We recommend thin-section CT and intraoperative frozen section diagnosis to determine whether or not limited operation should be performed.View full abstractDownload PDF (1881K) -
Makoto Nishio, Atsuya Karato, Sakae Okumura, Shigehiro Tsuchiya, Yuich ...1999 Volume 39 Issue 2 Pages 153-157
Published: April 20, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe report an extremely rare case of endobronchial plasmacytoma. A 50-year-old man was seen in our institute for assessment of a left hilar mass that had been noted on a routine chest radiograph 3 years previously. A CT scan of the chest showed an endobronchial lesion in the left B3b bronchus. Bronchoscopy revealed the presence of an endobronchial polypoid tumor totally obstructing the left B3b bronchus. The histological examination of the biopsy specimens demonstrated atypical plasmacytoid cells infiltrating in the bronchial mucosa, which was monoclonally stained for immunoglobulin x-chain, suggesting plasmacytoma in the bronchus. Bone marrow biopsy did not show myeloma cells and there were 1.0% plasma cells. Serum and urine protein studies did not show M-protein. However, screening of skeletal bone showed punched out lesions in the skull. The patient was treated with radiation therapy and the endobronchial tumor disappeared. The patient is currently alive and free of disease 16 months after radiation therapy.View full abstractDownload PDF (5124K) -
Yoshiharu Ohno, Masahiko Kusumoto, Eiichiro Itouji, Chiho Ohbayashi, H ...1999 Volume 39 Issue 2 Pages 159-164
Published: April 20, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 60-year-old woman in whom progressive systemic sclerosis (PSS) had been diagnosed 2 years previously was admitted because of an abnormal mass shadow on a follow-up chest X-ray. On the plain chest X-ray taken on the admission, right hilar adenopathy and a mass in the right lower lobe were recognized. Ground glass shadow and linear shadows were shown in the bilateral lower lobes. However, on a contrast enhanced CT image, soft tissue density masses, which were concomitant with subpleural curvilinear lines, were observed in the right S9, and right hilar adenopathy was also determined. From the results of these examinations including a biopsy, the lesions were diagnosed as resectable primary lung cancer. Subsequently, a right middle and lower lobectomy was performed. The tumor was determined to be a large cell neuroendocrine carcinoma by microscopic and immmunohistochemical studies. The subpleural curvilinear line was also diagnosed as pulmonary fibrosis with PSS by a microscopic study. As a result, we diagnosed this case as a LCNEC with pulmonary fibrosis combined with PSS. We reported this case because large cell neuroendocrine carcinoma is rarely combined with PSS.View full abstractDownload PDF (8456K) -
Ryuji Takahashi, Hisashi Nakata, Yuji Mori, Shosaku Abe1999 Volume 39 Issue 2 Pages 165-170
Published: April 20, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 44-year-old man with a history of smoking was admitted to our hospital. Because he was noted to have a 16mm diameter mass lesion in right S6 on a chest computed tomogram. Three years before this admission, he had come to our hospital for a health examination. At that time, however, no abnormal shadow was seen on his chest roentgenogram, except for bullous change. Chest CT showed a sharply demarcated polypoid mass growing inside the bulla. We suspected a carcinoma or fungus ball contiguous to an area of bullous disease. The histological diagnosis of the tumor resected by open lung biopsy was adenocarcinoma growing inside the bulla. Right lower lobectomy was carried out. Histopathological examination revealed a proliferation of a dumb-bell shaped tumor most of which showed polypoid growth inside the bulla. The pathological staging was T1N0M0, stage I A. We discussed 100 similar cases of carcinoma reported in Japan with our case.View full abstractDownload PDF (5988K) -
Toshio Fujimoto, Akira Yamanaka, Takashi Hirai, Ryuta Yanagimoto, Shin ...1999 Volume 39 Issue 2 Pages 171-175
Published: April 20, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 56-year-old man, whose serum carcinoembryonic antigen (CEA) level had been 7.3ng/ml (normal <5.0) seven years earlier and increased as high as 237.9ng/ml, was referred to our hospital to investigate the causative malignancy. Chest roentgenography on admission showed no abnormal opacities. Chest computed tomography (CT) revealed a small irregular opacity 1 cm in diameter in right S3, and pretracheal (# 3) lymphadenopathy. This micronodule could be recognized on chest CT taken two years earlier, but could not be confirmed as a lung cancer. Exploratory thoracotomy was performed and the pretracheal lymph nodes were extirpated for frozen sectioning. The diagnosis of lymph node metastases of adenocarcinoma was obtained and subsequently right upper lobectomy and mediastinal lymph node dissection were performed. Immunohistochemical examination showed that the tumor cells stained positively with anti-CEA antibodies. Serum CEA declined remarkably after the operation. We reviewed the diagnostic significance of serum CEA with regard to unknown primary malignancies and evaluated preand postoperative levels of CEA as a prognostic indicator.View full abstractDownload PDF (7982K) -
Hideo Ichimura, Katsuyuki Endo, Mikio Doi1999 Volume 39 Issue 2 Pages 177-182
