All issues
Volume 39, Issue 7
Displaying 1-14 of 14 articles from this issue
- |<
- <
- 1
- >
- >|
-
Akira Yokoyama1999 Volume 39 Issue 7 Pages 943-953
Published: December 25, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSGemcitabine hydrochloride, a novel antitumor agent, is a nucleoside analogue which is a competitive deoxycytidine inhibitor in DNA synthesis.
The efficacy of gemcitabine has been evaluated in numerous clinical trials in patients with non-small cell lung cancer (NSCLC) in many countries. In those studies, gemcitabine monotherapy produced a high response rate of over 20% and was well tolerated. The main adverse reactions were myelosuppression and mild non-hematologic toxicities. Furthermore gemcitabine produced better treatment results than monotherapy in combination with cisplatin which is the key drug for NSCLC. In randomized trials, single-agent gemcitabine was as effective as an established combination regimen and was more effective than that regimen in combination with cisplatin.
Since gemcitabine has a different mechanism of action from other anticancer agents for NSCLC and a mild toxicity profile, and it may be useful in developing new effective therapies for NSCLC.
Further investigation is warranted to assess the efficacy of gemcitabine combination therapy, not only with cisplatin, but with other new anticancer agents.View full abstractDownload PDF (1360K) -
Kiyoshi Takenaka, Akinobu Yoshimura, Tetsuya Okano, Masahiro Seike, Ko ...1999 Volume 39 Issue 7 Pages 955-962
Published: December 25, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn 64 patients with lung cancer complicated by idiopathic interstitial pneumonia (IIP), we retrospectively studied the outcome of the treatment for lung cancer and clinical features of acute exacerbation of TIP after treatment for lung cancer.
The incidence of acute exacerbation of TIP was 8.7%(2 of 23 patients) after anticancer chemotherapy, 14.3%(2 of 14 patients) after operation, and 25%(2 of 8 patients) after radiation therapy. Serum C-reactive protein level was significantly higher in the patients who developed acute exacerbation of IIP than in those who did not (CRP=5.12± 2.27, 2.26±2.29, respectively). On the contrary, there were no differences in the levels of serum lactate dehydrogenase, white blood cell count, erythrocyte sedimentation rate, PaO2, and %VC between the two groups. Pathologic presentations of surgically resected lungs did not show significant differences in the activity of IIP between the two groups.
Five of 6 patients who developed acute exacerbation of IIP died within 3 months after the treatment for lung cancer. We conclude that we should evaluate the activity of IIP more precisely using new markers for activity of IIP and on that basis select patients to be treated for lung cancer.View full abstractDownload PDF (897K) -
Focus on Stages I A and I BKazuro Sugi, Yoshikazu Kaneda, Hiroshi Hongou, Hiroshi Miyashita, Tats ...1999 Volume 39 Issue 7 Pages 963-968
Published: December 25, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe validity of the new TNM classification (1997) was assessed for resected lung cancer and some problems were discussed. Of 1034 patients with non-small cell carcinoma of the lung undergoing surgical resection after 1980, 908 patients with evaluable TNM factors were reviewed. According to the old staging system, the five-year survival rate was 70.7% for stage I patients, 45.6% for stage II patients, and 24.6% for stage III A patients, 0% for stage III B patients, and 13% for stage IV patients. According to the new classification, it was 71.6% for stage I A, 68.5% for stage I B, 50.0% for stage II A, 36.8% for stage II B, 25.7% for stage IIIA, 4.2% for stage IIIB, and 13% for stage N. With the new classification, the only significant differences were between stage II A and II B as well as between stages 1IIA and IIIB. Regarding stages I A and I B, if the tumor diameter was defined as<2cm for stage I A and≥2cm for stage I B, the five-year survival rate was 82.7% and 70.3%, respectively, (p=0.04), thus the tumor diameter probably more accurately reflected the prognosis.View full abstractDownload PDF (561K) -
Shun Xu, Satoru Kobayashi1999 Volume 39 Issue 7 Pages 969-974
Published: December 25, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSObjective: We evaluated the clinical significance of serum soluble Fas antigen (sFas) in patients with untreated primary lung cancer.
