Out of 1180 patients in National Tama Zensei-en Leprosy Hospital between 1938 and 1943 the author's investigation on upper respiratory organ leprosy has enabled him to find the following result.
(1) Clinical observation: Nasal morbidity was found to be 83.1%-in light cases, 97.2% in medium cases, and 992% in serious cases. Pharyngeal and laryngeal morbidity was 18.1-19.3% in light cases, 60.2-71.0% in medium cases, and 96.0-93.6% in serious cases. In the K-type microbes were found in snot to 63.4%, in the N-type to 5.0%, and in the M-type to 6.7%.
As a prodrome epistasis or nasal catarrh was found very few. As an initial symptom rubefacient swellings in nasal mucous membrane, or miliary rashes or nodulous lesions were observed. In cases of lepra maculosa some times tuberculoid macula was produced. The lesions mentioned above caused ulcers which resulted cicatrix atrophy followed by various deformities.
(2) Autopsical observation: Observation on laryngeal leprosy revealed that the hearth is likely to develop on cartilago epigiottic parts and cartilago arytaenoidean parts. Histologically the initial hearth was found around the nerve branches located deep in suhmucons layers. It has a tendency to grow sideward among connective tissues or mucous membranes. when it reaches perichondrium it will cause perichondritis. Lesions in larynx is easier to cure than tuberculous iesiors. In one case healed lesions were often found together with new lesiors, which shows that the circulatory spreading of bacillus leprae is always repeated.

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Out of 1180 patients in National Tama Zensei-en Leprosy Hospital between 1938 and 1943 the author's investigation on upper respiratory organ leprosy has enabled him to find the following result.
(1) Clinical observation: Nasal morbidity was found to be 83.1%-in light cases, 97.2% in medium cases, and 992% in serious cases. Pharyngeal and laryngeal morbidity was 18.1-19.3% in light cases, 60.2-71.0% in medium cases, and 96.0-93.6% in serious cases. In the K-type microbes were found in snot to 63.4%, in the N-type to 5.0%, and in the M-type to 6.7%.
As a prodrome epistasis or nasal catarrh was found very few. As an initial symptom rubefacient swellings in nasal mucous membrane, or miliary rashes or nodulous lesions were observed. In cases of lepra maculosa some times tuberculoid macula was produced. The lesions mentioned above caused ulcers which resulted cicatrix atrophy followed by various deformities.
(2) Autopsical observation: Observation on laryngeal leprosy revealed that the hearth is likely to develop on cartilago epigiottic parts and cartilago arytaenoidean parts. Histologically the initial hearth was found around the nerve branches located deep in suhmucons layers. It has a tendency to grow sideward among connective tissues or mucous membranes. when it reaches perichondrium it will cause perichondritis. Lesions in larynx is easier to cure than tuberculous iesiors. In one case healed lesions were often found together with new lesiors, which shows that the circulatory spreading of bacillus leprae is always repeated.

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The author's 15 year research on mycobacterium leprae murium has been summed up as follows.
(1) Whenever Mycobacterium leprae murium is found out case must be taken to assure the existence of pseudo acid fast morbidity.
(2) Rat leprosy has been divided into two types, a latent and a manifest type, the former is classified into two stages, first and second, and the latter is classified as the third stage.
(3) Citellus and Eutamias had susceptibility of experimental Mycobacterium leprae murium as well as rats and mice.
(4) Biologically a slight katalase reaction was found in Mycobacterium leprae murium. Among the same strains of Mycobacterium leprae murium there is a considerable difference of resistence to heat eaqual to that of boiling. The range of pathogenicity was variable according to strains.
(5) Many experiments on cultivation of Mycobacterium leprae murium through solid culture medium and fluid culture medium have been found short of satisfaction.
On a few initial culture media an increase of bacilli was perceived, successive plantation was found unsuccessful though.
(6) On cultivation, the author and others found some development of pseudo acid fast organisms which has given us a suggestion on experimental cultivation of the bacillus.

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