Published: April 20, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 70-year-old man was referred to our hospital for evaluation of a cavitary lesion in the left lung. Chest CT showed a mass lesion with a cavity, 17×12mm in size, in the peripheral region of left S1+2a. On thoracotomy giant cell carcinoma was diagnosed by frozen section, and left upper lobectomy was performed. Themaximum diameter of the resected tumor was 18 mm and no metastatic lymph node was detected, therefore this was an early peripheral lung cancer. This tumor was partly composed of well differentiated adenocarcinoma and electron microscopically, the giant cells had microvilli. An immunohistochemical comparison of the labelling indices of p53 protein and MIB-1 antibody among tumor components showed those of the giant cell carcinoma area to be higher than those of the adenocarcinoma area. This giant cell carcinoma may have been transformed by a dedifferentiation of an adenocarcinoma.View full abstractDownload PDF (9966K) -
Kenji Tsushima, Tomonori Koizumi, Orie Hatayama, Takashi Kobayashi, Ke ...1999 Volume 39 Issue 2 Pages 183-190
Published: April 20, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 53-year-old woman was referred to our hospital because of pleural effusion in the left side on chest X-ray on March, 1998. She had undergone an operation for left breast cancer in September 1995. The initial histological examination revealed grade II papillotubular type. After operation she was treated with radiotherapy and hormonal therapy. In 1998, she had dyspnea on effort, and the serum NCC-ST-439 level was 15.3 U/ml (normal range, <7U/ml). Her chest computed tomography (CT) revealed multiple masses in the left thoracic wall, left pleural effusion and mediosternal lymph nodes swelling. The patient was given a diagnosis of intrathoracic metastasis of breast cancer and received 6 courses of combination chemotherapy with Taxotere (40mg/body, days 1, 2), Adriamycin (40mg/body, days 1, 2) and Cyclophosphamide (400mg/body, days 1, 2) (TAC). After the chemotherapy, she achieved complete remission based on chest CT and the serum tumor marker levels. These was grade 4 of neutropenia, and bilateral pleural effusion, probably caused by fluid retention. However, the pleural effusion was not critical and quickly disappeared after the cessation of chemotherapy. The present case indicates that TAC combination chemotherapy can be effective as first line therapy of recurrent breast cancer.View full abstractDownload PDF (7839K) -
Masahiro Endo, Yoshiki Takada, Kiyonori Takatsuki, Masahiro Yoshimura, ...1999 Volume 39 Issue 2 Pages 191-195
Published: April 20, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe present a case report of very rare mediastinal leiomyosarcoma, describing mainly its diagnostic imagings. A 69-year-old-woman was admitted for dyspnea on exertion and an abnormal shadow on chest X-ray. The chest X-ray showed enlargement of the mediastinum and right pleural effusion. Chest computed tomography and magnetic resonance imagings showed a well-defined huge expanding tumor like a snowman in the middle and posterior mediastinum. As the tumor was non-homogeneously enhanced with contrast media, soft tissue sarcoma such as malignant schwannoma or leiomyosarcoma was suspected. As the symptoms, such as dyspnea, progressed rapidly, surgical treatment was immediately performed. Dyspnea improved after the en-bloc resection of the tumor, and the histological diagnosis was leiomyosarcoma based on immunohistochemical and electron microscopic findings.View full abstractDownload PDF (6685K) -
Takahiko Misao, Katashi Satoh, Takuya Kobayashi, Hideharu Nakano, Junp ...1999 Volume 39 Issue 2 Pages 197-201
Published: April 20, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 67-year-old man, a heavy smoker, visited our hospital after level D was diagnosed by sputum cytology in a lung cancer screening. Chest CT scan showed severe pulmonary emphysema and a small nodular lesion contiguous to emphysematous bullae in the left lower lobe. Six months later, level C was diagnosed by sputum cytology in our hospital. Serial examination of the sputum showed tumor cells resembling small cell carcinoma. A well defined nodular lesion 1.5 cm in diameter in left S10 was recognized on CT scan, and this was diagnosed as small cell lung cancer by bronchofiberscopic examination and CT-guided lung biopsy. The clinical stage was I A (T1NOMO). Left lower lobectomy and lymph node dissection was performed. The pathological specimen showed small cell carcinoma of the intermediate type. The pathological stage was I A (T1NOM0). We reported a rare case of peripheral early small cell lung cancer contiguous to emphysematous bullae in which tumor cells were detected in sputum.View full abstractDownload PDF (6401K) -
Kei Takeshita, Kazuhiro Yamaguchi, Toshinori Hashizume, Keiichi Kikuch ...1999 Volume 39 Issue 2 Pages 203-208
Published: April 20, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 46-year-old Japanese man was referred to us for evaluation of a huge mediastinal tumor with bilateral massive pleural effusion. Histological examination of the specimen obtained with percutaneous needle biopsy from the mediastinal tumor demonstrated Tcell type lymphoblastic malignant lymphoma. The pleural fluid was sanguineous and included atypical mononuclear cells. Adenosine deaminase activity (ADA) in the pleural effusion was 963.2U/L, higher than ever reported. Serum ADA was 19.9U/L. Multiple combination chemotherapy successfully induced complete remission. Although it has been reported that ADA of the pleural fluid in lymphoproliferative disorders and other diseases could increase, a high level of ADA in the pleural fluid is generally utilized as a marker to distinguish tuberculous from nontuberculous effusions. Since activated or immature T lymphocytes produce ADA, the extremely high ADA in the pleural effusion in the present case was considered to originate from T cell type lymphoma cells. The authors emphasize that T cell type lymphoma may be one of the important causes when extremely increased levels of ADA in the pleural fluid are found.View full abstractDownload PDF (7665K) -
1999 Volume 39 Issue 2 Pages 209-230
Published: April 20, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (3151K)
- |<
- <
- 1
- >
- >|