Methods: Forty-five cases of untreated primary lung cancer, including 22 squamous cell carcinomas, 17 adenocarcinomas, 6 small cell carcinomas and 15 healthy controls were studied. Serum samples were obtained. The sandwich method with an sFas kit reagent (MBL Company, Nagoya, Japan) was used.
Results: Compared with healthy controls, the levels of serum sFas in all cases of lung cancer were increased significantly in each pathological type and in each stage of lung cancer. In stage IV, sFas was significantly higher than in all other stages.
Conclusion: Serum sFas was increased in primary lung cancer. Its elevation may be related with the situation of carcinoma. In stage IV, sFas was significantly higher than other stags.View full abstractDownload PDF (608K) -
Yoshimasa Maniwa, Keiji Ataka, Tadanori Ohara, Kazue Kiyooka, Makiko K ...1999 Volume 39 Issue 7 Pages 975-980
Published: December 25, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSPurpose: The effect of an adenovirus mutant which replicated selectively in p53 mutant human tumor cells was investigated to establish a novel therapy for primary lung cancer.
Materials and Methods: AxE1AdB, a recombinant adenovirus which contains a deletion in the E1B region, was used for the following lung cancer experiments. For target cells, small cell lung cancer cell lines (SBC-3 and SBC-5), a pulmonary adenocarcinoma cell line (PC-3) and a squamous cell carcinoma (EBC-1) were used. SBC-3 retains wild-type p53 but the others show p53 mutation. These cells were infected with AxE1AdB at various multiplicities of infection (MOI), and cells death or growth were assessed after 4days by crystal violet staining.
Results: Growth of SBC-3 was not inhibited by AxE1AdB infection. SBC-5, PC-3, and EBC-1 were strongly damaged at MOIs more than 5.
Conclusions: AxElAdB killed the lung carcinoma with p53 mutation. Systemic medication of AxElAdB might target the cancer cells which have p53 mutation.View full abstractDownload PDF (6402K) -
Hiroshi Fujii, Shunji Takakura, Takashi Nishimura, Tsuyoshi Hasegawa, ...1999 Volume 39 Issue 7 Pages 981-985
Published: December 25, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe usefulness of ultrasonically guided needle biopsies (UGNB) for mediastinal tumors was retrospectively evaluated in 31 patients with mediastinal tumors who were admitted to our hospital from April 1995 to April 1998. In 18 cases of these, tumors were detected by ultrasonic examinations. Most of these (n=15) were located in the anterior mediastinum. UGNB were performed in 15 cases, but not in 3 cases because safer procedures could not be performed. An average of 3.2 punctures were done at each biopsy session. A definitive diagnosis was made in 9 (60.0%) of 15 cases. Aspiration biopsies were also useful in 1 lymphoma and 1 thymic cancer. UGNB showed highly diagnostic values but, in 3 cysts and 3 of 7 thymomas, specimens taken from UGNB were insufficient for diagnosis. Complications (Homer's syndrome due to hemorrhage in 1 patient and back pain in another one) were temporary and no special medications were necessary. We believe that real-time ultrasonographic guidance is a safe, easy and reliable method for biopsy of mediastinal tumors adjacent to the chest wall, apart from some limitations caused by cysts and thymomas.View full abstractDownload PDF (3635K) -
Masanori Tsuchida, Yasushi Yamato, Takahiro Souma, Katsuo Yoshiya, Tad ...1999 Volume 39 Issue 7 Pages 987-994
Published: December 25, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSObjective: The objective of this study was to evaluate perioperative problems in patients who underwent lung surgery for lung cancer associated with interstitial pneumonia (IP).
Study design: Retrospective study.
Results: There were 8 patients who underwent pulmonary resection for lung cancer associated with IP. Most were male heavy smokers. None had active IP at the time of operation. Standard surgery was performed in 4 patients, extended resection in 2, and limited resection in 2 patients. There was no correlation between surgical invasiveness and postoperative complications. There was one case of acute exacerbation of interstitial pneumonia, which developed into acute respiratory failure. That patient was treated with steroid pulse therapy and recovered. It seemed difficult to anticipate postoperative exacerbation of IP based on preoperative patient evaluation and the degree of surgical invasiveness.
