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Volume 40, Issue 3
Displaying 1-11 of 11 articles from this issue
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Hiroyuki Nakamura, Toshio Hashimoto, Hisanaga Yagyu, Gen Sarashina, Fu ...2000 Volume 40 Issue 3 Pages 179-184
Published: June 20, 2000
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSObjective Although bone metastasis from lung cancer is generally revealed by bone scintigraphy, this diagnostic method has many shortcomings, such as false positive results, high cost, limited availability to certain institutes, flare phenomenon, and difficulty in evaluating therapeutic responses of bone metastatic lesions. In recent years, development of new bone metabolic markers has dramatically advanced. In the present study, we evaluated the usefulness of Type I collagen N-terminal telopeptide (NTx), a metabolite of type I collagen, for the diagnosis of bone metastasis from lung cancer.
Methods and Results: The mean urinary NTx level was 112.7±83.9 nM BCE/mM Cr in lung cancer patients with bone metastasis, whereas lung cancer patients without bone metastasis had a significantly lower level (p<0.001). In patients who could be followed up, the urinary NTx levels significantly increased as bone metastasis progressed (p=0.008). The NTx levels at the time of detection of bone metastasis during follow up were significantly higher than those observed at initial examination (p=0.028).
Conclusions: NTx is useful for auxiliary diagnosis of bone metastasis, and can quantify bone metastasis with some accuracy. This marker is also thought to be an auxiliary parameter for the evaluation of progression of bone metastasis.View full abstractDownload PDF (911K) -
Yasuhiro Ieda, Nobuyuki Yamamoto, Sachiko Sakai, Makoto Yoshida, Takeh ...2000 Volume 40 Issue 3 Pages 185-189
Published: June 20, 2000
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSPurpose: We conducted a pilot study of Docetaxel (60mg/m2) in patients with advanced non-small cell lung cancer (NSCLC) who were refractory to prior cisplatin (CDDP) or irinotecan (CPT-11)-containing chemotherapy regimens.
Subjects: Twelve patients were entered into the study, and were treated with 60mg/m2 of Docetaxel intravenously over 1.5 hours every 3 or 4 weeks. Most patients had a performance status (PS) (ECOG) of 1, the predominant histologic type was adenocarcinoma (58%), and all patients had stage IV disease. Prior chemotherapy had resulted in no change in of seven of 12 patients and progressive disease in two of 12 patients.
Results: Two of 12 assessable patients achieved a partial response (16.7%) to treatment. The response duration (from response to progression) was 5.8 and 2.3 months, and the projected median survival time of all patients was 170 days (285 days for PS 0, 1 and 116 days for PS 2). Grade 3/4 neutropenia occurred in 58% of patients and was not associated with fever. Other acute side effects included easily treated nonhematologic toxicities. Primary side effects were neutropenia.
Conclusions: Although our data are preliminary, it is possible that Docetaxel administered at a based 60mg/m2 intra-venously every 3 or 4 weeks has notable activity against CDDP or CPT-11 -refractory NSCLC with good PS.View full abstractDownload PDF (655K) -
Hidehito Matsuoka, Noriaki Tsubota, Masahiro Yoshimura, Yoshihumi Miya ...2000 Volume 40 Issue 3 Pages 191-194
Published: June 20, 2000
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSObjective: To investigate the relationship between the malignant potential of carcinomas and an extended segmentectomy;(segmentectomy with resection of an adjacent subsegment and hilar and mediastinal lymph nodes).
Materials and Methods: Ninety-four patients with peripheral pulmonary adenocarcinomas 20 mm or less in diameter underwent operations from 1992 to 1998. Segmentectomy with mediastinal lymphnode dissection or lymphadenectomy was performed. They were examined pathologically on the basis of the Noguchi's criteria.
Results: Of 57 cases (60.6%) of Noguchi's type C adenocarcinomas, conventional lobectomies were performed in thirty-two cases. Of these patients, 17 cases were converted from segmentectomy with various reasons intraoperatively. Twelve cases that underwent lobectomy were advanced cancer patients and 4 of those died of recurrence. The 5-yearsurvival rate of lobectomy group was 69.0%(mean observation period 30 months) and that of type D, E and F was 70.5%. Twenty-three patients with the segmentectomy were classified as early cancer by the postoperative pathological examination. All patients are alive (mean observation period 35 months) without recurrence.
