All issues
Volume 41, Issue 7
Displaying 1-9 of 9 articles from this issue
- |<
- <
- 1
- >
- >|
-
[in Japanese], [in Japanese]2001 Volume 41 Issue 7 Pages 747
Published: December 20, 2001
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (49K) -
Miki Nishikubo, Keiko Kuriyama, Jun Arisawa, Chikazumi Kuroda, Masayuk ...2001 Volume 41 Issue 7 Pages 749-753
Published: December 20, 2001
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSObjective: The detection of localized ground-glass opacity (GGO) on HRCT is important for the diagnosis of peripheral adenocarcinomas with a bronchioloalveolar growth pattern of alveolar lining cells. We report two cases of benign lesions 2 cm or less in diameter that showed localized GGO (80% or more of the lesion area).
Materials and Methods: The extent of GGO within lesions on preoperative HRCT in 232 surgically resected small lung nodules (≤2cm) was reviewed retrospectively by three chest radiologists. Forty-nine lesions (≤2cm) with GGO (80%≥) on HRCT in 49 patients (22 men and 27 women; mean age, 58.2 years) were studied.
Results: Forty-seven out of 49 lesions with GGO (80%≥) were adenocarcinomas (Noguchi's classification for small adenocarcinoma: type A; 22, type B;, 20, type C; 5), and two lesions were benign lesions, pulmonary lymphoproliferative disorder and sarcoidosis. In a 37-year-old-man with pulmonary lymphoproliferative disorder, HRCT revealed a nodule with GGO (15mm), and a slight increase in size, 2 year later. Wedge resection was performed, and analysis showed that the resected specimen was pulmonary lymphoproliferative disorder. In a 69-year-old-woman with sarcoidosis, bilateral hilar lymph node enlargement was noted on chest radiographs, and HRCT revealed a nodule with GGO (8mm). Partial resection and hilar lymph node biopsy was performed, and analysis showed that the resected specimen was sarcoidosis.
Conclusion: Most peripheral lung lesions (≤2cm) with an 80% or greater area of GGO on HRCT are adenocarcinomas, type A or type B; however, in such cases it is also necessary to consider benign lesions such as pulmonary lymphoproliferative disorder and sarcoidosis.View full abstractDownload PDF (3073K) -
Yoshinori Kawabata, Satoshi Kanauchi, Toshiko Hoshi, Tomohiko Ikeya, K ...2001 Volume 41 Issue 7 Pages 755-762
Published: December 20, 2001
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSObjective: To reevaluate the pathogenesis of pulmonary infarction following lung tumors, after an experience with venous infarction. To date, pulmonary infarction is considered arterial, especially pulmonary thrombo-embolism.
Subjects and Methods: Twenty-six patients with pulmonary infarctions following lung tumors among 594 lobectomies and one surgical lung biopsy. Patients with infarction consisted of 21 men and 6 women and the mean age was 59.
Pulmonary infarctions were divided into arterial, mixed, and venous according to the degree of arterial and venous obstruction or stenosis and location of the infarction; centrilobular or centri-septal. Infarctions were evaluated macroscopically and microscopically and scored semi-quantitatively.
Results: There were 7 arterial, 16 mixed, and 4 venous infarctions. Although marked overlaps existed among all three groups, the degree of arterial lesions (2.7±0.5: 1.3±0.5) and venous lesions (0.7±0.5: 2.8±0.5) around the infarction significantly differed (<5%) between the arterial and venous infarction groups. There was no thrombus in or around fresh infarction. The location of infarction (centrilobular: centriseptal) was also significantly different (<1%) between the two groups (arterial 5: 0, venous 0: 13).
Conclusion: Recognition of venous infarction is important in understanding the pathogenesis of pulmonary infarction.View full abstractDownload PDF (3176K) -
Masao Nakata, Hideyuki Saeki, Akira Kurita, Shigemitsu Takashima2001 Volume 41 Issue 7 Pages 763-766
Published: December 20, 2001
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSObjective: The purpose of this study was to evaluate the clinical significance of video -assisted thoracoscopic lobec -tomy (VATS lobectomy) for primary lung cancer.
Method: From April 1995 to December 2000, 98 patients with non-small cell lung cancer underwent VATS lobectomy in our institution. Of these patients, 80 were classified as cIA, 13 as cIB, 2 as cIIA, 2 as cIIIA, and 1 as cIIIB. The pathological stages were IA in 65 patients, IB in 18, IIA in 4, IIB in 3, IIIA in 7, and IIIB in 1. The clinical outcome of these patients was compared with that of open thoracotomy performed during the same period.
Results: Three-year survival rates of VATS lobectomy and open thoracotomy for cIA lung cancer were 91.7% and 73.0%, respectively. The outcome of VATS lobectomy was significantly better compared with thoracotomy (p=0.02). There were no differences in 3-year disease free survival in all cIA lung cancer patients, even in cIA lung cancer 2cm or more in diameter. The operation time of VATS lobectomy was 183.7±52.5 minutes (95-330) and the intraoperative blood loss was 203.9±230.0ml (15-1345). Postoperative hospital stay was significantly shorter in VATS lobectomy (10.8<4.1 days; p<0.0001).