Conclusion: We propose following points to prevent complications associated with surgery for lung cancer patients with IP: 1) appropriate evaluation of activity of IP, 2) selection of appropriate operative procedure, 3) oxygen supplementation should be limited, 4) careful observation of respiratory state after surgery. We believe that surgical treatment taking these points into consideration may improve survival in case of lung cancer associated with IP.View full abstractDownload PDF (6875K) -
Masahiro Yamasaki, Yukio Takeshima, Satoshi Fujii, Kouki Inai1999 Volume 39 Issue 7 Pages 995-1000
Published: December 25, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSObjective: The objective of this study was to examine correlations between histologi cal subtypes of lung adenocarcinoma according to the classification proposed by Noguchi et al. (Cancer 75: 2844-2852, 1995) and its clinicopathological factors, expression of p53 protein and proliferative activity.
Study Design: We encountered 107 lung adenocarcinomas measuring less than 3cm in greatest dimension which were surgically resected and divided into six histological subtypes according to Noguchi's classification. We examined clinicopathological factors, expression of p53 protein and proliferative activity by immunohistochemical stains.
Result: The number of cases were 4 of type A, 19 of type B, 46 of type C, 19 of type D, 8 of type E and 11 of type F. No correlation was found between histological subtype and age, but the number of male cases was much larger than that of female cases in type D. Lymph node metastasis was present in 28% of type C, 53% of type D, 50% of type E and 45% of type F, while type A and B had no metastasis. Expression of p53 protein was detected in 0%, 26%, 43%, 58%, 63% and 45% of types A, B, C, D, E and F, respectively. The mean values of the Ki-67 labeling index in types A, B, C, D, E and F were 3.4%, 5.0%, 12.4%, 29.4%, 22.8% and 17.7%, respectively.
Conclusion: We demonstrated correlations between histological subtypes according to Noguchi's classification and the rate of lymph node metastasis, expression of p53 protein and proliferative activity.View full abstractDownload PDF (3153K) -
Akihiro Yoshimoto, Hiroshi Tsuji, Eisuke Takazakura, Toshio Watanabe, ...1999 Volume 39 Issue 7 Pages 1001-1005
Published: December 25, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSAn 81-year-old man presented with productive cough. He was admitted because of an abnormal shadow in the left upper lung field on chest X-ray. Chest CT scan showed a multilocular mass shadow in left S1+2 with cavity formation and small shadows suggestive of metastases around the primary mass. One of the latter shadows also contained a cavity. Sputum cytology and pleural effusion cytology showed class V, small cell carcinoma. The transbronchial lung biopsy specimen showed many small cells with dense nuclei and scanty cytoplasm, so a diagnosis of small cell carcinoma was made.
Cavity formation in primary carcinoma of the lung is fairly common, with the reported incidence ranging from 2 to 16 percent. However most such cases are squamous cell carcinoma or adenocarcinoma, not small cell carcinoma. Small cell carcinoma showing a multilocular mass shadow with cavities in the primary and a metastatic lesion, as seen in the present case, is rare.View full abstractDownload PDF (5204K) -
Kyosuke Kawakami, Kazuhiro Minou, Hiroiku Hara, Shigeki Sugiyama, Masa ...1999 Volume 39 Issue 7 Pages 1007-1012
Published: December 25, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSBackground: Cases of lung cancer associated with cardiac sarcoidosis, cardiomyopathy and pulmonary sarcoidosis are extremely rare.
Case: A 61-year-old woman, treated for 5 years for dilated type cardiomyopathy and ventricular tachycardia, was admitted with sputum and dyspnea. Despite treatment for pneumonia, an abnormal nodular shadow remained in the left upper lung field on chest X-ray. Further examinations revealed lung cancer in the left upper lobe with small multiple nodules in the left lower lobe suspicious of pulmonary metastasis. Since they did not seem to be typical pulmonary metastatic lesions, thoracoscopic biopsy was performed. Frozen sections of the lower lobe lesions revealed sarcoid granulomas. The present case was thought to be primary lung cancer associated with sarcoidosis. We subsequently performed segmental resection of left S1+2 and S3.