Conclusions: 1) Noguchi's type C are classified into two groups of favorable and poor C prognosis. 2) Extended segmentectomy is indicated to some cases selected on the basis of intraoperative examinations including pathological examinations of frozen section.View full abstractDownload PDF (517K) -
Takashi Hirano, Hiromi Takekawa, Toshimitsu Hiyoshi, Fumiko Taguchi, T ...2000 Volume 40 Issue 3 Pages 195-200
Published: June 20, 2000
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSObjective: The usefulness of two-dimensional polyacrylamide gel electrophoresis (2-DE) combined with nonenzymatic sample preparation technique of surgically resected primary lung adenocarcinoma was discussed in terms of tumor malignancy.
Study Design: Measurment of clinical materials was successful in 70 patients with primary lung adenocarcinoma between 1994 and 1996. We estimated the expression levels of the polypeptides associated with histopathological type as previously described (i. e. polypeptides associated with adenocarcinoma, TA01-05; polypeptides associated with squamous cell lung carcinoma, TSq01-04; polypeptides associated with neuroendocrine tumor, TS01-04) and proliferating cell nuclear antigen (PCNA) on 2-DE gels at the same time. Based on these data, all adenocarcinoma cases were classified into two groups and we attempted to evaluate the relationship between histopathological factors and prognosis in both groups.
Results: We classified 26 cases (37.1%) as adenocarcinoma case with a typical 2-DE pattern and 44 cases (62.9%) as aadenocarcinoma with an atypical 2-DE pattern. The 3-year disease-free survival rates were 69.2% and 27.1%in typical cases and atypical cases, respectively, showing a statistically significant difference (p=0.0011). In stage I cases therewas also a statistically significant difference (3-year disease-free survival rate: typical cases, 94.1%; atypical cases, 46.7%; p=0.0030).
Conclusion: There is a strong possibility that 2DE evaluation may reflect biological malignancy of surgically resected primary lung adenocarcinoma.View full abstractDownload PDF (1860K) -
Hidenori Hara, Shi Xu Jiang, Keiichi Iwabuchi, Jun Shinada, Hirokuni Y ...2000 Volume 40 Issue 3 Pages 201-205
Published: June 20, 2000
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSBackground: Making a diagnosis of primary malignant melanoma of the lung is difficult, because it must meet strict criteria to interpret the lesion as primary.
Case: A 63-year-old woman was referred to us for an abnormal shadow on routine chest X-ray film. A nodular lesion of about 3 cm in diameter was found in S8 of the right lower lobe. Since a definitive diagnosis was not obtained by fiberoptic bronchoscopy, thoracotomy was performed. A diagnosis of malignant melanoma was made by frozen section, and right lower lobectomy with mediastinal lymph node dissection (R2a) was performed. Histologically, the tumor was malignant melanoma with “junctional change” in the adjacent bronchial epithelium. Furthermore, multiple melanocytes regarded as non-neoplastic were present in some bronchioles distal to the tumor. Postsurgically, extensive examinations of various sites including the skin, mucosa, scalp, genital and anal regions, and eyes revealed no melanocytic lesion. She had also no past history of excision or fulguration of any skin lesions. Therefore, we presumed the lesion in the lung to be primary.
Conclusion: We report a case of primary malignant melanoma of the lung. It is extremely rare and only less than 25 cases have been reported so far to the best of our knowledge.View full abstractDownload PDF (3026K) -
Arifumi Iwamaru, Tomohiro Abiko, Hirohisa Horinouchi, Makio Mukai, Koi ...2000 Volume 40 Issue 3 Pages 207-211
Published: June 20, 2000
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSBackground: Pleomorphic carcinoma of the lung is a type of carcinoma with spindle and/or giant cells. This new histological concept was first described in the new Histological Typing of Lung and Pleural Tumors (third edition) which was updated in 1999. We reported a 71-year-old woman with pleomorphic carcinoma of the lung.
Case: Chest CT revealed atelectasis of the left lung. Bronchoscopic findings revealed a polypoid tumor from the left upper lobe, which extended to the left main bronchus. After effective electrosurgical snare polypectomy and laser ablation, we successfully performed left upper lobectomy. Histological findings showed a mixture of spindle and giant cell features.
Conclusion: This histological findings yielded a pathological diagnosis of pleomorphic carcinoma. Pleomorphic carcinoma has often been mistaken for sarcma or carcinosarcoma, however this concept was newly definited in the WHO Classification of Lung and Pleural Tumors in 1999.View full abstractDownload PDF (3425K) -
Hidehiko Matsumoto, Hiroki Ogawa, Hironobu Toyoyama, Masakazu Yanagi, ...2000 Volume 40 Issue 3 Pages 213-218
Published: June 20, 2000
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSBackground: Generally, lung cancer with pulmonary metastasis has poorer prognosis than cases without metastasis. We report a long-surviving lung cancer with pulmonary metastasis.