Conclusion: The prognosis of VATS lobectomy for cIA lung cancer was equivalent to thoracotomy. We concluded VATS lobectomy could be the standard treatment for cIA lung cancer.View full abstractDownload PDF (677K) -
Masataka Hirabayashi, Masato Okuda, Kazuo Endoh, Masayoshi Teramachi, ...2001 Volume 41 Issue 7 Pages 767-772
Published: December 20, 2001
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSPurpose: This study aimed to determine the maximum tolerated doses of paclitaxel administered weekly in combination with a fixed dose of carboplatin, and to assess the toxicity and preliminary activity of this combination in patients with previously untreated, advanced non-small cell lung cancer.
Patients and Methods: Fifteen patients (10 men and 5 women) were enrolled. The median age was 67 years (range 46 to 76 years). Carboplatin was administered on day 1 (area under the curve=6mg/ml·min), and paclitaxel was administered on days 1, 8, and 15. The starting dose of paclitaxel was 50mg/m2, which was increased in 10mg increments. Chemotherapy was repeated every 4 weeks.
Results: Two of the three level 4 patients (paclitaxel 80mg/m2) experienced dose-limiting toxicities: one patient experienced neutropenic fever with grade 3 diarrhea; the other experienced grade 3 lethargy with grade 3 diarrhea and grade 3 hyponatremia, and the performance status of this patient gradually deteriorated. Thus, 80mg/m2 was defined as the maximum tolerated dose in this schedule. The objective response rate was 46.7%(7/15).
Conclusion: The dose level of paclitaxel 70mg/m2 on days 1, 8, and 15 in combination with carboplatin AUC=6 on day 1 of a four week cycle was recommended for a phase II study.View full abstractDownload PDF (897K) -
Takanari Tokunaga, Naohiko Saku, Shoji Ohno, Yasunori Sohara, Ken Kuri ...2001 Volume 41 Issue 7 Pages 773-777
Published: December 20, 2001
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSBackground: Malignant mesothelioma is relatively rare but is increasing in frequency. Diagnosis can not be made based on the analysis of blood and pleural effusion alone, since the findings are not specific to this tumor. We report a case of malignant mesothelioma similar to empyema in clinical symptoms.
Case: A 55-year-old man was admitted to our hospital with cough, dyspnea and fever. On admission, he had leukocytosis, increased CRP level in serum, and left pleural effusion on chest radiography. Neutrophilia in the pleural effusion suggested empyema. Since his symptoms did not improve under the administration of antibiotics and chest tube drainage, pleurectomy was performed. Post-operative pathological examination revealed a malignant mesothelioma.
Conclusion: Even in patients with fever and leukocytosis, malignant mesothelioma should be considered in the differential diagnosis.View full abstractDownload PDF (3698K) -
Katsuyasu Yamada, Masayuki Suzuki, Yuko Akita, Tomohiko Ogasawara, Toy ...2001 Volume 41 Issue 7 Pages 779-782
Published: December 20, 2001
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSBackground: A granular cell tumor is a soft tissue neoplasm which is thought to originate from Schwann cells. Most granular cell tumors are benign and malignant ones are extremely rare.
Case: The patient was a 61-year-old woman complaining of pain in her right chest. A chest X-ray film showed a mass in the right apex of the pleura. A fine-needle biopsy revealed a tumor that contained large cells typically with granular cyto -plasm. Clinically, we diagnosed the case as malignant granular cell tumor (MGCT), as symptoms progressed with pain worsening and the tumor becoming larger on subsequent x-ray films. Radiotherapy was not effective and the patient died of respiratory failure nine months after the original diagnosis. The autopsy showed a large tumor that could be separated from the lung. Histology revealed large granular cells and spindle cells exhibiting nuclear pleomorphism and necrosis. Immunohistochemically, S-100 protein and vimentin were detected in most tumor cells. In conclusion, we diagnosed this case as MGCT.
Conclusion: On review of the literature, malignant granular cell tumors were found to be extremely rare.View full abstractDownload PDF (2485K) -
Ichiro Takata, Yoshihiko Segawa, Masahiro Tabata, Katsuyuki Kiura, Hir ...2001 Volume 41 Issue 7 Pages 783-785
Published: December 20, 2001
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSBackground: Prognosis of patients with lung cancer developing small bowel metastasis, a rare event, is generally believed extremely poor, but it could be improved by early diagnosis and appropriate treatment. We report two cases with small bowel metastasis with different prognoses.
Cases: Case 1: A 72-year-old man, who had undergone right upper lobectomy seven months previously because of large cell carcinoma of the lung, visited us complaining of abdominal fullness. A huge mass in the small bowel was detected with computed tomography scans of the abdomen, and it was immediately resected. The pathologic diagnosis was metastasis of large cell carcinoma to the jejunum. After receiving adjuvant chemotherapy, the patient has survived for 3 years. Case 2: A 51-year-old man, receiving whole brain irradiation and salvage chemotherapy for brain relapse of large cell carcinoma of the lung after surgical resection, suddenly complained of severe abdominal pain. A chest radiograph revealed free air under the diaphragm. He underwent an emergency laparotomy and resection of the perforated jejunum with perforation. The pathologic diagnosis of the resected specimen was metastasis of large cell carcinoma to the jejunum. He died of brain metastasis one month after surgery.
Conclusion: These cases indicate that the prognosis of patients with lung cancer developing small bowel metastasis can be improved by early detection and intensive treatment of this complication.View full abstractDownload PDF (2091K) -
2001 Volume 41 Issue 7 Pages 786-795
Published: December 20, 2001
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (1900K)
- |<
- <
- 1
- >
- >|