Conclusion: In lung cancer cases associated with other diseases, care should be taken not to overestimate the stage.View full abstractDownload PDF (6402K) -
Hiroshi Yuasa1999 Volume 39 Issue 7 Pages 1013-1016
Published: December 25, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSCase: A 50-year-old man was admitted with a bulging right anterior chest wall due to a mass 10cm in diameter, and laboratory data revealed systemic inflammation. The chest X-ray film showed infiltration in the right lung field, and a CT scan showed a mass shadow measuring 10cm in diameter in the lung and chest wall. Lung cancer invading the chest wall was suspected, but cytology by bronchofiberscopy and biopsy through the chest wall did not yield a diagnosis. Gram staining showed actinomycosis. Treatment with penicillin was started, and the mass disappeared within one month.
Conclusion: Actinomycosis should be considered in the differential diagnosis of a mass in the chest wall.View full abstractDownload PDF (4171K) -
Shingi Takahashi, Shinichirou Iwakami, Kiichi Hasunuma, Yoshinosuke Fu ...1999 Volume 39 Issue 7 Pages 1017-1023
Published: December 25, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSBackground: There have been very few reports describing the association between mediastinal germ cell tumor and hematologic malignancies. We here present a case with a review of the literature.
Case: A 24-year-old man was admitted to our hospital for further evaluation of a mass shadow in the anterior mediastinum. The diagnosis of germ cell tumor was made by the elevation of serum AFP, LDH and the findings on the chest CT and MRI, although we could not obtain a pathological specimen due to severe thrombocytopenia. After induction chemotherapy consisting of CDDP, VP-16 and BLM, serum levels of AFP, LDH decreased to within the normal range, and his thrombocytopenia improved. Subsequently, tumor resection was performed. The peripheral blood smear showed blast cells and blasts were positive for the platelet glycoprotein CD41 and CD61. A bone marrow biopsy specimen showed atypical megakaryocytes. From these results, a diagnosis of acute megakaryoblastic leukemia (M7) was made. The patient was treated by chemotherapy and bone marrow transplantation, but he died of the progression of M7, 11 months after admission.
Conclusion: This is the fourth case report of the syndrome of mediastinal germ cell tumors associated with hematologic malignancies in Japan, and two of these hematologic malignancies were M7.View full abstractDownload PDF (10245K) -
Masahiro Endo, Yoshifumi Miyamoto, Masahiro Yoshimura, Yoshiki Takada, ...1999 Volume 39 Issue 7 Pages 1025-1030
Published: December 25, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSBackground: Primary mediastinal liposarcoma is rare. We report a case of liposarcoma diagnosed preoperatively by computed tomography and magnetic resonance imaging.
Case: A 59-year-old man with an abnormal shadow on chest X-ray and complaining of hoarseness was referred to our center for further investigations and treatment. The chest X-ray showed enlargement of the right upper mediastinum and leftward shift of the trachea. Contrast-enhanced chest computed tomography (CT) demonstrated a tumor with fatty density extended from the upper mediastinum to the right side of the neck, containing a heterogeneously enhanced area in the right subclavicular region. Magnetic resonance (MR) imaging of the tumor showed the same signal intensity as fatty tissue in the posterotracheal region and a slightly lower signal intensity in the cervical region. The differences of signal intensity were considered to reflect the difference in the fat component content. The tumor in the right subclavicular region, which showed a high signal intensity on the T2-weighted image, was considered to be myxomatous. The pathological diagnosis was mixed-type liposarcoma composed of well-differentiated and myxoid area.
Conclusion: CT and MR images were useful in the diagnosis of mediastinal liposarcoma and corresponded well with the pathologic findings.View full abstractDownload PDF (8789K) -
1999 Volume 39 Issue 7 Pages 1031-1057
Published: December 25, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (4306K)
- |<
- <
- 1
- >
- >|