Case: A 62-year-old man was admitted because of slight fever and hemoptysis. Chest X-ray and chest CT film revealed a right hilar mass shadow and multiple nodular shadows in the right lower lobe of the lung. Right middle and lower lobectomy was done, and histological examination of the right hilar tumor and 12 nodules in the right S8 segment revealed moderately differentiated squamous cell carcinoma, probably due to intrabronchial metastasis from primary hilar tumor. The patient survived more than 12 years and died of cardiac failure.
Conclusion: We report a long surviving lung cancer patient with concomitant multiple intrapulmonary metastases.View full abstractDownload PDF (4635K) -
Kenichiro Inoue, Noriya Hiraoka, Yoshihiro Kasamatsu, Yutaka Kawahito, ...2000 Volume 40 Issue 3 Pages 219-221
Published: June 20, 2000
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe report a case of pneumonitis caused by irinotecan (CPT-11). A 55-year-old man was admitted for further evaluation and treatment of small cell lung cancer (SCLC). After irradiation for a focal brain metastatic lesion, irinotecan was administered intravenously. Three weeks after the chemotherapy, he had a high fever with diffuse patchy attenuation on a chest computed tomography (CT) scan. A significant increase in the number of mast cells in his bronchoalveolar lavage (BAL) fluid was also found. The pneumonitis was subsequently controlled by steroid therapy, with a decrease in the number of mast cells in the BAL fluid.View full abstractDownload PDF (1512K) -
Shinya Okada, Motoshige Kudo, Yoshiro Ebihara, Dilinur Payzulla, Hisas ...2000 Volume 40 Issue 3 Pages 223-229
Published: June 20, 2000
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSBackground: We encountered a case of granular cell tumor (GCT) arising in the left B1+2c. GCT, first described in the bronchus by Kramer in 1939. This type of case is still rare and only about 33 cases have been reported so far in Japan. Clinicopathological aspects of GCT arising in the lung so far reported in Japan are reviewed.
Case: An abnormal shadow was detected by chest x-ray in the left upper lung field of a 39-year-old man. Bronchoscopy disclosed a polypoid, yellowish-tan submucosal tumor, obstructing the lumen of left B1+2c. Brushing smear and postbrushing lavage fluid cytologic preparations obtained numerous tumor cell clusters composed of cells with small round nuclei and abundant granular cytoplasm, often possessing intracytoplasmic inclusion bodies. Left upper lobectomy was performed and the 1.2×1.2×1.2cm tumor was histologically shown to be GCT, consisting of round to oval cells with abundant oxyphilic granular cytoplasm with diastase-resistant PAS-positive intracytoplasmic bodies. Hyalinized thickening of the subepithelial basement membrane was seen, and the overlying epithelium showed squamous metaplasia or ulceration. Immunohistochemically, tumor cells were positive for S-100 and NSE. p53 oncoprotein was also strongly positive (79%). Ultrastructurally, angulate body-like lysosomes, myelin structures, desmosome-like apparatus, and basal lamina were observed. DNA image cytometry demonstrated DNA diploidy. No tumor recurrence or metastasis has been noted in the four years since surgery.
Conclusion: Our case supports the concept of a peripheral nerve sheath origin of GCT.View full abstractDownload PDF (3197K) -
Norihiko Ishikawa, Toshihiko Hashizume, Toshihiro Ishikawa, Yushi Kawa ...2000 Volume 40 Issue 3 Pages 231-235
Published: June 20, 2000
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSBackground: Lung cancer arising from the wall of bulla is rare.
Case: A 63-year-old man was admitted complaining of back pain and hemosputum. His chest CT and MRI revealed an emphysematous bulla with a thickened wall in the right lower lobe and a chest wall mass involving the 7th and 8th ribs. Percutaneous aspiration cytology revealed malignant cells and percutaneous biopsy suggested large cell carcinoma of the lung. Right lower lobectomy with chest wall resection and lymph node dissection was performed. The pathological diagnosis was a poorly differentiated squamous cell carcinoma arising from the wall of the bulla (p-T3N0M0 stage IIB). Radiation therapy was started after the operation and the patient has been doing well for five months without a sign of recurrence.
Conclusion: We report a case of squamous cell carcinoma arising from an emphysematous bulla with chest wall invasion.View full abstractDownload PDF (2411K) -
2000 Volume 40 Issue 3 Pages 237-243
Published: June 20, 2000
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (1249K)
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